ON-01910 (BioDeep_00000654125)
代谢物信息卡片
化学式: C21H24NNaO8S (473.112)
中文名称: ON 01910 钠盐, 瑞格色替钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
InChI: /q
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:145421
- KEGGdrug: D10155
- PubChem: 23696523
- ChEMBL: CHEMBL2013119
- CAS: 1225497-78-8
- CAS: 592542-60-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Simin Luo, Xuan Zhang, Xiang Xiao, Wenting Luo, Zixuan Yang, Songqi Tang, Wei Huang. Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology.
International journal of molecular sciences.
2023 Mar; 24(7):. doi:
10.3390/ijms24076511. [PMID: 37047484] - Marie O Pohl, Jessica von Recum-Knepper, Ariel Rodriguez-Frandsen, Caroline Lanz, Emilio Yángüez, Stephen Soonthornvacharin, Thorsten Wolff, Sumit K Chanda, Silke Stertz. Identification of Polo-like kinases as potential novel drug targets for influenza A virus.
Scientific reports.
2017 08; 7(1):8629. doi:
10.1038/s41598-017-08942-7. [PMID: 28819179] - Isuzu Kobayashi, Kumi Ubukawa, Kotomi Sugawara, Ken Asanuma, Yong-Mei Guo, Junsuke Yamashita, Naoto Takahashi, Kenichi Sawada, Wataru Nunomura. Erythroblast enucleation is a dynein-dependent process.
Experimental hematology.
2016 Apr; 44(4):247-56.e12. doi:
10.1016/j.exphem.2015.12.003. [PMID: 26724640] - Silpa Nuthalapati, Ping Guo, Qingyu Zhou, M V Ramana Reddy, E Premkumar Reddy, James M Gallo. Application of a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to the pharmacokinetics of ON01910 in brain tumor-bearing mice.
Journal of pharmaceutical and biomedical analysis.
2011 Dec; 56(5):1117-20. doi:
10.1016/j.jpba.2011.08.003. [PMID: 21880454] - Sool Yeon Cho, Takao Ohnuma, Lewis R Silverman, James F Holland, John Roboz. Discontinuous drug binding to proteins: binding of an antineoplastic benzyl styryl sulfone to albumin and enzymes in vitro and in phase I clinical trials.
Drug metabolism and disposition: the biological fate of chemicals.
2010 Sep; 38(9):1480-5. doi:
10.1124/dmd.110.033001. [PMID: 20501913] - Amy W Chun, Stephen C Cosenza, David R Taft, Manoj Maniar. Preclinical pharmacokinetics and in vitro activity of ON 01910.Na, a novel anti-cancer agent.
Cancer chemotherapy and pharmacology.
2009 Dec; 65(1):177-86. doi:
10.1007/s00280-009-1022-9. [PMID: 19466411] - Jing Li, Ming Zhao, Antonio Jimeno, Ping He, M V Ramana Reddy, Manuel Hidalgo, Ross C Donehower, Michelle A Rudek. Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate ON 01910.Na, a mitotic progression modulator, in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 856(1-2):198-204. doi:
10.1016/j.jchromb.2007.05.047. [PMID: 17588831]
