Trospectomycin (BioDeep_00000650614)
代谢物信息卡片
Trospectomycin
化学式: C17H30N2O7 (374.205291)
中文名称: 丙大观霉素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O
InChI: InChI=1S/C17H30N2O7/c1-4-5-6-8-7-9(20)17(23)16(24-8)25-15-13(22)10(18-2)12(21)11(19-3)14(15)26-17/h8,10-16,18-19,21-23H,4-7H2,1-3H3/t8-,10-,11+,12+,13+,14-,15-,16+,17+/m1/s1
描述信息
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - D J Nichols, A Bye, E Novak. Pharmacokinetics of trospectomycin sulphate in healthy subjects after single intravenous and intramuscular doses.
British journal of clinical pharmacology.
1991 Aug; 32(2):255-7. doi:
10.1111/j.1365-2125.1991.tb03893.x. [PMID: 1834145] - D J Nichols, M Burrows, A Bye, D A Constable, L G Dring, P Jeffrey. Pharmacokinetics and fate of [3H]trospectomycin sulfate, a novel aminocyclitol antibiotic, in male and female dogs and rabbits. Allometric scaling with human.
Drug metabolism and disposition: the biological fate of chemicals.
1991 Jul; 19(4):781-6. doi:
NULL. [PMID: 1680655] - D J Nichols, M Burrows, A Bye, D A Constable, L G Dring, P Jeffrey. Pharmacokinetics and fate of 3H-trospectomycin sulphate, a novel aminocyclitol antibiotic, in male and female rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1991 Jul; 21(7):827-37. doi:
10.3109/00498259109039522. [PMID: 1837966] - N Khardori, E Wong, H Nguyen, C Jeffery-Wiseman, E Wallin, R P Tewari, G P Bodey. Effect of subinhibitory concentrations of clindamycin and trospectomycin on the adherence of Staphylococcus epidermidis in an in vitro model of vascular catheter colonization.
The Journal of infectious diseases.
1991 Jul; 164(1):108-13. doi:
10.1093/infdis/164.1.108. [PMID: 1829103] - E Novak, L M Paxton, A Bye, R Patel, G E Zurenko, S F Francom. Human safety and pharmacokinetics of a single intramuscular dose of a novel spectinomycin analog, trospectomycin (U-63,366F).
Antimicrobial agents and chemotherapy.
1990 Dec; 34(12):2342-7. doi:
10.1128/aac.34.12.2342. [PMID: 2150907] - J I Cialdella, R G Ulrich, W F Liggett, L D Adams, V P Marshall. Effects of trospectomycin on serum sensitivity of Escherichia coli UC 9451.
Antimicrobial agents and chemotherapy.
1990 Nov; 34(11):2086-92. doi:
10.1128/aac.34.11.2086. [PMID: 2149919] - G R Peters, E Novak, D H Batts, A Bye, D J Nichols, S F Francom. Multiple-dose, double-blind, placebo controlled intravenous tolerance and pharmacokinetic study of trospectomycin sulfate (U-63, 366F) in healthy male volunteers.
International journal of clinical pharmacology, therapy, and toxicology.
1990 Sep; 28(9):361-8. doi:
NULL. [PMID: 2146231] - J W Cox, L G Dring, L C Ginsberg, P G Larson, D A Constable, R G Ulrich. Distribution and disposition of trospectomycin sulfate in the in vivo rat, perfused rat liver, and cultured rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals.
1990 Sep; 18(5):726-31. doi:
NULL. [PMID: 1981727] - N Khardori, M Gandhi, J Adame, L Kalvakuntla, B Rosenbaum, G P Bodey. The activity in vitro of trospectomycin sulphate (U-63366F) against aminoglycoside-resistant enterococci.
The Journal of antimicrobial chemotherapy.
1990 May; 25(5):777-85. doi:
10.1093/jac/25.5.777. [PMID: 2142683] - E Novak, D L Griffith, L M Paxton, C M Metzler, A Bye. Safety and pharmacokinetics of intravenously administered trospectomycin sulfate.
Clinical therapeutics.
1990 May; 12(3):269-80. doi:
NULL. [PMID: 2143104] - R G Ulrich, D K Petrella, E R Larsen, J W Cox, C T Cramer, R C Piper, J E Gray. Hepatic changes produced by 30-day administration of a novel aminocyclitol antibiotic, trospectomycin sulfate, to laboratory animals.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1990 Jan; 14(1):60-70. doi:
10.1016/0272-0590(90)90231-8. [PMID: 2137804] - R J Rice, S E Thompson, R J Arko, E F Hunter, P M Burleigh, B T Craig, S A Larsen. Tissue fluid penetration and anti-treponemal activity of trospectomycin (a new spectinomycin analog) in the rabbit syphilis model.
Sexually transmitted diseases.
1988 Jul; 15(3):152-5. doi:
10.1097/00007435-198807000-00008. [PMID: 2976206] - I Casin, M J Sanson-Le Pors, A Felten, Y Perol. Biotypes, serotypes, and susceptibility to antibiotics of 60 Haemophilus influenzae strains from genitourinary tracts.
Genitourinary medicine.
1988 Jun; 64(3):185-8. doi:
10.1136/sti.64.3.185. [PMID: 2970427] - G E Zurenko, C W Ford, E Novak. Trospectomycin, a novel spectinomycin analogue: antibacterial activity and preliminary human pharmacokinetics.
Drugs under experimental and clinical research.
1988; 14(6):403-9. doi:
. [PMID: 2975212] - T J Wargovich, J Mehta, W W Nichols, M B Ward, D Lawson, D Franzini, C R Conti. Reduction in myocardial neutrophil accumulation and infarct size following administration of thromboxane inhibitor U-63,557A.
American heart journal.
1987 Nov; 114(5):1078-85. doi:
10.1016/0002-8703(87)90182-7. [PMID: 2960223]