Moricizine hydrochloride (BioDeep_00000647000)

   


代谢物信息卡片


Moricizine hydrochloride

化学式: C22H26ClN3O4S (463.1332)
中文名称: 盐酸莫雷西嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4.Cl
InChI: 1H

描述信息

D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

2 个代谢物同义名

Moricizine hydrochloride; MORACIZINE HYDROCHLORIDE



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • Hiroki Konishi, Kunihiko Morita, Tokuzo Minouchi, Akira Yamaji. Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A. Pharmacology. 2002 Dec; 66(4):190-8. doi: 10.1159/000065533. [PMID: 12393941]
  • H J Pieniaszek, A F Davidson, J E Chaney, L Shum, C A Robinson, M Mayersohn. Human moricizine metabolism. II. Quantification and pharmacokinetics of plasma and urinary metabolites. Xenobiotica; the fate of foreign compounds in biological systems. 1999 Sep; 29(9):945-55. doi: 10.1080/004982599238182. [PMID: 10548454]
  • L E Richards, H J Pieniaszek, S Shatzmiller, G O Page, K F Blom, J M Read, A F Davidson, P N Confalone. Human moricizine metabolism. I. Isolation and identification of metabolites in human urine. Xenobiotica; the fate of foreign compounds in biological systems. 1997 Feb; 27(2):217-29. doi: 10.1080/004982597240703. [PMID: 9058534]
  • L Shum, H J Pieniaszek, C A Robinson, A F Davidson, P J Widner, I H Benedek, W Flamenbaum. Pharmacokinetic interactions of moricizine and diltiazem in healthy volunteers. Journal of clinical pharmacology. 1996 Dec; 36(12):1161-8. doi: 10.1002/j.1552-4604.1996.tb04171.x. [PMID: 9013374]
  • B M Regmi, J P Liu, X D Tu. [Studies on ethmozine sustained-release tablet remaining-floating in stomach]. Yao xue xue bao = Acta pharmaceutica Sinica. 1996; 31(1):54-8. doi: NULL. [PMID: 8762461]
  • P J Rice, I O LeClair, W L Stone, A V Mehta. Pharmacokinetics of moricizine in young patients. Journal of clinical pharmacology. 1995 Oct; 35(10):1016-9. doi: 10.1002/j.1552-4604.1995.tb04019.x. [PMID: 8568009]
  • J M Yang, K Chan. Isolation and characterization of sulphoxidation metabolites of moricizine in rat and human biological fluids. Methods and findings in experimental and clinical pharmacology. 1995 Jul; 17(6):415-21. doi: NULL. [PMID: 8642903]
  • J M Yang, K Chan. Simultaneous determination of moricizine and its sulphoxidation metabolites in biological fluids by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1995 Jan; 663(1):172-6. doi: 10.1016/0378-4347(94)00413-y. [PMID: 7704207]
  • E G Giardina, M E Wechsler, M Dolgopiatova, R Sciacca. Moricizine concentration to guide arrhythmia treatment: with attention to elderly patients. Journal of clinical pharmacology. 1994 Jul; 34(7):725-33. doi: 10.1002/j.1552-4604.1994.tb02032.x. [PMID: 7523457]
  • H J Pieniaszek, A F Davidson, C M McEntegart, C Y Quon, R E Sampliner, M Mayersohn. The effect of hepatic disease on the disposition of moricizine in humans. Biopharmaceutics & drug disposition. 1994 Apr; 15(3):243-52. doi: 10.1002/bdd.2510150306. [PMID: 7880984]
  • M A Vos, T Fazekas, A P Gorgels, J D Leunissen, H J Wellens. Action of MgSO4 differs from moricizine and verapamil on ouabain-induced ventricular tachycardia in normomagnesemic conscious dogs. Journal of cardiovascular pharmacology. 1994 Feb; 23(2):252-8. doi: 10.1097/00005344-199402000-00012. [PMID: 7511755]
  • L Tan, Y B Xia, X D Tu, Y S Yuan. [Determination of ethmozine in human plasma by high performance liquid chromatography and its pharmacokinetics]. Yao xue xue bao = Acta pharmaceutica Sinica. 1994; 29(3):232-6. doi: NULL. [PMID: 8079651]
  • W Y Guo, J R Zhu, Z S Li, W D Jiang, J M Yang. [Pharmacokinetics of moracizine and moracizine sulfoxide in healthy volunteers]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1993 Sep; 14(5):433-6. doi: NULL. [PMID: 8010035]
  • H J Pieniaszek, A F Davidson, I H Benedek. Effect of moricizine on the pharmacokinetics of single-dose theophylline in healthy subjects. Therapeutic drug monitoring. 1993 Jun; 15(3):199-203. doi: 10.1097/00007691-199306000-00004. [PMID: 8332999]
  • T Fazekas, M A Vos, J D Leunissen, H J Wellens. Effects of magnesium and ethmozin on ventricular tachycardia induced by ouabain and ventricular pacing in conscious dogs with complete atrioventricular block. Acta physiologica Hungarica. 1993; 81(1):59-70. doi: . [PMID: 8178656]
  • I H Benedek, S Y King, R J Powell, A M Agra, W L Schary, H J Pieniaszek. Effect of moricizine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Journal of clinical pharmacology. 1992 Jun; 32(6):558-63. doi: 10.1177/009127009203200612. [PMID: 1634644]
  • V V Iakushkin, G N Baldenkov, V V Tertov, A N Orekhov. [Atherogenic properties of phenothiazine drugs manifesting in cultured cells of the human aortic intima]. Kardiologiia. 1992 Jun; 32(6):66-8. doi: . [PMID: 1405301]
  • H J Pieniaszek, C M McEntegart, M Mayersohn, U F Michael. Moricizine pharmacokinetics in renal insufficiency: reevaluation of elimination half-life. Journal of clinical pharmacology. 1992 May; 32(5):412-4. doi: 10.1002/j.1552-4604.1992.tb03855.x. [PMID: 1587958]
  • N V Kaverina, S F Sokolov. Pharmacology and clinical use of a new group of antiarrhythmic drugs: derivatives of tricyclic nitrogen-containing systems. Pharmacological research. 1992 Apr; 25(3):217-25. doi: 10.1016/s1043-6618(05)80070-2. [PMID: 1518765]
  • H J Pieniaszek, D C Rakestraw, W L Schary, R L Williams. Influence of food on the oral absorption and bioavailability of moricizine. Journal of clinical pharmacology. 1991 Sep; 31(9):792-5. doi: 10.1002/j.1552-4604.1991.tb01912.x. [PMID: 1804860]
  • M E Wechsler, J S Steinberg, E G Giardina. Time course of moricizine's effect on signal-averaged and 12 lead electrocardiograms: insights into mechanism of action. Journal of the American College of Cardiology. 1991 Jun; 17(7):1626-33. doi: 10.1016/0735-1097(91)90658-v. [PMID: 1709654]
  • I H Benedek, D M Garner, H J Pieniaszek. Dose proportionality of moricizine after escalating multiple doses in healthy volunteers. Journal of clinical pharmacology. 1991 Mar; 31(3):229-32. doi: 10.1002/j.1552-4604.1991.tb04966.x. [PMID: 2019664]
  • H J Mann. Moricizine: a new class I antiarrhythmic. Clinical pharmacy. 1990 Nov; 9(11):842-52. doi: . [PMID: 2272151]
  • C A Carnes, J D Coyle. Moricizine: a novel antiarrhythmic agent. DICP : the annals of pharmacotherapy. 1990 Jul; 24(7-8):745-53. doi: 10.1177/106002809002400719. [PMID: 2197817]
  • L A Siddoway, S L Schwartz, J T Barbey, R L Woosley. Clinical pharmacokinetics of moricizine. The American journal of cardiology. 1990 Feb; 65(8):21D-25D; discussion 68D. doi: 10.1016/0002-9149(90)91413-z. [PMID: 2407090]
  • A P Kurapov, O V Nekrasova, E T Gneushev, A P Ryzhenkova, V G Kukes. [Ethmozine pharmacokinetics in liver insufficiency]. Sovetskaia meditsina. 1990; ?(5):34-6. doi: NULL. [PMID: 2202059]
  • J M Yang, K Chan, W T Chiang. Distribution of moricizine in human blood: binding to plasma proteins and erythrocytes. Therapeutic drug monitoring. 1990 Jan; 12(1):59-64. doi: 10.1097/00007691-199001000-00011. [PMID: 1689514]
  • H L Kennedy, M K Sprague, S M Homan, S M Seiler, R D Wiens, D L Janosik, R M Redd, T A Buckingham. Natural history of potentially lethal ventricular arrhythmias in patients treated with long-term antiarrhythmic drug therapy. The American journal of cardiology. 1989 Dec; 64(19):1289-97. doi: 10.1016/0002-9149(89)90570-5. [PMID: 2686388]
  • K Chan, J M Yang, M K Wai, W D Jiang. Disposition of ethmozine in cerebrospinal fluid and plasma of rabbits. European journal of drug metabolism and pharmacokinetics. 1989 Oct; 14(4):279-82. doi: 10.1007/bf03190111. [PMID: 2699288]
  • H J Pieniaszek, H S Shen, D M Garner, G O Page, L M Shalaby, R K Isensee, C C Whitney. Determination of unlabeled and 13C6-labeled moricizine in human plasma using thermospray liquid chromatography-mass spectrometry. Journal of chromatography. 1989 Aug; 493(1):79-92. doi: 10.1016/s0378-4347(00)82711-5. [PMID: 2674179]
  • J M Yang, K Chan, W D Jiang. Improved column liquid chromatographic method for the determination of moricizine in plasma or serum. Journal of chromatography. 1989 May; 490(2):458-63. doi: 10.1016/s0378-4347(00)82806-6. [PMID: 2670987]
  • I N Merkulova, V K Piotrovskiĭ, V I Metelitsa, I N Romina, M L Blank. [Effectiveness of intravenous infusion of ethmozin in patients with chronic ventricular arrhythmias]. Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR. 1989; 12(1):25-31. doi: NULL. [PMID: 2472818]
  • D R Vincent, P J Gillies, K P Lee, C K Wood, L E Arthaud. Alterations in lipid metabolism and cellular morphology in the liver of female rats treated with ethmozine. Toxicology and applied pharmacology. 1988 Sep; 95(3):456-63. doi: 10.1016/0041-008x(88)90363-8. [PMID: 3055426]
  • H L Kennedy, A J Wood, R T MacFarland. Drug interactions with Ethmozine (moricizine HCl). The American journal of cardiology. 1987 Oct; 60(11):79F-82F. doi: 10.1016/0002-9149(87)90726-0. [PMID: 3310590]
  • R L Woosley, J Morganroth, R N Fogoros, F G McMahon, J O Humphries, D T Mason, R L Williams. Pharmacokinetics of moricizine HCl. The American journal of cardiology. 1987 Oct; 60(11):35F-39F. doi: 10.1016/0002-9149(87)90718-1. [PMID: 3310583]
  • D M Salerno, P J Sharkey, G A Granrud, R W Asinger, M Hodges. Efficacy, safety, hemodynamic effects, and pharmacokinetics of high-dose moricizine during short- and long-term therapy. Clinical pharmacology and therapeutics. 1987 Aug; 42(2):201-9. doi: 10.1038/clpt.1987.133. [PMID: 3301153]
  • E M Antman, M Arnold, P L Friedman, H White, M Bosak, T W Smith. Drug interactions with cardiac glycosides: evaluation of a possible digoxin-ethmozine pharmacokinetic interaction. Journal of cardiovascular pharmacology. 1987 May; 9(5):622-7. doi: 10.1097/00005344-198705000-00017. [PMID: 2439845]
  • D L Howrie, H J Pieniaszek, R N Fogoros, R P Juhl, W L Schary, C C Whitney, L W Dittert. Disposition of moracizine (ethmozine) in healthy subjects after oral administration of radiolabelled drug. European journal of clinical pharmacology. 1987; 32(6):607-10. doi: 10.1007/bf02455996. [PMID: 3308487]
  • L V Rosenshtraukh, K K Shugushev, A S Smetnev. Ethacizin: a new efficacious Soviet antiarrhythmic drug of the phenothiazine group. American heart journal. 1986 Nov; 112(5):932-9. doi: 10.1016/0002-8703(86)90303-0. [PMID: 3535466]
  • A P Rodionov, S Iu Berdiaev, N V Shestakova, N V Darinskiĭ, N V Kaverina. [Correlation between the anti-arrhythmia effect of ethacizin and pharmacokinetic parameters in a model of rhythm adoption by the heart]. Kardiologiia. 1986 Apr; 26(4):45-8. doi: NULL. [PMID: 3712951]
  • H L Kennedy, M K Sprague, R M Redd, R D Wiens, R I Blum, T A Buckingham. Serum digoxin concentrations during ethmozine antiarrhythmic therapy. American heart journal. 1986 Apr; 111(4):667-72. doi: 10.1016/0002-8703(86)90096-7. [PMID: 2420164]
  • J Morganroth. Safety and efficacy of a twice-daily dosing regimen for moricizine (ethmozine). American heart journal. 1985 Dec; 110(6):1188-92. doi: 10.1016/0002-8703(85)90010-9. [PMID: 3907314]
  • V K Piotrovskiĭ, N N Veĭko, D O Rumiantsev, Iu A Zhirkov, A R El'man. [Use of ion-exchange sorbents for determining drug preparations and their metabolites in biological fluids by high-performance liquid chromatography]. Farmakologiia i toksikologiia. 1985 Nov; 48(6):62-7. doi: . [PMID: 3910451]
  • J Biollaz, O Shaheen, A J Wood. Cimetidine inhibition of ethmozine metabolism. Clinical pharmacology and therapeutics. 1985 Jun; 37(6):665-8. doi: 10.1038/clpt.1985.108. [PMID: 3891190]
  • Kh Kh Shugushev, E T Gneushev, A S Smetnev, V G Kukes, L V Rozenshtraukh. [Comparison of the results of ethacizin pharmacodynamics and pharmacokinetics in a single intravenous administration]. Kardiologiia. 1985 Apr; 25(4):32-5. doi: NULL. [PMID: 2410654]
  • L V Rozenshtraukh, Kh Kh Shugushev, A S Smetnev, N M Mukharliamov, E L Ponomarenko. [Initial results of clinical research on a tabletted form of ethacizin (the diethylamino analog of ethmozine) in ventricular arrhythmias]. Kardiologiia. 1985 Mar; 25(3):43-50. doi: . [PMID: 2582177]
  • R T MacFarland, V R Moeller, H J Pieniaszek, C C Whitney, F I Marcus. Assessment of the potential pharmacokinetic interaction between digoxin and ethmozine. Journal of clinical pharmacology. 1985 Mar; 25(2):138-43. doi: 10.1002/j.1552-4604.1985.tb02814.x. [PMID: 3886709]
  • J M Poirier. Sensitive high performance liquid chromatographic analysis of ethmozin in plasma. Therapeutic drug monitoring. 1985; 7(4):439-41. doi: 10.1097/00007691-198512000-00013. [PMID: 3909535]
  • G P Sanna. New drugs in the management of ventricular arrhythmias. Giornale italiano di cardiologia. 1984 Oct; 14(10):788-97. doi: . [PMID: 6083894]
  • G P Ul'ianov. [Effect of ethmozine on kidney function]. Biulleten' eksperimental'noi biologii i meditsiny. 1984 Jul; 98(7):51-3. doi: NULL. [PMID: 6380616]
  • C M Pratt, J B Young, M J Francis, A A Taylor, H J Norton, L English, D E Mann, H Kopelen, M A Quinones, R Roberts. Comparative effect of disopyramide and ethmozine in suppressing complex ventricular arrhythmias by use of a double-blind, placebo-controlled, longitudinal crossover design. Circulation. 1984 Feb; 69(2):288-97. doi: 10.1161/01.cir.69.2.288. [PMID: 6360413]
  • A V Mazurov, V L Leĭtin, V S Repin, L V Rozenshtraukh, V N Smirnov. [Inhibiting action of anti-arrhythmia agents of the phenothiazine series--etmozin and its diethylamino analog--on platelet aggregation and metabolism of endogenous arachidonic acid]. Biulleten' eksperimental'noi biologii i meditsiny. 1984 Jan; 97(1):63-5. doi: . [PMID: 6419795]
  • R D Kurbanov, N A Mazur. [Results of prolonged ethmozine treatment in patients with ventricular arrhythmias]. Kardiologiia. 1983 Nov; 23(11):51-5. doi: NULL. [PMID: 6197557]
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  • V K Piotrovskiĭ, I N Merkulova, N N Romina, V I Metelitsa. [Ethmozin pharmacokinetics after a single intravenous administration]. Kardiologiia. 1982 May; 22(5):75-80. doi: NULL. [PMID: 7047858]
  • B I Tolstopiatov. [Study of the interrelations of ethmozine, cordarone and phenycaberan with heparin]. Farmakologiia i toksikologiia. 1981 Sep; 44(5):586-9. doi: . [PMID: 7030776]
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