Heroin hydrochloride (BioDeep_00000651997)
代谢物信息卡片
Heroine hydrochloride
化学式: C21H24ClNO5 (405.13429240000005)
中文名称: 盐酸海洛因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C.Cl
InChI: /m0./s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nikolaos Rousis, Richard Bade, Iván Romero-Sánchez, Jochen F Mueller, Nikolaos S Thomaidis, Kevin V Thomas, Emma Gracia-Lor. Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs.
Environment international.
2023 Jun; 178(?):108075. doi:
10.1016/j.envint.2023.108075. [PMID: 37399770] - Marco Carnevale Miino, Tomáš Macsek, Taťána Halešová, Tomáš Chorazy, Petr Hlavínek. Pharmaceutical and narcotics monitoring in Brno wastewater system and estimation of seasonal effect on the abuse of illicit drugs by a wastewater-based epidemiology approach.
The Science of the total environment.
2023 May; ?(?):164386. doi:
10.1016/j.scitotenv.2023.164386. [PMID: 37263433] - Fataneh Hashem-Dabaghian, Saeed Kianbakht. A randomized controlled trial on the seeds of Sophora alopecuroides var. alopecuroides for the treatment of acute heroin withdrawal syndrome.
Complementary therapies in clinical practice.
2023 Feb; 51(?):101740. doi:
10.1016/j.ctcp.2023.101740. [PMID: 36827871] - Yingbiao Yue, Lei Zou, Jie Tao, Lin Yin, Zhenrong Xie, Yu Xia, Zunyue Zhang, Kunhua Wang, Mei Zhu. Transcriptomics and metabolomics together reveal the underlying mechanism of heroin hepatotoxicity.
Toxicology.
2023 01; 483(?):153393. doi:
10.1016/j.tox.2022.153393. [PMID: 36502556] - Yanjun Zhang, Jing Wang, Lulu Yang, Jiaxin Niu, Ruoqi Huang, Fang Yuan, Qiong Liang. Development of SSR and SNP markers for identifying opium poppy.
International journal of legal medicine.
2022 Sep; 136(5):1261-1271. doi:
10.1007/s00414-022-02810-4. [PMID: 35316386] - Tina Lam, Monica J Barratt, Mark Bartlett, Julie Latimer, Marianne Jauncey, Sarah Hiley, Nico Clark, Dimitri Gerostamoulos, Linda Glowacki, Claude Roux, Marie Morelato, Suzanne Nielsen. Infrequent detection of unintentional fentanyl use via urinalysis among people who regularly inject opioids in Sydney and Melbourne, Australia.
Addiction (Abingdon, England).
2022 Aug; 117(8):2331-2337. doi:
10.1111/add.15832. [PMID: 35129225] - Penn Whitley, Leah LaRue, Soledad A Fernandez, Steven D Passik, Eric Dawson, Rebecca D Jackson. Analysis of Urine Drug Test Results From Substance Use Disorder Treatment Practices and Overdose Mortality Rates, 2013-2020.
JAMA network open.
2022 06; 5(6):e2215425. doi:
10.1001/jamanetworkopen.2022.15425. [PMID: 35657623] - Shahnaz Akhtar, Abdul Razaq, Khalid Sajjad Faras, Muhammad Irfan Ashiq, Mohammad Ashraf Tahir. Identification of the polymer-bounded drugs on the fabric surface: A challenge to the forensic drug analysts.
Journal of forensic sciences.
2022 May; 67(3):1267-1273. doi:
10.1111/1556-4029.14980. [PMID: 35005790] - Namkee G Choi, Bryan Y Choi, Diana M DiNitto, C Nathan Marti, S David Baker. Heroin and fentanyl overdose deaths among cases age 50+ in the National Poison Data System, 2015-2020.
Clinical toxicology (Philadelphia, Pa.).
2022 May; 60(5):639-646. doi:
10.1080/15563650.2021.2016798. [PMID: 34985395] - Tung-Hsia Liu, Hsiao-Hui Tsou, Ren-Hua Chung, Shu Chih Liu, Sheng-Chang Wang, Hsiang-Wei Kuo, Chiu-Ping Fang, Andrew C H Chen, Yu-Li Liu. Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment.
Journal of human genetics.
2022 May; 67(5):273-278. doi:
10.1038/s10038-021-01008-7. [PMID: 34983973] - Darshan Singh, Suresh Narayanan, Balasingam Vicknasingam, Walter C Prozialeck, Kirsten Elin Smith, Ornella Corazza, Jack E Henningfield, Oliver Grundmann. The Use of Kratom (Mitragyna speciosa Korth.) Among People Who Co-use Heroin and Methamphetamine in Malaysia.
Journal of addiction medicine.
2022 Mar; 16(2):223-228. doi:
10.1097/adm.0000000000000876. [PMID: 34001777] - Maximilian Meyer, Johannes Strasser, Patrick Köck, Marc Walter, Marc Vogel, Kenneth M Dürsteler. Experiences with take-home dosing in heroin-assisted treatment in Switzerland during the COVID-19 pandemic-Is an update of legal restrictions warranted?.
The International journal on drug policy.
2022 03; 101(?):103548. doi:
10.1016/j.drugpo.2021.103548. [PMID: 34920218] - Kai Yue, Jonathan L Katz, Xiji Shu. Physiological dependence to mitragynine indicated by a rapid cross-dependence procedure with heroin-dependent mice.
Psychopharmacology.
2022 Mar; 239(3):897-908. doi:
10.1007/s00213-022-06080-1. [PMID: 35107609] - Wei-Ru Chen, Po-Hsin Kong, Christoph Sauer, Huei-Wen Chen, Hsiang-Yu Chan, Da-Peng Yang, Yung-Cheng Jair, Hsin-Tung Liu, Tsang-Yaw Lin, Muh-Yong Yen, Yung-Feng Yen, Sheng-Huang Chang, Lan-Hui Li, Claire George, Ya-Chi Chang, Yi-Hsin Wu, Hsiao-Lin Hwa, Chia-Yang Chen, Jung-Hsuan Chen, Andrew T Kicman, Hans H Maurer, Pai-Shan Chen. A proposed approach to confirm heroin administration - Regional differences in heroin purity is a major factor.
Regulatory toxicology and pharmacology : RTP.
2022 Feb; 128(?):105097. doi:
10.1016/j.yrtph.2021.105097. [PMID: 34902532] - André Niebel, Fritz Pragst, Franziska Krumbiegel, Sven Hartwig. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs.
Forensic science international.
2022 Feb; 331(?):111148. doi:
10.1016/j.forsciint.2021.111148. [PMID: 34923263] - Liang Li, Jieyan Li, Haijie Cao, Qiuhong Wang, Zhengzheng Zhou, Hu Zhao, Haixue Kuang. Determination of metabolic phenotype and potential biomarkers in the liver of heroin addicted mice with hepatotoxicity.
Life sciences.
2021 Dec; 287(?):120103. doi:
10.1016/j.lfs.2021.120103. [PMID: 34743944] - Jianbo Zhang, Yajuan Fan, Jinting Zhou, Tengfei Ma, Keqiang Gao, Min Xu, Yifan Xiao, Yongsheng Zhu. Methylation quantitative trait locus rs5326 is associated with susceptibility and effective dosage of methadone maintenance treatment for heroin use disorder.
Psychopharmacology.
2021 Dec; 238(12):3511-3518. doi:
10.1007/s00213-021-05968-8. [PMID: 34476566] - Rodell C Barrientos, Connor Whalen, Oscar B Torres, Agnieszka Sulima, Eric W Bow, Essie Komla, Zoltan Beck, Arthur E Jacobson, Kenner C Rice, Gary R Matyas. Bivalent Conjugate Vaccine Induces Dual Immunogenic Response That Attenuates Heroin and Fentanyl Effects in Mice.
Bioconjugate chemistry.
2021 11; 32(11):2295-2306. doi:
10.1021/acs.bioconjchem.1c00179. [PMID: 34076427] - Margarida L F Martins, Erica A Wilthagen, Eugenia Oviedo-Joekes, Jos H Beijnen, Nelda de Grave, Ambros Uchtenhagen, Thilo Beck, Wim Van den Brink, Alfred H Schinkel. The suitability of oral diacetylmorphine in treatment-refractory patients with heroin dependence: A scoping review.
Drug and alcohol dependence.
2021 10; 227(?):108984. doi:
10.1016/j.drugalcdep.2021.108984. [PMID: 34482044] - Giuliano Boscutti, Vittorio Di Maso, Alessandra Marega, Ugo Gerini, Alberto Zacchi, Francesco Bianco. [Droghe d'abuso e rene].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2021 Sep; 38(Suppl 77):. doi:
NULL. [PMID: 34669304] - Amadeo Pesce, Raymond Sundyhanata, Dennis Ritz, Richard Thomas, Gregory Ackerman, Katie Bollman. Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients.
Annals of clinical and laboratory science.
2021 Sep; 51(5):694-697. doi:
. [PMID: 34686512] - John J Mariani, Amy L Mahony, Samuel C Podell, Daniel J Brooks, Christina Brezing, Sean X Luo, Nasir H Naqvi, Frances R Levin. Open-label trial of a single-day induction onto buprenorphine extended-release injection for users of heroin and fentanyl.
The American journal on addictions.
2021 09; 30(5):470-476. doi:
10.1111/ajad.13193. [PMID: 34223681] - Tathagata Mahintamani, Abhishek Ghosh, Rajeev Jain. Serious health threats of novel adulterants of the street heroin: a report from India during the COVID-19 pandemic.
BMJ case reports.
2021 Aug; 14(8):. doi:
10.1136/bcr-2021-242239. [PMID: 34433525] - Yong Zhou, Zhenrong Xie, Zunyue Zhang, Jiqing Yang, Minghui Chen, Fengrong Chen, Yuru Ma, Cheng Chen, Qingyan Peng, Lei Zou, Jianyuan Gao, Yu Xu, Yiqun Kuang, Mei Zhu, Dingyun You, Juehua Yu, Kunhua Wang. Plasma metabolites changes in male heroin addicts during acute and protracted withdrawal.
Aging.
2021 07; 13(14):18669-18688. doi:
10.18632/aging.203311. [PMID: 34282053] - Hao Wang, Zhaolin Xue, Yuxuan Wu, John Gilmore, Lu Wang, Laura Fabris. Rapid SERS Quantification of Trace Fentanyl Laced in Recreational Drugs with a Portable Raman Module.
Analytical chemistry.
2021 07; 93(27):9373-9382. doi:
10.1021/acs.analchem.1c00792. [PMID: 34191499] - Nicola Metrebian, Tim Weaver, Kimberley Goldsmith, Stephen Pilling, Jennifer Hellier, Andrew Pickles, James Shearer, Sarah Byford, Luke Mitcheson, Prun Bijral, Nadine Bogdan, Owen Bowden-Jones, Edward Day, John Dunn, Anthony Glasper, Emily Finch, Sam Forshall, Shabana Akhtar, Jalpa Bajaria, Carmel Bennett, Elizabeth Bishop, Vikki Charles, Clare Davey, Roopal Desai, Claire Goodfellow, Farjana Haque, Nicholas Little, Hortencia McKechnie, Franziska Mosler, Jo Morris, Julian Mutz, Ruth Pauli, Dilkushi Poovendran, Elizabeth Phillips, John Strang. Using a pragmatically adapted, low-cost contingency management intervention to promote heroin abstinence in individuals undergoing treatment for heroin use disorder in UK drug services (PRAISE): a cluster randomised trial.
BMJ open.
2021 07; 11(7):e046371. doi:
10.1136/bmjopen-2020-046371. [PMID: 34210725] - Roberto Scendoni, Dora Mirtella, Rino Froldi, Marco Valsecchi, Luigi Ferrante, Mariano Cingolani. Correlation study between anatomopathological data and levels of blood morphine concentrations in heroin-related deaths.
Legal medicine (Tokyo, Japan).
2021 Jul; 51(?):101877. doi:
10.1016/j.legalmed.2021.101877. [PMID: 33848788] - Gerard Calzada, Julie Giustiniani, Tiago Gois, André Kuntz, Yasser Khazaal, Daniele Zullino. [Learning to expand medical heroin prescribing modalities with Covid-19].
Revue medicale suisse.
2021 Jun; 17(742):1111-1114. doi:
NULL. [PMID: 34106535] - Michele Mitaritonno, Mariarosaria Lupo, Ivana Greco, Angela Mazza, Gianfranco Cervellin. Severe rhabdomyolysis induced by co-administration of cocaine and heroin in a 45 years old man treated with rosuvastatin: a case report.
Acta bio-medica : Atenei Parmensis.
2021 04; 92(S1):e2021089. doi:
10.23750/abm.v92is1.8858. [PMID: 33944852] - Kari M Midthun, Lewis S Nelson, Barry K Logan. Levamisole-a Toxic Adulterant in Illicit Drug Preparations: a Review.
Therapeutic drug monitoring.
2021 04; 43(2):221-228. doi:
10.1097/ftd.0000000000000851. [PMID: 33298746] - Joseph J Palamar, Austin Le, Thomas H Carr, Linda B Cottler. Shifts in drug seizures in the United States during the COVID-19 pandemic.
Drug and alcohol dependence.
2021 04; 221(?):108580. doi:
10.1016/j.drugalcdep.2021.108580. [PMID: 33674175] - Lindsay P Schwartz, Lillian Blank, Steven R Hursh. Behavioral economic demand in opioid treatment: Predictive validity of hypothetical purchase tasks for heroin, cocaine, and benzodiazepines.
Drug and alcohol dependence.
2021 04; 221(?):108562. doi:
10.1016/j.drugalcdep.2021.108562. [PMID: 33556658] - Gerd Jakobsson, Michael T Truver, Sonja A Wrobel, Henrik Gréen, Robert Kronstrand. Heroin-Related Compounds and Metabolic Ratios in Postmortem Samples Using LC-MS-MS.
Journal of analytical toxicology.
2021 Mar; 45(3):215-225. doi:
10.1093/jat/bkaa157. [PMID: 33031535] - Tracy-Lynn E Lockwood, Alexandra Vervoordt, Marya Lieberman. High concentrations of illicit stimulants and cutting agents cause false positives on fentanyl test strips.
Harm reduction journal.
2021 03; 18(1):30. doi:
10.1186/s12954-021-00478-4. [PMID: 33750405] - Eugenia Oviedo-Joekes, Scott MacDonald, Charles Boissonneault, Kelli Harper. Take home injectable opioids for opioid use disorder during and after the COVID-19 Pandemic is in urgent need: a case study.
Substance abuse treatment, prevention, and policy.
2021 03; 16(1):22. doi:
10.1186/s13011-021-00358-x. [PMID: 33673847] - Adrianna N Masterson, Sumon Hati, Greta Ren, Thakshila Liyanage, Nicholas E Manicke, John V Goodpaster, Rajesh Sardar. Enhancing Nonfouling and Sensitivity of Surface-Enhanced Raman Scattering Substrates for Potent Drug Analysis in Blood Plasma via Fabrication of a Flexible Plasmonic Patch.
Analytical chemistry.
2021 02; 93(4):2578-2588. doi:
10.1021/acs.analchem.0c04643. [PMID: 33432809] - Zohreh Nazmara, Peymaneh Shirinbayan, Hamid Reza Asgari, Reza Ahadi, Fatemeh Asgari, Chad B Maki, Fahimeh Fattahi, Bitasadat Hosseini, Ehsan Janzamin, Morteza Koruji. The epigenetic alterations of human sperm cells caused by heroin use disorder.
Andrologia.
2021 Feb; 53(1):e13799. doi:
10.1111/and.13799. [PMID: 33099803] - Shanti Nassibou, Camille Richeval, Jean-François Wiart, Florian Hakim, Delphine Allorge, Jean-Michel Gaulier. In Heroin-Related Fatalities, Testing for 6-Acetylmorphine in Vitreous Humor Seems to Be of Higher Sensitivity than in Blood or Urine.
Journal of analytical toxicology.
2021 Jan; 44(9):e9-e10. doi:
10.1093/jat/bkaa116. [PMID: 32860697] - Vijayapandi Pandy, Yasmin Khan, Durga Priyanka Yarlagadda, Sri Pravallika Tatinada. Morinda citrifolia Linn. fruit extract mitigates heroin seeking behavior in mice.
Acta neurobiologiae experimentalis.
2021; 81(4):328-334. doi:
". [PMID: 35014982] - Benjamin H Han, Elizabeth Mello, Ellenie Tuazon, Denise Paone. Using Urine Drug Testing to Estimate the Prevalence of Drug Use : Lessons Learned From the New York City Health and Nutrition Examination Survey, 2013-2014.
Public health reports (Washington, D.C. : 1974).
2021 Jan; 136(1):47-51. doi:
10.1177/0033354920965264. [PMID: 33108963] - Yingying Wang, Jinsong Zuo, Long Wang, Qianjin Wang, Xin Wang, Qian Yang, Hanjing Emily Wu, Colin B Goodman, Dongmei Wang, Tieqiao Liu, Xiangyang Zhang. The Association of Drug-Use Characteristics and Active Coping Styles With Positive Affect in Patients With Heroin-Use Disorder and Methamphetamine-Use Disorder During the COVID-19 Pandemic.
Frontiers in public health.
2021; 9(?):739068. doi:
10.3389/fpubh.2021.739068. [PMID: 34926370] - Jacqueline E Paniccia, Taylor N Weckstein, Christina L Lebonville, Donald T Lysle. Female rats express heroin-induced and -conditioned suppression of peripheral nitric oxide production in response to endotoxin challenge.
Brain, behavior, and immunity.
2021 01; 91(?):315-323. doi:
10.1016/j.bbi.2020.10.009. [PMID: 33039661] - Dominic P Isaacs, Ryan P Leman, Thomas J Everett, Hendrick Lopez-Beltran, Lindsey R Hamilton, Erik B Oleson. Buprenorphine is a weak dopamine releaser relative to heroin, but its pretreatment attenuates heroin-evoked dopamine release in rats.
Neuropsychopharmacology reports.
2020 12; 40(4):355-364. doi:
10.1002/npr2.12139. [PMID: 32935483] - Kuen-Hong Wu, Shao-Chiu Juan, Chia-Hsiang Chan, Sun-Yuan Chou, Hung-Yu Chan. Factors Affecting Changes of Cluster of Differentiation 4 Cell Counts Among Human Immunodeficiency Virus-positive People Who Inject Heroin and Receive Methadone Maintenance Treatment.
Journal of addiction medicine.
2020 12; 14(6):e310-e315. doi:
10.1097/adm.0000000000000658. [PMID: 32433362] - Sao Mai Le, Philippe Trouiller, Huong Duong Thi, Oanh Khuat Thi Hai, Khue Pham Minh, Roselyne Vallo, Delphine Rapoud, Catherine Quillet, Thuy Linh Nguyen, Quang Duc Nguyen, Tuyet Thanh NhamThi, Giang Hoang Thi, Jonathan Feelemyer, Vinh Vu Hai, Jean-Pierre Moles, Hong Quang Doan, Didier Laureillard, Don C Des Jarlais, Nicolas Nagot, Laurent Michel. Daily heroin injection and psychiatric disorders: A cross-sectional survey among People Who Inject Drugs (PWID) in Haiphong, Vietnam.
Drug and alcohol dependence.
2020 11; 216(?):108334. doi:
10.1016/j.drugalcdep.2020.108334. [PMID: 33038638] - Shi Qiao, Haishan Xu, Wenfang Zhang, Wei Yang, Danming Guo, Wei Wang, Weizhe Xu, Yongsuo Liu, Guoru Liu, Yujing Cui, Hongyan Yu, Qingyan Li. Identification of characteristic heroin metabolites in urine based on data-mining technology and multivariate statistics analysis combined with a targeted verification approach for distinguishing heroin abusers.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Sep; 1152(?):122251. doi:
10.1016/j.jchromb.2020.122251. [PMID: 32673834] - N Molavi, A Ghaderi, H R Banafshe. Determination of thallium in urine, blood, and hair in illicit opioid users in Iran.
Human & experimental toxicology.
2020 Jun; 39(6):808-815. doi:
10.1177/0960327120903487. [PMID: 32009467] - E Andrew Townsend, Paul T Bremer, Kaycee E Faunce, S Stevens Negus, Alaina M Jaster, Hannah L Robinson, Kim D Janda, Matthew L Banks. Evaluation of a Dual Fentanyl/Heroin Vaccine on the Antinociceptive and Reinforcing Effects of a Fentanyl/Heroin Mixture in Male and Female Rats.
ACS chemical neuroscience.
2020 05; 11(9):1300-1310. doi:
10.1021/acschemneuro.0c00064. [PMID: 32271538] - E Marinelli. The impact of heroin illicit market in the framework of COVID 19 pandemic.
European review for medical and pharmacological sciences.
2020 05; 24(10):5197-5198. doi:
10.26355/eurrev_202005_21299. [PMID: 32495850] - Wan-Jian Gu, Cuiping Zhang, Yujie Zhong, Jun Luo, Chen-Yu Zhang, Chunni Zhang, Cheng Wang. Altered serum microRNA expression profile in subjects with heroin and methamphetamine use disorder.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 May; 125(?):109918. doi:
10.1016/j.biopha.2020.109918. [PMID: 32036213] - Juleigh Nowinski Konchak, Kevin McGurk, Keiki Hinami, Margaret Vacchiano, Steven Aks. Effect of positive urine fentanyl screen on attitudes toward heroin use.
Drug and alcohol dependence.
2020 04; 209(?):107934. doi:
10.1016/j.drugalcdep.2020.107934. [PMID: 32126456] - Tracey M D'Cunha, Alexandra Chisholm, Cecile Hryhorczuk, Stephanie Fulton, Uri Shalev. A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.
Psychopharmacology.
2020 Mar; 237(3):787-800. doi:
10.1007/s00213-019-05415-9. [PMID: 31811350] - Luying Wang, Chunfang Ni, Hongliang Shen, Zhenhai Sheng, Chen Liang, Rong Wang, Yurong Zhang. Comparison of the Detection Windows of Heroin Metabolites in Human Urine Using Online SPE and LC-MS/MS: Importance of Morphine-3-Glucuronide.
Journal of analytical toxicology.
2020 Jan; 44(1):22-28. doi:
10.1093/jat/bkz040. [PMID: 31095707] - Robert K Twillman, Eric Dawson, Leah LaRue, Maria G Guevara, Penn Whitley, Angela Huskey. Evaluation of Trends of Near-Real-Time Urine Drug Test Results for Methamphetamine, Cocaine, Heroin, and Fentanyl.
JAMA network open.
2020 01; 3(1):e1918514. doi:
10.1001/jamanetworkopen.2019.18514. [PMID: 31899527] - Adrian Groh, Mathias Rhein, Mandy Roy, Christine Gessner, Ralf Lichtinghagen, Annemarie Heberlein, Thomas Hillemacher, Stefan Bleich, Marc Walter, Helge Frieling. Trauma Severity in Early Childhood Correlates with Stress and Satiety Hormone Levels in a Pilot Cohort Receiving Diamorphine Maintenance Treatment.
European addiction research.
2020; 26(2):103-108. doi:
10.1159/000505293. [PMID: 31940647] - Don C Des Jarlais, Kamyar Arasteh, Courtney McKnight, Jonathan Feelemyer, David C Perlman, Susan Tross. Prescription opiate analgesics, heroin, HIV and HCV among persons who inject drugs in New York City, 2016-2018.
Drug and alcohol dependence.
2019 11; 204(?):107459. doi:
10.1016/j.drugalcdep.2019.04.030. [PMID: 31521951] - Jan Gryczynski, Helen Nichols, Robert P Schwartz, Shannon Gwin Mitchell, Paulette Hill, Kim Wireman. Fentanyl exposure and preferences among individuals starting treatment for opioid use disorder.
Drug and alcohol dependence.
2019 11; 204(?):107515. doi:
10.1016/j.drugalcdep.2019.06.017. [PMID: 31525569] - Amy J Reisinger, Autumn C Miller, Lacey A Shaw, Jana L Champion, Marc A Neiswonger. Oral Cavity Fluid as an Investigative Approach for Qualitative and Quantitative Evaluations of Drugs in Postmortem Subjects.
Journal of analytical toxicology.
2019 Jul; 43(6):444-451. doi:
10.1093/jat/bkz032. [PMID: 31062851] - Rong-Jun Zhang, Xiao-Rong Hou, Xing-Hui Cai, Xiao-Ge Song, Sheng-Bing Wu, Meng-Jie Zhao. [Influence of acupuncture plus moxibustion on changes of synaptic structure and expression of synaptic skeleton related genes and proteins in prefrontal cortex of heroin re-addicted rats].
Zhen ci yan jiu = Acupuncture research.
2019 May; 44(5):323-8. doi:
10.13702/j.1000-0607.180437. [PMID: 31155863] - Michael Böttcher, Stefan Lierheimer, Andreas Peschel, Olof Beck. Detection of heroin intake in patients in substitution treatment using oral fluid as specimen for drug testing.
Drug and alcohol dependence.
2019 05; 198(?):136-139. doi:
10.1016/j.drugalcdep.2019.02.011. [PMID: 30927716] - Satnam Singh. Dynamics of heroin molecule inside the lipid membrane: a molecular dynamics study.
Journal of molecular modeling.
2019 Apr; 25(5):121. doi:
10.1007/s00894-019-4002-y. [PMID: 31020452] - Brantley P Jarvis, August F Holtyn, Anthony DeFulio, Mikhail N Koffarnus, Jeannie-Marie S Leoutsakos, Annie Umbricht, Michael Fingerhood, George E Bigelow, Kenneth Silverman. The effects of extended-release injectable naltrexone and incentives for opiate abstinence in heroin-dependent adults in a model therapeutic workplace: A randomized trial.
Drug and alcohol dependence.
2019 04; 197(?):220-227. doi:
10.1016/j.drugalcdep.2018.12.026. [PMID: 30852374] - Trajche Ivanovski, Ana María Espino Ibañez, Bernardino Barcelo Martin, Isabel Gomila Muñiz. Acute extensive myelopathy after single heroin and cocaine exposure in a patient with toxicological evidence of long-term drug abstinence.
BMJ case reports.
2019 Mar; 12(3):. doi:
10.1136/bcr-2018-228335. [PMID: 30936344] - Fabian Picht, Olof Beck, Michael Böttcher. Evaluation of an on-site test device for the heroin metabolite 6-acetylmorphine in urine.
Drug testing and analysis.
2019 Mar; 11(3):536-540. doi:
10.1002/dta.2559. [PMID: 30569568] - Sharon L Smith, Reginald L Dean, Mark S Todtenkopf, David J Heal. Investigation of the reinforcing potential of samidorphan and naltrexone by fixed and progressive ratio intravenous self-administration testing in heroin-maintained rats.
Journal of psychopharmacology (Oxford, England).
2019 03; 33(3):383-391. doi:
10.1177/0269881118822111. [PMID: 30676189] - Mei-Yun Cheng, Shy-Chyi Chin, Yen-Chung Chang, Tony Wu, Siew-Na Lim, Hsiang-Yao Hsieh, Jung-Lung Hsu, Chun-Wei Chang, Wei-En Johnny Tseng, Han-Tao Li, Hsing-I Chiang, Bao-Luen Chang, Meng-Han Tsai, Long-Sun Ro. Different routes of heroin intake cause various heroin-induced leukoencephalopathies.
Journal of neurology.
2019 Feb; 266(2):316-329. doi:
10.1007/s00415-018-9131-1. [PMID: 30478618] - Maxwell S Krieger, William C Goedel, Jane A Buxton, Mark Lysyshyn, Edward Bernstein, Susan G Sherman, Josiah D Rich, Scott E Hadland, Traci C Green, Brandon D L Marshall. Use of rapid fentanyl test strips among young adults who use drugs.
The International journal on drug policy.
2018 11; 61(?):52-58. doi:
10.1016/j.drugpo.2018.09.009. [PMID: 30344005] - Monica J Barratt, Julie Latimer, Marianne Jauncey, Emma Tay, Suzanne Nielsen. Urine drug screening for early detection of unwitting use of fentanyl and its analogues among people who inject heroin in Sydney, Australia.
Drug and alcohol review.
2018 11; 37(7):847-850. doi:
10.1111/dar.12864. [PMID: 30289187] - Kai Yue, Theresa A Kopajtic, Jonathan L Katz. Abuse liability of mitragynine assessed with a self-administration procedure in rats.
Psychopharmacology.
2018 Oct; 235(10):2823-2829. doi:
10.1007/s00213-018-4974-9. [PMID: 30039246] - Rebecca T DeRienz, Daniel D Baker, Nancy E Kelly, Amber M Mullins, Rachel Y Barnett, Jennifer M Hobbs, John A Daniels, Kent E Harshbarger, Anahi M Ortiz. Child Fatalities Due to Heroin/Fentanyl Exposure: What the Case History Missed.
Journal of analytical toxicology.
2018 Oct; 42(8):581-585. doi:
10.1093/jat/bky052. [PMID: 30371840] - Kyungbo Kim, Jianzhuang Yao, Zhenyu Jin, Fang Zheng, Chang-Guo Zhan. Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphine.
Chemico-biological interactions.
2018 Sep; 293(?):107-114. doi:
10.1016/j.cbi.2018.08.002. [PMID: 30080993] - Mohammad Karamouzian, Carolyn Dohoo, Sara Forsting, Ryan McNeil, Thomas Kerr, Mark Lysyshyn. Evaluation of a fentanyl drug checking service for clients of a supervised injection facility, Vancouver, Canada.
Harm reduction journal.
2018 09; 15(1):46. doi:
10.1186/s12954-018-0252-8. [PMID: 30200991] - Cecilie Hasselø Thaulow, Åse Marit Leere Øiestad, Sidsel Rogde, Jannike Mørch Andersen, Gudrun Høiseth, Marte Handal, Jørg Mørland, Vigdis Vindenes. Can measurements of heroin metabolites in post-mortem matrices other than peripheral blood indicate if death was rapid or delayed?.
Forensic science international.
2018 Sep; 290(?):121-128. doi:
10.1016/j.forsciint.2018.06.041. [PMID: 30015276] - Sanjeev Sethi. The Changing Spectrum of Heroin-Associated Kidney Disease.
Clinical journal of the American Society of Nephrology : CJASN.
2018 07; 13(7):975-976. doi:
10.2215/cjn.06080518. [PMID: 29907616] - Cecilie Hasselø Thaulow, Åse Marit Leere Øiestad, Sidsel Rogde, Ritva Karinen, Gerd Wenche Brochmann, Jannike Mørch Andersen, Gudrun Høiseth, Marte Handal, Jørg Mørland, Marianne Arnestad, Elisabeth Leere Øiestad, Dag Helge Strand, Vigdis Vindenes. Metabolites of Heroin in Several Different Post-mortem Matrices.
Journal of analytical toxicology.
2018 Jun; 42(5):311-320. doi:
10.1093/jat/bky002. [PMID: 29409037] - Oscar B Torres, Alexander J Duval, Agnieszka Sulima, Joshua F G Antoline, Arthur E Jacobson, Kenner C Rice, Carl R Alving, Gary R Matyas. A rapid solution-based method for determining the affinity of heroin hapten-induced antibodies to heroin, its metabolites, and other opioids.
Analytical and bioanalytical chemistry.
2018 Jun; 410(16):3885-3903. doi:
10.1007/s00216-018-1060-4. [PMID: 29675707] - M Soichot, S Julliand, J Filatriau, A Hurbain, E Bourgogne, A Mihoubi, H Gourlain, B Delhotal-Landes. Diagnosis of Heroin Overdose in an 8-Year-Old Boy: Reliable Contribution of Toxicological Investigations.
Journal of analytical toxicology.
2018 May; 42(4):255-264. doi:
10.1093/jat/bkx111. [PMID: 29301012] - Michael D Raleigh, Megan Laudenbach, Federico Baruffaldi, Samantha J Peterson, Michaela J Roslawski, Angela K Birnbaum, F Ivy Carroll, Scott P Runyon, Scott Winston, Paul R Pentel, Marco Pravetoni. Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats.
The Journal of pharmacology and experimental therapeutics.
2018 05; 365(2):346-353. doi:
10.1124/jpet.117.247049. [PMID: 29535156] - Thai Hoang, Hong Nguyen, Ray W Shiraishi, Mai Nguyen, Trista Bingham, Diep Nguyen, Tam Nguyen, Hao Duong, Sheryl Lyss, Hien Tran. Factors associated with concurrent heroin use among patients on methadone maintenance treatment in Vietnam: A 24-month retrospective analysis of a nationally representative sample.
The International journal on drug policy.
2018 05; 55(?):113-120. doi:
10.1016/j.drugpo.2018.02.020. [PMID: 29550740] - Tingting Ning, Changlong Leng, Lin Chen, Baomiao Ma, Xiaokang Gong. Metabolomics analysis of serum in a rat heroin self-administration model undergoing reinforcement based on 1H-nuclear magnetic resonance spectra.
BMC neuroscience.
2018 03; 19(1):4. doi:
10.1186/s12868-018-0404-5. [PMID: 29502536] - Mohammad-Javad Morabbi, Emran Razaghi, Ehsan Moazen-Zadeh, Hamideh Safi-Aghdam, Mohamad R Zarrindast, Nasim Vousoghi, Shahin Akhondzadeh. Pexacerfont as a CRF1 antagonist for the treatment of withdrawal symptoms in men with heroin/methamphetamine dependence: a randomized, double-blind, placebo-controlled clinical trial.
International clinical psychopharmacology.
2018 03; 33(2):111-119. doi:
10.1097/yic.0000000000000200. [PMID: 29064909] - Michael A Marciano, Sini X Panicker, Garrett D Liddil, Danielle Lindgren, Kevin S Sweder. Development of a Method to Extract Opium Poppy (Papaver somniferum L.) DNA from Heroin.
Scientific reports.
2018 02; 8(1):2590. doi:
10.1038/s41598-018-20996-9. [PMID: 29416103] - Brantley P Jarvis, August F Holtyn, Meredith S Berry, Shrinidhi Subramaniam, Annie Umbricht, Michael Fingerhood, George E Bigelow, Kenneth Silverman. Predictors of induction onto extended-release naltrexone among unemployed heroin-dependent adults.
Journal of substance abuse treatment.
2018 02; 85(?):38-44. doi:
10.1016/j.jsat.2017.04.012. [PMID: 28449955] - Agnieszka Sulima, Rashmi Jalah, Joshua F G Antoline, Oscar B Torres, Gregory H Imler, Jeffrey R Deschamps, Zoltan Beck, Carl R Alving, Arthur E Jacobson, Kenner C Rice, Gary R Matyas. A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse.
Journal of medicinal chemistry.
2018 01; 61(1):329-343. doi:
10.1021/acs.jmedchem.7b01427. [PMID: 29236495] - Ernesto de Bernardis. Comment on 'Methadone Dose Adjustments, Plasma R-Methadone Levels and Therapeutic Outcome of Heroin Users: A Randomized Clinical Trial'.
European addiction research.
2018; 24(2):88. doi:
10.1159/000488719. [PMID: 29902789] - Ling Shen, Sawitri Assanangkornchai, Wei Liu, Le Cai, Fei Li, Songyuan Tang, Jiucheng Shen, Edward B McNeil, Virasakdi Chongsuvivatwong. Influence of social network on drug use among clients of methadone maintenance treatment centers in Kunming, China.
PloS one.
2018; 13(7):e0200105. doi:
10.1371/journal.pone.0200105. [PMID: 29969481] - Matthew K Griswold, Peter R Chai, Alex J Krotulski, Melissa Friscia, Brittany Chapman, Edward W Boyer, Barry K Logan, Kavita M Babu. Self-identification of nonpharmaceutical fentanyl exposure following heroin overdose.
Clinical toxicology (Philadelphia, Pa.).
2018 Jan; 56(1):37-42. doi:
10.1080/15563650.2017.1339889. [PMID: 28681615] - Elena G Shcherbakova, Ben Zhang, Samer Gozem, Tsuyoshi Minami, Peter Y Zavalij, Mariia Pushina, Lyle D Isaacs, Pavel Anzenbacher. Supramolecular Sensors for Opiates and Their Metabolites.
Journal of the American Chemical Society.
2017 10; 139(42):14954-14960. doi:
10.1021/jacs.7b06371. [PMID: 28820934] - Belin G Teklezgi, Annapurna Pamreddy, Sooraj Baijnath, Nirmala D Gopal, Tricia Naicker, Hendrik G Kruger, Thavendran Govender. Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging.
Journal of molecular histology.
2017 Aug; 48(4):285-292. doi:
10.1007/s10735-017-9726-3. [PMID: 28550642] - Olafur Sveinsson, Lars Herrman, Max Albert Hietala. Heroin-induced acute myelopathy with extreme high levels of CSF glial fibrillar acidic protein indicating a toxic effect on astrocytes.
BMJ case reports.
2017 Jun; 2017(?):. doi:
10.1136/bcr-2017-219903. [PMID: 28659367] - Yixin Li, Baijuan Xia, Rongrong Li, Dan Yin, Wenmei Liang. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression.
Medical science monitor : international medical journal of experimental and clinical research.
2017 Jun; 23(?):2805-2815. doi:
10.12659/msm.904670. [PMID: 28598964] - Gudrun Høiseth, André Gottås, Thomas Berg, Marianne Arnestad, Per Steinar Halvorsen, Liliana C Bachs. Urinary Kinetics of Heroin Metabolites in Pigs Shortly After Intake.
Journal of analytical toxicology.
2017 Jun; 41(5):451-454. doi:
10.1093/jat/bkx017. [PMID: 28335030] - Heather Palis, Kirsten Marchand, Daphne Guh, Suzanne Brissette, Kurt Lock, Scott MacDonald, Scott Harrison, Aslam H Anis, Michael Krausz, David C Marsh, Martin T Schechter, Eugenia Oviedo-Joekes. Men's and women's response to treatment and perceptions of outcomes in a randomized controlled trial of injectable opioid assisted treatment for severe opioid use disorder.
Substance abuse treatment, prevention, and policy.
2017 05; 12(1):25. doi:
10.1186/s13011-017-0110-9. [PMID: 28526048] - Luke N Rodda, Jennifer L Pilgrim, Matthew Di Rago, Kerryn Crump, Dimitri Gerostamoulos, Olaf H Drummer. A Cluster of Fentanyl-Laced Heroin Deaths in 2015 in Melbourne, Australia.
Journal of analytical toxicology.
2017 May; 41(4):318-324. doi:
10.1093/jat/bkx013. [PMID: 28158759] - Lee W Hutson, Christina L Lebonville, Meghan E Jones, Rita A Fuchs, Donald T Lysle. Interleukin-1 signaling in the basolateral amygdala is necessary for heroin-conditioned immunosuppression.
Brain, behavior, and immunity.
2017 May; 62(?):171-179. doi:
10.1016/j.bbi.2017.01.017. [PMID: 28131792] - Jia-Wu Zhu, Feng-Liang Liu, Dan Mu, De-Yao Deng, Yong-Tang Zheng. Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication.
Microbes and infection.
2017 Apr; 19(4-5):288-294. doi:
10.1016/j.micinf.2017.01.002. [PMID: 28104465] - Arani Nanavati, Leal C Herlitz. Tubulointerstitial Injury and Drugs of Abuse.
Advances in chronic kidney disease.
2017 03; 24(2):80-85. doi:
10.1053/j.ackd.2016.09.008. [PMID: 28284383] - Alexandra Maas, Michael Krämer, Konrad Sydow, Pai-Shan Chen, Torsten Dame, Frank Musshoff, Bernd W K Diehl, Burkhard Madea, Cornelius Hess. Urinary excretion study following consumption of various poppy seed products and investigation of the new potential street heroin marker ATM4G.
Drug testing and analysis.
2017 Mar; 9(3):470-478. doi:
10.1002/dta.2058. [PMID: 27565444] - Rilana Schuster, Alexandra Kleimann, Marie-Kathrin Rehme, Leonie Taschner, Alexander Glahn, Adrian Groh, Helge Frieling, Ralf Lichtinghagen, Thomas Hillemacher, Stefan Bleich, Annemarie Heberlein. Elevated methylation and decreased serum concentrations of BDNF in patients in levomethadone compared to diamorphine maintenance treatment.
European archives of psychiatry and clinical neuroscience.
2017 Feb; 267(1):33-40. doi:
10.1007/s00406-016-0668-7. [PMID: 26801497]