Vardenafil dihydrochloride (BioDeep_00000647794)
代谢物信息卡片
Vardenafil dihydrochloride
化学式: C23H34Cl2N6O4S (560.1739184)
中文名称: 伐地那非
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl.Cl
InChI: 2*1H
描述信息
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058986 - Phosphodiesterase 5 Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor > C2127 - cGMP Phosphodiesterase Inhibitor
D000089162 - Genitourinary Agents > D064804 - Urological Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D02731
- PubChem: 135414253
- ChEMBL: CHEMBL2106480
- MeSH: Vardenafil Dihydrochloride
- CAS: 224789-15-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rakesh C Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai, Lei Xi. Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-a possible prevention strategy for COVID-19?.
Molecular and cellular biochemistry.
2023 Mar; 478(3):679-696. doi:
10.1007/s11010-022-04520-2. [PMID: 36036333] - Milos Krivokapic, Israpil Alisultanovich Omarov, Vladimir Zivkovic, Tamara Nikolic Turnic, Vladimir Jakovljevic. Changes in Left Ventricular Ejection Fraction and Oxidative Stress after Phosphodiesterase Type-5 Inhibitor Treatment in an Experimental Model of Retrograde Rat Perfusion.
Medicina (Kaunas, Lithuania).
2023 Feb; 59(3):. doi:
10.3390/medicina59030458. [PMID: 36984459] - Silvia Limoncella, Clara Lazzaretti, Elia Paradiso, Sara D'Alessandro, Federica Barbagallo, Salvatore Pacifico, Remo Guerrini, Simonetta Tagliavini, Tommaso Trenti, Daniele Santi, Manuela Simoni, Marco Sola, Giulia Di Rocco, Livio Casarini. Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line.
Molecular and cellular endocrinology.
2022 02; 542(?):111527. doi:
10.1016/j.mce.2021.111527. [PMID: 34875337] - Heba Samir Elama, Shereen M Shalan, Yasser El-Shabrawy, Manal I Eid, Abdallah M Zeid. Utilization of a micellar matrix for simultaneous spectrofluorimetric estimation of alfuzosin hydrochloride and vardenafil hydrochloride.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Feb; 266(?):120420. doi:
10.1016/j.saa.2021.120420. [PMID: 34619505] - Michael A Eldon, Edwin L Parsley, Mari Maurer, Thomas E Tarara, Jerry Okikawa, Jeffry G Weers. Safety, Tolerability, and Pharmacokinetics of RT234 (Vardenafil Inhalation Powder): A First-in-Human, Ascending Single- and Multiple-Dose Study in Healthy Subjects.
Journal of aerosol medicine and pulmonary drug delivery.
2021 08; 34(4):251-261. doi:
10.1089/jamp.2020.1651. [PMID: 33325799] - Barbara Dhooghe, Caroline Bouzin, Angélique Mottais, Emmanuel Hermans, Martial Delion, Nadtha Panin, Sabrina Noel, Teresinha Leal. Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells.
Biology open.
2020 08; 9(8):. doi:
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Zhonghua xin xue guan bing za zhi.
2020 Jun; 48(6):507-512. doi:
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Andrology.
2019 11; 7(6):804-817. doi:
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Journal of pediatric surgery.
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Annales pharmaceutiques francaises.
2019 Jan; 77(1):28-37. doi:
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Journal of separation science.
2019 Jan; 42(2):475-483. doi:
10.1002/jssc.201800734. [PMID: 30358113] - Mai Ahmed Tawfik, Mina Ibrahim Tadros, Magdy Ibrahim Mohamed. Lipomers (Lipid-polymer Hybrid Particles) of Vardenafil Hydrochloride: a Promising Dual Platform for Modifying the Drug Release Rate and Enhancing Its Oral Bioavailability.
AAPS PharmSciTech.
2018 Nov; 19(8):3650-3660. doi:
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Human & experimental toxicology.
2018 Mar; 37(3):256-264. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 47(2):523-534. doi:
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PloS one.
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Nitric oxide : biology and chemistry.
2017 Sep; 69(?):28-34. doi:
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Endocrine.
2017 May; 56(2):426-437. doi:
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Experimental biology and medicine (Maywood, N.J.).
2017 05; 242(10):1051-1061. doi:
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International journal of impotence research.
2017 Mar; 29(2):82-85. doi:
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Journal of biochemical and molecular toxicology.
2017 Mar; 31(3):. doi:
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Journal of chromatographic science.
2017 03; 55(3):232-242. doi:
10.1093/chromsci/bmw175. [PMID: 27881492] - O A El-Kawy, J A García-Horsman, R K Tuominen. Labelling, molecular modelling and biological evaluation of vardenafil: a potential agent for diagnostic evaluation of erectile dysfunction.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2016 Dec; 118(?):258-265. doi:
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European journal of endocrinology.
2016 Apr; 174(4):513-22. doi:
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Luminescence : the journal of biological and chemical luminescence.
2016 Feb; 31(1):173-8. doi:
10.1002/bio.2941. [PMID: 26019060] - Dan Henrohn, Anna Sandqvist, Hanna Egeröd, Mikael Hedeland, Lisa Wernroth, Ulf Bondesson, Gerhard Wikström. Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension.
Vascular pharmacology.
2015 Oct; 73(?):71-7. doi:
10.1016/j.vph.2015.04.010. [PMID: 25934511] - Renato Chavasco de Sousa, Antonio Augusto Moreira Neto, Vera Luíza Capelozzi, Alexandre Muxfeldt Ab'Saber, Olavo Ribeiro Rodrigues. Effects of vardenafil on the kidney of Wistar rats submitted to acute ischemia and reperfusion.
Acta cirurgica brasileira.
2015 May; 30(5):339-44. doi:
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Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2015 Apr; 90(3):167-78. doi:
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Drug design, development and therapy.
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World journal of urology.
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Molecular and cellular endocrinology.
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Profiles of drug substances, excipients, and related methodology.
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10.1016/b978-0-12-800173-8.00009-x. [PMID: 24794912] - Dhavalkumar Narendrabhai Patel, Lin Li, Chee-Leong Kee, Xiaowei Ge, Min-Yong Low, Hwee-Ling Koh. Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges.
Journal of pharmaceutical and biomedical analysis.
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The journal of sexual medicine.
2013 Dec; 10(12):3110-20. doi:
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2013 Oct; 115(?):482-9. doi:
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Cardiovascular research.
2013 Aug; 99(3):395-403. doi:
10.1093/cvr/cvt109. [PMID: 23650288] - Changqin Xiao, Minqiong Tang, Jian Li, Chen-ru Yin, Guangya Xiang, Li Xu. Determination of sildenafil, vardenafil and aildenafil in human plasma by dispersive liquid-liquid microextraction-back extraction based on ionic liquid and high performance liquid chromatography-ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Jul; 931(?):111-6. doi:
10.1016/j.jchromb.2013.05.013. [PMID: 23774245] - Asghar Ali, Andrew Binder, Asad Mohmand, Helen Stewart, Margaret Pipkin, Lisa Martin, Szabolcs Szentpetery, Gundars Katlaps, Ion S Jovin. The safety of preoperative vardenafil in patients undergoing coronary artery bypass graft surgery.
Journal of cardiovascular pharmacology.
2013 Jul; 62(1):106-9. doi:
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World journal of urology.
2013 Jun; 31(3):597-602. doi:
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Journal of pharmaceutical and biomedical analysis.
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European journal of clinical pharmacology.
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British journal of clinical pharmacology.
2012 Dec; 74(6):990-8. doi:
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Therapeutic drug monitoring.
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2012 Nov; 70(?):529-33. doi:
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Cancer science.
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The journal of sexual medicine.
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Neurobiology of learning and memory.
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Pharmacogenetics and genomics.
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The journal of sexual medicine.
2011 Apr; 8(4):1061-71. doi:
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The Kaohsiung journal of medical sciences.
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International journal of impotence research.
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BJU international.
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Zhonghua nan ke xue = National journal of andrology.
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The journal of sexual medicine.
2010 Sep; 7(9):3161-9. doi:
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Biomedical chromatography : BMC.
2010 Aug; 24(8):846-51. doi:
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Journal of pharmaceutical and biomedical analysis.
2010 Jul; 52(3):406-9. doi:
10.1016/j.jpba.2009.05.021. [PMID: 19540696] - Sabina Strano-Rossi, Luca Anzillotti, Xavier de la Torre, Francesco Botrè. A gas chromatography/mass spectrometry method for the determination of sildenafil, vardenafil and tadalafil and their metabolites in human urine.
Rapid communications in mass spectrometry : RCM.
2010 Jun; 24(11):1697-706. doi:
10.1002/rcm.4568. [PMID: 20486268] - Du Geon Moon, Min Gu Park, Sung Won Lee, Kwangsung Park, Jong Kwan Park, Sae Woong Kim, Nam Cheol Park, Tai Young Ahn, Jae Seung Paick, Ju Tae Seo, Dae Yul Yang, June Young Lee, Je Jong Kim. The efficacy and safety of testosterone undecanoate (Nebido(®)) in testosterone deficiency syndrome in Korean: a multicenter prospective study.
The journal of sexual medicine.
2010 Jun; 7(6):2253-2260. doi:
10.1111/j.1743-6109.2010.01765.x. [PMID: 20345732] - Martin M Miner, Allison Barnes, Stephen Janning. Efficacy of phosphodiesterase type 5 inhibitor treatment in men with erectile dysfunction and dyslipidemia: a post hoc analysis of the vardenafil statin study.
The journal of sexual medicine.
2010 May; 7(5):1937-47. doi:
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American family physician.
2010 Feb; 81(3):305-12. doi:
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Analytica chimica acta.
2010 Jan; 658(2):197-203. doi:
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Micron (Oxford, England : 1993).
2009 Dec; 40(8):845-50. doi:
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Journal of chromatography. A.
2009 Nov; 1216(47):8426-30. doi:
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European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2009 Oct; 36(4):657-64. doi:
10.1016/j.ejcts.2009.03.065. [PMID: 19523842] - David Montani, Marie-Camille Chaumais, Laurent Savale, Delphine Natali, Laura C Price, Xavier Jaïs, Marc Humbert, Gérald Simonneau, Olivier Sitbon. Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension.
Advances in therapy.
2009 Sep; 26(9):813-25. doi:
10.1007/s12325-009-0064-z. [PMID: 19768639] - Z-C Jing, X Jiang, B-X Wu, X-Q Xu, Y Wu, C-R Ma, Y Wang, Y-J Yang, J-L Pu, W Gao. Vardenafil treatment for patients with pulmonary arterial hypertension: a multicentre, open-label study.
Heart (British Cardiac Society).
2009 Sep; 95(18):1531-6. doi:
10.1136/hrt.2009.169417. [PMID: 19549620] - Giuseppe Carlucci, Paola Palumbo, Piera Iuliani, Giancarlo Palumbo. Development of a method for the determination of vardenafil in human plasma by high performance liquid chromatography with UV detection.
Biomedical chromatography : BMC.
2009 Jul; 23(7):759-63. doi:
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The Journal of thoracic and cardiovascular surgery.
2009 Jun; 137(6):1508-14. doi:
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Journal of pharmaceutical and biomedical analysis.
2009 Apr; 49(3):601-6. doi:
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Journal of neurochemistry.
2009 Feb; 108(3):755-66. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jan; 877(1-2):95-100. doi:
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Urologia internationalis.
2009; 83(3):316-22. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Dec; 876(2):283-7. doi:
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European journal of pharmacology.
2008 Dec; 600(1-3):98-104. doi:
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Urologiia (Moscow, Russia : 1999).
2008 Nov; ?(6):52-5. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Nov; 23(11):3427-36. doi:
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Zhonghua nan ke xue = National journal of andrology.
2008 Oct; 14(10):911-3. doi:
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The journal of sexual medicine.
2008 Jun; 5(6):1455-67. doi:
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European urology.
2008 Jun; 53(6):1236-44. doi:
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The Journal of clinical psychiatry.
2008 Feb; 69(2):206-12. doi:
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Hong Kong medical journal = Xianggang yi xue za zhi.
2007 Oct; 13(5):359-63. doi:
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In vivo (Athens, Greece).
2007 Sep; 21(5):851-4. doi:
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Journal of analytical toxicology.
2007 Jul; 31(6):328-33. doi:
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Urologiia (Moscow, Russia : 1999).
2007 Jul; ?(4):63-6, 69. doi:
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Journal of chromatography. A.
2007 Jun; 1154(1-2):222-9. doi:
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Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2007 Apr; 27(4):532-4. doi:
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Transplantation proceedings.
2006 Jun; 38(5):1379-81. doi:
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Zhonghua nan ke xue = National journal of andrology.
2006 May; 12(5):473-6. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2006 Feb; 29(2):123-8. doi:
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Alimentary pharmacology & therapeutics.
2006 Jan; 23(1):121-8. doi:
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Se pu = Chinese journal of chromatography.
2005 Jul; 23(4):358-61. doi:
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2005 Feb; 1066(1-2):89-95. doi:
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European journal of pharmacology.
2004 Oct; 502(3):163-7. doi:
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