Fursultiamine (BioDeep_00000650419)
代谢物信息卡片
化学式: C17H26N4O3S2 (398.1446246)
中文名称: 呋喃硫胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC=C(C(=N1)N)CN(C=O)C(=C(CCO)SSCC2CCCO2)C
InChI: InChI=1S/C17H26N4O3S2/c1-12(16(5-6-22)26-25-10-15-4-3-7-24-15)21(11-23)9-14-8-19-13(2)20-17(14)18/h8,11,15,22H,3-7,9-10H2,1-2H3,(H2,18,19,20)/b16-12+
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135636
- ChEBI: CHEBI:91836
- PubChem: 3002119
- DrugBank: DB08966
- ChEMBL: CHEMBL1740659
- MeSH: Fursultiamin
- CAS: 10238-39-8
- CAS: 804-30-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yasuyoshi Watanabe, Aya Mawatari, Kazuki Aita, Yuzuru Sato, Yasuhiro Wada, Takayoshi Nakaoka, Kayo Onoe, Emi Yamano, Go Akamatsu, Akihito Ohnishi, Keiji Shimizu, Masahiro Sasaki, Hisashi Doi, Michio Senda. PET imaging of 11C-labeled thiamine tetrahydrofurfuryl disulfide, vitamin B1 derivative: First-in-human study.
Biochemical and biophysical research communications.
2021 05; 555(?):7-12. doi:
10.1016/j.bbrc.2021.03.119. [PMID: 33812058] - Wen-Ching Huang, Hui-Yu Huang, Yi-Ju Hsu, Wan-Hsiung Su, Sih-Yu Shen, Mon-Chien Lee, Che-Li Lin, Chi-Chang Huang. The Effects of Thiamine Tetrahydrofurfuryl Disulfide on Physiological Adaption and Exercise Performance Improvement.
Nutrients.
2018 Jun; 10(7):. doi:
10.3390/nu10070851. [PMID: 29966293] - Tomoki Takeda, Yuki Matsuo, Kyoko Nishida, Akihisa Fujiki, Yukiko Hattori, Takayuki Koga, Yuji Ishii, Hideyuki Yamada. α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis.
The Journal of toxicological sciences.
2017; 42(1):13-23. doi:
10.2131/jts.42.13. [PMID: 28070105] - Wan-Su Park, Jongtae Lee, Taegon Hong, Gabjin Park, Sunil Youn, Youngwhan Seo, Sanghun Lee, Seunghoon Han. Comparative Pharmacokinetic Analysis of Thiamine and Its Phosphorylated Metabolites Administered as Multivitamin Preparations.
Clinical therapeutics.
2016 Oct; 38(10):2277-2285. doi:
10.1016/j.clinthera.2016.08.009. [PMID: 27707509] - Eileen Fung, Priscilla Sugianto, Jason Hsu, Robert Damoiseaux, Tomas Ganz, Elizabeta Nemeth. High-throughput screening of small molecules identifies hepcidin antagonists.
Molecular pharmacology.
2013 Mar; 83(3):681-90. doi:
10.1124/mol.112.083428. [PMID: 23292796] - Judith I Hills, Mari S Golub, Lucien Bettendorff, Carl L Keen. The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice.
Neurotoxicology and teratology.
2012 Mar; 34(2):242-52. doi:
10.1016/j.ntt.2011.07.006. [PMID: 21816221] - Yosuke Suzuki, Hiroki Itoh, Tomohide Abe, Fumihiro Nishimura, Yuhki Sato, Masaharu Takeyama. Comparison of the effects of pantethine and fursultiamine on plasma gastrointestinal peptide levels in healthy volunteers.
Biological & pharmaceutical bulletin.
2011; 34(10):1640-3. doi:
10.1248/bpb.34.1640. [PMID: 21963510] - Satoshi Nozaki, Hiroshi Mizuma, Masaaki Tanaka, Guanghua Jin, Tsuyoshi Tahara, Kei Mizuno, Masanori Yamato, Kaori Okuyama, Asami Eguchi, Kouji Akimoto, Takahito Kitayoshi, Noriko Mochizuki-Oda, Yosky Kataoka, Yasuyoshi Watanabe. Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats.
Nutrition research (New York, N.Y.).
2009 Dec; 29(12):867-72. doi:
10.1016/j.nutres.2009.10.007. [PMID: 19963160] - Derrick Lonsdale, Raymond J Shamberger, Tapan Audhya. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study.
Neuro endocrinology letters.
2002 Aug; 23(4):303-8. doi:
NULL. [PMID: 12195231] - Hiroshi Tomita, Kenji Ohtuka. Taste disturbance after tonsillectomy.
Acta oto-laryngologica. Supplementum.
2002; ?(546):164-72. doi:
10.1080/00016480260046571. [PMID: 12132617] - A Greb, R Bitsch. Comparative bioavailability of various thiamine derivatives after oral administration.
International journal of clinical pharmacology and therapeutics.
1998 Apr; 36(4):216-21. doi:
NULL. [PMID: 9587048] - B H Robinson, J Taylor, W G Sherwood. Deficiency of dihydrolipoyl dehydrogenase (a component of the pyruvate and alpha-ketoglutarate dehydrogenase complexes): a cause of congenital chronic lactic acidosis in infancy.
Pediatric research.
1977 Dec; 11(12):1198-202. doi:
10.1203/00006450-197712000-00006. [PMID: 413089]