Desmethylescitalopram (BioDeep_00000653430)
代谢物信息卡片
(S)-Desmethylcitalopram
化学式: C19H19FN2O (310.1481336)
中文名称: N-去甲基西酞普兰
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNCCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
InChI: InChI=1S/C19H19FN2O/c1-22-10-2-9-19(16-4-6-17(20)7-5-16)18-8-3-14(12-21)11-15(18)13-23-19/h3-8,11,22H,2,9-10,13H2,1H3/t19-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jeffrey R Strawn, Jeffrey A Mills, Heidi Schroeder, Sarah A Mossman, Sara T Varney, Laura B Ramsey, Ethan A Poweleit, Zeruesenay Desta, Kim Cecil, Melissa P DelBello. Escitalopram in Adolescents With Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study.
The Journal of clinical psychiatry.
2020 08; 81(5):. doi:
10.4088/jcp.20m13396. [PMID: 32857933] - Shoko Tsuchimine, Shinichiro Ochi, Misuzu Tajiri, Yutaro Suzuki, Norio Sugawara, Yoshimasa Inoue, Norio Yasui-Furukori. Effects of Cytochrome P450 (CYP) 2C19 Genotypes on Steady-State Plasma Concentrations of Escitalopram and its Desmethyl Metabolite in Japanese Patients With Depression.
Therapeutic drug monitoring.
2018 06; 40(3):356-361. doi:
10.1097/ftd.0000000000000506. [PMID: 29570504] - Danielle Krout, Meghan Rodriquez, Stephen A Brose, Mikhail Y Golovko, L Keith Henry, Brent J Thompson. Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms.
ACS chemical neuroscience.
2017 05; 8(5):1011-1018. doi:
10.1021/acschemneuro.6b00343. [PMID: 27959497] - Etienne Weisskopf, Alice Panchaud, Kim An Nguyen, Delphine Grosjean, Jean-Michel Hascoët, Chantal Csajka, Chin B Eap, Nicolas Ansermot. Stereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2016 Nov; 131(?):233-245. doi:
10.1016/j.jpba.2016.08.014. [PMID: 27606925] - Norio Yasui-Furukori, Shoko Tsuchimine, Kazutoshi Kubo, Masamichi Ishioka, Kazuhiko Nakamura, Yoshimasa Inoue. The Effects of Fluvoxamine on the Steady-State Plasma Concentrations of Escitalopram and Desmethylescitalopram in Depressed Japanese Patients.
Therapeutic drug monitoring.
2016 08; 38(4):483-6. doi:
10.1097/ftd.0000000000000303. [PMID: 27002781] - Michael Paulzen, Sarah E Lammertz, Gerhard Gründer, Tanja Veselinovic, Christoph Hiemke, Simone C Tauber. Measuring citalopram in blood and cerebrospinal fluid: revealing a distribution pattern that differs from other antidepressants.
International clinical psychopharmacology.
2016 05; 31(3):119-26. doi:
10.1097/yic.0000000000000114. [PMID: 26650488] - Nieves Velez de Mendizabal, Kimberley Jackson, Brian Eastwood, Steven Swanson, David M Bender, Stephen Lowe, Robert R Bies. A population PK model for citalopram and its major metabolite, N-desmethyl citalopram, in rats.
Journal of pharmacokinetics and pharmacodynamics.
2015 Dec; 42(6):721-33. doi:
10.1007/s10928-015-9448-7. [PMID: 26395999] - Luca Morini, Claudia Vignali, Paolo Tricomi, Angelo Groppi. Analytical Challenge in Postmortem Toxicology Applied to a Human Body Found into a Lake after Three Years Immersion.
Journal of forensic sciences.
2015 Sep; 60(5):1383-6. doi:
10.1111/1556-4029.12815. [PMID: 26258895] - Nora Unceta, Alberto Gómez-Caballero, Deiene García, Goretti Díaz, Antonio Guerreiro, Sergey Piletsky, M Aránzazu Goicolea, Ramón J Barrio. Enantioselective extraction of (+)-(S)-citalopram and its main metabolites using a tailor-made stir bar chiral imprinted polymer for their LC-ESI-MS/MS quantitation in urine samples.
Talanta.
2013 Nov; 116(?):448-53. doi:
10.1016/j.talanta.2013.07.004. [PMID: 24148428] - Tao Jiang, Zhengxing Rong, Liang Peng, Bing Chen, Yifan Xie, Congying Chen, Jing Sun, Yiping Xu, Yang Lu, Hongzhuan Chen. Simultaneous determination of citalopram and its metabolite in human plasma by LC-MS/MS applied to pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Feb; 878(5-6):615-9. doi:
10.1016/j.jchromb.2010.01.004. [PMID: 20116349] - I Rudberg, J L E Reubsaet, M Hermann, H Refsum, E Molden. Identification of a novel CYP2C19-mediated metabolic pathway of S-citalopram in vitro.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Dec; 37(12):2340-8. doi:
10.1124/dmd.109.029355. [PMID: 19773541] - Andrew F Leuchter, Ian A Cook, Lauren B Marangell, William S Gilmer, Karl S Burgoyne, Robert H Howland, Madhukar H Trivedi, Sidney Zisook, Rakesh Jain, James T McCracken, Maurizio Fava, Dan Iosifescu, Scott Greenwald. Comparative effectiveness of biomarkers and clinical indicators for predicting outcomes of SSRI treatment in Major Depressive Disorder: results of the BRITE-MD study.
Psychiatry research.
2009 Sep; 169(2):124-31. doi:
10.1016/j.psychres.2009.06.004. [PMID: 19712979] - Jean D Deupree, Megan D Montgomery, David B Bylund. Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram.
European journal of pharmacology.
2007 Dec; 576(1-3):55-60. doi:
10.1016/j.ejphar.2007.08.017. [PMID: 17850785] - Ophelia Q P Yin, Yun-Kwok Wing, Yun-Kowk Wing, Yuet Cheung, Zhi-Jun Wang, Siu-Ling Lam, Helen F K Chiu, Moses S S Chow. Phenotype-genotype relationship and clinical effects of citalopram in Chinese patients.
Journal of clinical psychopharmacology.
2006 Aug; 26(4):367-72. doi:
10.1097/01.jcp.0000227355.54074.14. [PMID: 16855453] - Sarah M R Wille, Kristof E Maudens, Carlos H Van Peteghem, Willy E E Lambert. Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
Journal of chromatography. A.
2005 Dec; 1098(1-2):19-29. doi:
10.1016/j.chroma.2005.08.059. [PMID: 16314157] - Qing H Meng, Donna Gauthier. Simultaneous analysis of citalopram and desmethylcitalopram by liquid chromatography with fluorescence detection after solid-phase extraction.
Clinical biochemistry.
2005 Mar; 38(3):282-5. doi:
10.1016/j.clinbiochem.2004.12.009. [PMID: 15708552] - Karin Herrlin, Norio Yasui-Furukori, Gunnel Tybring, Jolanta Widén, Lars L Gustafsson, Leif Bertilsson. Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes.
British journal of clinical pharmacology.
2003 Oct; 56(4):415-21. doi:
10.1046/j.1365-2125.2003.01874.x. [PMID: 12968986] - Solveig Andersen, Trine Grønhaug Halvorsen, Stig Pedersen-Bjergaard, Knut E Rasmussen, Lars Tanum, Helge Refsum. Stereospecific determination of citalopram and desmethylcitalopram by capillary electrophoresis and liquid-phase microextraction.
Journal of pharmaceutical and biomedical analysis.
2003 Sep; 33(2):263-73. doi:
10.1016/s0731-7085(03)00264-4. [PMID: 12972091] - Margareta Reis, Jöns Lundmark, Finn Bengtsson. Therapeutic drug monitoring of racemic citalopram: a 5-year experience in Sweden, 1992-1997.
Therapeutic drug monitoring.
2003 Apr; 25(2):183-91. doi:
10.1097/00007691-200304000-00007. [PMID: 12657912] - Margareta Reis, Gunilla Olsson, Björn Carlsson, Jöns Lundmark, Marja-Liisa Dahl, Jan Wålinder, Johan Ahlner, Finn Bengtsson. Serum levels of citalopram and its main metabolites in adolescent patients treated in a naturalistic clinical setting.
Journal of clinical psychopharmacology.
2002 Aug; 22(4):406-13. doi:
10.1097/00004714-200208000-00012. [PMID: 12172341] - T G Halvorsen, S Pedersen-Bjergaard, K E Rasmussen. Liquid-phase microextraction and capillary electrophoresis of citalopram, an antidepressant drug.
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2001 Feb; 909(1):87-93. doi:
10.1016/s0021-9673(00)00868-2. [PMID: 11218145] - K K Akerman, J Jolkkonen, H Huttunen, I Penttilä. High-performance liquid chromatography method for analyzing citalopram and desmethylcitalopram from human serum.
Therapeutic drug monitoring.
1998 Feb; 20(1):25-9. doi:
10.1097/00007691-199802000-00005. [PMID: 9485550] - P N Jensen, O V Olesen, A Bertelsen, K Linnet. Citalopram and desmethylcitalopram concentrations in breast milk and in serum of mother and infant.
Therapeutic drug monitoring.
1997 Apr; 19(2):236-9. doi:
10.1097/00007691-199704000-00021. [PMID: 9108657] - O V Olesen, K Linnet. Simplified high-performance liquid chromatographic method for the determination of citalopram and desmethylcitalopram in serum without interference from commonly used psychotropic drugs and their metabolites.
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1996 Jan; 675(1):83-8. doi:
10.1016/0378-4347(95)00347-9. [PMID: 8634772] - B Rochat, M Amey, P Baumann. Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography.
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