norethandrolone (BioDeep_00000654755)
代谢物信息卡片
化学式: C20H30O2 (302.224568)
中文名称: 诺乙雄龙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C)O
InChI: InChI=1S/C20H30O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h12,15-18,22H,3-11H2,1-2H3/t15-,16+,17+,18-,19-,20-/m0/s1
描述信息
A - Alimentary tract and metabolism > A14 - Anabolic agents for systemic use > A14A - Anabolic steroids > A14AA - Androstan derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D045930 - Anabolic Agents
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:135282
- KEGGdrug: D07127
- PubChem: 5858
- DrugBank: DB12787
- ChEMBL: CHEMBL1697845
- MeSH: Norethandrolone
- CAS: 52-78-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Edna Grünblatt, Jasmin Bartl, Zoya Marinova, Susanne Walitza. In vitro study methodologies to investigate genetic aspects and effects of drugs used in attention-deficit hyperactivity disorder.
Journal of neural transmission (Vienna, Austria : 1996).
2013 Jan; 120(1):131-9. doi:
10.1007/s00702-012-0869-9
. [PMID: 22833045] - Francesco Arioli, Matteo P Gavinelli, Maria L Fracchiolla, Alessio Casati, Marco Fidani, Emilia Ferrer, Giuseppe Pompa. Evaluation of boldenone formation and related steroids transformations in veal faeces by liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2008; 22(2):217-23. doi:
10.1002/rcm.3361
. [PMID: 18085508] - Christine Trivin, Eliane Gluckman, Thierry Leblanc, Marie-Noëlle Cousin, Jean Soulier, Raja Brauner. Factors and markers of growth hormone secretion and gonadal function in Fanconi anemia.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
2007 Apr; 17(2):122-9. doi:
10.1016/j.ghir.2006.12.007
. [PMID: 17336561] - Marco Fidani, Eleonora Casagni, Marco Montana, Emanuela Pasello, Chiara Pecoraro, Veniero Gambaro. Rapid test by liquid chromatography/tandem mass spectrometry to evaluate equine urine reactivity towards 17beta-OH steroids.
Rapid communications in mass spectrometry : RCM.
2006; 20(16):2441-6. doi:
10.1002/rcm.2608
. [PMID: 16862626] - Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murphy. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter.
Neuropharmacology.
2005 Nov; 49(6):798-810. doi:
10.1016/j.neuropharm.2005.08.010
. [PMID: 16183083] - Jitka Kuncová, Jitka Svíglerová, Zbynek Tonar, Jana Slavíková. Heterogenous changes in neuropeptide Y, norepinephrine and epinephrine concentrations in the hearts of diabetic rats.
Autonomic neuroscience : basic & clinical.
2005 Aug; 121(1-2):7-15. doi:
10.1016/j.autneu.2005.05.005
. [PMID: 15955747] - A R McKinney, D D Ridley, C J Suann. The metabolism of norethandrolone in the horse: characterization of 16-, 20- and 21-oxygenated metabolites by gas chromatography/mass spectrometry.
Journal of mass spectrometry : JMS.
2001 Feb; 36(2):145-50. doi:
10.1002/jms.111
. [PMID: 11288196] - M Van Puymbroeck, M E Kuilman, R F Maas, R F Witkamp, L Leyssens, A S Van Miert, L Hendriks, D Vanderzande, P Adriaensens, M P Jacobs, J Raus. 17alpha-ethyl-5beta-estrane-3alpha, 17beta-diol, a biological marker for the abuse of norethandrolone and ethylestrenol in slaughter cattle.
Journal of chromatography. B, Biomedical sciences and applications.
1999 May; 728(2):217-32. doi:
10.1016/s0378-4347(99)00091-2
. [PMID: 10406207] - F H Bronson, C M Matherne. Exposure to anabolic-androgenic steroids shortens life span of male mice.
Medicine and science in sports and exercise.
1997 May; 29(5):615-9. doi:
10.1097/00005768-199705000-00005
. [PMID: 9140897] - H F De Brabander, P Batjoens, D Courtheyn, J Vercammen, K De Wasch. Comparison of the possibilities of gas chromatography-mass spectrometry and tandem mass spectrometry systems for the analysis of anabolics in biological material.
Journal of chromatography. A.
1996 Oct; 750(1-2):105-14. doi:
10.1016/0021-9673(96)00411-6
. [PMID: 8938384] - J Segura, J A Pascual, R Ventura, J I Ustaran, A Cuevas, R Gonzalez. International cooperation in analytical chemistry: experience of antidoping control at the XI Pan American Games.
Clinical chemistry.
1993 May; 39(5):836-45. doi:
NULL
. [PMID: 8485874] - C S Liu, J Zhang, T H Zhou. [GC-MS analysis of norethandrolone and its metabolites in man].
Yao xue xue bao = Acta pharmaceutica Sinica.
1991; 26(10):777-81. doi:
NULL
. [PMID: 1823721] - C Stebler, A Tichelli, A Gratwohl, T Hoffmann, C Nissen, B Speck. Androgen dependence in patients with severe aplastic anemia after antilymphocyte globuline therapy.
Bone marrow transplantation.
1991; 7 Suppl 2(?):101. doi:
NULL
. [PMID: 1878664] - B Zumoff. Norethandrolone produces temporary loss of the ability to escape from salt-retaining steroids.
Steroids.
1989 Jan; 53(1-2):233-40. doi:
10.1016/0039-128x(89)90155-4
. [PMID: 2772969] - A Rolland, J C Job. [Treatment of pituitary nanism: is it necessary to treat adrenal androgen deficiency?].
Archives francaises de pediatrie.
1984 Jun; 41(6):381-4. doi:
NULL
. [PMID: 6237627] - R Vilalta, J J Ortega, G Javier, J Tusell. [Acquired aplastic anemia in children. Therapy using androgens and antilymphocyte gamma globulin].
Anales espanoles de pediatria.
1984 Feb; 20(2):91-9. doi:
NULL
. [PMID: 6370064] - B Speck, A Gratwohl, C Nissen, B Osterwalder, E Signer, M Jeannet. Treatment of severe aplastic anemia: a prospective study of antilymphocyte globulin versus bone marrow transplantation.
Progress in clinical and biological research.
1984; 148(?):249-58. doi:
NULL
. [PMID: 6379663] - M Beran, G Spitzer, D S Verma. Testosterone and synthetic and androgens improve the in vitro survival of human marrow progenitor cells in serum-free suspension cultures.
The Journal of laboratory and clinical medicine.
1982 Feb; 99(2):247-53. doi:
. [PMID: 7061919]
- P Cornu, B Speck, A Gratwohl, C Nissen, J Sartorius, M Jeannet. [Immunosuppression, bone marrow infusion and low dose androgens, successful therapy of severe aplastic anemia].
Schweizerische medizinische Wochenschrift.
1979 Sep; 109(37):1384-5. doi:
NULL
. [PMID: 384511] - V A Rogozkin, V I Morozov, V S Tchaikovsky. Rapid radioimmunoassay for anabolic steroids in urine.
Schweizerische Zeitschrift fur Sportmedizin.
1979; 27(4):169-73. doi:
NULL
. [PMID: 547418] - R J Ward, A M Lawson, C H Shackleton. Metabolism of anabolic steroid drugs in man and the marmoset monkey (Callithrix jacchus)--I. Nilevar and Orabolin.
Journal of steroid biochemistry.
1977 Oct; 8(10):1057-63. doi:
10.1016/0022-4731(77)90274-6
. [PMID: 410996] - G Lambert, J Brodeur. [Influence of various enzyme inductors and combinations of inductors on DDT residue elimination in rats].
Revue canadienne de biologie.
1976 Mar; 35(1):33-41. doi:
NULL
. [PMID: 1273350] - W M Watrous, R Lacombe, J Brodeur. The effect of norethandrolone on organic ion transport by rat renal cortical slices.
Canadian journal of physiology and pharmacology.
1975 Oct; 53(5):748-54. doi:
10.1139/y75-104
. [PMID: 1201480] - I D Walker, J F Davidson, P Young, J A Conkie. Effect of anabolic steroids on plasma antithrombin III. alpha2 macroglobulin and alpha1 antitrypsin levels.
Thrombosis et diathesis haemorrhagica.
1975 Sep; 34(1):106-14. doi:
. [PMID: 52896]
- R J Ward, C H Shackleton, A M Lawson. Gas chromatographic - mass spectrometric methods for the detection and identification of anabolic steroid drugs.
British journal of sports medicine.
1975 Jul; 9(2):93-7. doi:
10.1136/bjsm.9.2.93
. [PMID: 1182417] - P F Brenner, G S Bernstein, S Roy, E W Jecht, D R Mishell. Administration of norethandrolone and testosterone as a contraceptive agent for men.
Contraception.
1975 Feb; 11(2):193-207. doi:
10.1016/0010-7824(75)90030-x
. [PMID: 1112088] - E N Wardle, W Schardt, P R Uldall, A Brown, D Jonfiah, A Moore, R Park, E Wood. Study of the lipid-lowering action of choloxin and nilevar in patients with chronic renal failure.
Postgraduate medical journal.
1974 Dec; 50(590):737-40. doi:
10.1136/pgmj.50.590.737
. [PMID: 4469041] - J T McCormick, J Senior. The effect of sex hormones on plasma kininogen levels in the rat.
Archives internationales de pharmacodynamie et de therapie.
1974 Aug; 210(2):221-31. doi:
NULL
. [PMID: 4441190] - A G Vagenakis, C Hamilton, F Maloof, L E Braverman, S H Ingbar. The concentration and binding of thyroxine in the serum of patients with the testicular feminization syndrome: observations on the effects of ethinyl estradiol and norethandrolone.
The Journal of clinical endocrinology and metabolism.
1972 Feb; 34(2):327-31. doi:
10.1210/jcem-34-2-327
. [PMID: 4621809] - J Barbosa, U S Seal, R P Doe. Effects of anabolic steroids on haptoglobin, orosomucoid, plasminogen, fibrinogen, transferrin, ceruloplasmin, alpha-1-antitrypsin, beta-glucuronidase and total serum proteins.
The Journal of clinical endocrinology and metabolism.
1971 Sep; 33(3):388-98. doi:
10.1210/jcem-33-3-388
. [PMID: 4105857] - L E Braverman, T AvRuskin, M J Cullen, A G Vagenakis, S H Ingbar. Effects of norethandrolone on the transport and peripheral metabolism of thyroxine in patients lacking thyroxine-binding globulin. Observations on the physiological role of thyroxine-binding prealbumin.
The Journal of clinical investigation.
1971 Aug; 50(8):1644-9. doi:
10.1172/jci106653
. [PMID: 4106461] - J Barbosa, U S Seal, R P Doe. Effects of anabolic steroids on hormone-binding proteins, serum cortisol and serum nonprotein-bound cortisol.
The Journal of clinical endocrinology and metabolism.
1971 Feb; 32(2):232-40. doi:
10.1210/jcem-32-2-232
. [PMID: 4992507] - A Despopoulos. Hepatic and renal excretory metabolism of bile salts: a background for understanding steroid-induced cholestasis.
The Journal of pharmacology and experimental therapeutics.
1971 Feb; 176(2):273-83. doi:
NULL
. [PMID: 4254976] - P M Adhikary, R A Harkness. The use of carbon skeleton chromatography for the detection of steroid drug metabolites: the metabolism of anabolic steroids in man.
Acta endocrinologica.
1971; 67(4):721-32. doi:
10.1530/acta.0.0670721
. [PMID: 5109144] - B Zumoff, J Fishman, J Levin, T F Gallagher, L Hellman. Reversible reproduction of the abnormal estradiol metabolism of biliary obstruction by administration of norethandrolone.
The Journal of clinical endocrinology and metabolism.
1970 May; 30(5):598-601. doi:
10.1210/jcem-30-5-598
. [PMID: 5444551] - J A Thomas, E T Knych, M W Mawhinney, S R Smith. Action of various 19-norsteroids on the uptake of radioactive testosterone by sex accessory organs of the mouse.
European journal of pharmacology.
1970 Feb; 9(2):235-8. doi:
10.1016/0014-2999(70)90305-5
. [PMID: 5437158] - J L de Gennes, E Karame, B de Tregomain. [Therapeutic experience in 7 cases of hypophyseal dwarfism treated by human growth hormone].
Annales d'endocrinologie.
1970 Jan; 31(1):131-43. doi:
NULL
. [PMID: 4314693] - C L Mendenhall. Anabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosis.
The American journal of digestive diseases.
1968 Sep; 13(9):783-91. doi:
10.1007/bf02233094
. [PMID: 5672729] - L E Braverman, E L Socolow, K A Woeber, S H Ingbar. Effect of norethandrolone on the metabolism of 125-I-labeled thyroxine-binding prealbumin.
The Journal of clinical endocrinology and metabolism.
1968 Jun; 28(6):831-5. doi:
10.1210/jcem-28-6-831
. [PMID: 4968525] - B Zumoff, H L Bradlow, J Cassouto, T F Gallagher, L Hellman. Reversible reproduction of the abnormal cortisol metabolite pattern of cirrhosis by administration of norethandrolone.
The Journal of clinical endocrinology and metabolism.
1968 Jan; 28(1):92-9. doi:
10.1210/jcem-28-1-92
. [PMID: 5635451] - M H Sigler, B Issekutz. Effects of anabolic steroids in chronic renal failure. I. Short-term effects.
Archives of internal medicine.
1967 Oct; 120(4):408-16. doi:
NULL
. [PMID: 6058096] - B C Ashley, H M Whyte. Studies in acute undernutrition: the effects of carbohydrate, coritsone and anabolic hormone on protein, water and electrolyte metabolism.
The Australian journal of experimental biology and medical science.
1967 Jun; 45(3):245-59. doi:
NULL
. [PMID: 6058106] - M Reed. The effect of norethandrolone (Nilevar) on serum proteins in the female guinea-pig.
The Journal of endocrinology.
1967 Mar; 37(3):253-60. doi:
10.1677/joe.0.0370253
. [PMID: 6020254] - L E Braverman, S H Ingbar. Effects of norethandrolone on the transport in serum and peripheral turnover of thyroxine.
The Journal of clinical endocrinology and metabolism.
1967 Mar; 27(3):389-96. doi:
10.1210/jcem-27-3-389
. [PMID: 4164659] - M Schmid. [Pruritus from the view of the internist].
Praxis.
1967 Feb; 56(6):208-13. doi:
NULL
. [PMID: 5631567] - I Kriskó, J B Walker. Influence of sex hormones on amidinotransferase levels. Metabolic control of creatine biosynthesis.
Acta endocrinologica.
1966 Dec; 53(4):655-62. doi:
10.1530/acta.0.0530655
. [PMID: 5953691] - A L Rosenbloom. Growth hormone replacement therapy.
JAMA.
1966 Oct; 198(4):364-8. doi:
NULL
. [PMID: 4162161] - S Ishihara. [Experimental studies on the aromatization of synthetic progestins].
Nihon Naibunpi Gakkai zasshi.
1966 Apr; 42(1):55-68. doi:
10.1507/endocrine1927.42.1_55
. [PMID: 6007485] - G J Hamwi, F A Kruger, M J Eymontt, D G Scarpelli, G Gwinup, R Byron. Lipoatrophic diabetes.
Diabetes.
1966 Apr; 15(4):262-8. doi:
10.2337/diab.15.4.262
. [PMID: 5929541] - J GROSSMAN, A A YALOW. EFFECTS OF ANABOLIC STEROIDS ON ALBUMIN METABOLISM.
The Journal of clinical endocrinology and metabolism.
1965 May; 25(?):698-707. doi:
10.1210/jcem-25-5-698
. [PMID: 14313764] - Y YOSHITOSHI. [THE METABOLIC EFFECT OF ANABOLIC STEROIDS AND THEIR CLINICAL APPLICATION].
Nihon Naibunpi Gakkai zasshi.
1964 Dec; 40(?):1155-65. doi:
NULL
. [PMID: 14267839] - S H INGBAR, C WATERHOUSE, P CUSHMAN. OBSERVATIONS ON THE NATURE OF THE UNDERLYING DISORDER AND THE OCCURRENCE OF ASSOCIATED PLASMA TRANSPORT ABNORMALITIES IN A PATIENT WITH AN IDIOPATHIC INCREASE IN THE PLASMA THYROXINE-BINDING GLOBULIN.
The Journal of clinical investigation.
1964 Dec; 43(?):2266-71. doi:
10.1172/jci105100
. [PMID: 14234822] - C CHATAGNON, P A CHATAGNON. [VARIOUS BIOLOGICAL EXPLORATIONS: PHOSPHO-CALCIUM, PLASMA AND URINARY EQUILIBRIA; PHOSPHATASES IN THE COURSE OF THE THERAPEUTIC ACTION OF 8075 C.B. (17-BETA-HYDROXY-17-ALPHA-METHYL-2-OXO-2-ANDROSTANONE)].
Annales medico-psychologiques.
1964 Jun; 122(?):89-98. doi:
NULL
. [PMID: 14169448] - B C ASHLEY. NITROGEN METABOLISM IN RENAL FAILURE.
Bulletin of the Post-Graduate Committee in Medicine, University of Sydney.
1964 May; 20(?):51-7. doi:
NULL
. [PMID: 14170341] - P BORRIE. ELEVATION OF SERUM-CHOLESTEROL BY AN ANABOLIC STEROID.
Lancet (London, England).
1964 Apr; 1(7337):828-9. doi:
10.1016/s0140-6736(64)93015-6
. [PMID: 14108023] - A G RAMSAY. ACUTE RENAL FAILURE.
Clinical obstetrics and gynecology.
1964 Mar; 13(?):219-32. doi:
10.1097/00003081-196403000-00019
. [PMID: 14136590] - R G VAN WAYJEN. LONG-TERM METABOLIC BALANCE STUDIES OF THE PROTEIN AND CALCIUM METABOLISM IN NORMAL SUBJECTS AND PATIENTS WITH OSTEOPOROSIS.
Israel medical journal.
1964 Jan; 23(?):29-44. doi:
NULL
. [PMID: 14173524] - J GELLER. THE EFFECT OF 17-ALPHA-ETHYL-19-NORTESTOSTERONE AND 17-ALPHA-ETHYL-19-NORTESTERONE 3-ENOL-PROPIONATE ON GROWTH AND ENDOCRINE FUNCTION IN NORMAL YOUNG MALES OF SHORT STATURE.
Acta endocrinologica.
1964 Jan; 45(?):13-25. doi:
10.1530/acta.0.0450013
. [PMID: 14102665] - C M LEEVY, J BENDER. PHYSIOLOGY OF DYE EXTRACTION BY THE LIVER: COMPARATIVE STUDIES OF SULFOBROMOPHTHALEIN AND INDOCYANINE GREEN.
Annals of the New York Academy of Sciences.
1963 Dec; 111(?):161-76. doi:
10.1111/j.1749-6632.1963.tb36956.x
. [PMID: 14085840] - C CHATAGNON, P A CHATAGNON. [URINARY ELIMINATION OF CALCIUM, PHOSPHORUS, NEURAMINIC ACID AND SEVERAL NITROGENOUS ELEMENTS BEFORE AND AFTER NORETHANDROLONE TREATMENT].
Semaine therapeutique.
1963 Dec; 39(?):637-40. doi:
NULL
. [PMID: 14111258] - A H TASHJIAN, G D WHEDON. KINETICS OF HUMAN CITRATE METABOLISM: STUDIES IN NORMAL SUBJECTS AND IN PATIENTS WITH BONE DISEASE.
The Journal of clinical endocrinology and metabolism.
1963 Oct; 23(?):1029-43. doi:
10.1210/jcem-23-10-1029
. [PMID: 14067890] - W METCALF, E L DARGAN, C SUWANRAKS, A OHIN. A QUANTITATIVE EXPRESSION FOR NITROGEN RETENTION WITH ANABOLIC STEROIDS. II. NORETHANDROLONE PROPIONATE; COMPARISON WITH TESTOSTERONE PROPIONATE AND NORETHANDROLONE.
Metabolism: clinical and experimental.
1963 Oct; 12(?):910-23. doi:
NULL
. [PMID: 14068082] - C M LEEVY, G R CHERRICK, C S DAVIDSON. Observations on norethandrolone-induced abnormalities in plasma decay of sulfobromophthalein and indocvanine green.
The Journal of laboratory and clinical medicine.
1961 Jun; 57(?):918-26. doi:
NULL
. [PMID: 13760319] - O CASTREN, L KALLIOMAKI, A PEKKARINEN, K SOIVA, S VIIKARI. Effect of norethandrolone on the urinary excretion of 17-ketosteroids, total 17-hydroxycorticosteroids and uropepsin and on the gastric secretory activity.
Acta endocrinologica.
1960 Nov; 35(?):426-34. doi:
10.1530/acta.0.xxxv0426
. [PMID: 13691464] - C R BLAGG, F M PARSONS. The use of norethandrolone in acute renal failure from obstetric causes.
Lancet (London, England).
1960 Sep; 2(7150):577-81. doi:
10.1016/s0140-6736(60)91646-9
. [PMID: 13801213] - H BRENDLER, B S WINKLER. Effect of norethandrolone on 17-ketosteroid excretion in prostatic cancer patients.
The Journal of clinical endocrinology and metabolism.
1959 Feb; 19(2):183-92. doi:
10.1210/jcem-19-2-183
. [PMID: 13620743] - R M DOWBEN. Effect of norethandrolone on serum enzyme levels.
The Journal of clinical endocrinology and metabolism.
1958 Nov; 18(11):1308-9. doi:
10.1210/jcem-18-11-1308
. [PMID: 13587648] - B H McCRACKEN, F M PARSONS. Use of nilevar (17-ethyl-19-nortestosterone) to suppress protein catabolism in acute renal failure.
Lancet (London, England).
1958 Oct; 2(7052):885-6. doi:
10.1016/s0140-6736(58)92309-2
. [PMID: 13589035] - F PLUM, M F DUNNING. Amelioration of hypercalciuria following poliomyelitis by 17-ethyl, 19-nortestosterone (nilevar).
The Journal of clinical endocrinology and metabolism.
1958 Aug; 18(8):860-71. doi:
10.1210/jcem-18-8-860
. [PMID: 13563612]