Ilomastat (BioDeep_00000653379)
代谢物信息卡片
化学式: C20H28N4O4 (388.2110448)
中文名称: 伊洛马司他
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC
InChI: InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:137236
- KEGGdrug: D03793
- PubChem: 132519
- DrugBank: DB02255
- ChEMBL: CHEMBL19611
- CAS: 142880-36-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yousuke Yamada, Hajime Takashima, David Lee Walmsley, Fumihito Ushiyama, Yohei Matsuda, Harumi Kanazawa, Toru Yamaguchi-Sasaki, Nozomi Tanaka-Yamamoto, Junya Yamagishi, Risa Kurimoto-Tsuruta, Yuya Ogata, Norikazu Ohtake, Hayley Angove, Lisa Baker, Richard Harris, Alba Macias, Alan Robertson, Allan Surgenor, Hayato Watanabe, Koichiro Nakano, Masashi Mima, Kunihiko Iwamoto, Atsushi Okada, Iichiro Takata, Kosuke Hitaka, Akihiro Tanaka, Kiyoko Fujita, Hiroyuki Sugiyama, Roderick E Hubbard. Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
Journal of medicinal chemistry.
2020 12; 63(23):14805-14820. doi:
10.1021/acs.jmedchem.0c01215. [PMID: 33210531] - Eduard Sarró, Conxita Jacobs-Cachá, Emilio Itarte, Anna Meseguer. A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Toxicology and applied pharmacology.
2012 Jan; 258(2):275-87. doi:
10.1016/j.taap.2011.11.007. [PMID: 22155090] - Baoman Li, Shiquen Zhang, Min Li, Leif Hertz, Liang Peng. Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.
Psychopharmacology.
2009 Nov; 207(1):1-12. doi:
10.1007/s00213-009-1631-3. [PMID: 19662385] - Magdalena Chadzinska, Pawel Baginski, Elzbieta Kolaczkowska, Huub F J Savelkoul, B M Lidy Verburg-van Kemenade. Expression profiles of matrix metalloproteinase 9 in teleost fish provide evidence for its active role in initiation and resolution of inflammation.
Immunology.
2008 Dec; 125(4):601-10. doi:
10.1111/j.1365-2567.2008.02874.x. [PMID: 18557954] - Aphrodite Caragounis, Tai Du, Gulay Filiz, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Robert A Cherny, Colin L Masters, Simon C Drew, Andrew F Hill, Qiao-Xin Li, Peter J Crouch, Kevin J Barnham, Anthony R White. Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.
The Biochemical journal.
2007 Nov; 407(3):435-50. doi:
10.1042/bj20070579. [PMID: 17680773] - Mayya Meriane, Stéphanie Duhamel, Laurence Lejeune, Jacques Galipeau, Borhane Annabi. Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells.
Stem cells (Dayton, Ohio).
2006 Nov; 24(11):2557-65. doi:
10.1634/stemcells.2006-0209. [PMID: 16931773] - Chen Cheng-Hsien, Hsu Yung-Ho, Sue Yuh-Mou, Hou Chun-Cheng, Lee Horng-Mo, Huang Huei-Mei, Chen Tso-Hsiao. Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptor transactivation in rat renal tubular cell NRK-52E.
Pflugers Archiv : European journal of physiology.
2006 Apr; 452(1):16-24. doi:
10.1007/s00424-005-0006-9. [PMID: 16261333]