Domperidone maleate (BioDeep_00000653627)
代谢物信息卡片
化学式: C26H28ClN5O6 (541.1728018000001)
中文名称: 马来酸多潘立酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O.C(=CC(=O)O)C(=O)O
InChI: 2-1-
描述信息
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
同义名列表
5 个代谢物同义名
5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one (2Z)-but-2-enedioate; 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one maleate; Domperidone maleate; R33812 (monomaleate); Domperidone (monomaleate)
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:59812
- KEGGdrug: D07868
- PubChem: 46878575
- PubChem: 6604595
- ChEMBL: CHEMBL3436365
- MeSH: Domperidone
- CAS: 83898-65-1
- CAS: 99497-03-7
- medchemexpress: HY-B0411A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Jia Chen, Feng-Xia Liang, Song Wu, Zi-Qin Chen, Bei Chen, Ting Zhou, Xiao-Lei Gu, Chong-Li Li, Yan-Ping Shi, Peng Yan, Ling-Ling Tian, Chi-Cheng Xu, Bo-Lin Chen, Song Chen. [Clinical research of acupuncture therapy combined with domperidone in treatment of diabetic gastroparesis of liver stagnation and spleen deficiency].
Zhen ci yan jiu = Acupuncture research.
2023 Jan; 48(1):88-94. doi:
10.13702/j.1000-0607.20211215
. [PMID: 36734504] - Si-Min Xu, Ze-Qi Dai, Xue Wu, Miao-Miao Li, Xing Liao. [Four Chinese patent medicines for regulating stomach for functional dyspepsia: a rapid health technology assessment].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(17):4778-4788. doi:
10.19540/j.cnki.cjcmm.20220520.501
. [PMID: 36164885] - Nayyer Islam, Muhammad Irfan, Talib Hussain, Maria Mushtaq, Ikram Ullah Khan, Abid Mehmood Yousaf, Muhammad Usman Ghori, Yasser Shahzad. Piperine phytosomes for bioavailability enhancement of domperidone.
Journal of liposome research.
2022 Jun; 32(2):172-180. doi:
10.1080/08982104.2021.1918153
. [PMID: 33944662] - James Daniel Obray, Eun Young Jang, Anneke M Klomp, Christina A Small, Aaron P Richardson, Joshua J LeBaron, Jin Gyeom Lee, Jordan T Yorgason, Chae Ha Yang, Scott C Steffensen. The peripheral dopamine 2 receptor antagonist domperidone attenuates ethanol enhancement of dopamine levels in the nucleus accumbens.
Alcoholism, clinical and experimental research.
2022 03; 46(3):396-409. doi:
10.1111/acer.14775
. [PMID: 35040146] - Irene Sarosiek, Mark Van Natta, Henry P Parkman, Thomas Abell, Kenneth L Koch, Braden Kuo, Robert J Shulman, Gianrico Farrugia, Madhusudan Grover, Frank A Hamilton, Pankaj J Pasricha, Katherine P Yates, Laura Miriel, Laura Wilson, Goro Yamada, James Tonascia, Richard W McCallum. Effect of Domperidone Therapy on Gastroparesis Symptoms: Results of a Dynamic Cohort Study by NIDDK Gastroparesis Consortium.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2022 03; 20(3):e452-e464. doi:
10.1016/j.cgh.2021.05.063
. [PMID: 34089855] - Maria Alfonsa Cavalera, Floriana Gernone, Annamaria Uva, Paola D'Ippolito, Xavier Roura, Saverio Paltrinieri, Andrea Zatelli. Effect of domperidone (leisguard®) on antibody titers, inflammatory markers and creatinine in dogs with leishmaniosis and chronic kidney disease.
Parasites & vectors.
2021 Oct; 14(1):525. doi:
10.1186/s13071-021-05030-8
. [PMID: 34629081] - Roger L Whiting, Agnes Choppin, Gary Luehr, Jeffrey R Jasper. Preclinical Evaluation of the Effects of Trazpiroben (TAK-906), a Novel, Potent Dopamine D2/D3 Receptor Antagonist for the Management of Gastroparesis.
The Journal of pharmacology and experimental therapeutics.
2021 10; 379(1):85-95. doi:
10.1124/jpet.121.000698
. [PMID: 34253646] - Braden Kuo, Cecilia Scimia, George Dukes, Wenwen Zhang, Saurabh Gupta, Chunlin Chen, Emil Chuang, Michael Camilleri. Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK-906), a dopamine D2 /D3 receptor antagonist, in patients with gastroparesis.
Alimentary pharmacology & therapeutics.
2021 08; 54(3):267-280. doi:
10.1111/apt.16451
. [PMID: 34148244] - François Sicard, Vladimir Koskin, Alessia Annibale, Edina Rosta. Position-Dependent Diffusion from Biased Simulations and Markov State Model Analysis.
Journal of chemical theory and computation.
2021 Apr; 17(4):2022-2033. doi:
10.1021/acs.jctc.0c01151
. [PMID: 33728916] - AbdolMajid Valipour, Behrooz Heidari, S Mohsen Asghari, Saeed Balalaie, Hanieh Rabouti, Navid Omidian. The effect of different exogenous kisspeptins on sex hormones and reproductive indices of the goldfish (Carassius auratus) broodstock.
Journal of fish biology.
2021 Apr; 98(4):1137-1143. doi:
10.1111/jfb.14645
. [PMID: 33314092] - Camilla L Nord, Edwin S Dalmaijer, Thomas Armstrong, Kate Baker, Tim Dalgleish. A Causal Role for Gastric Rhythm in Human Disgust Avoidance.
Current biology : CB.
2021 02; 31(3):629-634.e3. doi:
10.1016/j.cub.2020.10.087
. [PMID: 33238154] - Joanna Nowosad, Dariusz Kucharczyk, Mateusz Sikora, Krzysztof Kupren. Optimization of barbel (Barbus Barbus L.) fertilization and effects of ovarian fluid when there are controlled conditions for gamete activations.
Animal reproduction science.
2021 Jan; 224(?):106652. doi:
10.1016/j.anireprosci.2020.106652
. [PMID: 33249355] - Kun-Siang Huang, Bo-Lin Pan, Wei-An Lai, Pin-Jie Bin, Yao-Hsu Yang, Chia-Pei Chou. Could prokinetic agents protect long-term nasogastric tube-dependent patients from being hospitalized for pneumonia? A nationwide population-based case-crossover study.
PloS one.
2021; 16(4):e0249645. doi:
10.1371/journal.pone.0249645
. [PMID: 33819293] - Yingkai Xiao, Zhimei He, Yi Long, Weisheng Chen, Dezhu Chen, Ruibin Chi, Heng Ye, Xi Deng, Bo Lv, Cheng Sun, Bei Hu, Zhiqiang Nie, Shaodong Gu, Chunbo Chen. Simo decoction versus domperidone suspension for post-pyloric spiral nasoenteric tube placement: A multicenter, randomized, non-inferiority trial.
Clinical nutrition (Edinburgh, Scotland).
2020 08; 39(8):2406-2412. doi:
10.1016/j.clnu.2019.11.009
. [PMID: 31759771] - Pramod K Kalambate, Dhanjai, Ankita Sinha, Yankai Li, Yue Shen, Yunhui Huang. An electrochemical sensor for ifosfamide, acetaminophen, domperidone, and sumatriptan based on self-assembled MXene/MWCNT/chitosan nanocomposite thin film.
Mikrochimica acta.
2020 06; 187(7):402. doi:
10.1007/s00604-020-04366-9
. [PMID: 32572633] - Siew Cheng Foong, May Loong Tan, Wai Cheng Foong, Lisa A Marasco, Jacqueline J Ho, Joo Howe Ong. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants.
The Cochrane database of systematic reviews.
2020 05; 5(?):CD011505. doi:
10.1002/14651858.cd011505.pub2
. [PMID: 32421208] - Caie Wang, Zhiying Qin, Guanghui Ren, Yuntong Zhai, Kejia Fu, Chengcan Lu, Changqing Yang, Xijing Chen. Development of a sensitive UPLC-MS/MS assay for domperidone and pharmacokinetics of domperidone tablet formulations in fasting and fed Chinese healthy subjects
.
International journal of clinical pharmacology and therapeutics.
2020 Mar; 58(3):177-182. doi:
10.5414/cp203529
. [PMID: 31933472] - Beata Irena Cejko, Sławomir Krejszeff, Sylwia Judycka, Katarzyna Targońska, Dariusz Kucharczyk. Effect of different treatment agents and post-treatment latency times on spermiation stimulation of northern pike (Esox lucius) under controlled conditions.
Theriogenology.
2020 Jan; 142(?):260-267. doi:
10.1016/j.theriogenology.2019.10.035
. [PMID: 31711700] - Marcus W Koch, Wei-Qiao Liu, Carlos Camara-Lemarroy, Yunyan Zhang, G Bruce Pike, Luanne Metz, V Wee Yong. Domperidone-induced elevation of serum prolactin levels and immune response in multiple sclerosis.
Journal of neuroimmunology.
2019 09; 334(?):576974. doi:
10.1016/j.jneuroim.2019.576974
. [PMID: 31174092] - Carolin Tetyczka, Aden Hodzic, Manfred Kriechbaum, Krunoslav Juraić, Christina Spirk, Sonja Hartl, Elisabeth Pritz, Gerd Leitinger, Eva Roblegg. Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2019 Jun; 139(?):153-160. doi:
10.1016/j.ejpb.2019.03.017
. [PMID: 30905779] - Stephan von Düring, Corinne Challet, Laurent Christin. Endoscopic removal of a gastric pharmacobezoar induced by clomipramine, lorazepam, and domperidone overdose: a case report.
Journal of medical case reports.
2019 Feb; 13(1):45. doi:
10.1186/s13256-019-1984-0
. [PMID: 30808405] - Stalielson Tatenda Ndlovu, Naseem Ullah, Shahzeb Khan, Pritika Ramharack, Mahmoud Soliman, Marcel de Matas, Muhammad Shahid, Muhammad Sohail, Muhammad Imran, Syed Wadood Ali Shah, Zahid Hussain. Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction.
Drug delivery and translational research.
2019 02; 9(1):284-297. doi:
10.1007/s13346-018-00596-w
. [PMID: 30387048] - Parama Paul, Sreekumar Ramachandran, Sheng Xia, Jay R Unruh, Juliana Conkright-Fincham, Rong Li. Dopamine receptor antagonists as potential therapeutic agents for ADPKD.
PloS one.
2019; 14(5):e0216220. doi:
10.1371/journal.pone.0216220
. [PMID: 31059522] - Magd Badaoui, Adam Kells, Carla Molteni, Callum J Dickson, Viktor Hornak, Edina Rosta. Calculating Kinetic Rates and Membrane Permeability from Biased Simulations.
The journal of physical chemistry. B.
2018 12; 122(49):11571-11578. doi:
10.1021/acs.jpcb.8b07442
. [PMID: 30247032] - Cheol Min Shin, Yoon Jin Lee, Jong-Min Kim, Jee Young Lee, Kyung-Joon Kim, Yoon Jin Choi, Nayoung Kim, Dong Ho Lee. DA-9701 on gastric motility in patients with Parkinson's disease: A randomized controlled trial.
Parkinsonism & related disorders.
2018 09; 54(?):84-89. doi:
10.1016/j.parkreldis.2018.04.018
. [PMID: 29705555] - Vahid Zadmajid, Somayeh Bashiri, Nastaran Sharafi, Ian Anthony Ernest Butts. Effect of hCG and Ovaprim™ on reproductive characteristics of male Levantine scraper, Capoeta damascina (Valenciennes, 1842).
Theriogenology.
2018 Jul; 115(?):45-56. doi:
10.1016/j.theriogenology.2018.04.017
. [PMID: 29705659] - Beata Irena Cejko, Sławomir Krejszeff, Daniel Żarski, Sylwia Judycka, Katarzyna Targońska, Dariusz Kucharczyk. Effect of carp pituitary homogenate (CPH) and sGnRHa (Ovaprim) on northern pike (Esox lucius) spermiation stimulation and its effect on quantity and quality of sperm.
Animal reproduction science.
2018 Jun; 193(?):217-225. doi:
10.1016/j.anireprosci.2018.04.073
. [PMID: 29705131] - Gamal A Shazly, Sultan Alshehri, Mohamed A Ibrahim, Hesham M Tawfeek, Jelan A Razik, Yasser A Hassan, Faiyaz Shakeel. Development of Domperidone Solid Lipid Nanoparticles: In Vitro and In Vivo Characterization.
AAPS PharmSciTech.
2018 May; 19(4):1712-1719. doi:
10.1208/s12249-018-0987-2
. [PMID: 29532427] - E C Shontz, C L Souders, J T Schmidt, C J Martyniuk. Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio).
Genes, brain, and behavior.
2018 04; 17(4):e12460. doi:
10.1111/gbb.12460
. [PMID: 29377542] - Veronika Jablonická, Jörg Ziegler, Zuzana Vatehová, Desana Lišková, Ingo Heilmann, Marek Obložinský, Mareike Heilmann. Inhibition of phospholipases influences the metabolism of wound-induced benzylisoquinoline alkaloids in Papaver somniferum L.
Journal of plant physiology.
2018 Apr; 223(?):1-8. doi:
10.1016/j.jplph.2018.01.007
. [PMID: 29433083] - Amanda R Noble, Norman J Maitland, Daniel M Berney, Martin G Rumsby. Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation.
British journal of cancer.
2018 01; 118(2):189-199. doi:
10.1038/bjc.2017.391
. [PMID: 29136407] - Vahid Zadmajid, Rahman Mirzaee, Hamid Hoseinpour, Nazir Vahedi, Ian Anthony Ernest Butts. Hormonal induction of ovulation using Ovaprim™ [(D-Arg6, Pro9NEt)-sGnRH+domperidone] and its impact on embryonic development of wild-caught Longspine scraper, Capoeta trutta (Heckel, 1843).
Animal reproduction science.
2017 Dec; 187(?):79-90. doi:
10.1016/j.anireprosci.2017.10.009
. [PMID: 29113725] - A Acharjee, R Chaube, K P Joy. Ovaprim, a commercial spawning inducer, stimulates gonadotropin subunit gene transcriptional activity: A study correlated with plasma steroid profile, ovulation and fertilization in the catfish Heteropneustes fossilis.
General and comparative endocrinology.
2017 09; 251(?):66-73. doi:
10.1016/j.ygcen.2016.10.001
. [PMID: 27720753] - Carolin Tetyczka, Martin Griesbacher, Markus Absenger-Novak, Eleonore Fröhlich, Eva Roblegg. Development of nanostructured lipid carriers for intraoral delivery of Domperidone.
International journal of pharmaceutics.
2017 Jun; 526(1-2):188-198. doi:
10.1016/j.ijpharm.2017.04.076
. [PMID: 28461264] - Xuyu Chai, Hongyu Chai, Xiaoyu Wang, Jingjing Yang, Jin Li, Yan Zhao, Weimin Cai, Tao Tao, Xiaoqiang Xiang. Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone.
Scientific reports.
2017 06; 7(1):2829. doi:
10.1038/s41598-017-03097-x
. [PMID: 28588251] - Pakinaz Y Khashaba, Hassan Refat H Ali, Mohamed M El-Wekil. Simultaneous voltammetric analysis of anti-ulcer and D2-antagonist agents in binary mixture using redox sensor and their determination in human serum.
Materials science & engineering. C, Materials for biological applications.
2017 Jun; 75(?):733-741. doi:
10.1016/j.msec.2017.02.092
. [PMID: 28415523] - Ahmed Madisch, Bettina R Vinson, Heba Abdel-Aziz, Olaf Kelber, Karen Nieber, Karin Kraft, Martin Storr. Modulation of gastrointestinal motility beyond metoclopramide and domperidone : Pharmacological and clinical evidence for phytotherapy in functional gastrointestinal disorders.
Wiener medizinische Wochenschrift (1946).
2017 May; 167(7-8):160-168. doi:
10.1007/s10354-017-0557-3
. [PMID: 28424994] - Emilie Zingler, Angélica Amorim Amato, Alysson Zanatta, Maria de Fátima Brito Vogt, Miriam da Silva Wanderley, Coríntio Mariani Neto, Alberto Moreno Zaconeta. Lactation Induction in a Commissioned Mother by Surrogacy: Effects on Prolactin Levels, Milk Secretion and Mother Satisfaction.
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia.
2017 Feb; 39(2):86-89. doi:
10.1055/s-0037-1598641
. [PMID: 28257588] - B Ponchon, X Zhao, S Ollier, P Lacasse. Relationship between glucocorticoids and prolactin during mammary gland stimulation in dairy cows.
Journal of dairy science.
2017 Feb; 100(2):1521-1534. doi:
10.3168/jds.2016-11490
. [PMID: 28012629] - Carsten Stoetzer, Marc Voelker, Thorben Doll, Joerg Heineke, Florian Wegner, Andreas Leffler. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels.
Anesthesia and analgesia.
2017 01; 124(1):52-60. doi:
10.1213/ane.0000000000001673
. [PMID: 27861438] - Bhargavi Latha Athukuri, Prasad Neerati. Enhanced Oral Bioavailability of Domperidone with Piperine in Male Wistar Rats: Involvement of CYP3A1 and P-gp Inhibition.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2017; 20(?):28-37. doi:
10.18433/j3mk72
. [PMID: 28459658] - Yuki Inaba, Yuki Kato, Azumi Itou, Aoi Chiba, Ken Sawai, Ferenc Fülöp, György Miklos Nagy, Tsutomu Hashizume. Effects of extracerebral dopamine on salsolinol- or thyrotropin-releasing hormone-induced prolactin (PRL) secretion in goats.
Animal science journal = Nihon chikusan Gakkaiho.
2016 Dec; 87(12):1522-1527. doi:
10.1111/asj.12586
. [PMID: 26997651] - Xin Chang, Shuai Wang, Yong-Rui Bao, Tian-Jiao Li, Xiao-Meng Yu, Xian-Sheng Meng. Multicomponent, multitarget integrated adjustment - Metabolomics study of Qizhiweitong particles curing gastrointestinal motility disorders in mice induced by atropine.
Journal of ethnopharmacology.
2016 Aug; 189(?):14-21. doi:
10.1016/j.jep.2016.05.024
. [PMID: 27180317] - Simin Salehi, Sara Rasoul-Amini, Noushin Adib, Maryam Shekarchi. Synthesis of molecular imprinted polymers for selective extraction of domperidone from human serum using high performance liquid chromatography with fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Aug; 1027(?):165-73. doi:
10.1016/j.jchromb.2016.05.035
. [PMID: 27288934] - Magdalena Bamburowicz-Klimkowska, Tadeusz Szost, Anna Małkowska, Mirosław Szutowski. QUINIDINE AND DOMPERIDONE INTERACTIONS IN THE RAT EXPERIMENTAL MODEL OF REPEATED ADMINISTRATION.
Acta poloniae pharmaceutica.
2016 07; 73(4):1057-1066. doi:
NULL
. [PMID: 29648732] - Mirjam Clemens-Hemmelmann, Christiane Kuffner, Verena Metz, Linda Kircher, Ulrich Schmitt, Christoph Hiemke, Rolf Postina, Rudolf Zentel. Amphiphilic Copolymers Shuttle Drugs Across the Blood-Brain Barrier.
Macromolecular bioscience.
2016 05; 16(5):655-65. doi:
10.1002/mabi.201500388
. [PMID: 26766666] - Amjad Khan, Zafar Iqbal, Ibrahim Khadra, Lateef Ahmad, Abad Khan, Muhammad Imran Khan, Zia Ullah, Ismail. Simultaneous determination of domperidone and Itopride in pharmaceuticals and human plasma using RP-HPLC/UV detection: Method development, validation and application of the method in in-vivo evaluation of fast dispersible tablets.
Journal of pharmaceutical and biomedical analysis.
2016 Mar; 121(?):6-12. doi:
10.1016/j.jpba.2015.12.036
. [PMID: 26773534] - Yoonjin Nam, Jong Mi Lee, Yiyi Wang, Hyun Su Ha, Uy Dong Sohn. The effect of Flos Lonicerae Japonicae extract on gastro-intestinal motility function.
Journal of ethnopharmacology.
2016 Feb; 179(?):280-90. doi:
10.1016/j.jep.2015.12.056
. [PMID: 26743226] - M K VanKlompenberg, R Manjarín, C E Donovan, J F Trott, R C Hovey. Regulation and localization of vascular endothelial growth factor within the mammary glands during the transition from late gestation to lactation.
Domestic animal endocrinology.
2016 Jan; 54(?):37-47. doi:
10.1016/j.domaniend.2015.09.003
. [PMID: 26490114] - Ian Templeton, Paulien Ravenstijn, Carlo Sensenhauser, Jan Snoeys. A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4.
Biopharmaceutics & drug disposition.
2016 Jan; 37(1):15-27. doi:
10.1002/bdd.1992
. [PMID: 26356245] - Takavar Mohammadian, Pedram Malekpouri, Mojtaba Zare, Mohammad Anwar Zainodini. Effects of different spawning agents on serum levels of reproductive steroid hormones and cortisol level in adult female Barbus sharpeyi (Gunther, 1874).
Fish physiology and biochemistry.
2015 Dec; 41(6):1475-89. doi:
10.1007/s10695-015-0100-7
. [PMID: 26164861] - P Lacasse, S Ollier. The dopamine antagonist domperidone increases prolactin concentration and enhances milk production in dairy cows.
Journal of dairy science.
2015 Nov; 98(11):7856-64. doi:
10.3168/jds.2015-9865
. [PMID: 26298751] - Rosy, Rajendra N Goyal. Gold nanoparticles decorated poly-melamine modified glassy carbon sensor for the voltammetric estimation of domperidone in pharmaceuticals and biological fluids.
Talanta.
2015 Aug; 141(?):53-9. doi:
10.1016/j.talanta.2015.03.018
. [PMID: 25966380] - Bei Hu, Heng Ye, Cheng Sun, Yichen Zhang, Zhigang Lao, Fanghong Wu, Zhaohui Liu, Linxi Huang, Changchun Qu, Lewu Xian, Hao Wu, Yingjie Jiao, Junling Liu, Juyu Cai, Weiying Chen, Zhiqiang Nie, Zaiyi Liu, Chunbo Chen. Metoclopramide or domperidone improves post-pyloric placement of spiral nasojejunal tubes in critically ill patients: a prospective, multicenter, open-label, randomized, controlled clinical trial.
Critical care (London, England).
2015 Feb; 19(?):61. doi:
10.1186/s13054-015-0784-1
. [PMID: 25880172] - M S Alhumayyd, I A Bukhari, A A Almotrefi. Effect of piperine, a major component of black pepper, on the pharmacokinetics of domperidone in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2014 Dec; 65(6):785-9. doi:
NULL
. [PMID: 25554982] - L S Babinets', I M Halabits'ka, N Ie Botsiuk, S S Riabokon'. [Pathogenetic grounds of trophological impact of chronic pancreatitis complex therapy].
Likars'ka sprava.
2014 Nov; ?(11):128-31. doi:
"
. [PMID: 25528850] - Lei Lan, Fang Zeng, Guan J Liu, Li Ying, Xi Wu, Mailan Liu, Fan-Rong Liang. Acupuncture for functional dyspepsia.
The Cochrane database of systematic reviews.
2014 Oct; ?(10):CD008487. doi:
10.1002/14651858.cd008487.pub2
. [PMID: 25306866] - Yannick Comoglio, Joshua Levitz, Michael A Kienzler, Florian Lesage, Ehud Y Isacoff, Guillaume Sandoz. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Proceedings of the National Academy of Sciences of the United States of America.
2014 Sep; 111(37):13547-52. doi:
10.1073/pnas.1407160111
. [PMID: 25197053] - Tsuneaki Yoshizato, Kimiko Tsutsumi, Tsutomu Kotegawa, Hiromitsu Imai, Shigeyuki Nakano. Determination of domperidone in human plasma using high performance liquid chromatography with fluorescence detection for clinical application.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jun; 961(?):86-90. doi:
10.1016/j.jchromb.2014.05.004
. [PMID: 24869944] - X-J Qiu, S-L Zheng, Y-F Wang, R Wang, L Ye. Rapid and sensitive UPLC-MS/MS method for the determination of domperidone in human plasma and its application to pharmacokinetic study.
Drug research.
2014 Jun; 64(6):330-4. doi:
10.1055/s-0034-1368702
. [PMID: 24549964] - R Chaube, R K Singh, K P Joy. Effects of ovaprim, a commercial spawning inducer, on vasotocin and steroid hormone profiles in the catfish Heteropneustes fossilis: in vivo and in vitro studies.
General and comparative endocrinology.
2014 Jan; 195(?):190-200. doi:
10.1016/j.ygcen.2013.11.009
. [PMID: 24246310] - Amir S Youssef, Upendra A Argikar, Murali Pathikonda, Henry P Parkman, Swati Nagar. Identification of domperidone metabolites in plasma and urine of gastroparesis patients with LC-ESI-MS/MS.
Xenobiotica; the fate of foreign compounds in biological systems.
2013 Dec; 43(12):1073-83. doi:
10.3109/00498254.2013.797623
. [PMID: 23705785] - David Stegner, Ina Thielmann, Peter Kraft, Michael A Frohman, Guido Stoll, Bernhard Nieswandt. Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report.
Arteriosclerosis, thrombosis, and vascular biology.
2013 Sep; 33(9):2212-7. doi:
10.1161/atvbaha.113.302030
. [PMID: 23868933] - Maria Isabel Roth Carvalho-Freitas, Janete A Anselmo-Franci, João Palermo-Neto, Luciano F Felicio. Prior reproductive experience alters prolactin-induced macrophage responses in pregnant rats.
Journal of reproductive immunology.
2013 Sep; 99(1-2):54-61. doi:
10.1016/j.jri.2013.03.005
. [PMID: 23714392] - Jorge E Nieto, Omar Maher, Scott D Stanley, Richard Larson, Jack R Snyder. In vivo and in vitro evaluation of the effects of domperidone on the gastrointestinal tract of healthy horses.
American journal of veterinary research.
2013 Aug; 74(8):1103-10. doi:
10.2460/ajvr.74.8.1103
. [PMID: 23879848] - Jing-Jing Deng, Hui-Min Fan, Ai-Min Zhang, Min Xie, Xing-Hua Tan. [Efficacy controlled observation on acupuncture and western medicine for gastrointestinal dysmotility in liver cirrhosis].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2013 May; 33(5):389-93. doi:
NULL
. [PMID: 23885607] - Hung Quoc Pham, Augustine Arukwe. Effects of dopamine 2 receptor antagonist on sex steroid levels, oocyte maturation and spawning performances in Waigieu seaperch (Psammoperca waigiensis).
Fish physiology and biochemistry.
2013 Apr; 39(2):403-11. doi:
10.1007/s10695-012-9708-z
. [PMID: 22911104] - Xintao Wang, Feng Qin, Lijuan Jing, Qiang Zhu, Famei Li, Zhili Xiong. Development and validation of UPLC-MS/MS method for determination of domperidone in human plasma and its pharmacokinetic application.
Biomedical chromatography : BMC.
2013 Mar; 27(3):371-6. doi:
10.1002/bmc.2801
. [PMID: 22893392] - Luc M Hondeghem. Domperidone: limited benefits with significant risk for sudden cardiac death.
Journal of cardiovascular pharmacology.
2013 Mar; 61(3):218-25. doi:
10.1097/fjc.0b013e31827afd0d
. [PMID: 23188128] - M K Vanklompenberg, R Manjarin, J F Trott, H F McMicking, R C Hovey. Late gestational hyperprolactinemia accelerates mammary epithelial cell differentiation that leads to increased milk yield.
Journal of animal science.
2013 Mar; 91(3):1102-11. doi:
10.2527/jas.2012-5903
. [PMID: 23296835] - Lin Xiao, Yan Li. [Randomized controlled trial of modified banxia houpo decoction in treating functional dyspepsia patients with psychological factors].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2013 Mar; 33(3):298-302. doi:
"
. [PMID: 23713238] - Liang-mei Zhang, Xin-yi Zhu, Chang-song Wang, Hai-chuan Qu, Guo-xiang Dou. [Effects of tongfu decoction on rats' rapid gastric emptying].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2013 Mar; 33(3):343-5. doi:
"
. [PMID: 23713247] - Qing Ye, Samuel Kantonen, Julian Gomez-Cambronero. Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion.
Journal of molecular biology.
2013 Feb; 425(4):755-66. doi:
10.1016/j.jmb.2012.11.035
. [PMID: 23238254] - D L Cross, C R Reinemeyer, J C Prado, R L Donnell, K G Bond, H Farr, S L Longhofer. Efficacy of domperidone gel in an induced model of fescue toxicosis in periparturient mares.
Theriogenology.
2012 Oct; 78(6):1361-70. doi:
10.1016/j.theriogenology.2012.06.002
. [PMID: 22898028] - Tsuneaki Yoshizato, Tsutomu Kotegawa, Hiromitsu Imai, Kimiko Tsutsumi, Junko Imanaga, Tetsuji Ohyama, Kyoichi Ohashi. Itraconazole and domperidone: a placebo-controlled drug interaction study.
European journal of clinical pharmacology.
2012 Sep; 68(9):1287-94. doi:
10.1007/s00228-012-1258-x
. [PMID: 22418831] - Noriko Nishikawa, Masahiro Nagai, Tomoaki Tsujii, Hirotaka Iwaki, Hayato Yabe, Masahiro Nomoto. Coadministration of domperidone increases plasma levodopa concentration in patients with Parkinson disease.
Clinical neuropharmacology.
2012 Jul; 35(4):182-4. doi:
10.1097/wnf.0b013e3182575cdb
. [PMID: 22751085] - Gurpreetarora, Karan Malik, Vikas Rana, Inderbir Singh. Gum Ghatti--a pharmaceutical excipient: development, evaluation and optimization of sustained release mucoadhesive matrix tablets of domperidone.
Acta poloniae pharmaceutica.
2012 Jul; 69(4):725-37. doi:
"
. [PMID: 22876617] - S M Sharaf. Effect of GnRHa, pimozide and Ovaprim on ovulation and plasma sex steroid hormones in African catfish Clarias gariepinus.
Theriogenology.
2012 May; 77(8):1709-16. doi:
10.1016/j.theriogenology.2011.12.019
. [PMID: 22365698] - Malcolm J Boyce, Kathy J Baisley, Steven J Warrington. Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo-controlled, double-blind, crossover study.
British journal of clinical pharmacology.
2012 Mar; 73(3):411-21. doi:
10.1111/j.1365-2125.2011.04093.x
. [PMID: 21883386] - D Zhang, K Chen, Y Teng, J Zhang, S Liu, C Wei, B Wang, X Liu, G Yuan, R Zhang, R Guo. Determination of domperidone in human plasma using liquid chromatography coupled to tandem mass spectrometry and its pharmacokinetic study.
Arzneimittel-Forschung.
2012 Mar; 62(3):128-33. doi:
10.1055/s-0031-1298010
. [PMID: 22297684] - Makoto Arai, Tomoaki Matsumura, Naoko Tsuchiya, Chiharu Sadakane, Ryouhei Inami, Takuto Suzuki, Masaharu Yoshikawa, Fumio Imazeki, Osamu Yokosuka. Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin.
Hepato-gastroenterology.
2012 Jan; 59(113):62-6. doi:
10.5754/hge11246
. [PMID: 22260823] - N E Stacey, G J Van Der Kraak, K H Olsén. Male primer endocrine responses to preovulatory female cyprinids under natural conditions in Sweden.
Journal of fish biology.
2012 Jan; 80(1):147-65. doi:
10.1111/j.1095-8649.2011.03162.x
. [PMID: 22220895] - Jordan D Secor, Sainath R Kotha, Travis O Gurney, Rishi B Patel, Nicholas R Kefauver, Niladri Gupta, Andrew J Morris, Boyd E Haley, Narasimham L Parinandi. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells.
International journal of toxicology.
2011 Dec; 30(6):619-38. doi:
10.1177/1091581811422413
. [PMID: 21994240] - Edwena D Miles, Yan Xue, James R Strickland, James A Boling, James C Matthews. Ergopeptines bromocriptine and ergovaline and the dopamine type-2 receptor inhibitor domperidone inhibit bovine equilibrative nucleoside transporter 1-like activity.
Journal of agricultural and food chemistry.
2011 Sep; 59(17):9691-9. doi:
10.1021/jf201713m
. [PMID: 21790119] - Shamim Nemati, Bradley A Edwards, Scott A Sands, Philip J Berger, Andrew Wellman, George C Verghese, Atul Malhotra, James P Butler. Model-based characterization of ventilatory stability using spontaneous breathing.
Journal of applied physiology (Bethesda, Md. : 1985).
2011 Jul; 111(1):55-67. doi:
10.1152/japplphysiol.01358.2010
. [PMID: 21474696] - Maria Isabel Roth Carvalho-Freitas, Janete A Anselmo-Franci, Paulo Cesar Maiorka, João Palermo-Neto, Luciano F Felicio. Prolactin differentially modulates the macrophage activity of lactating rats: possible role of reproductive experience.
Journal of reproductive immunology.
2011 Apr; 89(1):38-45. doi:
10.1016/j.jri.2010.12.008
. [PMID: 21420738] - Rishi B Patel, Sainath R Kotha, Shariq I Sherwani, Sean M Sliman, Travis O Gurney, Brooke Loar, Susan O'Connor Butler, Andrew J Morris, Clay B Marsh, Narasimham L Parinandi. Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells.
International journal of toxicology.
2011 Feb; 30(1):69-90. doi:
10.1177/1091581810388850
. [PMID: 21131602] - Inderbir Singh, Pradeep Kumar, Harinderjit Singh, Malvika Goyal, Vikas Rana. Formulation and evaluation of domperidone loaded mineral oil entrapped emulsion gel (MOEG) buoyant beads.
Acta poloniae pharmaceutica.
2011 Jan; 68(1):121-6. doi:
"
. [PMID: 21485710] - Veronique Michaud, Jacques Turgeon. Assessment of competitive and mechanism-based inhibition by clarithromycin: use of domperidone as a CYP3A probe-drug substrate and various enzymatic sources including a new cell-based assay with freshly isolated human hepatocytes.
Drug metabolism letters.
2010 Apr; 4(2):69-76. doi:
10.2174/187231210791292717
. [PMID: 20446912] - S-Y Chang, R M Fancher, H Zhang, J Gan. Mechanism-based inhibition of human cytochrome P4503A4 by domperidone.
Xenobiotica; the fate of foreign compounds in biological systems.
2010 Feb; 40(2):138-45. doi:
10.3109/00498250903406762
. [PMID: 20082577] - Marsha L Campbell-Yeo, Alexander C Allen, K S Joseph, Joyce M Ledwidge, Kim Caddell, Victoria M Allen, Kent C Dooley. Effect of domperidone on the composition of preterm human breast milk.
Pediatrics.
2010 Jan; 125(1):e107-14. doi:
10.1542/peds.2008-3441
. [PMID: 20008425] - J E Ochoa-Amaya, B E Malucelli, P E Cruz-Casallas, A G Nasello, L F Felicio, M I R Carvalho-Freitas. Acute and chronic stress and the inflammatory response in hyperprolactinemic rats.
Neuroimmunomodulation.
2010; 17(6):386-95. doi:
10.1159/000292063
. [PMID: 20516720] - Yuhki Yanase, Nicolas Carvou, Michael A Frohman, Shamshad Cockcroft. Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6.
The Biochemical journal.
2009 Dec; 425(1):179-93. doi:
10.1042/bj20091122
. [PMID: 19845506] - Frederique Fenneteau, Jun Li, Fahima Nekka. Assessing drug distribution in tissues expressing P-glycoprotein using physiologically based pharmacokinetic modeling: identification of important model parameters through global sensitivity analysis.
Journal of pharmacokinetics and pharmacodynamics.
2009 Dec; 36(6):495-522. doi:
10.1007/s10928-009-9134-8
. [PMID: 19847628] - Zhan Li, Jing Yao, Ziqiang Zhang, Luyong Zhang. Simultaneous determination of omeprazole and domperidone in dog plasma by LC-MS method.
Journal of chromatographic science.
2009 Nov; 47(10):881-4. doi:
10.1093/chromsci/47.10.881
. [PMID: 19930799] - K L Jones, S S King. Effect of domperidone supplementation of fescue-fed heifers on plasma and follicular fluid fatty acid composition and oocyte quality.
Journal of animal science.
2009 Jul; 87(7):2227-38. doi:
10.2527/jas.2008-1641
. [PMID: 19329482] - Guo-ying Zhou, Guo-sheng Zhou, Jin Jian-hong. [Clinical observation on transcutaneous electrical acupoint stimulation for treatment of functional dyspepsia].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2009 Jun; 29(6):436-40. doi:
NULL
. [PMID: 19563187] - Jorge Soliz, Jonas Juhl Thomsen, Christophe Soulage, Carsten Lundby, Max Gassmann. Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Jun; 296(6):R1837-46. doi:
10.1152/ajpregu.90967.2008
. [PMID: 19321698] - G Mari, M Morganti, B Merlo, C Castagnetti, F Parmeggiani, N Govoni, G Galeati, C Tamanini. Administration of sulpiride or domperidone for advancing the first ovulation in deep anestrous mares.
Theriogenology.
2009 Apr; 71(6):959-65. doi:
10.1016/j.theriogenology.2008.11.001
. [PMID: 19117600]