(R)?-?PIA (BioDeep_00000659056)
代谢物信息卡片
(R)-N-(1-Methyl-2-phenylethyl)adenosine
化学式: C19H23N5O4 (385.17499580000003)
中文名称: (-)-N⁶-(2-苯基异丙基)腺苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=CC=C1)NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O
InChI: InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1
描述信息
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D020011 - Protective Agents
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:184076
- PubChem: 93205
- ChEMBL: CHEMBL139000
- MeSH: Phenylisopropyladenosine
- CAS: 38594-96-6
- CAS: 29-36-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- María Ángeles Ruiz, David Agustín León, José Luis Albasanz, Mairena Martín. Desensitization of adenosine A(1) receptors in rat immature cortical neurons.
European journal of pharmacology.
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Nov; 31(44):15629-39. doi:
10.1523/jneurosci.2526-11.2011. [PMID: 22049406] - Susan K Fried, Thomas Tittelbach, Jacob Blumenthal, Urmila Sreenivasan, Linda Robey, Jamie Yi, Sumbul Khan, Courtney Hollender, Alice S Ryan, Andrew P Goldberg. Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women.
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American journal of physiology. Cell physiology.
2010 Jan; 298(1):C56-65. doi:
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Neuroscience.
2009 Oct; 163(2):524-32. doi:
10.1016/j.neuroscience.2009.06.050. [PMID: 19559760] - Andrei A Ivanov, Ben Wang, Athena M Klutz, Vincent L Chen, Zhan-Guo Gao, Kenneth A Jacobson. Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.
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2008 Apr; 51(7):2088-99. doi:
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2007 Jul; 322(1):332-40. doi:
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2007 May; 48(5):1099-107. doi:
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2007 Apr; 50(8):1810-27. doi:
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2005 Nov; 70(11):1601-12. doi:
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2005 Feb; 270(1-2):209-14. doi:
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Brain research.
2005 Jan; 1031(2):211-21. doi:
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2004 Nov; 68(10):1985-93. doi:
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Molecular and cellular biology.
2004 Apr; 24(7):2710-9. doi:
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2003 Mar; 17(3):279-81. doi:
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Biochimica et biophysica acta.
2002 Dec; 1593(1):69-75. doi:
10.1016/s0167-4889(02)00330-0. [PMID: 12431785] - Timothy J Martin, Kenneth J Broadley. Contractile responses to adenosine, R-PIA and ovalbumen in passively sensitized guinea-pig isolated airways.
British journal of pharmacology.
2002 Nov; 137(6):729-38. doi:
10.1038/sj.bjp.0704902. [PMID: 12411402] - Zhan-Guo Gao, Soo-Kyung Kim, Thibaud Biadatti, Wangzhong Chen, Kyeong Lee, Dov Barak, Seong Gon Kim, Carl R Johnson, Kenneth A Jacobson. Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
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2002 Sep; 45(20):4471-84. doi:
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Molecular pharmacology.
2002 Jul; 62(1):81-9. doi:
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Experimental nephrology.
2002; 10(1):43-50. doi:
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2001 Dec; 142(12):5069-75. doi:
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2001 Aug; 91(2):552-60. doi:
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2001 Mar; 61(6):657-63. doi:
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2000 Jul; 20(14):5164-74. doi:
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The Journal of biological chemistry.
1999 Oct; 274(43):30571-9. doi:
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1998 Mar; 36(3):231-5. doi:
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1998 Feb; 23(2):211-8. doi:
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Molecular pharmacology.
1997 Sep; 52(3):456-64. doi:
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1997 Sep; 36(9):1157-65. doi:
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1995 Jun; 50(1):45-7. doi:
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1995 Jun; 270(23):13987-97. doi:
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Polish journal of pharmacology and pharmacy.
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