MK-2206 (BioDeep_00000654262)
代谢物信息卡片
8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one
化学式: C25H21N5O (407.1746016)
中文名称: 8-[4-(1-氨基环丁基)苯基]-9-苯基-1,2,4-噻唑并[3,4-f][1,6]萘啶-3(2H)-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N
InChI: InChI=1S/C25H21N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C155764 - AKT Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinsheng Gao, Yousong Li, Jiaohua Chen, Wen Feng, Jianchen Bu, Zixuan Lu, Jiandong Wang. Emodin ameliorates acute radiation proctitis in mice by regulating AKT/MAPK/NF-κB/VEGF pathways.
International immunopharmacology.
2024 May; 132(?):111945. doi:
10.1016/j.intimp.2024.111945. [PMID: 38555816] - Ruyang Yu, Jia Zhong, Qilyu Zhou, Wei Ren, Zhongjie Liu, Yifei Bian. Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity.
Chemico-biological interactions.
2022 Oct; 366(?):110135. doi:
10.1016/j.cbi.2022.110135. [PMID: 36049518] - Chun Pan, Haixiang Qin, Haibo Jin, Wenyuan Chen, Hongqian Guo, Xiaodong Han. Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Toxicology.
2022 10; 480(?):153326. doi:
10.1016/j.tox.2022.153326. [PMID: 36115647] - Jiandong Sun, Weiwei Xu, Shuyuan Zheng, Chengyu Lv, Jianmin Lin, Siqi Chen, Yonghong Qiu, Xia Jiang, Eman Draz, Shie Wang. Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway.
Toxicology and applied pharmacology.
2022 04; 441(?):115969. doi:
10.1016/j.taap.2022.115969. [PMID: 35259346] - Ya-Qin Tang, Zhi-Wei Li, Yu-Fan Feng, Hong-Qin Yang, Cui-Liu Hou, Chi Geng, Pei-Ran Yang, Hong-Mei Zhao, Jing Wang. MK2206 attenuates atherosclerosis by inhibiting lipid accumulation, cell migration, proliferation, and inflammation.
Acta pharmacologica Sinica.
2022 Apr; 43(4):897-907. doi:
10.1038/s41401-021-00729-x. [PMID: 34316032] - Pei Zhang, Jiale Zhang, Huahong Quan, Pengtao Chen, Jingcheng Wang, Yuan Liang. Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221074346. doi:
10.1177/09603271221074346. [PMID: 35130734] - Carolin Torregroza, Chiara O Glashoerster, Katharina Feige, Martin Stroethoff, Annika Raupach, André Heinen, Markus W Hollmann, Ragnar Huhn. Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212471. [PMID: 34830353] - Xiaofeng Wan, Meng Zhou, Fuqiang Huang, Na Zhao, Xu Chen, Yuncui Wu, Wanhui Zhu, Zhaofei Ni, Fuquan Jin, Yani Wang, Zhongdong Hu, Xianguo Chen, Min Ren, Hongbing Zhang, Xiaojun Zha. AKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development.
Cell death & disease.
2021 02; 12(2):172. doi:
10.1038/s41419-021-03433-0. [PMID: 33568640] - Haiyan Cui, Yuanxiong Cheng, Yi He, Weiying Cheng, Wenqu Zhao, Haijin Zhao, Fiona H Zhou, Liping Wang, Jianghui Dong, Shaoxi Cai. The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
Molecular medicine reports.
2020 Nov; 22(5):3723-3734. doi:
10.3892/mmr.2020.11450. [PMID: 33000187] - Jenika D Marshall, Emily R Courage, Ryan F Elliott, Madeline N Fitzpatrick, Anne D Kim, Andrea F Lopez-Clavijo, Bronwyn A Woolfrey, Mireille Ouimet, Michael J O Wakelam, Robert J Brown. THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation.
PloS one.
2020; 15(5):e0233180. doi:
10.1371/journal.pone.0233180. [PMID: 32437392] - Meiling Liu, Xuegao Yu, Liying Lin, Jiankai Deng, Kanglong Wang, Yong Xia, Xiaohua Tang, Honghai Hong. ATGL promotes the proliferation of hepatocellular carcinoma cells via the p-AKT signaling pathway.
Journal of biochemical and molecular toxicology.
2019 Nov; 33(11):e22391. doi:
10.1002/jbt.22391. [PMID: 31476254] - Nazma Malik, Raja S Nirujogi, Julien Peltier, Thomas Macartney, Melanie Wightman, Alan R Prescott, Robert Gourlay, Matthias Trost, Dario R Alessi, Athanasios Karapetsas. Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44.
The Biochemical journal.
2019 10; 476(20):3081-3107. doi:
10.1042/bcj20190608. [PMID: 31665227] - Janice M Mehnert, Amanda D Kaveney, Jyoti Malhotra, Kristen Spencer, Daniella Portal, Susan Goodin, Antoinette R Tan, Joseph Aisner, Rebecca A Moss, Hongxia Lin, Joseph R Bertino, Darlene Gibbon, Laurence A Doyle, Eileen P White, Mark N Stein. A phase I trial of MK-2206 and hydroxychloroquine in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology.
2019 10; 84(4):899-907. doi:
10.1007/s00280-019-03919-x. [PMID: 31463691] - Yan Xing, Nancy U Lin, Matthew A Maurer, Huiqin Chen, Armeen Mahvash, Aysegul Sahin, Argun Akcakanat, Yisheng Li, Vandana Abramson, Jennifer Litton, Mariana Chavez-MacGregor, Vicente Valero, Sarina A Piha-Paul, David Hong, Kim-Anh Do, Emily Tarco, Dianna Riall, Agda Karina Eterovic, Gerburg M Wulf, Lewis C Cantley, Gordon B Mills, L Austin Doyle, Eric Winer, Gabriel N Hortobagyi, Ana Maria Gonzalez-Angulo, Funda Meric-Bernstam. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation.
Breast cancer research : BCR.
2019 07; 21(1):78. doi:
10.1186/s13058-019-1154-8. [PMID: 31277699] - Cholpon S Djuzenova, Vanessa Fiedler, Simon Memmel, Astrid Katzer, Dmitri Sisario, Philippa K Brosch, Alexander Göhrung, Svenja Frister, Heiko Zimmermann, Michael Flentje, Vladimir L Sukhorukov. Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells.
BMC cancer.
2019 Apr; 19(1):299. doi:
10.1186/s12885-019-5517-4. [PMID: 30943918] - Anqi Wang, Fayang Zhou, Dan Li, Jin-Jian Lu, Yitao Wang, Ligen Lin. γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.
Toxicology and applied pharmacology.
2019 01; 363(?):142-153. doi:
10.1016/j.taap.2018.11.011. [PMID: 30502394] - Er-Shun Liang, Wen-Wu Bai, Hao Wang, Jian-Ning Zhang, Fan Zhang, Yang Ma, Fan Jiang, Mei Yin, Ming-Xiang Zhang, Xiao-Mei Chen, Wei-Dong Qin. PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice.
Hypertension (Dallas, Tex. : 1979).
2018 11; 72(5):1189-1199. doi:
10.1161/hypertensionaha.118.11184. [PMID: 30354818] - Ognian C Ikonomov, George Altankov, Diego Sbrissa, Assia Shisheva. PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation.
Toxicology and applied pharmacology.
2018 10; 356(?):151-158. doi:
10.1016/j.taap.2018.08.001. [PMID: 30098992] - Katrine Bjune, Hilde Sundvold, Trond P Leren, Soheil Naderi. MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent.
Atherosclerosis.
2018 09; 276(?):28-38. doi:
10.1016/j.atherosclerosis.2018.07.009. [PMID: 30025252] - Cheng-Tien Wu, Ching-Chia Wang, Li-Chen Huang, Shing-Hwa Liu, Chih-Kang Chiang. Plasticizer Di-(2-Ethylhexyl)Phthalate Induces Epithelial-to-Mesenchymal Transition and Renal Fibrosis In Vitro and In Vivo.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 07; 164(1):363-374. doi:
10.1093/toxsci/kfy094. [PMID: 29669060] - Mengqiu Song, Xuejiao Liu, Kangdong Liu, Ran Zhao, Hai Huang, Yuanyuan Shi, Man Zhang, Silei Zhou, Hua Xie, Hanyong Chen, Yin Li, Yan Zheng, Qiong Wu, Fangfang Liu, Enmin Li, Ann M Bode, Zigang Dong, Mee-Hyun Lee. Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell Carcinoma In Vitro and Patient-Derived Xenografts In Vivo.
Molecular cancer therapeutics.
2018 07; 17(7):1540-1553. doi:
10.1158/1535-7163.mct-17-0823. [PMID: 29695636] - Zehe Ge, Haipeng Diao, Xiaoli Ji, Qingping Liu, Xiaoyan Zhang, Qing Wu. Gap junctional intercellular communication and endoplasmic reticulum stress regulate chronic cadmium exposure induced apoptosis in HK-2 cells.
Toxicology letters.
2018 May; 288(?):35-43. doi:
10.1016/j.toxlet.2018.02.013. [PMID: 29444456] - Xiaoyan Yang, Xiaofang Mao, Gao Xu, Shasha Xing, Ansuman Chattopadhyay, Si Jin, Guy Salama. Estradiol up-regulates L-type Ca2+ channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway.
Heart rhythm.
2018 05; 15(5):741-749. doi:
10.1016/j.hrthm.2018.01.019. [PMID: 29330129] - Shaopeng Wei, Li Li, Yaping Shu, Kun Zhao, Zhiqin Ji. Synthesis, antifungal and antitumor activity of two new types of imidazolin-2-ones.
Bioorganic & medicinal chemistry.
2017 12; 25(24):6501-6510. doi:
10.1016/j.bmc.2017.10.033. [PMID: 29100733] - Lei Yu, Xiuguo Gan, Xukun Liu, Ruihua An. Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway.
Renal failure.
2017 Nov; 39(1):440-451. doi:
10.1080/0886022x.2017.1305968. [PMID: 28335665] - Masayuki Yamaji, Akinobu Ota, Md Wahiduzzaman, Sivasundaram Karnan, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa, Masayuki Haniuda. Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.
Cancer medicine.
2017 Nov; 6(11):2646-2659. doi:
10.1002/cam4.1179. [PMID: 28960945] - Hui-Wen Lue, Jennifer Podolak, Kevin Kolahi, Larry Cheng, Soumya Rao, Devin Garg, Chang-Hui Xue, Juha K Rantala, Jeffrey W Tyner, Kent L Thornburg, Ann Martinez-Acevedo, Jen-Jane Liu, Christopher L Amling, Charles Truillet, Sharon M Louie, Kimberly E Anderson, Michael J Evans, Valerie B O'Donnell, Daniel K Nomura, Justin M Drake, Anna Ritz, George V Thomas. Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade.
Genes & development.
2017 10; 31(20):2067-2084. doi:
10.1101/gad.305292.117. [PMID: 29138276] - Ayodeji Odunewu-Aderibigbe, Larry Fliegel. Protein mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells. A regulatory role of Hsp90 and AKT kinase.
Cellular signalling.
2017 08; 36(?):145-153. doi:
10.1016/j.cellsig.2017.05.003. [PMID: 28483634] - Ru-Fang Xiang, Yan Wang, Nan Zhang, Wen-Bin Xu, Yang Cao, Jia Tong, Jun-Min Li, Ying-Li Wu, Hua Yan. MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway.
Cell death & disease.
2017 05; 8(5):e2776. doi:
10.1038/cddis.2017.188. [PMID: 28492559] - E Jonasch, E Hasanov, P G Corn, T Moss, K R Shaw, S Stovall, V Marcott, B Gan, S Bird, X Wang, K A Do, P F Altamirano, A J Zurita, L A Doyle, P N Lara, N M Tannir. A randomized phase 2 study of MK-2206 versus everolimus in refractory renal cell carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology.
2017 04; 28(4):804-808. doi:
10.1093/annonc/mdw676. [PMID: 28049139] - Zhenwen Zhang, Penghua Fang, Lili Guo, Biao He, Mingyi Shi, Yan Zhu, Ping Bo. Akt2-Dependent Beneficial Effect of Galanin on Insulin-Induced Glucose Uptake in Adipocytes of Diabetic Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(5):1777-1787. doi:
10.1159/000471870. [PMID: 28365702] - Ting Li, Xin Chen, Xiuping Chen, Dik Lung Ma, Chung Hang Leung, Jin Jian Lu. Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells.
Scientific reports.
2016 11; 6(?):37997. doi:
10.1038/srep37997. [PMID: 27897231] - Kari B Wisinski, Amye J Tevaarwerk, Mark E Burkard, Murtuza Rampurwala, Jens Eickhoff, Maria C Bell, Jill M Kolesar, Christopher Flynn, Glenn Liu. Phase I Study of an AKT Inhibitor (MK-2206) Combined with Lapatinib in Adult Solid Tumors Followed by Dose Expansion in Advanced HER2+ Breast Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2016 06; 22(11):2659-67. doi:
10.1158/1078-0432.ccr-15-2365. [PMID: 27026198] - Hui Wang, Yujian Zhang, Yongning Lu, Jiajia Song, Min Huang, Jin Zhang, Yiran Huang. The role of stearoyl-coenzyme A desaturase 1 in clear cell renal cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2016 Jan; 37(1):479-89. doi:
10.1007/s13277-015-3451-x. [PMID: 26224474] - B B Y Ma, B C Goh, W T Lim, E P Hui, E H Tan, G de Lima Lopes, K W Lo, L Li, H Loong, N R Foster, C Erlichman, A D King, M K M Kam, S F Leung, K C Chan, A T C Chan. Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the mayo phase II consortium and the cancer therapeutics research group (MC1079).
Investigational new drugs.
2015 Aug; 33(4):985-91. doi:
10.1007/s10637-015-0264-0. [PMID: 26084990] - Ramesh K Ramanathan, Shannon L McDonough, Hagen F Kennecke, Syma Iqbal, Joaquina C Baranda, Tara E Seery, Howard J Lim, Aram F Hezel, Gina M Vaccaro, Charles D Blanke. Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005).
Cancer.
2015 Jul; 121(13):2193-7. doi:
10.1002/cncr.29363. [PMID: 25827820] - Esi Kajno, Timothy E McGraw, Eva Gonzalez. Development of a new model system to dissect isoform specific Akt signalling in adipocytes.
The Biochemical journal.
2015 Jun; 468(3):425-34. doi:
10.1042/bj20150191. [PMID: 25856301] - Manuela Piazzi, William L Blalock, Alberto Bavelloni, Irene Faenza, Mirco Raffini, Francesca Tagliavini, Lucia Manzoli, Lucio Cocco. PI-PLCβ1b affects Akt activation, cyclin E expression, and caspase cleavage, promoting cell survival in pro-B-lymphoblastic cells exposed to oxidative stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2015 Apr; 29(4):1383-94. doi:
10.1096/fj.14-259051. [PMID: 25550457] - Ana M Gonzalez-Angulo, Ian Krop, Argun Akcakanat, Huiqin Chen, Shuying Liu, Yisheng Li, Kirk S Culotta, Emily Tarco, Sarina Piha-Paul, Stacy Moulder-Thompson, Vivianne Velez-Bravo, Aysegul A Sahin, Laurence A Doyle, Kim-Anh Do, Eric P Winer, Gordon B Mills, Razelle Kurzrock, Funda Meric-Bernstam. SU2C phase Ib study of paclitaxel and MK-2206 in advanced solid tumors and metastatic breast cancer.
Journal of the National Cancer Institute.
2015 Mar; 107(3):. doi:
10.1093/jnci/dju493. [PMID: 25688104] - Ellen L Berg, Mark A Polokoff, Alison O'Mahony, Dat Nguyen, Xitong Li. Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.
International journal of molecular sciences.
2015 Jan; 16(1):1008-29. doi:
10.3390/ijms16011008. [PMID: 25569083] - Timothy A Yap, Li Yan, Amita Patnaik, Nina Tunariu, Andrea Biondo, Ivy Fearen, Kyriakos P Papadopoulos, David Olmos, Richard Baird, Liliana Delgado, Ernestina Tetteh, Robert A Beckman, Lisa Lupinacci, Ruth Riisnaes, Shaun Decordova, Simon P Heaton, Karen Swales, Nandita M deSouza, Martin O Leach, Michelle D Garrett, Daniel M Sullivan, Johann S de Bono, Anthony W Tolcher. Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014 Nov; 20(22):5672-85. doi:
10.1158/1078-0432.ccr-14-0868. [PMID: 25239610] - Mary Taub, Robert Parker, Paremala Mathivanan, Muhamad Asnawi Mohd Ariff, Trina Rudra. Antagonism of the prostaglandin E2 EP1 receptor in MDCK cells increases growth through activation of Akt and the epidermal growth factor receptor.
American journal of physiology. Renal physiology.
2014 Sep; 307(5):F539-50. doi:
10.1152/ajprenal.00510.2013. [PMID: 25007872] - Joshua A Smith, L Jay Stallons, Rick G Schnellmann. Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.
American journal of physiology. Renal physiology.
2014 Aug; 307(4):F435-44. doi:
10.1152/ajprenal.00271.2014. [PMID: 24990892] - Kota Fujiki, Hisako Inamura, Masato Matsuoka. PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium.
Archives of toxicology.
2014 Feb; 88(2):403-14. doi:
10.1007/s00204-013-1129-y. [PMID: 24057571] - Ronald C Bruntz, Harry E Taylor, Craig W Lindsley, H Alex Brown. Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.
The Journal of biological chemistry.
2014 Jan; 289(2):600-16. doi:
10.1074/jbc.m113.532978. [PMID: 24257753] - A Tsuchiya, T Kanno, T Nishizaki. PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
The Journal of endocrinology.
2014 Jan; 220(1):49-59. doi:
10.1530/joe-13-0172. [PMID: 24169049] - Yuan-Yuan Zhao, Ying Tian, Jing Zhang, Fei Xu, Yun-Peng Yang, Yan Huang, Hong-Yun Zhao, Jian-Wei Zhang, Cong Xue, Michael H Lam, Li Yan, Zhi-Huang Hu, Xiao-Xiao Dinglin, Li Zhang. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo.
Drug design, development and therapy.
2014; 8(?):1827-37. doi:
10.2147/dddt.s67961. [PMID: 25336925] - Xiaoyan Bai, Xiao Li, Jianwei Tian, Zhanmei Zhou. Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local AKT in early experimental diabetes.
PloS one.
2014; 9(4):e96117. doi:
10.1371/journal.pone.0096117. [PMID: 24759991] - Elizabeth C Sefton, Wenan Qiang, Vanida Serna, Takeshi Kurita, Jian-Jun Wei, Debabrata Chakravarti, J Julie Kim. MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growth.
Endocrinology.
2013 Nov; 154(11):4046-57. doi:
10.1210/en.2013-1389. [PMID: 24002033] - Hidenori Nishida, Eisei Sohara, Naohiro Nomura, Motoko Chiga, Dario R Alessi, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida. Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.
Hypertension (Dallas, Tex. : 1979).
2012 Oct; 60(4):981-90. doi:
10.1161/hypertensionaha.112.201509. [PMID: 22949526] - Jason G Kettle, Simon Brown, Claire Crafter, Barry R Davies, Phillippa Dudley, Gary Fairley, Paul Faulder, Shaun Fillery, Hannah Greenwood, Janet Hawkins, Michael James, Keith Johnson, Clare D Lane, Martin Pass, Jennifer H Pink, Helen Plant, Sabina C Cosulich. Diverse heterocyclic scaffolds as allosteric inhibitors of AKT.
Journal of medicinal chemistry.
2012 Feb; 55(3):1261-73. doi:
10.1021/jm201394e. [PMID: 22248236] - Timothy A Yap, Li Yan, Amita Patnaik, Ivy Fearen, David Olmos, Kyriakos Papadopoulos, Richard D Baird, Liliana Delgado, Adekemi Taylor, Lisa Lupinacci, Ruth Riisnaes, Lorna L Pope, Simon P Heaton, George Thomas, Michelle D Garrett, Daniel M Sullivan, Johann S de Bono, Anthony W Tolcher. First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2011 Dec; 29(35):4688-95. doi:
10.1200/jco.2011.35.5263. [PMID: 22025163]