Procyclidine hydrochloride (BioDeep_00000650499)

   


代谢物信息卡片


Procyclidine hydrochloride

化学式: C19H30ClNO (323.20158000000004)
中文名称: 丙环定盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O.Cl
InChI: 1H

描述信息

D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy[1][2].

同义名列表

4 个代谢物同义名

Procyclidine hydrochloride; Tricyclamol (hydrochloride); (±)-Procyclidine (hydrochloride); Procyclidine (hydrochloride)



数据库引用编号

8 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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文献列表

  • Helen Elizabeth Mackey, Oliver Hawksley. Dystonia not dystopia: effects of the legal high, 'Clockwork Orange'. BMJ case reports. 2015 Dec; 2015(?):. doi: 10.1136/bcr-2015-212934. [PMID: 26660763]
  • Babiker El-Haj, Abdulkader Al-Amri, Heyam Saad Ali. Target urinary analytes for the gas chromatographic- mass spectrometric detection of procyclidine and benzhexol in drug abuse cases. Journal of analytical toxicology. 2011 Mar; 35(2):92-8. doi: 10.1093/anatox/35.2.92. [PMID: 21396228]
  • Kamal A Hadidi. Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden. Legal medicine (Tokyo, Japan). 2004 Oct; 6(4):233-41. doi: 10.1016/j.legalmed.2004.06.001. [PMID: 15363448]
  • Xiaocui Zhao, Tianyan You, Jifeng Liu, Xiuhua Sun, Jilin Yan, Xiurong Yang, Erkang Wang. Drug-human serum albumin binding studied by capillary electrophoresis with electrochemiluminescence detection. Electrophoresis. 2004 Oct; 25(20):3422-6. doi: 10.1002/elps.200305930. [PMID: 15490448]
  • E J Jang, Y J Lee, S J Chung, C K Shim. Nasal absorption of procyclidine in rats and dogs. Archives of pharmacal research. 2001 Jun; 24(3):219-23. doi: 10.1007/bf02978261. [PMID: 11440081]
  • T Zarnowski, Z Kleinrok, W A Turski, S J Czuczwar. The NMDA antagonist procyclidine, but not ifenprodil, enhances the protective efficacy of common antiepileptics against maximal electroshock-induced seizures in mice. Journal of neural transmission. General section. 1994; 97(1):1-12. doi: 10.1007/bf01277958. [PMID: 7888145]
  • D T Martin, M Swash. Muscle pathology in the neuroleptic malignant syndrome. Journal of neurology. 1987 Dec; 235(2):120-1. doi: 10.1007/bf00718024. [PMID: 3430190]
  • T G Dinan. Neuroleptic effects on platelet aggregation: a study in normal volunteers and schizophrenics. Psychological medicine. 1987 Nov; 17(4):875-81. doi: 10.1017/s0033291700000672. [PMID: 2893407]
  • J S Bamrah, V Kumar, J Krska, S D Soni. Interactions between procyclidine and neuroleptic drugs. Some pharmacological and clinical aspects. The British journal of psychiatry : the journal of mental science. 1986 Dec; 149(?):726-33. doi: 10.1192/bjp.149.6.726. [PMID: 2878700]
  • P D Whiteman, A S Fowle, M J Hamilton, A W Peck, A Bye, K Dean, A Webster. Pharmacokinetics and Pharmacodynamics of procyclidine in man. European journal of clinical pharmacology. 1985; 28(1):73-8. doi: 10.1007/bf00635711. [PMID: 3987788]
  • G Paeme, R Grimee, A Vercruysse. In vitro metabolism of procyclidine in the rat. European journal of drug metabolism and pharmacokinetics. 1984 Oct; 9(4):311-3. doi: 10.1007/bf03189682. [PMID: 6532804]
  • G Paeme, R Grimee, A Vercruysse. Isolation and identification of eight procyclidine metabolites from rat urine. European journal of drug metabolism and pharmacokinetics. 1984 Apr; 9(2):103-8. doi: 10.1007/bf03189612. [PMID: 6745301]
  • G Paeme, R Grimee, A Vercruysse. Isolation and identification of eight procyclidine metabolites from rat urine. Archives internationales de pharmacodynamie et de therapie. 1982 Dec; 260(2):291-2. doi: NULL. [PMID: 7165433]
  • M G Guliamov. [Experience with the use of new Bulgarian psychotropic drugs]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1982; 82(11):115-22. doi: ". [PMID: 6758442]
  • K Dean, D Land, A Bye. Analysis of procyclidine in human plasma and urine by gas-liquid chromatography. Journal of chromatography. 1980 Dec; 221(2):408-13. doi: 10.1016/s0378-4347(00)84331-5. [PMID: 7217311]
  • G Paeme, W Sonck, D Tourwé, R Grimée, A Vercruysse. 1-(3-Hydroxycyclohexyl)-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, a procyclidine metabolite. Drug metabolism and disposition: the biological fate of chemicals. 1980 Mar; 8(2):115-6. doi: NULL. [PMID: 6103784]
  • R Varma. Simultaneous gas chromatographic determination of diphenylhydantoin, carbamazepin (Tegretol), phenobarbital and primidone in presence of Kemadrin (procyclidine) and Prolixin (fluphenazine) in plasma of psychiatric patients. Journal of chromatography. 1978 Aug; 155(1):182-6. doi: 10.1016/s0021-9673(00)83948-5. [PMID: 681486]
  • J Majkowski, K Lysakowska-Sernicka, B Bilińska-Nigot. [Anti-epileptic and side effects of Didepil]. Neurologia i neurochirurgia polska. 1978 Jul; 12(4):421-5. doi: . [PMID: 714222]
  • G Chouinard, L Annable, S Cooper. Antiparkinsonian drug administration and plasma levels of penfluridol, a new long-acting neuroleptic. Communications in psychopharmacology. 1977; 1(4):325-31. doi: NULL. [PMID: 615695]
  • E Gründig, J Weiss. [The influence of neuroleptic drugs on urinary excretion of non-protein nitrogen (author's transl)]. Arzneimittel-Forschung. 1976 Feb; 26(2):286-90. doi: . [PMID: 7281]
  • G B Muscettola, M Giovannucci, R Montanini, P L Morselli, S Garattini. Relationship between desipramine plasma levels and the effect in Parkinson's syndrome. Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research. 1972 Apr; 17(4):375-9. doi: NULL. [PMID: 5079227]