Toceranib (BioDeep_00000654124)
代谢物信息卡片
Toceranib
化学式: C22H25FN4O2 (396.19614419999994)
中文名称: Toceranib
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)C=C3C4=C(C=CC(=C4)F)NC3=O
InChI: InChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-
描述信息
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ling Qiao, Siyuan Qin, Ningna Weng, Bowen Li, Maochao Luo, Zhe Zhang, Li Zhou, Dong Wang, Canhua Huang. Discovery of Canine Drug Toceranib Phosphate as a Repurposed Agent Against Human Hepatocellular Carcinoma.
Liver international : official journal of the International Association for the Study of the Liver.
2023 Feb; ?(?):. doi:
10.1111/liv.15540. [PMID: 36776105] - D Alonso-Miguel, P García-San José, S González Sanz, I Clarés Moral, M D Pérez-Alenza. Evaluation of palliative therapy, alone or in combination with toceranib phosphate, in dogs diagnosed with metastatic or recurrent beta-cell neoplasia.
New Zealand veterinary journal.
2021 Jul; 69(4):234-239. doi:
10.1080/00480169.2021.1905569. [PMID: 33944682] - Shannon M Remerowski, Chamisa L Herrera, Lindsay L Donnelly. Toceranib phosphate-associated nephrotic syndrome in a dog: a case report.
BMC veterinary research.
2021 Apr; 17(1):146. doi:
10.1186/s12917-021-02850-9. [PMID: 33827545] - Donghun Lee, Seok Jung Kim, Hocheol Kim. A 12 week, randomized, double-blind, placebo-controlled clinical trial for the evaluation of the efficacy and safety of HT083 on mild osteoarthritis.
Medicine.
2020 Jul; 99(28):e20907. doi:
10.1097/md.0000000000020907. [PMID: 32664084] - Rachel L Kovac, Gregory Ballash, Joelle Fenger, Cheryl London, Emma Warry. Plasma cytokeratin-18 concentrations as noninvasive biomarker of early gastrointestinal toxicosis in dogs receiving toceranib.
Journal of veterinary internal medicine.
2018 Nov; 32(6):2061-2068. doi:
10.1111/jvim.15326. [PMID: 30353992] - Sindy L Piscoya, Kelly R Hume, Cheryl E Balkman. A retrospective study of proteinuria in dogs receiving toceranib phosphate.
The Canadian veterinary journal = La revue veterinaire canadienne.
2018 06; 59(6):611-616. doi:
NULL. [PMID: 29910474] - T Laver, C A London, D M Vail, B J Biller, J Coy, D H Thamm. Prospective evaluation of toceranib phosphate in metastatic canine osteosarcoma.
Veterinary and comparative oncology.
2018 Mar; 16(1):E23-E29. doi:
10.1111/vco.12328. [PMID: 28621057] - Tracy L Gieger, Julie Nettifee-Osborne, Briana Hallman, Chad Johannes, Dawn Clarke, Michael W Nolan, Laurel E Williams. The impact of carboplatin and toceranib phosphate on serum vascular endothelial growth factor (VEGF) and metalloproteinase-9 (MMP-9) levels and survival in canine osteosarcoma.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2017 Jul; 81(3):199-205. doi:
NULL. [PMID: 28725110] - Kimberly A Thompson, Jon Patterson, Scott D Fitzgerald, David Needle, Tara Harrison. TREATMENT OF RENAL CARCINOMA IN A BINTURONG (ARCTICTIS BINTURONG) WITH NEPHRECTOMY AND A TYROSINE KINASE INHIBITOR.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2016 Dec; 47(4):1109-1113. doi:
10.1638/2015-0285.1. [PMID: 28080923] - Corri B Levine, Julie Bayle, Vincent Biourge, Joseph J Wakshlag. Effects and synergy of feed ingredients on canine neoplastic cell proliferation.
BMC veterinary research.
2016 Aug; 12(1):159. doi:
10.1186/s12917-016-0774-9. [PMID: 27484718] - S S Tjostheim, R L Stepien, L E Markovic, T J Stein. Effects of Toceranib Phosphate on Systolic Blood Pressure and Proteinuria in Dogs.
Journal of veterinary internal medicine.
2016 Jul; 30(4):951-7. doi:
10.1111/jvim.13951. [PMID: 27149912] - Luis Feo Bernabe, Roberta Portela, Sandra Nguyen, William C Kisseberth, Michael Pennell, Mark F Yancey, Cheryl A London. Evaluation of the adverse event profile and pharmacodynamics of toceranib phosphate administered to dogs with solid tumors at doses below the maximum tolerated dose.
BMC veterinary research.
2013 Sep; 9(?):190. doi:
10.1186/1746-6148-9-190. [PMID: 24079884] - L Mitchell, D H Thamm, B J Biller. Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer.
Journal of veterinary internal medicine.
2012 Mar; 26(2):355-62. doi:
10.1111/j.1939-1676.2011.00883.x. [PMID: 22303814] - M F Yancey, D A Merritt, J A White, S A Marsh, C W Locuson. Distribution, metabolism, and excretion of toceranib phosphate (Palladia, SU11654), a novel tyrosine kinase inhibitor, in dogs.
Journal of veterinary pharmacology and therapeutics.
2010 Apr; 33(2):154-61. doi:
10.1111/j.1365-2885.2009.01120.x. [PMID: 20444040] - M F Yancey, D A Merritt, S P Lesman, J F Boucher, G M Michels. Pharmacokinetic properties of toceranib phosphate (Palladia, SU11654), a novel tyrosine kinase inhibitor, in laboratory dogs and dogs with mast cell tumors.
Journal of veterinary pharmacology and therapeutics.
2010 Apr; 33(2):162-71. doi:
10.1111/j.1365-2885.2009.01133.x. [PMID: 20444041] - Nancy K Pryer, Leslie B Lee, Regina Zadovaskaya, Xiaoming Yu, Juthamas Sukbuntherng, Julie M Cherrington, Cheryl A London. Proof of target for SU11654: inhibition of KIT phosphorylation in canine mast cell tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Nov; 9(15):5729-34. doi:
NULL. [PMID: 14654558]