Afloqualone (BioDeep_00000647893)
代谢物信息卡片
化学式: C16H14FN3O (283.1120846)
中文名称: 氟喹酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=CC=C1N2C(=NC3=C(C2=O)C=C(C=C3)N)CF
InChI: InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3
描述信息
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
D002491 - Central Nervous System Agents
D003879 - Dermatologic Agents
Afloqualone (HQ-495) is a GABAergic agent and has agonist activity at the β subtype of the?GABAα receptor. Afloqualone has antivertiginous effects thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site[1].
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:31177
- KEGGdrug: D95096
- KEGGdrug: D01638
- PubChem: 2040
- ChEMBL: CHEMBL2105918
- CAS: 56287-74-2
- medchemexpress: HY-B1833
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Hwi-Yeol Yun, Seo-Pan Lee, Hae Hum Jeong, Young-Ran Yoon, Soo Jung Sohn, Sang Kyum Kim, Wonku Kang, Kwang-Il Kwon. Determination of afloqualone in human plasma using liquid chromatography/tandem mass spectrometry: Application to pharmacokinetic studies in humans.
Talanta.
2007 Oct; 73(4):635-43. doi:
10.1016/j.talanta.2007.04.039. [PMID: 19073082] - Hidefumi Kaji, Toshiyuki Kume. Characterization of afloqualone N-glucuronidation: species differences and identification of human UDP-glucuronosyltransferase isoform(s).
Drug metabolism and disposition: the biological fate of chemicals.
2005 Jan; 33(1):60-7. doi:
10.1124/dmd.104.001925. [PMID: 15475412] - Y Tokura, M Ogai, H Yagi, M Takigawa. Afloqualone photosensitivity: immunogenicity of afloqualone-photomodified epidermal cells.
Photochemistry and photobiology.
1994 Sep; 60(3):262-7. doi:
10.1111/j.1751-1097.1994.tb05102.x. [PMID: 7972379] - K Hayakawa, I Matsuo. Afloqualone phototoxicity--photosensitized lipid peroxidative potency and its biological significance.
The Tokai journal of experimental and clinical medicine.
1989 Mar; 14(1):15-24. doi:
". [PMID: 2636465] - M Otsuka, S Furuuchi, S Usuki, S Nitta, S Harigaya. Metabolism of afloqualone, a new centrally acting muscle relaxant, in monkeys and dogs.
Journal of pharmacobio-dynamics.
1983 Oct; 6(10):708-20. doi:
10.1248/bpb1978.6.708. [PMID: 6663441] - S Furuuchi, M Otsuka, Y Miura, S Harigaya. Identification and measurement of urinary metabolites of afloqualone in man.
Drug metabolism and disposition: the biological fate of chemicals.
1983 Jul; 11(4):371-6. doi:
NULL. [PMID: 6137346]