Sulotroban (BioDeep_00000655806)

   


代谢物信息卡片


Sulotroban

化学式: C16H17NO5S (335.08273920000005)
中文名称: 磺曲苯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)S(=O)(=O)NCCC2=CC=C(C=C2)OCC(=O)O
InChI: InChI=1S/C16H17NO5S/c18-16(19)12-22-14-8-6-13(7-9-14)10-11-17-23(20,21)15-4-2-1-3-5-15/h1-9,17H,10-12H2,(H,18,19)

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
D050299 - Fibrin Modulating Agents

同义名列表

1 个代谢物同义名

Sulotroban



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Liang-Wu Fu, Andrew Phan, John C Longhurst. Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2?. American journal of physiology. Heart and circulatory physiology. 2008 Dec; 295(6):H2530-40. doi: 10.1152/ajpheart.00790.2008. [PMID: 18952714]
  • J M Dogné, X de Leval, P Neven, S Rolin, J Wauters, J L David, J Delarge, B Massereel. Effects of a novel non-carboxylic thromboxane A2 receptor antagonist (BM-531) derived from torasemide on platelet function. Prostaglandins, leukotrienes, and essential fatty acids. 2000 May; 62(5):311-7. doi: 10.1054/plef.2000.0160. [PMID: 10883063]
  • T Ogawa, A Sugidachi, F Asai, H Koike. Involvement of platelet-derived 5-hydroxytryptamine in thromboxane A2-induced aggregation in cat platelets. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 1998 Apr; 9(3):233-40. doi: 10.1097/00001721-199804000-00003. [PMID: 9663705]
  • D Komiotis, J D Wencel-Drake, J P Dieter, C T Lim, G C Le Breton. Labeling of human platelet plasma membrane thromboxane A2/prostaglandin H2 receptors using SQB, a novel biotinylated receptor probe. Biochemical pharmacology. 1996 Sep; 52(5):763-70. doi: 10.1016/0006-2952(96)00359-0. [PMID: 8765474]
  • L Somova. Prostaglandin H2/thromboxane A2 pathway in platelet aggregation and activity of Dahl salt-sensitive rat--a sulotroban study. Methods and findings in experimental and clinical pharmacology. 1996 Jun; 18(5):309-13. doi: . [PMID: 8817465]
  • L Brizio-Molteni, H M Loick, L D Traber, D L Traber, A Molteni. Plasma copper and iron changes in sheep after left lung inhalation injury: effect of the thromboxane antagonist BM 13.177 (Solutroban). The Journal of burn care & rehabilitation. 1995 Jan; 16(1):16-22. doi: 10.1097/00004630-199501000-00003. [PMID: 7721903]
  • K Uriu, K Kaizu, O Hashimoto, N Komine, S Etoh. Acute and chronic effects of thromboxane A2 inhibition on the renal hemodynamics in streptozotocin-induced diabetic rats. Kidney international. 1994 Mar; 45(3):794-802. doi: 10.1038/ki.1994.105. [PMID: 8196281]
  • R A Armstrong, P P Humphrey, P Lumley. Reduction in the number of thromboxane receptors on human platelets after exposure to GR32191. British journal of pharmacology. 1993 Oct; 110(2):548-52. doi: 10.1111/j.1476-5381.1993.tb13845.x. [PMID: 8242229]
  • H J Kramer, M G Mohaupt, F Pinoli, A Bäcker, H Meyer-Lehnert, H Schlebusch. Effects of thromboxane A2 receptor blockade on oliguric ischemic acute renal failure in conscious rats. Journal of the American Society of Nephrology : JASN. 1993 Jul; 4(1):50-7. doi: 10.1681/asn.v4150. [PMID: 8400069]
  • E Ohshima, H Sato, H Obase, I Miki, A Ishii, M Kawakage, S Shirakura, A Karasawa, K Kubo. Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule. Journal of medicinal chemistry. 1993 May; 36(11):1613-8. doi: 10.1021/jm00063a011. [PMID: 8496929]
  • T Tomiyama, M Yokota, S Wakabayashi, K Kosakai, T Yanagisawa. Design, synthesis, and pharmacology of 3-substituted sodium azulene-1-sulfonates and related compounds: non-prostanoid thromboxane A2 receptor antagonists. Journal of medicinal chemistry. 1993 Apr; 36(7):791-800. doi: 10.1021/jm00059a001. [PMID: 8464032]
  • G Lueddeckens, H Bigl, J Sperling, K Becker, P Braquet, W Förster. Importance of secondary TXA2 release in mediating of endothelin-1 induced bronchoconstriction and vasopressin in the guinea-pig. Prostaglandins, leukotrienes, and essential fatty acids. 1993 Mar; 48(3):261-3. doi: 10.1016/0952-3278(93)90095-e. [PMID: 8469685]
  • R J Lonsdale, S Heptinstall, J C Westby, D C Berridge, P W Wenham, B R Hopkinson, G S Makin. A study of the use of the thromboxane A2 antagonist, sulotroban, in combination with streptokinase for local thrombolysis in patients with recent peripheral arterial occlusions: clinical effects, platelet function and fibrinolytic parameters. Thrombosis and haemostasis. 1993 Feb; 69(2):103-11, 123. doi: 10.1055/s-0038-1651563. [PMID: 8456421]
  • B Brüne, V Ullrich. Cyclic nucleotides and intracellular-calcium homeostasis in human platelets. European journal of biochemistry. 1992 Jul; 207(2):607-13. doi: 10.1111/j.1432-1033.1992.tb17087.x. [PMID: 1321718]
  • A A Horton, J M Wood. Prevention of Ca(2+)-induced or thromboxane B2-induced hepatocyte plasma membrane bleb formation by thromboxane receptor antagonists. Biochimica et biophysica acta. 1991 Dec; 1133(1):31-7. doi: 10.1016/0167-4889(91)90238-s. [PMID: 1836358]
  • Z S Ercan, S Sindel, R Türker. Possible thromboxane A2 mediated effect of angiotensin II in the rabbit isolated perfused kidney. Archives internationales de physiologie, de biochimie et de biophysique. 1991 Dec; 99(6):397-400. doi: NULL. [PMID: 1725738]
  • W A Mann, G E Welzel, R S Goldstein, R S Sozio, M J Cyronak, J Kao, L B Kinter. Characterization of the renal effects and renal elimination of sulotroban in the dog. The Journal of pharmacology and experimental therapeutics. 1991 Dec; 259(3):1231-40. doi: NULL. [PMID: 1762070]
  • A Karasawa, M Kawakage, S Shirakura, K Higo, K Kubo, E Ohshima, H Obase. Antiplatelet effects of the novel thromboxane A2 receptor antagonist sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)-ethylidene]-6,11- dihydrodibenz[b,e] oxepine-2-carboxylate monohydrate. Arzneimittel-Forschung. 1991 Dec; 41(12):1230-6. doi: NULL. [PMID: 1840011]
  • A A Horton, J M Wood. Prevention of paracetamol-induced hepatotoxicity in the rat by the thromboxane receptor antagonist, Sulotroban (BM 13177). Journal of lipid mediators. 1991 Sep; 4(2):245-7. doi: ". [PMID: 1835408]
  • A O Oyekan, J C McGiff, J Quilley. Cytochrome P-450-dependent vasodilator responses to arachidonic acid in the isolated, perfused kidney of the rat. Circulation research. 1991 Apr; 68(4):958-65. doi: 10.1161/01.res.68.4.958. [PMID: 1901256]
  • J M Wood, A A Horton. A possible role for eicosanoids in ATP-induced plasma membrane bleb formation in isolated hepatocytes. Biochemical Society transactions. 1991 Apr; 19(2):230S. doi: 10.1042/bst019230s. [PMID: 1909660]
  • T Ito, F Asai, T Oshima, S Kobayashi. Role of activated platelets in endotoxin-induced DIC in rats. Thrombosis research. 1990 Aug; 59(4):735-47. doi: 10.1016/0049-3848(90)90055-h. [PMID: 2080492]
  • J Das, S E Hall, M Nakane, M F Haslanger, J A Reid, D Garber, V C Truc, D N Harris, A Hedberg, M L Ogletree. 9,11-epoxy-9-homoprosta-5-enoic acid analogues as thromboxane A2 receptor antagonists. Journal of medicinal chemistry. 1990 Jun; 33(6):1741-8. doi: 10.1021/jm00168a032. [PMID: 2140414]
  • D de Chaffoy de Courcelles, F De Clerck. Effect of thromboxane A2 synthetase inhibition, singly and combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on inositol phospholipid turnover and on 5-HT release by washed human platelets. European journal of pharmacology. 1990 Mar; 188(2-3):161-9. doi: 10.1016/0922-4106(90)90051-x. [PMID: 2318257]
  • M Ohtani, M Narisada. Synthesis and in vitro activity of stereoisomers of a novel thromboxane receptor antagonist, (+-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo [2.2.1]hept-2-exo-yl]heptenoic acid. Journal of medicinal chemistry. 1990 Mar; 33(3):1027-31. doi: 10.1021/jm00165a022. [PMID: 2137879]
  • C Piper, C Staiger, Y Jumeau-Ziemendorff, V Uebis, B Kaufmann, K Stein. Pharmacokinetics of the thromboxane A2 receptor antagonist sulotroban (BM 13.177) in renal failure. British journal of clinical pharmacology. 1989 Sep; 28(3):281-8. doi: 10.1111/j.1365-2125.1989.tb05428.x. [PMID: 2528984]
  • G A Kopia, L J Kopaciewicz, E H Ohlstein, S Horohonich, B L Storer, R J Shebuski. Combination of the thromboxane receptor antagonist, sulotroban (BM 13.177; SK&F 95587), with streptokinase: demonstration of thrombolytic synergy. The Journal of pharmacology and experimental therapeutics. 1989 Sep; 250(3):887-95. doi: NULL. [PMID: 2528630]
  • A Ernst, J Syka, A Riedel, H J Mest. Local effects of PAF in guinea-pig inner ear. Journal of lipid mediators. 1989 Sep; 1(5):297-301. doi: ". [PMID: 2535272]
  • P Gresele, H Deckmyn, J Arnout, G G Nenci, J Vermylen. Characterization of N,N'-bis(3-picolyl)-4-methoxy-isophtalamide (picotamide) as a dual thromboxane synthase inhibitor/thromboxane A2 receptor antagonist in human platelets. Thrombosis and haemostasis. 1989 Jun; 61(3):479-84. doi: NULL. [PMID: 2552606]
  • A Pierucci, B M Simonetti, G Pecci, G Mavrikakis, S Feriozzi, G A Cinotti, P Patrignani, G Ciabattoni, C Patrono. Improvement of renal function with selective thromboxane antagonism in lupus nephritis. The New England journal of medicine. 1989 Feb; 320(7):421-5. doi: 10.1056/nejm198902163200703. [PMID: 2643773]
  • J Quilley, J C McGiff, A Nasjletti. Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat. British journal of pharmacology. 1989 Jan; 96(1):111-6. doi: 10.1111/j.1476-5381.1989.tb11790.x. [PMID: 2522332]
  • S Stürzebecher, W Witt. The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation. Prostaglandins. 1988 Dec; 36(6):751-60. doi: 10.1016/0090-6980(88)90053-6. [PMID: 2469101]
  • W J van der Giessen, F J Zijlstra, L Berk, P D Verdouw. The effect of the thromboxane receptor antagonist BM 13.177 on experimentally induced coronary artery thrombosis in the pig. European journal of pharmacology. 1988 Mar; 147(2):241-8. doi: 10.1016/0014-2999(88)90782-0. [PMID: 2966742]
  • A H Köhler, A R Köhler, C Taube, H J Mest. Decrease in arterial blood pressure in spontaneously hypertensive rats by the TXA2 receptor antagonist BM 13177 and by acetylsalicylic acid. Biomedica biochimica acta. 1988; 47(10-11):S269-73. doi: NULL. [PMID: 2977724]
  • B Müller, M Schmidtke, W Witt. Adherence of leucocytes to electrically damaged venules in vivo. Effects of iloprost, PGE1, indomethacin, forskolin, BW 755 C, sulotroban, hirudin, and thrombocytopenia. Eicosanoids. 1988; 1(1):13-7. doi: . [PMID: 2483344]
  • P Gresele, J Arnout, H Deckmyn, E Huybrechts, G Pieters, J Vermylen. Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism. The Journal of clinical investigation. 1987 Nov; 80(5):1435-45. doi: 10.1172/jci113223. [PMID: 2960694]
  • A R Saniabadi, G D Lowe, R Madhok, K Spowart, B Shaw, J C Barbenel, C D Forbes. Red blood cells mediate spontaneous aggregation of platelets in whole blood. Atherosclerosis. 1987 Aug; 66(3):175-80. doi: 10.1016/0021-9150(87)90061-x. [PMID: 2443148]
  • P Hüttemeier, K Eliasen, T Mogensen, M Bell, J N Sørensen, J Qvist. Effects of a thromboxane antagonist (BM 13.177) during endotoxin-induced pulmonary vasoconstriction in sheep. Clinical physiology (Oxford, England). 1986 Oct; 6(5):415-22. doi: 10.1111/j.1475-097x.1986.tb00072.x. [PMID: 3536270]
  • S Hamid-Bloomfield, B J Whittle. Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets. British journal of pharmacology. 1986 Aug; 88(4):931-6. doi: 10.1111/j.1476-5381.1986.tb16268.x. [PMID: 3017497]
  • H Riess, B Höfling, T von Arnim, E Hiller. Thromboxane receptor blockade versus cyclooxigenase inhibition: antiplatelet effects in patients. Thrombosis research. 1986 Apr; 42(2):235-45. doi: 10.1016/0049-3848(86)90299-9. [PMID: 3012819]
  • K Schrör, C Thiemermann. Treatment of acute myocardial ischaemia with a selective antagonist of thromboxane receptors (BM 13.177). British journal of pharmacology. 1986 Apr; 87(4):631-7. doi: 10.1111/j.1476-5381.1986.tb14579.x. [PMID: 3011166]
  • H Patscheke, C Staiger, G Neugebauer, B Kaufmann, K Strein, R Endele, K Stegmeier. The pharmacokinetic and pharmacodynamic profiles of the thromboxane A-2 receptor blocker BM 13.177. Clinical pharmacology and therapeutics. 1986 Feb; 39(2):145-50. doi: 10.1038/clpt.1986.25. [PMID: 3002702]
  • C Staiger, H Patscheke, G Neugebauer, B Kaufmann, K Strein, R Endele, K Stegmeier. Single dose pharmacokinetics and effects on platelet function of the thromboxane receptor blocker BM 13.177. European journal of clinical pharmacology. 1986; 29(5):573-9. doi: 10.1007/bf00635895. [PMID: 3754215]
  • H Patscheke. Thromboxane synthase inhibition potentiates washed platelet activation by endogenous and exogenous arachidonic acid. Biochemical pharmacology. 1985 Apr; 34(8):1151-6. doi: 10.1016/0006-2952(85)90488-5. [PMID: 3922373]
  • H Riess, E Hiller, B Reinhardt, C Bräuning. Effects of BM 13.177, a new antiplatelet drug in patients with atherosclerotic disease. Thrombosis research. 1984 Aug; 35(4):371-8. doi: 10.1016/0049-3848(84)90229-9. [PMID: 6237460]
  • I M Nilsson, S E Bergentz, U Hedner, K Kullenberg. Gastric fibrinolysis. Thrombosis et diathesis haemorrhagica. 1975 Nov; 34(2):409-18. doi: 10.1055/s-0038-1651400. [PMID: 807]