Delapril (BioDeep_00000653607)
代谢物信息卡片
Delapril
化学式: C26H32N2O5 (452.2311102)
中文名称: 地拉普利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2
InChI: InChI=1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1
描述信息
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135735
- KEGGdrug: D07781
- PubChem: 5362116
- DrugBank: DB13312
- ChEMBL: CHEMBL589583
- CAS: 83435-66-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Piero Ruggenenti, Giuseppe Lauria, Ilian Petrov Iliev, Anna Fassi, Aneliya Parvanova Ilieva, Stefano Rota, Carlos Chiurchiu, Drazenka Pongrac Barlovic, Angelo Sghirlanzoni, Raffaella Lombardi, Paola Penza, Guido Cavaletti, Maria Luisa Piatti, Barbara Frigeni, Marco Filipponi, Nadia Rubis, Greta Noris, Nicola Motterlini, Bogdan Ene-Iordache, Flavio Gaspari, Annalisa Perna, Jelka Zaletel, Antonio Bossi, Alessandro Roberto Dodesini, Roberto Trevisan, Giuseppe Remuzzi. Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial.
Hypertension (Dallas, Tex. : 1979).
2011 Nov; 58(5):776-83. doi:
10.1161/hypertensionaha.111.174474. [PMID: 21931073] - Osvaldo Kohlmann, Alejandro Roca-Cusachs, Stéphane Laurent, Roland E Schmieder, René R Wenzel, Roberto Fogari. Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria.
Advances in therapy.
2009 Mar; 26(3):313-24. doi:
10.1007/s12325-009-0015-8. [PMID: 19330493] - Roberto Fogari, Giuseppe Derosa, Annalisa Zoppi, Pierangelo Lazzari, Luca Corradi, Paola Preti, Amedeo Mugellini. Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients.
Internal medicine (Tokyo, Japan).
2008; 47(5):361-6. doi:
10.2169/internalmedicine.47.0449. [PMID: 18310964] - Roberto Fogari, Giuseppe Derosa, Annalisa Zoppi, Andrea Rinaldi, Paola Preti, Pierangelo Lazzari, Amedeo Mugellini. Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Jan; 31(1):43-50. doi:
10.1291/hypres.31.43. [PMID: 18360017] - A Mugellini, P Preti, A Zoppi, L Corradi, E Fogari, G Derosa, R Fogari. Effect of delapril-manidipine combination vs irbesartan-hydrochlorothiazide combination on fibrinolytic function in hypertensive patients with type II diabetes mellitus.
Journal of human hypertension.
2004 Oct; 18(10):687-91. doi:
10.1038/sj.jhh.1001726. [PMID: 15071488] - Salvatore Paterna, Vincenzo Di Garbo, Gino Avellone, Pietro Di Pasquale, Antonio Tuttolomondo, Giuseppe Follone, Antonietta Cardinale, Tiziana Maniscalchi, Giuseppe Licata. Different effects of losartan and delapril on plasma PAI-1 levels in patients with mild to moderate hypertension.
International journal of cardiology.
2003 Dec; 92(2-3):303-4. doi:
10.1016/s0167-5273(03)00113-x. [PMID: 14659871] - Chihiro Shikata, Atsushi Takeda, Nobuakira Takeda. Effect of an ACE inhibitor and an AT1 receptor antagonist on cardiac hypertrophy.
Molecular and cellular biochemistry.
2003 Jun; 248(1-2):197-202. doi:
10.1023/a:1024109007392. [PMID: 12870674] - Armel Stockis, Christophe Gengler, Fabienne Goethals, Bernard Jeanbaptiste, Simone Lens, Gianluigi Poli, Daniela Acerbi. Single oral dose pharmacokinetic interaction study of manidipine and delapril in healthy volunteers.
Arzneimittel-Forschung.
2003; 53(9):627-34. doi:
10.1055/s-0031-1297159. [PMID: 14558436] - Armel Stockis, Steven De Bruyn, Christophe Gengler, Fabienne Goethals, Simone Lens, Gianluigi Poli, Daniela Acerbi. Pharmacokinetics and tolerability of a new manidipine and delapril fixed oral combination in young and elderly subjects.
Arzneimittel-Forschung.
2003; 53(8):554-61. doi:
10.1055/s-0031-1297149. [PMID: 13677245] - Kohji Takara, Mikio Kakumoto, Yusuke Tanigawara, Junko Funakoshi, Toshiyuki Sakaeda, Katsuhiko Okumura. Interaction of digoxin with antihypertensive drugs via MDR1.
Life sciences.
2002 Feb; 70(13):1491-500. doi:
10.1016/s0024-3205(01)01494-1. [PMID: 11895100] - Hideaki Nakaya, Hiroyuki Sasamura, Matsuhiko Hayashi, Takao Saruta. Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosis.
Journal of the American Society of Nephrology : JASN.
2001 Apr; 12(4):659-666. doi:
10.1681/asn.v124659. [PMID: 11274226] - C Deerochanawong, P Kornthong, S Phongwiratchai, S Serirat. Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2001 Feb; 84(2):234-41. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2000 Sep; 23(5):483-90. doi:
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Diabetes research and clinical practice.
2000 Feb; 47(2):97-104. doi:
10.1016/s0168-8227(99)00114-x. [PMID: 10670908] - M Matoba, T Asaji, S Matsui, N Takekoshi. Long-term effects of delapril hydrochloride on procollagen type III amino-terminal peptide, left ventricular mass and left ventricular function in hypertensive patients.
Japanese circulation journal.
1998 Dec; 62(12):900-2. doi:
10.1253/jcj.62.900. [PMID: 9890202] - R Razzetti, S Bongrani, G Oberto, R Ferrari, G Biagini. Protective effects of delapril, indapamide and their combination on stroke occurrence and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats.
Arzneimittel-Forschung.
1998 Nov; 48(11):1083-7. doi:
NULL. [PMID: 9850429] - D Acanfora, D T Lowenthal, G Furgi, L Trojano, C Picone, G L Iannuzzi, A Papa, F Rengo. The effects of delapril in combination with indapamide on glomerular filtration rate in elderly hypertensive patients.
American journal of therapeutics.
1997 Nov; 4(11-12):405-8. doi:
10.1097/00045391-199711000-00011. [PMID: 10423638] - G Biagini, M Zoli, C Torri, S Boschi, G Vantaggiato, M Ballestri, A Baraldi, L F Agnati. Protective effects of delapril, indapamide and their combination chronically administered to stroke-prone spontaneously hypertensive rats fed a high-sodium diet.
Clinical science (London, England : 1979).
1997 Nov; 93(5):401-11. doi:
10.1042/cs0930401. [PMID: 9486085] - S Suzuki, M Ohtomo, Y Satoh, H Kawasaki, M Hirai, A Hirai, S Hirai, M Onoda, Y Hinokio, H Akai, T Toyota. Effect of manidipine and delapril on insulin sensitivity in type 2 diabetic patients with essential hypertension.
Diabetes research and clinical practice.
1996 Jun; 33(1):43-51. doi:
10.1016/0168-8227(96)01273-9. [PMID: 8877275] - K Shimamoto, N Ura, M Nakagawa, K Higashiura, H Takizawa, Y Miyazaki, N Nomura, A Hirata, Y Takagawa, H Murakami, O Iimura. The mechanisms of the improvement of insulin sensitivity by angiotensin converting enzyme inhibitor.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1996 Feb; 18(2):257-66. doi:
10.3109/10641969609081768. [PMID: 8869004] - A Kubo, N Fukuda, M Soma, Y Izumi, K Kanmatsuse. Inhibitory effect of an angiotensin II type 1 receptor antagonist on growth of vascular smooth muscle cells from spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
1996 Jan; 27(1):58-63. doi:
10.1097/00005344-199601000-00010. [PMID: 8656659] - R Razzetti, D Acerbi. Pharmacokinetic and pharmacologic properties of delapril, a lipophilic nonsulfhydryl angiotensin-converting enzyme inhibitor.
The American journal of cardiology.
1995 Jun; 75(18):7F-12F. doi:
10.1016/s0002-9149(99)80508-6. [PMID: 7778536] - O Iimura, K Shimamoto, K Matsuda, A Masuda, H Takizawa, K Higashiura, Y Miyazaki, A Hirata, N Ura, M Nakagawa. Effects of angiotensin receptor antagonist and angiotensin converting enzyme inhibitor on insulin sensitivity in fructose-fed hypertensive rats and essential hypertensives.
American journal of hypertension.
1995 Apr; 8(4 Pt 1):353-7. doi:
10.1016/0895-7061(94)00245-7. [PMID: 7619347] - Y Inada, M Ojima, K Itoh, A Shino, K Nishikawa. Effects of delapril on stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats.
Drugs under experimental and clinical research.
1995; 21(2):41-9. doi:
NULL. [PMID: 7555608] - T Yoshimoto, M Naruse, A Tanabe, K Naruse, K Takagi, T Muraki, M Itakura, H Hagiwara, S Hirose, H Demura. Angiotensin converting enzyme inhibitor but not calcium blocker down-regulates gene expression of vascular natriuretic peptide receptor in hypertensive rats.
Biochemical and biophysical research communications.
1994 Dec; 205(3):1595-600. doi:
10.1006/bbrc.1994.2849. [PMID: 7811241] - Y Akiyama, M Yoshioka, H Horibe, Y Inada, S Hirai, N Kitamori, H Toguchi. Anti-hypertensive effect of oral controlled-release microspheres containing an ACE inhibitor (delapril hydrochloride) in rats.
The Journal of pharmacy and pharmacology.
1994 Aug; 46(8):661-5. doi:
10.1111/j.2042-7158.1994.tb03878.x. [PMID: 7815280] - A Fujimura, T Sudoh, A Ebihara. Effect of angiotensin II type 1 receptor antagonist on urinary prostaglandin E2 excretion following furosemide in rats.
Life sciences.
1994; 55(9):707-11. doi:
10.1016/0024-3205(94)00678-4. [PMID: 8065233] - V Hutt, G Pabst, C Dilger, G Poli, D Acerbi. Bioavailability and pharmacokinetics of a fixed combination of delapril/indapamide following single and multiple dosing in healthy volunteers.
European journal of drug metabolism and pharmacokinetics.
1994 Jan; 19(1):59-69. doi:
10.1007/bf03188824. [PMID: 7957454] - H Yu, H Rakugi, J Higaki, R Morishita, H Mikami, T Ogihara. The role of activated vascular angiotensin II generation in vascular hypertrophy in one-kidney, one clip hypertensive rats.
Journal of hypertension.
1993 Dec; 11(12):1347-55. doi:
10.1097/00004872-199312000-00005. [PMID: 8133017] - H Yamagishi, S Kim, T Nishikimi, K Takeuchi, T Takeda. Contribution of cardiac renin-angiotensin system to ventricular remodelling in myocardial-infarcted rats.
Journal of molecular and cellular cardiology.
1993 Nov; 25(11):1369-80. doi:
10.1006/jmcc.1993.1149. [PMID: 8301670] - K Kohara, H Mikami, N Okuda, J Higaki, T Ogihara. Angiotensin blockade and the progression of renal damage in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979).
1993 Jun; 21(6 Pt 2):975-9. doi:
10.1161/01.hyp.21.6.975. [PMID: 8505110] - T S Chu, M S Wu, Y M Chen, K D Wu. [Blood pressure and metabolic response to converting enzyme inhibitor in hypertensive patients: comparison between delapril and captopril].
Journal of the Formosan Medical Association = Taiwan yi zhi.
1992 Dec; 91 Suppl 4(?):S288-92. doi:
NULL. [PMID: 1363526] - K Saku, B Zhang, K Hirata, R Liu, N Sasaki, T Sakai, H Ying, K Arakawa. Effects of manidipine and delapril on serum lipids, lipoproteins, and apolipoproteins in patients with mild to moderate essential hypertension: a randomized trial with one-year follow-up.
Clinical therapeutics.
1992 Nov; 14(6):813-20. doi:
NULL. [PMID: 1286488] - T Okura, Y Kitami, R Wakamiya, K Marumoto, T Iwata, K Hiwada. Renal and extra-renal renin gene expression in spontaneously hypertensive rats.
Blood pressure. Supplement.
1992; 3(?):6-11. doi:
NULL. [PMID: 1343292] - K Atarashi, M Takagi, M Minami, Y Kimura, H Matsuoka, T Sugimoto. Effects of manidipine and delapril on glucose and lipid metabolism in hypertensive patients with non-insulin-dependent diabetes mellitus.
Blood pressure. Supplement.
1992; 3(?):130-4. doi:
NULL. [PMID: 1343282] - Y Kitami, T Okura, R Wakamiya, K Marumoto, T Iwata, K Hiwada. Regulation of the gene expression of type-1 angiotensin II receptor in spontaneously hypertensive rats.
Blood pressure. Supplement.
1992; 3(?):12-6. doi:
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Nihon Jinzo Gakkai shi.
1991 Nov; 33(11):1089-96. doi:
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Nihon Jinzo Gakkai shi.
1991 Apr; 33(4):417-21. doi:
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American journal of hypertension.
1991 Jan; 4(1 Pt 2):15S-22S. doi:
10.1093/ajh/4.1.15s. [PMID: 2009142] - K Nishiyama, T Igari, S Nanba, M Ishii. Long-term effects of delapril on renal function and urinary excretion of kallikrein, prostaglandin E2, and thromboxane B2 in hypertensive patients.
American journal of hypertension.
1991 Jan; 4(1 Pt 2):52S-53S. doi:
10.1093/ajh/4.1.52s. [PMID: 2009149] - K Minamisawa, H Shionoiri, K Sugimoto, S Ueda, K Ashino, T Ebina, E Gotoh, M Ishii. Depressor effects and pharmacokinetics of single and consecutive doses of delapril in hypertensive patients with normal or impaired renal function.
Cardiovascular drugs and therapy.
1990 Oct; 4(5):1417-23. doi:
10.1007/bf02018270. [PMID: 2177631] - K Nishiyama, T Igari, S Nanba, M Ishii. [The long-term effects of a new converting enzyme inhibitor, delapril hydrochloride, on renal function, renin-angiotensin-aldosterone system and kallikrein-kinin prostaglandin system in hypertensive patients].
Nihon Jinzo Gakkai shi.
1990 Jul; 32(7):801-7. doi:
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Clinical pharmacology and therapeutics.
1988 Mar; 43(3):242-9. doi:
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Clinical nephrology.
1987 Feb; 27(2):65-70. doi:
NULL. [PMID: 3030595] - Y Inada, Z Terashita, Y Imura, M Tanabe, K Nishikawa, S Kikuchi. Inhibition of angiotensin converting enzyme by CV-3317, a non-sulfhydryl compound.
Japanese journal of pharmacology.
1986 Sep; 42(1):99-108. doi:
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Japanese journal of pharmacology.
1986 Sep; 42(1):1-8. doi:
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Fukuoka igaku zasshi = Hukuoka acta medica.
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