Ivachtin (BioDeep_00000648978)
代谢物信息卡片
化学式: C13H18N2O6 (298.1164808)
中文名称: 美他多辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC=C(C(=C1O)CO)CO.C1CC(=O)NC1C(=O)O
InChI: 3-/m.0/s1
描述信息
A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy
D002491 - Central Nervous System Agents > D000427 - Alcohol Deterrents
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- L S Babinets, K Yu Kytsai, Yu Ya Kotsaba, I M Halabitska, N A Melnyk, I V Semenova, O S Zemlyak. Improvement of the complex medical treatment for the patients wіth chronic biliary pancreatitis.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2017 ; 70(2):213-216. doi:
". [PMID: 28511162] - Dae Young Lee, Hee Eun Kang, Sang Geon Kim, Myung Gull Lee. Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats.
Archives of pharmacal research.
2010 Jul; 33(7):1005-8. doi:
10.1007/s12272-010-0705-4. [PMID: 20661709] - Yoon Mee Yang, Hyun Eun Kim, Sung Hwan Ki, Sang Geon Kim. Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.
Archives of biochemistry and biophysics.
2009 Aug; 488(2):91-9. doi:
10.1016/j.abb.2009.07.007. [PMID: 19607801] - Sung Hwan Ki, Jae Hoon Choi, Choon Won Kim, Sang Geon Kim. Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity.
Chemico-biological interactions.
2007 Aug; 169(2):80-90. doi:
10.1016/j.cbi.2007.05.008. [PMID: 17606256] - J Fehér, G Lengyel. A new approach to drug therapy in non-alcoholic steatohepatitis (NASH).
The Journal of international medical research.
2003 Nov; 31(6):537-51. doi:
10.1177/147323000303100610. [PMID: 14708419] - Pablo Muriel, Rogelio Deheza. Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.
Liver international : official journal of the International Association for the Study of the Liver.
2003 Aug; 23(4):262-8. doi:
10.1034/j.1600-0676.2003.00837.x. [PMID: 12895266] - M C Gutiérrez-Ruiz, L Bucio, A Correa, V Souza, E Hernández, L E Gómez-Quiroz, D Kershenobich. Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture.
Pharmacological research.
2001 Nov; 44(5):431-6. doi:
10.1006/phrs.2001.0883. [PMID: 11712874] - J Caballería, A Parés, C Brú, J Mercader, A García Plaza, L Caballería, G Clemente, L Rodrigo, J Rodés. Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial. Spanish Group for the Study of Alcoholic Fatty Liver.
Journal of hepatology.
1998 Jan; 28(1):54-60. doi:
10.1016/s0168-8278(98)80202-x. [PMID: 9537864] - V Calabrese, G Randazzo, N Ragusa, V Rizza. Long-term ethanol administration enhances age-dependent modulation of redox state in central and peripheral organs of rat: protection by metadoxine.
Drugs under experimental and clinical research.
1998; 24(2):85-91. doi:
NULL. [PMID: 9675549] - V Calabrese, A Calderone, N Ragusa, V Rizza. Effects of Metadoxine on cellular status of glutathione and of enzymatic defence system following acute ethanol intoxication in rats.
Drugs under experimental and clinical research.
1996; 22(1):17-24. doi:
NULL. [PMID: 8839633] - V Calabrese, A Calderone, N Ragusa, V Rizza. Effects of metadoxine on cellular formation of fatty acid ethyl esters in ethanol treated rats.
International journal of tissue reactions.
1995; 17(3):101-8. doi:
NULL. [PMID: 8867649] - V Calabrese, G Bombaci, A Calderone, V Rizza. Effects of metadoxine on cellular free fatty acid levels in ethanol treated rats.
International journal of tissue reactions.
1993; 15(6):235-43. doi:
". [PMID: 8088945] - G Annoni, L Contu, M A Tronci, A Caputo, B Arosio. Pyridoxol L,2-pyrrolidon-5 carboxylate prevents active fibroplasia in CCl4-treated rats.
Pharmacological research.
1992 Jan; 25(1):87-93. doi:
10.1016/s1043-6618(05)80067-2. [PMID: 1310810] - S Marchi, A Polloni, F Costa, M Bellini, V Bonifazi, E Tumino, B Grassi, M R Romano, G De Bartolo, A Bertelli. Liver triglyceride accumulation after chronic ethanol administration: a possible protective role of metadoxina and ubiquinone.
International journal of tissue reactions.
1990; 12(4):247-50. doi:
NULL. [PMID: 2283204]