Nortilidine (BioDeep_00000653902)
代谢物信息卡片
化学式: C16H21NO2 (259.1572206)
中文名称: 盐酸去甲替利定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C1(CCC=CC1NC)C2=CC=CC=C2
InChI: InChI=1S/C16H21NO2/c1-3-19-15(18)16(13-9-5-4-6-10-13)12-8-7-11-14(16)17-2/h4-7,9-11,14,17H,3,8,12H2,1-2H3/t14-,16+/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- C Wolfert, M Merbach, G Stammler, O Emrich, A D Meid, J Burhenne, A Blank, G Mikus. [Management of chronic pain using extended release tilidine : Quality of life and implication of comedication on tilidine metabolism].
Schmerz (Berlin, Germany).
2017 10; 31(5):516-523. doi:
10.1007/s00482-017-0228-8. [PMID: 28597312] - Christine Eichbaum, Kristin Mathes, Jürgen Burhenne, Christoph Markert, Antje Blank, Gerd Mikus. Pre-systemic elimination of tilidine: localization and consequences for the formation of the active metabolite nortilidine.
Basic & clinical pharmacology & toxicology.
2015 Feb; 116(2):129-33. doi:
10.1111/bcpt.12328. [PMID: 25223231] - Barbara Grün, Ulrike Merkel, Klaus-Dieter Riedel, Johanna Weiss, Gerd Mikus. Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine.
British journal of clinical pharmacology.
2012 Nov; 74(5):854-63. doi:
10.1111/j.1365-2125.2012.04261.x. [PMID: 22381043] - Christoph Köhler, Thomas Grobosch, Torsten Binscheck. Rapid quantification of tilidine, nortilidine, and bisnortilidine in urine by automated online SPE-LC-MS/MS.
Analytical and bioanalytical chemistry.
2011 Apr; 400(1):17-23. doi:
10.1007/s00216-010-4466-1. [PMID: 21140136] - Barbara Grün, Stefanie Krautter, Klaus-Dieter Riedel, Gerd Mikus. Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole.
British journal of clinical pharmacology.
2009 Nov; 68(5):712-20. doi:
10.1111/j.1365-2125.2009.03498.x. [PMID: 19916995] - Annette Thierauf, Reinhard Dettmeyer, Heike Wollersen, Burkhard Madea. Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman.
Forensic science international.
2007 Dec; 173(2-3):178-81. doi:
10.1016/j.forsciint.2007.01.001. [PMID: 17317059] - F Musshoff, J Trafkowski, U Kuepper, B Madea. An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites.
Journal of mass spectrometry : JMS.
2006 May; 41(5):633-40. doi:
10.1002/jms.1021. [PMID: 16541404] - Jacek Piotr Hajda, Eberhard Jähnchen, Svein Oie, Dietmar Trenk. Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine.
Journal of clinical pharmacology.
2002 Nov; 42(11):1257-61. doi:
10.1177/009127002762491352. [PMID: 12412825] - K U Seiler, E Jähnchen, D Trenk, U Brennscheidt, B Heintz. Pharmacokinetics of tilidine in terminal renal failure.
Journal of clinical pharmacology.
2001 Jan; 41(1):79-84. doi:
10.1177/00912700122009863. [PMID: 11144998] - W Martin, J Ring, M Gaupp, P Arnold, R Sennewald, K Doser. Bioavailability investigation of a new tilidine/naloxone liquid formulation compared to a reference formulation.
Arzneimittel-Forschung.
1999 Jul; 49(7):599-607. doi:
10.1055/s-0031-1300469. [PMID: 10442208] - S Bolze, R Boulieu. HPLC determination of ketamine, norketamine, and dehydronorketamine in plasma with a high-purity reversed-phase sorbent.
Clinical chemistry.
1998 Mar; 44(3):560-4. doi:
10.1093/clinchem/44.3.560. [PMID: 9510862] - K O Vollmer, P Thomann, H Hengy. Pharmacokinetics of tilidine and metabolites in man.
Arzneimittel-Forschung.
1989 Oct; 39(10):1283-8. doi:
NULL. [PMID: 2610722]