Caffeine Citrate (BioDeep_00000647951)
代谢物信息卡片
2-hydroxypropane-1,2,3-tricarboxylic acid,1,3,7-trimethylpurine-2,6-dione
化学式: C14H18N4O9 (386.1073738)
中文名称: 柠檬酸咖啡因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI: 13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
描述信息
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Xin He, Jin-Chun Qiu, Ke-Yu Lu, Hong-Li Guo, Ling Li, Wei-Wei Jia, Ming-Ming Ni, Yun Liu, Jing Xu, Feng Chen, Rui Cheng. Therapy for Apnoea of Prematurity: A Retrospective Study on Effects of Standard Dose and Genetic Variability on Clinical Response to Caffeine Citrate in Chinese Preterm Infants.
Advances in therapy.
2021 01; 38(1):607-626. doi:
10.1007/s12325-020-01544-2. [PMID: 33180318] - Jacob V Aranda, Kay D Beharry. Pharmacokinetics, pharmacodynamics and metabolism of caffeine in newborns.
Seminars in fetal & neonatal medicine.
2020 12; 25(6):101183. doi:
10.1016/j.siny.2020.101183. [PMID: 33293242] - Ting He, Zheng-Chang Liao, Ying Ding, Ming-Jie Wang, Wen Li, Ji-Min Gan, Shao-Jie Yue. [Comparison of the efficacy of domestic and imported caffeine citrate in the treatment of apnea in preterm infants: a prospective randomized double-blind controlled trial].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2020 Jul; 22(7):684-689. doi:
NULL. [PMID: 32669161] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Matthew W Harer, David J Askenazi, Louis J Boohaker, J Bryan Carmody, Russell L Griffin, Ronnie Guillet, David T Selewski, Jonathan R Swanson, Jennifer R Charlton. Association Between Early Caffeine Citrate Administration and Risk of Acute Kidney Injury in Preterm Neonates: Results From the AWAKEN Study.
JAMA pediatrics.
2018 06; 172(6):e180322. doi:
10.1001/jamapediatrics.2018.0322. [PMID: 29610830] - Amel Chaabane, Fatma Z Chioukh, Zohra Chadli, Nadia Ben Fredj, Karim Ben Ameur, Hayet Ben Hmida, Naceur A Boughattas, Kamel Monastiri, Karim Aouam. Therapeutic drug monitoring of caffeine in preterm infants: Could saliva be an alternative to serum?.
Therapie.
2017 Dec; 72(6):685-689. doi:
10.1016/j.therap.2017.06.004. [PMID: 28964570] - Tian Yu, Alfred H Balch, Robert M Ward, E Kent Korgenski, Catherine M T Sherwin. Incorporating pharmacodynamic considerations into caffeine therapeutic drug monitoring in preterm neonates.
BMC pharmacology & toxicology.
2016 06; 17(1):22. doi:
10.1186/s40360-016-0065-x. [PMID: 27266401] - Katherine Schoen, Tian Yu, Chris Stockmann, Michael G Spigarelli, Catherine M T Sherwin. Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity.
Paediatric drugs.
2014 Apr; 16(2):169-77. doi:
10.1007/s40272-013-0063-z. [PMID: 24399614] - Stacie J Lampkin, Ann Marie Turner, Satyan Lakshminrusimha, Bobby Mathew, Jack Brown, Cory E Fominaya, Kristin K Johnson. Association between caffeine citrate exposure and necrotizing enterocolitis in preterm infants.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2013 Apr; 70(7):603-8. doi:
10.2146/ajhp120457. [PMID: 23515513] - Bruce G Charles, Sarah R Townsend, Peter A Steer, Vicki J Flenady, Peter H Gray, Andrew Shearman. Caffeine citrate treatment for extremely premature infants with apnea: population pharmacokinetics, absolute bioavailability, and implications for therapeutic drug monitoring.
Therapeutic drug monitoring.
2008 Dec; 30(6):709-16. doi:
10.1097/ftd.0b013e3181898b6f. [PMID: 19057373] - Girija Natarajan, Mirjana-Lulic Botica, Ronald Thomas, Jacob V Aranda. Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise?.
Pediatrics.
2007 May; 119(5):936-40. doi:
10.1542/peds.2006-2986. [PMID: 17473094] - How Sung Lee, Yok Moi Khoo, Yazmin Chirino-Barcelo, Kim Leong Tan, Dorothy Ong. Caffeine in apnoeic Asian neonates: a sparse data analysis.
British journal of clinical pharmacology.
2002 Jul; 54(1):31-7. doi:
10.1046/j.1365-2125.2002.01589.x. [PMID: 12100222] - B A Gannon. Theophylline or caffeine: which is best for apnea of prematurity?.
Neonatal network : NN.
2000 Dec; 19(8):33-6. doi:
10.1891/0730-0832.19.8.33. [PMID: 11949272] - A Erenberg, R D Leff, D G Haack, K W Mosdell, G M Hicks, B A Wynne. Caffeine citrate for the treatment of apnea of prematurity: a double-blind, placebo-controlled study.
Pharmacotherapy.
2000 Jun; 20(6):644-52. doi:
10.1592/phco.20.7.644.35167. [PMID: 10853619] - A C Falcão, M M Fernández de Gatta, M F Delgado Iribarnegaray, D Santos Buelga, M J García, A Dominguez-Gil, J M Lanao. Population pharmacokinetics of caffeine in premature neonates.
European journal of clinical pharmacology.
1997; 52(3):211-7. doi:
10.1007/s002280050276. [PMID: 9218928] - M Amato, M Isenschmid, P Hüppi. Percutaneous caffeine application in the treatment of neonatal apnoea.
European journal of pediatrics.
1991 Jun; 150(8):592-4. doi:
10.1007/bf02072214. [PMID: 1954966] - M Yasuhara, G Levy. Caffeine as a potential risk factor for theophylline neurotoxicity.
Journal of pharmaceutical sciences.
1988 Sep; 77(9):745-7. doi:
10.1002/jps.2600770904. [PMID: 3225766] - O Carrier, G Pons, E Rey, M O Richard, C Moran, J Badoual, G Olive. Maturation of caffeine metabolic pathways in infancy.
Clinical pharmacology and therapeutics.
1988 Aug; 44(2):145-51. doi:
10.1038/clpt.1988.129. [PMID: 3396261] - H U Bucher, G Duc. Does caffeine prevent hypoxaemic episodes in premature infants? A randomized controlled trial.
European journal of pediatrics.
1988 Apr; 147(3):288-91. doi:
10.1007/bf00442697. [PMID: 3292249] - C Perrin, D Debruyne, J Lacotte, D Laloum, J B Bonte, M Moulin. Treatment of caffeine intoxication by exchange transfusion in a newborn.
Acta paediatrica Scandinavica.
1987 Jul; 76(4):679-81. doi:
10.1111/j.1651-2227.1987.tb10546.x. [PMID: 3630690] - H U Bucher, F Fallenstein, D Mieth, G Duc. [Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants].
Helvetica paediatrica acta.
1985 Jul; 40(2-3):153-62. doi:
NULL. [PMID: 3843246] - A D Rothberg, K H Marks, R M Ward, M J Maisels. The metabolic effects of caffeine in the newborn infant.
Pediatric pharmacology (New York, N.Y.).
1981; 1(3):181-6. doi:
NULL. [PMID: 6810291] - A K Chatterjee, U Kaveeshwar. Role of caffeine citrate on plasma transaminase & glucose levels of albino rats under high altitude stress conditions.
Indian journal of experimental biology.
1980 Jan; 18(1):99-100. doi:
NULL. [PMID: 7399591]
