Tetrahydrozoline hydrochloride (BioDeep_00000651842)

   


代谢物信息卡片


Tetrahydrozoline hydrochloride

化学式: C13H17ClN2 (236.1080192)
中文名称: 盐酸四氢唑啉
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(C2CCCC3=C2C=CC=C3)=NCCN1.Cl
InChI: 1H

描述信息

D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D019999 - Pharmaceutical Solutions > D009883 - Ophthalmic Solutions
D019141 - Respiratory System Agents > D014663 - Nasal Decongestants
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion[1][2].

同义名列表

3 个代谢物同义名

Tetrahydrozoline hydrochloride; Tetryzoline (hydrochloride); Tetrahydrozoline (hydrochloride)



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Dr Veronica Fowler, Dr Angela Douglas, Professor Keith Godfrey, Professor Anthony Williams, Professor Andrew Beggs, Stephen Kidd, Dr Nick Cortes, Professor Mark Wilcox, Dr Kerrie Davies, Melanie Smith, Professor Dame Sue Hill. Critical evaluation of the methodology used by Wilson-Davies et al., (2020) entitled 'Concerning the Optigene Direct LAMP assay, and it`s use in at-risk groups and hospital staff'. The Journal of infection. 2021 02; 82(2):282-327. doi: 10.1016/j.jinf.2021.01.012. [PMID: 33573778]
  • Eleri S W Wilson-Davies, Adhyana I K Mahanama, Buddhini Samaraweera, Nusreen Ahmed, Simon Friar, Emanuela Pelosi. Concerning the OptiGene Direct LAMP assay, and it’s use in at-risk groups and hospital staff. The Journal of infection. 2021 02; 82(2):282-327. doi: 10.1016/j.jinf.2021.01.013. [PMID: 33573779]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Danuta Nowakowska, Jolanta Saczko, Katarzyna Bieżuńska-Kusiak, Anna Choromańska, Magda Dubińska-Magiera, Marek Ziętek, Julita Kulbacka. The influence of retraction agents on cytoskeleton reorganization and oxidative stress in primary human gingival fibroblasts (HGFs). Archives of oral biology. 2014 Mar; 59(3):341-8. doi: 10.1016/j.archoralbio.2013.12.011. [PMID: 24581858]
  • Matthew E Stillwell, Joseph J Saady. Use of tetrahydrozoline for chemical submission. Forensic science international. 2012 Sep; 221(1-3):e12-6. doi: 10.1016/j.forsciint.2012.04.004. [PMID: 22554870]
  • Henry A Spiller, Dennis J Siewert. Drug-facilitated sexual assault using tetrahydrozoline. Journal of forensic sciences. 2012 May; 57(3):835-8. doi: 10.1111/j.1556-4029.2011.02026.x. [PMID: 22211761]
  • Mary E Carr, Kristin M Engebretsen, Benjamin Ho, Christopher P Anderson. Tetrahydrozoline (Visine®) concentrations in serum and urine during therapeutic ocular dosing: a necessary first step in determining an overdose. Clinical toxicology (Philadelphia, Pa.). 2011 Nov; 49(9):810-4. doi: 10.3109/15563650.2011.615064. [PMID: 21972870]
  • Jennifer A Lowry, Uttam Garg. Serum concentrations in three children with unintentional tetrahydrozoline overdose. Clinical toxicology (Philadelphia, Pa.). 2011 Jun; 49(5):434-5. doi: 10.3109/15563650.2011.586639. [PMID: 21740144]
  • Judy Peat, Uttam Garg. Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):501-8. doi: 10.1007/978-1-60761-459-3_49. [PMID: 20077102]
  • S D Pearson, K O Ash, F M Urry. Mechanism of false-negative urine cannabinoid immunoassay screens by Visine eyedrops. Clinical chemistry. 1989 Apr; 35(4):636-8. doi: 10.1093/clinchem/35.4.636. [PMID: 2467764]
  • S L Mikkelsen, K O Ash. Adulterants causing false negatives in illicit drug testing. Clinical chemistry. 1988 Nov; 34(11):2333-6. doi: 10.1093/clinchem/34.11.2333. [PMID: 3052928]
  • H ENGELBERG. Buccal and sublingual administration of heparin potassium (clarin); studies of plasma triglyceride lipolysis and heparin levels. Journal of the American Medical Association. 1959 Mar; 169(12):1322-5. doi: 10.1001/jama.1959.73000290002010a. [PMID: 13630759]