Diacylglycerol kinase inhibitor II (BioDeep_00000646758)
代谢物信息卡片
化学式: C28H25F2N3OS (489.1686304)
中文名称: DAG激酶抑制剂II
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCC1=C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)CCN4C(=O)C5=CC=CC=C5NC4=S
InChI: InChI=1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mi Ra Noh, Hee-Seong Jang, Dae-Kyu Song, Seong-Ryong Lee, Joshua H Lipschutz, Kwon Moo Park, Jee In Kim. Downregulation of exocyst Sec10 accelerates kidney tubule cell recovery through enhanced cell migration.
Biochemical and biophysical research communications.
2018 02; 496(2):309-315. doi:
10.1016/j.bbrc.2018.01.013. [PMID: 29326040] - Tetsuya Nakamura, Jun Kamishikiryo, Tetsuo Morita. Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II.
Pharmacological reports : PR.
2016 Jun; 68(3):649-53. doi:
10.1016/j.pharep.2016.02.001. [PMID: 27031052] - Pedro Torres-Ayuso, Manuel Daza-Martín, Jorge Martín-Pérez, Antonia Ávila-Flores, Isabel Mérida. Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.
Oncotarget.
2014 Oct; 5(20):9710-26. doi:
10.18632/oncotarget.2344. [PMID: 25339152] - Julie Massart, Juleen R Zierath, Alexander V Chibalin. A simple and rapid method to characterize lipid fate in skeletal muscle.
BMC research notes.
2014 Jun; 7(?):391. doi:
10.1186/1756-0500-7-391. [PMID: 24962347] - Yukiko Kurohane Kaneko, Yosuke Kobayashi, Keisuke Motoki, Kunihito Nakata, Shoko Miyagawa, Mao Yamamoto, Daiki Hayashi, Yasuhito Shirai, Fumio Sakane, Tomohisa Ishikawa. Depression of type I diacylglycerol kinases in pancreatic β-cells from male mice results in impaired insulin secretion.
Endocrinology.
2013 Nov; 154(11):4089-98. doi:
10.1210/en.2013-1356. [PMID: 24035999] - Mikio Marumo, Tomoyuki Nakano, Yuji Takeda, Kaoru Goto, Ichiro Wakabayashi. Inhibition of thrombin-induced Ca²⁺ influx in platelets by R59949, an inhibitor of diacylglycerol kinase.
The Journal of pharmacy and pharmacology.
2012 Jun; 64(6):855-61. doi:
10.1111/j.2042-7158.2012.01485.x. [PMID: 22571264] - Shuqiang Zhang, Xia Chen, Yumin Yang, Xinyang Zhou, Jie Liu, Fei Ding. Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by salidroside.
Molecular and cellular biochemistry.
2011 Aug; 354(1-2):161-70. doi:
10.1007/s11010-011-0815-4. [PMID: 21499890] - J Aragonés, D R Jones, S Martin, M A San Juan, A Alfranca, F Vidal, A Vara, I Mérida, M O Landázuri. Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.
The Journal of biological chemistry.
2001 Mar; 276(13):10548-55. doi:
10.1074/jbc.m006180200. [PMID: 11136721] - A Palicz, T R Foubert, A J Jesaitis, L Marodi, L C McPhail. Phosphatidic acid and diacylglycerol directly activate NADPH oxidase by interacting with enzyme components.
The Journal of biological chemistry.
2001 Feb; 276(5):3090-7. doi:
10.1074/jbc.m007759200. [PMID: 11060300] - I Flores, D R Jones, A Ciprés, E Díaz-Flores, M A Sanjuan, I Mérida. Diacylglycerol kinase inhibition prevents IL-2-induced G1 to S transition through a phosphatidylinositol-3 kinase-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950).
1999 Jul; 163(2):708-14. doi:
NULL. [PMID: 10395661]