Pranidipine (BioDeep_00000649991)
代谢物信息卡片
化学式: C25H24N2O6 (448.1634284)
中文名称: 普兰地平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
InChI: InChI=1S/C25H24N2O6/c1-16-21(24(28)32-3)23(19-12-7-13-20(15-19)27(30)31)22(17(2)26-16)25(29)33-14-8-11-18-9-5-4-6-10-18/h4-13,15,23,26H,14H2,1-3H3/b11-8+
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- T Nagahama, K Hayashi, K Fujiwara, Y Ozawa, T Saruta. Characterization of the renal action of pranidipine in the rat.
Arzneimittel-Forschung.
2000 Mar; 50(3):248-53. doi:
10.1055/s-0031-1300194. [PMID: 10758776] - S Yamada, S Uchida, A Urayama, R Kimura. In vivo receptor occupancy and plasma concentration of pranidipine, a potent and long-acting dihydropyridine calcium antagonist.
Pharmacology.
1999 Oct; 59(4):171-82. doi:
10.1159/000028318. [PMID: 10474077] - K Takeuchi, T Omura, M Yoshiyama, K Yoshida, R Otsuka, Y Shimada, K Ujino, J Yoshikawa. Long-acting calcium channel antagonist pranidipine prevents ventricular remodeling after myocardial infarction in rats.
Heart and vessels.
1999; 14(3):111-9. doi:
10.1007/bf02482294. [PMID: 10776803] - K Hashimoto, T Shirafuji, H Sekino, O Matsuoka, H Sekino, O Onnagawa, T Okamoto, S Kudo, J Azuma. Interaction of citrus juices with pranidipine, a new 1,4-dihydropyridine calcium antagonist, in healthy subjects.
European journal of clinical pharmacology.
1998 Nov; 54(9-10):753-60. doi:
10.1007/s002280050547. [PMID: 9923580] - J Rosenthal, N Hittel, K O Stumpe. Pranidipine, a novel calcium antagonist, once daily, for the treatment of hypertension: a multicenter, double-blind, placebo-controlled dose-finding study.
Cardiovascular drugs and therapy.
1996 Mar; 10(1):59-66. doi:
10.1007/bf00051131. [PMID: 8723171] - G Miyakoda, N Nakayama, K Matsui, Y Yabuuchi. Mechanisms of the potent and long-lasting antihypertensive action of the new calcium channel blocker pranidipine. Evidence for strong affinity to the calcium channels or membranes.
Arzneimittel-Forschung.
1995 Apr; 45(4):471-5. doi:
". [PMID: 7779144] - Y Uehara, Y Kawabata, N Ohshima, N Hirawa, S Takada, A Numabe, T Nagata, A Goto, S Yagi, M Omata. New dihydropyridine calcium channel antagonist, pranidipine, attenuates hypertensive renal injury in Dahl salt-sensitive rats.
Journal of cardiovascular pharmacology.
1994 Jun; 23(6):970-9. doi:
10.1097/00005344-199406000-00016. [PMID: 7523790] - M Nagasawa, H Sasabe, T Shimizu, H Mori. Use of a carrier for quantitation of a new dihydropyridine calcium antagonist (OPC-13340) in human plasma by highly sensitive gas chromatography with negative-ion chemical ionization mass spectrometry.
Journal of chromatography.
1992 Jun; 577(2):275-81. doi:
10.1016/0378-4347(92)80248-o. [PMID: 1400758] - J Cortés-Prieto, J Arencibia-Rocha, A Aranda, M D García-García, D H Coy, A V Schally. Attempts to induce ovulation in amenorrheic patients using D-Ala-6-LH-RH propylamide.
International journal of fertility.
1979; 24(2):108-13. doi:
. [PMID: 40903]