Methoxyflurane (BioDeep_00000006520)

 

Secondary id: BioDeep_00001868042

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


Ethane,2,2-dichloro-1,1-difluoro-1-methoxy-

化学式: C3H4Cl2F2O (163.96072579999998)
中文名称: 甲氧氟烷
谱图信息: 最多检出来源 Homo sapiens(blood) 28.57%

分子结构信息

SMILES: COC(C(Cl)Cl)(F)F
InChI: InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3

描述信息

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
N - Nervous system > N02 - Analgesics

同义名列表

21 个代谢物同义名

Ethane,2,2-dichloro-1,1-difluoro-1-methoxy-; Methyl 1,1-difluoro-2,2-dichloroethyl ether; 2,2-dichloro-1,1-difluoro-1-methoxyethane; Methoxyfluorane; Methoxifluranum; Methoxyfluranum; Methoxiflurane; Metossiflurano; methoxyflurane; Methoxyfluoran; Methofluranum; Metoxiflurano; Methoxyfluran; Metoxifluran; Methoflurane; Metoxfluran; Penthrane; Pentrane; Anecotan; Methoxyflurane; Methoxyflurane



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Serah Joan Allison, Paul David Docherty, Dirk Pons, James Geoffrey Chase. Serum fluoride levels in ambulance staff after commencement of methoxyflurane administration compared to meta-analysis results for the general public. International journal of occupational medicine and environmental health. 2021 Dec; 34(6):767-777. doi: 10.13075/ijomeh.1896.01704. [PMID: 34075252]
  • Serah J Allison, Paul D Docherty, Dirk Pons, J Geoffrey Chase. Methoxyflurane toxicity: historical determination and lessons for modern patient and occupational exposure. The New Zealand medical journal. 2021 04; 134(1534):76-90. doi: . [PMID: 33927440]
  • Shigemasa Ikeda. The Reincarnation of Methoxyflurane. Journal of anesthesia history. 2020 Jun; 6(2):79-83. doi: 10.1016/j.janh.2019.07.001. [PMID: 32593381]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • John Frangos, Antti Mikkonen, Christin Down. Derivation of an occupational exposure limit for an inhalation analgesic methoxyflurane (Penthrox(®)). Regulatory toxicology and pharmacology : RTP. 2016 Oct; 80(?):210-25. doi: 10.1016/j.yrtph.2016.05.012. [PMID: 27181451]
  • A D Dayan. Analgesic use of inhaled methoxyflurane: Evaluation of its potential nephrotoxicity. Human & experimental toxicology. 2016 Jan; 35(1):91-100. doi: 10.1177/0960327115578743. [PMID: 25926525]
  • Joao H N Soares, Robert J Brosnan, Fabíola B Fukushima, Joanne Hodges, Hong Liu. Solubility of haloether anesthetics in human and animal blood. Anesthesiology. 2012 Jul; 117(1):48-55. doi: 10.1097/aln.0b013e3182557cc9. [PMID: 22510863]
  • Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson, Steven J Collins. Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity. Molecular neurodegeneration. 2012 Apr; 7(?):18. doi: 10.1186/1750-1326-7-18. [PMID: 22534096]
  • Xueqin Song, Wenqiang Li, Yongfeng Yang, Jingping Zhao, Chengdi Jiang, Wei Li, Luxian Lv. The nuclear factor-κB inhibitor pyrrolidine dithiocarbamate reduces polyinosinic-polycytidilic acid-induced immune response in pregnant rats and the behavioral defects of their adult offspring. Behavioral and brain functions : BBF. 2011 Dec; 7(?):50. doi: 10.1186/1744-9081-7-50. [PMID: 22208616]
  • Joanne Grindlay, Franz E Babl. Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting. Emergency medicine Australasia : EMA. 2009 Feb; 21(1):4-11. doi: 10.1111/j.1742-6723.2009.01153.x. [PMID: 19254307]
  • K Deckardt, I Weber, U Kaspers, J Hellwig, H Tennekes, B van Ravenzwaay. The effects of inhalation anaesthetics on common clinical pathology parameters in laboratory rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007 Sep; 45(9):1709-18. doi: 10.1016/j.fct.2007.03.005. [PMID: 17459552]
  • Evan D Kharasch, Jesara L Schroeder, H Denny Liggitt, Sang B Park, Dale Whittington, Pamela Sheffels. New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. Anesthesiology. 2006 Oct; 105(4):726-36. doi: 10.1097/00000542-200610000-00019. [PMID: 17006072]
  • Evan D Kharasch, Jesara L Schroeder, H Denny Liggitt, Dustin Ensign, Dale Whittington. New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. Anesthesiology. 2006 Oct; 105(4):737-45. doi: 10.1097/00000542-200610000-00020. [PMID: 17006073]
  • Richard I Mazze. Methoxyflurane revisited: tale of an anesthetic from cradle to grave. Anesthesiology. 2006 Oct; 105(4):843-6. doi: 10.1097/00000542-200610000-00031. [PMID: 17006084]
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  • B S Selinsky, M E Perlman, R E London. In vivo nuclear magnetic resonance studies of hepatic methoxyflurane metabolism. I. Verification and quantitation of methoxydifluoroacetate. Molecular pharmacology. 1988 May; 33(5):559-66. doi: NULL. [PMID: 3367903]
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