Lexacalcitol (BioDeep_00000650569)
代谢物信息卡片
化学式: C29H48O4 (460.3552408)
中文名称: 来沙骨化醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(CC)(CCCOC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C)O
InChI: InChI=1S/C29H48O4/c1-6-29(32,7-2)16-9-17-33-21(4)25-13-14-26-22(10-8-15-28(25,26)5)11-12-23-18-24(30)19-27(31)20(23)3/h11-12,21,24-27,30-32H,3,6-10,13-19H2,1-2,4-5H3/b22-11+,23-12-/t21-,24-,25-,26+,27+,28-/m1/s1
描述信息
D018977 - Micronutrients > D014815 - Vitamins > D004100 - Dihydroxycholecalciferols
D018977 - Micronutrients > D014815 - Vitamins > D006887 - Hydroxycholecalciferols
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lee A Zella, Nirupama K Shevde, Bruce W Hollis, Nancy E Cooke, J Wesley Pike. Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo.
Endocrinology.
2008 Jul; 149(7):3656-67. doi:
10.1210/en.2008-0042. [PMID: 18372326] - H G Pálmer, J M González-Sancho, J Espada, M T Berciano, I Puig, J Baulida, M Quintanilla, A Cano, A G de Herreros, M Lafarga, A Muñoz. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.
The Journal of cell biology.
2001 Jul; 154(2):369-87. doi:
10.1083/jcb.200102028. [PMID: 11470825] - K Casteels, M Waer, J Laureys, D Valckx, J Depovere, R Bouillon, C Mathieu. Prevention of autoimmune destruction of syngeneic islet grafts in spontaneously diabetic nonobese diabetic mice by a combination of a vitamin D3 analog and cyclosporine.
Transplantation.
1998 May; 65(9):1225-32. doi:
10.1097/00007890-199805150-00014. [PMID: 9603172] - Y S López-Boado, X S Puente, S Alvarez, J Tolivia, L Binderup, C López-Otín. Growth inhibition of human breast cancer cells by 1,25-dihydroxyvitamin D3 is accompanied by induction of apolipoprotein D expression.
Cancer research.
1997 Sep; 57(18):4091-7. doi:
NULL. [PMID: 9307298] - T B Moore, H P Koeffler, J M Yamashiro, R K Wada. Vitamin D3 analogs inhibit growth and induce differentiation in LA-N-5 human neuroblastoma cells.
Clinical & experimental metastasis.
1996 May; 14(3):239-45. doi:
10.1007/bf00053897. [PMID: 8674278] - T Weinreich, A Müller, R P Wüthrich, C Booy, U Binswanger. 1,25-dihydroxyvitamin D3 and the synthetic vitamin D analogue, KH 1060, modulate the growth of mouse proximal tubular cells.
Kidney & blood pressure research.
1996; 19(6):325-31. doi:
10.1159/000174095. [PMID: 8990044] - K Wiberg, S Ljunghall, L Binderup, O Ljunggren. Studies on two new vitamin D analogs, EB 1089 and KH 1060: effects on bone resorption and osteoclast recruitment in vitro.
Bone.
1995 Oct; 17(4):391-5. doi:
10.1016/s8756-3282(95)00246-4. [PMID: 8573413] - E Elstner, M Linker-Israeli, J Said, T Umiel, S de Vos, I P Shintaku, D Heber, L Binderup, M Uskokovic, H P Koeffler. 20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.
Cancer research.
1995 Jul; 55(13):2822-30. doi:
". [PMID: 7796409] - C Mathieu, M Waer, K Casteels, J Laureys, R Bouillon. Prevention of type I diabetes in NOD mice by nonhypercalcemic doses of a new structural analog of 1,25-dihydroxyvitamin D3, KH1060.
Endocrinology.
1995 Mar; 136(3):866-72. doi:
10.1210/endo.136.3.7867594. [PMID: 7867594] - E Lewin, K Olgaard. The in vivo effect of a new, in vitro, extremely potent vitamin D3 analog KH1060 on the suppression of renal allograft rejection in the rat.
Calcified tissue international.
1994 Feb; 54(2):150-4. doi:
10.1007/bf00296066. [PMID: 8012870] - D D Branisteanu, P Leenaerts, B van Damme, R Bouillon. Partial prevention of active Heymann nephritis by 1 alpha, 25 dihydroxyvitamin D3.
Clinical and experimental immunology.
1993 Dec; 94(3):412-7. doi:
10.1111/j.1365-2249.1993.tb08210.x. [PMID: 8252801] - P Veyron, R Pamphile, L Binderup, J L Touraine. Two novel vitamin D analogues, KH 1060 and CB 966, prolong skin allograft survival in mice.
Transplant immunology.
1993; 1(1):72-6. doi:
10.1016/0966-3274(93)90062-d. [PMID: 8081764] - S T Lillevang, J Rosenkvist, C B Andersen, S Larsen, E Kemp, T Kristensen. Single and combined effects of the vitamin D analogue KH1060 and cyclosporin A on mercuric-chloride-induced autoimmune disease in the BN rat.
Clinical and experimental immunology.
1992 May; 88(2):301-6. doi:
10.1111/j.1365-2249.1992.tb03077.x. [PMID: 1572095]