Tebufelone (BioDeep_00000655823)

   


代谢物信息卡片


Tebufelone

化学式: C20H28O2 (300.2089)
中文名称: 特丁非隆
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C(=O)CCCC#C
InChI: InChI=1S/C20H28O2/c1-8-9-10-11-17(21)14-12-15(19(2,3)4)18(22)16(13-14)20(5,6)7/h1,12-13,22H,9-11H2,2-7H3

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents

同义名列表

1 个代谢物同义名

Tebufelone



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry. 2004 Feb; 47(5):1242-50. doi: 10.1021/jm030408h. [PMID: 14971904]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry. 2002 Jun; 45(13):2867-76. doi: 10.1021/jm0200409. [PMID: 12061889]
  • R L Dobson, M K Dirr, B L Merkt. Automated gas chromatography/tandem mass spectrometry with on-line chemical derivatization for the determination of tebufelone and two metabolites in human plasma. Journal of mass spectrometry : JMS. 1997 Dec; 32(12):1290-8. doi: 10.1002/(sici)1096-9888(199712)32:12<1290::aid-jms587>3.0.co;2-l. [PMID: 9423282]
  • K R Wehmeyer, P M Knight, R C Parry. Evaluation of a benchtop ion trap gas chromatographic-tandem mass spectrometric instrument for the analysis of a model drug, tebufelone, in plasma using a stable-isotope internal standard. Journal of chromatography. B, Biomedical applications. 1996 Feb; 676(1):53-9. doi: 10.1016/0378-4347(95)00417-3. [PMID: 8852044]
  • C A Cruze, G R Kelm, M P Meredith. Interspecies scaling of tebufelone pharmacokinetic data and application to preclinical toxicology. Pharmaceutical research. 1995 Jun; 12(6):895-901. doi: 10.1023/a:1016273306956. [PMID: 7667197]
  • R L Dobson, G R Kelm, D M Neal. Automated gas chromatography/tandem mass spectrometry assay for tebufelone and a 13C,(18)O-labeled analog in plasma: applicabilityto absolute bioavailability determination. Biological mass spectrometry. 1994 Feb; 23(2):75-81. doi: 10.1002/bms.1200230206. [PMID: 8123692]
  • M J Doyle, T H Eichhold, M E Loomans, R W Farmer, G R Kelm. Comparison of tebufelone distribution in rat blood plasma and inflamed and noninflamed tissues following peroral and intravenous administration. Journal of pharmaceutical sciences. 1993 Aug; 82(8):847-50. doi: 10.1002/jps.2600820819. [PMID: 8377126]
  • W K Sietsema, G R Kelm, R M Deibel, M J Doyle, M E Loomans, R E Smyth, G O Kinnett, T H Eichhold, R W Farmer. Absorption, bioavailability, and pharmacokinetics of tebufelone in the rat. Journal of pharmaceutical sciences. 1993 Jun; 82(6):610-2. doi: 10.1002/jps.2600820613. [PMID: 8331535]
  • R L Dobson, D M Neal, B R DeMark, S R Ward. Long-term performance of a gas chromatography/tandem mass spectrometry assay for tebufelone in plasma. Analytical chemistry. 1990 Sep; 62(17):1819-24. doi: 10.1021/ac00216a017. [PMID: 2240571]
  • T H Eichhold, M J Doyle. Determination of tebufelone, a new anti-inflammatory drug, in plasma and tissue using capillary gas chromatography/stable isotope dilution mass spectrometry. Biomedical & environmental mass spectrometry. 1990 Apr; 19(4):230-4. doi: 10.1002/bms.1200190405. [PMID: 2340361]
  • M J Doyle, T H Eichhold, B A Hynd, S M Weisman. Determination of leukotriene B4 in human plasma by gas chromatography using a mass selective detector and a stable isotope labelled internal standard. Effect of NE-11740 on arachidonic acid metabolism. Journal of pharmaceutical and biomedical analysis. 1990; 8(2):137-42. doi: 10.1016/0731-7085(90)80020-p. [PMID: 1965571]