flunoxaprofen (BioDeep_00000650564)

   


代谢物信息卡片


flunoxaprofen

化学式: C16H12FNO3 (285.0801174)
中文名称: 氟诺洛芬
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)F)C(=O)O
InChI: InChI=1S/C16H12FNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20)/t9-/m0/s1

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02C - Other gynecologicals > G02CC - Antiinflammatory products for vaginal administration
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

1 个代谢物同义名

flunoxaprofen



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jennifer Q Dong, Jianhua Liu, Philip C Smith. Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo. Biochemical pharmacology. 2005 Sep; 70(6):937-48. doi: 10.1016/j.bcp.2005.05.026. [PMID: 16046212]
  • M Dahms, H Spahn-Langguth. Covalent binding of acidic drugs via reactive intermediates: detection of benoxaprofen and flunoxaprofen protein adducts in biological material. Die Pharmazie. 1996 Nov; 51(11):874-81. doi: NULL. [PMID: 8985978]
  • B Liebmann, D Henke, H Spahn-Langguth, E Mutschler. Determination of the quaternary compound ciclotropium in human biological material after hydrolysis and derivatization with the fluorophor flunoxaprofen chloride. Journal of chromatography. 1991 Dec; 572(1-2):181-93. doi: 10.1016/0378-4347(91)80482-r. [PMID: 1818053]
  • H Spahn-Langguth, B Podkowik, E Stahl, E Martin, E Mutschler. Improved enantiospecific RP-HPLC assays for propranolol in plasma and urine with pronethalol as internal standard. Journal of analytical toxicology. 1991 Nov; 15(6):327-31. doi: 10.1093/jat/15.6.327. [PMID: 1685758]
  • S Iwakawa, H Spahn, L Z Benet, E T Lin. Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats. Drug metabolism and disposition: the biological fate of chemicals. 1991 Sep; 19(5):853-7. doi: . [PMID: 1686227]
  • A Filippelli, R Marrazzo, V Susanna, M L Cenicola, R Servodio, A R Romano, L Molinario, S Russo, E Marmo. Influence of rat prenatal and postnatal exposure to a non-steroidal anti-inflammatory agent (flunoxaprofen) on cardiovascular function in the progeny. Prostaglandins, leukotrienes, and essential fatty acids. 1989 Jul; 37(1):15-22. doi: 10.1016/0952-3278(89)90180-4. [PMID: 2762365]
  • G Segre, E Bianchi, G Zanolo. Pharmacokinetics of flunoxaprofen in rats, dogs, and monkeys. Journal of pharmaceutical sciences. 1988 Aug; 77(8):670-3. doi: 10.1002/jps.2600770806. [PMID: 3210155]
  • S Pedrazzini, M De Angelis, W Z Muciaccia, C Sacchi, A Forgione. Stereochemical pharmacokinetics of the 2-arylpropionic acid non-steroidal antiinflammatory drug flunoxaprofen in rats and in man. Arzneimittel-Forschung. 1988 Aug; 38(8):1170-5. doi: NULL. [PMID: 3196413]
  • S R Bareggi, S Pedrazzini, M De Angelis. Pharmacokinetic study in man with the non-steroidal antiinflammatory drug flunoxaprofen. Serum concentration-time profile after oral or topical preparations. Arzneimittel-Forschung. 1988 Apr; 38(4):574-7. doi: NULL. [PMID: 3401272]
  • P Palatini, G Montanari, A Perosa, A Forgione, S Pedrazzini, M Furlanut. Stereospecific disposition of flunoxaprofen enantiomers in human beings. International journal of clinical pharmacology research. 1988; 8(3):161-7. doi: NULL. [PMID: 3403103]
  • S Pedrazzini, W Zanoboni-Muciaccia, C Sacchi, A Forgione. Determination of flunoxaprofen enantiomers in biological fluids by high-performance liquid chromatography. Journal of chromatography. 1987 Mar; 415(1):214-20. doi: 10.1016/s0378-4347(00)83213-2. [PMID: 3584360]
  • S Pedrazzini, W Zanoboni-Muciaccia, A Forgione. Determination of the non-steroidal anti-inflammatory drug flunoxaprofen, S(+)-2-(4-fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid, in blood and urine by high-performance liquid chromatography. Journal of chromatography. 1987 Jan; 413(?):338-41. doi: 10.1016/0378-4347(87)80250-5. [PMID: 3558688]
  • G Segre, E Bianchi, L Mascaretti, G Quaglia, A Forgione. Flunoxaprofen pharmacokinetics in elderly subjects. International journal of clinical pharmacology research. 1987; 7(4):243-50. doi: NULL. [PMID: 3596866]
  • F Rossi, W Filippelli, V Guarino, S Russo, R Magliulo, E Marmo. Organ tolerance of non-steroidal anti-inflammatory drugs: effect on liver cells. Drugs under experimental and clinical research. 1985; 11(8):511-6. doi: NULL. [PMID: 3836872]