Recainam (BioDeep_00000655703)
代谢物信息卡片
化学式: C15H25N3O (263.199752)
中文名称: 瑞卡南
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=CC=C1)C)NC(=O)NCCCNC(C)C
InChI: InChI=1S/C15H25N3O/c1-11(2)16-9-6-10-17-15(19)18-14-12(3)7-5-8-13(14)4/h5,7-8,11,16H,6,9-10H2,1-4H3,(H2,17,18,19)
描述信息
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - J W Cheng, S L Charland, S Goldfarb, S A Spinler. Effects of renal function on recainam pharmacokinetics and pharmacodynamics.
Clinical pharmacology and therapeutics.
1995 May; 57(5):492-8. doi:
10.1016/0009-9236(95)90033-0. [PMID: 7768071] - J L Anderson, C P Reddy, R J Myerburg, H L Waxman, P J de Vane. Antiarrhythmic and pharmacokinetic evaluation of intravenous recainam in patients with frequent ventricular premature complexes and unsustained ventricular tachycardia.
The American journal of cardiology.
1993 Mar; 71(8):686-94. doi:
10.1016/0002-9149(93)91011-6. [PMID: 8447266] - S M Troy, W H Cevallos, K A Conrad, S T Chiang, J R Latts. The absolute bioavailability and dose proportionality of intravenous and oral dosage regimens of recainam.
Journal of clinical pharmacology.
1991 May; 31(5):433-9. doi:
10.1002/j.1552-4604.1991.tb01899.x. [PMID: 2050828] - J A Scatina, D S Wells, H B Kimmel, C J Kemper, S F Sisenwine. Excretion and metabolism of recainam, a new anti-arrhythmic drug, in laboratory animals and humans.
Drug metabolism and disposition: the biological fate of chemicals.
1990 Sep; 18(5):746-52. doi:
NULL. [PMID: 1981731] - J A Scatina, H B Kimmel, V Weinstein, S M Troy, S F Sisenwine, M N Cayen. Species differences in the pharmacokinetics of recainam, a new anti-arrhythmic drug.
Biopharmaceutics & drug disposition.
1990 Jul; 11(5):445-61. doi:
10.1002/bdd.2510110508. [PMID: 2207297] - R F Davies, M D Lineberry, C Funck-Brentano, D S Echt, J T Lee, D M Capuzzi, D M Roden, R L Woosley. Recainam dose titration and pharmacokinetics in patients with resistant arrhythmias.
Clinical pharmacology and therapeutics.
1989 Sep; 46(3):324-34. doi:
10.1038/clpt.1989.146. [PMID: 2673622] - L H Frame, J H Sheldon. Effect of recainam on the energy required for ventricular defibrillation in dogs as assessed with implanted electrodes.
Journal of the American College of Cardiology.
1988 Sep; 12(3):746-52. doi:
10.1016/0735-1097(88)90316-6. [PMID: 3403835] - T J Colatsky, L B Bird, J A Knowles. Cardiac electrophysiology of the antiarrhythmic agent recainam (Wy-42,362) in anesthetized dogs: relation to plasma and myocardial concentrations.
Journal of cardiovascular pharmacology.
1988 Mar; 11(3):308-16. doi:
10.1097/00005344-198803000-00007. [PMID: 2452923] - E M Hampton, M I Anastasiou-Nana, J N Nanas, J M Nappi, D M Capuzzi, J L Anderson. The disposition of recainam hydrochloride during and after intravenous loading and maintenance infusion in cardiac patients.
Journal of clinical pharmacology.
1987 Dec; 27(12):951-6. doi:
10.1002/j.1552-4604.1987.tb05595.x. [PMID: 3437067] - J L Anderson, M I Anastasiou-Nana, B M Heath, R L Menlove, J N Nanas, J Friedman. Efficacy of recainam, a new antiarrhythmic drug, for control of ventricular arrhythmias.
The American journal of cardiology.
1987 Aug; 60(4):281-7. doi:
10.1016/0002-9149(87)90228-1. [PMID: 2441587]