Mofezolac (BioDeep_00000652424)
代谢物信息卡片
化学式: C19H17NO5 (339.1106672)
中文名称: 莫非佐酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=C(C=C1)C2=C(ON=C2C3=CC=C(C=C3)OC)CC(=O)O
InChI: InChI=1S/C19H17NO5/c1-23-14-7-3-12(4-8-14)18-16(11-17(21)22)25-20-19(18)13-5-9-15(24-2)10-6-13/h3-10H,11H2,1-2H3,(H,21,22)
描述信息
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Miroslav Sisa, Lukáš Konečný, Veronika Temml, Alejandro Carazo, Přemysl Mladěnka, Přemysl Landa. SC-560 and mofezolac isosteres as new potent COX-1 selective inhibitors with antiplatelet effect.
Archiv der Pharmazie.
2023 Feb; ?(?):e2200549. doi:
10.1002/ardp.202200549. [PMID: 36772878] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Maria Laura Pati, Paola Vitale, Savina Ferorelli, Mariaclara Iaselli, Morena Miciaccia, Angelina Boccarelli, Giuseppe Davide Di Mauro, Cosimo G Fortuna, Thaisa Francielle Souza Domingos, Luiz Cláudio Rodrigues Pereira da Silva, Marcelo de Pádula, Lucio Mendes Cabral, Plínio Cunha Sathler, Angelo Vacca, Antonio Scilimati, Maria Grazia Perrone. Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.
European journal of medicinal chemistry.
2019 Feb; 164(?):59-76. doi:
10.1016/j.ejmech.2018.12.029. [PMID: 30590258] - Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
Journal of medicinal chemistry.
2012 Mar; 55(5):2287-300. doi:
10.1021/jm201528b. [PMID: 22263894] - Toshiaki Okumura, Izumi Hayashi, Tomoaki Ikezawa, Mariko Yamanaka, Tesshu Takata, Yoshikuni Fujita, Katsunori Saigenji, Shohei Yamashina, Masataka Majima. Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
2002 Nov; 25(6):927-38. doi:
10.1291/hypres.25.927. [PMID: 12484518] - K Goto, H Ochi, Y Yasunaga, H Matsuyuki, T Imayoshi, H Kusuhara, T Okumoto. Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice.
Prostaglandins & other lipid mediators.
1998 Jul; 56(4):245-54. doi:
10.1016/s0090-6980(98)00054-9. [PMID: 9777656] - H Kusuhara, H Matsuyuki, T Okumoto. Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.
Prostaglandins & other lipid mediators.
1998 Jan; 55(1):43-9. doi:
10.1016/s0090-6980(98)00004-5. [PMID: 9661217] - K Satoh, H Furukawa, Y Nasu, H Sone, T Ichiki, R Kodama, M Kuwata, K Yamashita. [Fifty two-week chronic oral toxicity study of mofezolac (N-22) in rats].
The Journal of toxicological sciences.
1990 Jun; 15 Suppl 2(?):77-109. doi:
10.2131/jts.15.supplementii_77. [PMID: 2231796] - K Shimpo, M Takeuchi, M Kiguchi, M Iwata, Y Nasu, H Yada, K Yamashita. [Three-month subacute oral toxicity study of mofezolac (N-22) in dogs].
The Journal of toxicological sciences.
1990 Jun; 15 Suppl 2(?):43-76. doi:
10.2131/jts.15.supplementii_43. [PMID: 2231795] - I Toteno, S Haguro, S Furukawa, T Morinaga, K Morino, S Fujii, O Yamakita. [Reproductive and developmental toxicity study of mofezolac (N-22) (2)--Study by oral administration of N-22 during the period of fetal organogenesis in rats].
The Journal of toxicological sciences.
1990 Jun; 15 Suppl 2(?):165-208. doi:
10.2131/jts.15.supplementii_165. [PMID: 2231789] - T Marunaka, M Maniwa. High-performance of liquid chromatographic determination of [3,4-di-(4-methoxyphenyl)-5-isoxazolyl]acetic acid and its metabolites in human plasma and urine.
Journal of chromatography.
1987 Nov; 422(?):227-33. doi:
10.1016/0378-4347(87)80455-3. [PMID: 3501788] - R A Klocke. Catalysis of CO2 reactions by lung carbonic anhydrase.
Journal of applied physiology: respiratory, environmental and exercise physiology.
1978 Jun; 44(6):882-8. doi:
10.1152/jappl.1978.44.6.882. [PMID: 97250] - M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm.
Biochimica et biophysica acta.
1976 Apr; 428(2):525-31. doi:
10.1016/0304-4165(76)90061-1. [PMID: 6049]