Amidonal (BioDeep_00000649998)
代谢物信息卡片
Aprindine hydrochloride
化学式: C22H31ClN2 (358.2175636)
中文名称: 盐酸茚丙胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCCN(C1CC2=CC=CC=C2C1)C3=CC=CC=C3.Cl
InChI: 1H
描述信息
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31229
- KEGGdrug: D01326
- PubChem: 71413
- ChEMBL: CHEMBL2104501
- MeSH: Aprindine
- CAS: 33237-74-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yoshimasa Tsuchishita, Kyoko Fukumoto, Masaaki Kusumoto, Kazuyuki Ueno. Relationship between serum aprindine concentration and neurologic side effects in Japanese.
Biological & pharmaceutical bulletin.
2009 Apr; 32(4):637-9. doi:
10.1248/bpb.32.637. [PMID: 19336897] - Akira Fujiki, Tamotsu Sakamoto, Kunihiro Nishida, Koichi Mizumaki, Hiroshi Inoue. Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation.
Journal of cardiovascular pharmacology.
2007 Sep; 50(3):264-6. doi:
10.1097/fjc.0b013e318074f952. [PMID: 17878753] - Masato Taguchi, Akira Fujiki, Jotaro Iwamoto, Hiroshi Inoue, Katsutoshi Tahara, Katsuya Saigusa, Isao Horiuchi, Yukari Oshima, Yukiya Hashimoto. Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.
Biological & pharmaceutical bulletin.
2006 Mar; 29(3):517-21. doi:
10.1248/bpb.29.517. [PMID: 16508157] - M Shimizu, K Takatori, M Kajiwara, H Ogata. Isolation of a major metabolite (i-OHAP) of aprindine and its identification as N-[3-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol.
Biological & pharmaceutical bulletin.
1998 May; 21(5):530-4. doi:
10.1248/bpb.21.530. [PMID: 9635514] - Y Takata, T Tsuchihashi, S Nakamura, Y Hirota. Chronic administration of aprindine during maintenance hemodialysis.
International journal of clinical pharmacology and therapeutics.
1997 Dec; 35(12):553-6. doi:
NULL. [PMID: 9455712] - G Misztal, L Przyborowski. Determination of aprindine in human plasma using reversed phase HPLC.
Die Pharmazie.
1995 Mar; 50(3):187-8. doi:
NULL. [PMID: 7732048] - A Gumieniczek, G Misztal, L Przyborowski. Determination of amiodarone in tablets and plasma by high-performance liquid chromatography.
Acta poloniae pharmaceutica.
1994; 51(4-5):325-8. doi:
NULL. [PMID: 7701947] - G Misztal, A Gumieniczek. Chromatographic analysis (TLC) aprindine and nadoxolol in human plasma.
Acta poloniae pharmaceutica.
1994; 51(3):215-8. doi:
NULL. [PMID: 7872014] - K Okishige, K Ohtomo, T Satoh, K Hiejima. Experimental study on the electrophysiological effects of the combination of the antiarrhythmic drugs aprindine and verapamil.
Archives internationales de pharmacodynamie et de therapie.
1991 Nov; 314(?):44-56. doi:
NULL. [PMID: 1824189] - R Sato, I Hisatome, Y Tanaka, N Sasaki, H Kotake, H Mashiba, R Katori. Aprindine blocks the sodium current in guinea-pig ventricular myocytes.
Naunyn-Schmiedeberg's archives of pharmacology.
1991 Sep; 344(3):331-6. doi:
10.1007/bf00183008. [PMID: 1660104] - E Rekka, R M Mannhold, A Bast, H Timmerman. Molecular pharmacological aspects of antiarrhythmic activity. I. Class I and class III compounds and lipid peroxidation.
Biochemical pharmacology.
1990 Jan; 39(1):95-100. doi:
10.1016/0006-2952(90)90652-2. [PMID: 2297363] - S Kasahara, N Shibata, H Mizobe, M Shoda, Y Miyazaki, M Miura, Y Miyazawa, Y Komatsu. [Clinical effects and plasma concentration levels of aprindine hydrochloride in patients with tachyarrhythmias].
Kokyu to junkan. Respiration & circulation.
1989 Nov; 37(11):1225-30. doi:
NULL. [PMID: 2602679] - D R Holland, W B Lacefield, C R Gonzales, S R Johnston, J A Turk. Indecainide: effects on arrhythmias, electrophysiology, and cardiovascular dynamics.
Journal of cardiovascular pharmacology.
1989 Sep; 14(3):454-61. doi:
NULL. [PMID: 2476626] - H Kawano, N Inotsume, H Arimoto, T Fujii, M Nakano. Rapid and sensitive determination of aprindine in serum by gas chromatography using a surface ionization detector.
Journal of chromatography.
1989 Aug; 493(1):71-8. doi:
10.1016/s0378-4347(00)82710-3. [PMID: 2778024] - S Iwasaki, H Araki, T Yamakawa, K Nishi, Y Miyauchi. Effects of aprindine and disopyramide on reperfusion-induced arrhythmias and cardiac function in isolated rat hearts.
Archives internationales de pharmacodynamie et de therapie.
1989 Jul; 300(?):174-85. doi:
. [PMID: 2619422] - T Tanabe, H Yoshikawa, H Furuya, Y Goto. Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias.
Japanese circulation journal.
1988 Mar; 52(3):298-305. doi:
10.1253/jcj.52.298. [PMID: 3373722] - R Stroobandt, G Holvoet, N Verbeke, H Kesteloot. Effects of intravenous sotalol, aprindine and the combination of sotalol and aprindine on chronic high frequency ventricular arrhythmias in man.
European heart journal.
1987 Apr; 8(4):372-7. doi:
10.1093/oxfordjournals.eurheartj.a062289. [PMID: 2440683] - M Yokota, H Inagaki, H Uematsu, N Enomoto, J Goto, I Sotobata, A Takahashi. Non-linear pharmacokinetics of aprindine hydrochloride in oral administration.
Arzneimittel-Forschung.
1987 Feb; 37(2):184-8. doi:
NULL. [PMID: 2437934] - C L Raehl, A K Patel, M LeRoy. Drug-induced torsade de pointes.
Clinical pharmacy.
1985 Nov; 4(6):675-90. doi:
. [PMID: 2416504] - H Kikuchi, T Honda, H Kugimiya, H Matuda, T Matunaga, S Takemiya, K Hayasaki. [Clinical efficacy and plasma levels of oral aprindine, a new antiarrhythmic drug].
Kokyu to junkan. Respiration & circulation.
1985 Mar; 33(3):433-40. doi:
NULL. [PMID: 4012073] - G P Sanna. New drugs in the management of ventricular arrhythmias.
Giornale italiano di cardiologia.
1984 Oct; 14(10):788-97. doi:
. [PMID: 6083894] - M A Boogaerts, M Peters, C Peersman, H Kesteloot, R L Verwilghen. Mechanism of aprindine induced agranulocytosis: direct toxicity on CFU-C and CFU-GEMM.
Scandinavian journal of haematology.
1984 Feb; 32(2):175-8. doi:
10.1111/j.1600-0609.1984.tb02174.x. [PMID: 6701462] - K Hashimoto, S Komori, M Ishii, J Kamiya. Effective plasma concentrations of aprindine in canine ventricular arrhythmias.
Journal of cardiovascular pharmacology.
1984 Jan; 6(1):12-9. doi:
NULL. [PMID: 6199593] - T Kobari, T Itoh, T Hirakawa, H Namekawa, T Suzuki, T Satoh, N Iida, F Ohtsu, H Hayakawa. Dose-dependent pharmacokinetics of aprindine in healthy volunteers.
European journal of clinical pharmacology.
1984; 26(1):129-31. doi:
10.1007/bf00546721. [PMID: 6714286] - T Kobari, H Namekawa, T Ito, M Ishizaka. High-performance liquid chromatographic determination of aprindine and its active desethyl metabolite in plasma.
Journal of chromatography.
1983 Nov; 278(1):220-4. doi:
10.1016/s0378-4347(00)84779-9. [PMID: 6662885] - K E Wirth, G Breithardt, L Michaelis. [Detection of aprindine and its metabolites in plasma and urine].
Herz.
1983 Oct; 8(5):302-8. doi:
NULL. [PMID: 6642401] - T Ito, H Namekawa, T Kobari. Determination of aprindine in plasma by gas chromatography--mass spectrometry.
Journal of chromatography.
1983 May; 274(?):341-5. doi:
10.1016/s0378-4347(00)84440-0. [PMID: 6874837] - A V Pisciotta, C Cronkite. Aprindine-induced agranulocytosis. Evidence for immunologic mechanism.
Archives of internal medicine.
1983 Feb; 143(2):241-3. doi:
NULL. [PMID: 6401987] - R Shimada, H Araki, Y Orita, O Nakagaki, M Nakamura. Cardiac effects of aprindine in patients with or without cardiac dysfunction: echocardiographic and clinical evaluation.
Clinical therapeutics.
1983; 5(4):348-56. doi:
NULL. [PMID: 6871919] - F Follath, U Ganzinger, E Schuetz. Reliability of antiarrhythmic drug plasma concentration monitoring.
Clinical pharmacokinetics.
1983 Jan; 8(1):63-82. doi:
10.2165/00003088-198308010-00004. [PMID: 6404580] - K Hashimoto, T Shibuya, H Satoh, S Imai. Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.
Japanese circulation journal.
1983 Jan; 47(1):92-7. doi:
10.1253/jcj.47.92. [PMID: 6827775] - P A Stryckmans, E Ronge-Collard, A Delforge, M Lambert, S Suciu. Effect of 2 anti-arrhythmic drugs aprindine and moxaprindine on the replication capacity of murine and human haemopoietic cells.
Scandinavian journal of haematology.
1982 Oct; 29(4):331-7. doi:
10.1111/j.1600-0609.1982.tb00603.x. [PMID: 7178839] - O Teirlynck, F M Belpaire, F Andreasen. Binding of aprindine and moxaprindine to human serum, alpha 1-acid glycoprotein and serum of healthy and diseased humans.
European journal of clinical pharmacology.
1982; 21(5):427-31. doi:
10.1007/bf00542331. [PMID: 7075647] - J M de Suray, A Lavis, F Breekpot. Pharmacokinetic study of aprindine and moxaprindine in dogs.
International journal of clinical pharmacology, therapy, and toxicology.
1981 May; 19(5):209-15. doi:
NULL. [PMID: 7251236] - J F Nash, R H Carmichael. GLC determination of aprindine in human plasma using a nitrogen--phosphorus flame-ionization detector.
Journal of pharmaceutical sciences.
1980 Sep; 69(9):1094-6. doi:
10.1002/jps.2600690929. [PMID: 7411417] - J Bouget, L Revillon, C Almange, A Michardière, J F Pinel. [Severe cerebellar symdrome during aprindine treatment (author's transl)].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris.
1980 Apr; 56(13-14):682-4. doi:
NULL. [PMID: 6246599] - F Andreasen, S Husted, P Jakobsen, E B Jensen. The binding of aprindine to serum proteins with statistical considerations concerning the analysis of binding data.
Acta pharmacologica et toxicologica.
1980 Feb; 46(2):105-12. doi:
10.1111/j.1600-0773.1980.tb02428.x. [PMID: 7361564] - P L Malini, E Ambrosioni, D Bracchetti, B Magnani. Evaluation of clinical efficacy and plasma levels of aprindine.
International journal of clinical pharmacology and biopharmacy.
1979 Oct; 17(10):396-403. doi:
NULL. [PMID: 500254] - H C Bodenheimer, A M Samarel. Agranulocytosis associated with aprindine therapy.
Archives of internal medicine.
1979 Oct; 139(10):1181-2. doi:
NULL. [PMID: 485754] - P O Lagerström, B A Persson. Liquid chromatography in the monitoring of plasma levels of antiarrhythmic drugs.
Journal of chromatography.
1978 Feb; 149(?):331-40. doi:
10.1016/s0021-9673(00)80996-6. [PMID: 649734] - M Lesne, R Dolphen. Development of a radioimmunoassay for aprindine.
Journal of immunological methods.
1977; 17(1-2):189-98. doi:
10.1016/0022-1759(77)90089-8. [PMID: 903616] - P R Foster, R M King, A B Nicoll, D P Zipes. Suppression of ouabain-induced ventricular rhythms with aprindine HCl. A comparison with other antiarrhythmic agents.
Circulation.
1976 Feb; 53(2):315-21. doi:
10.1161/01.cir.53.2.315. [PMID: 1245038] - F Hagemeijer. Suicide with aprindine and digoxin.
Acta cardiologica.
1976; 31(2):161-7. doi:
NULL. [PMID: 1087816] - W J Remme, P D Verdouw. Cardiovascular effects of aprindine, a new antiarrhythmic drug.
European journal of cardiology.
1975 Dec; 3(4):307-13. doi:
NULL. [PMID: 1193115] - F Hagemeijer. Absorption, half-life, and toxicity of oral aprindine in patients with acute myocardial infarction.
European journal of clinical pharmacology.
1975 Oct; 9(1):21-5. doi:
10.1007/bf00613425. [PMID: 1233249]