Buformin hydrochloride (BioDeep_00000647976)
代谢物信息卡片
化学式: C6H16ClN5 (193.10941660000003)
中文名称: 丁双胍盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN=C(N)N=C(N)N.Cl
InChI: 1H
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98234 - Biguanide Antidiabetic Agent
D007004 - Hypoglycemic Agents > D001645 - Biguanides
Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D02206
- PubChem: 84976
- MeSH: Buformin
- CAS: 15537-73-2
- CAS: 1190-53-0
- medchemexpress: HY-B2099A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Amin Wurita, Koutaro Hasegawa, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki. Postmortem distribution/redistribution of buformin in body fluids and solid tissues in an autopsy case using liquid chromatography-tandem mass spectrometry with QuEChERS extraction method.
Forensic science international.
2020 Sep; 314(?):110376. doi:
10.1016/j.forsciint.2020.110376
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Scientific reports.
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10.1038/srep25669
. [PMID: 27157976] - Zongjian Zhu, Weiqin Jiang, Matthew D Thompson, Dimas Echeverria, John N McGinley, Henry J Thompson. Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat.
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PloS one.
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Die Pharmazie.
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. [PMID: 6091156] - T Mothes, R Neubert, W Fürst. [Drug permeability through artificial lipid membranes. 15: Effect of anions on the transport of buformin in model membranes and isolated, lumen- and vessel-perfused small intestine].
Die Pharmazie.
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Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
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Diabetologia.
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Biulleten' eksperimental'noi biologii i meditsiny.
1980 Jul; 89(7):88-90. doi:
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Medizinische Klinik.
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Minerva medica.
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. [PMID: 450301] - E G Berger, V Brunner, H R Meier, P Moehr. [The effect of oral butyl-biguanide on oral glucose tolerance and renal glucose reabsorption in normal human subjects in vivo (author's transl)].
Klinische Wochenschrift.
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Vnitrni lekarstvi.
1978 Mar; 24(3):277-81. doi:
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. [PMID: 644896] - P Lefebvre, A Luyckx, F Mosora, M Lacroix, F Pirnay. Oxidation of an exogenous glucose load using naturally labelled 13C-glucose. Effect of butylbiguanide therapy in obese mildly diabetic subjects.
Diabetologia.
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. [PMID: 627331] - P H Althoff, W Fassbinder, M Neubauer, K M Koch, K Schöffling. [Haemodialysis in the treatment of biguanide-induced lactate acidosis (author's transl)].
Deutsche medizinische Wochenschrift (1946).
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Arzneimittel-Forschung.
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Medizinische Klinik.
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Klinische Wochenschrift.
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Arzneimittel-Forschung.
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Die Medizinische Welt.
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