Proadifen hydrochloride (BioDeep_00000646756)
代谢物信息卡片
Proadifen hydrochloride
化学式: C23H32ClNO2 (389.2121)
中文名称: 普罗地芬 盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(CC)CC.Cl
InChI: 1H
描述信息
C471 - Enzyme Inhibitor > C29574 - Nitric Oxide Synthase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Weicang Wang, Jun Yang, Matthew L Edin, Yuxin Wang, Ying Luo, Debin Wan, Haixia Yang, Chun-Qing Song, Wen Xue, Katherine Z Sanidad, Mingyue Song, Heather A Bisbee, Jennifer A Bradbury, Guanjun Nan, Jianan Zhang, Pei-An Betty Shih, Kin Sing Stephen Lee, Lisa M Minter, Daeyoung Kim, Hang Xiao, Jun-Yan Liu, Bruce D Hammock, Darryl C Zeldin, Guodong Zhang. Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis.
Cancer research.
2019 04; 79(8):1822-1830. doi:
10.1158/0008-5472.can-18-3221. [PMID: 30803995] - Wan-Ling Chang-Liao, Chao-Feng Chien, Lie-Chwen Lin, Tung-Hu Tsai. Isolation of gentiopicroside from Gentianae Radix and its pharmacokinetics on liver ischemia/reperfusion rats.
Journal of ethnopharmacology.
2012 Jun; 141(2):668-73. doi:
10.1016/j.jep.2011.08.001. [PMID: 21855624] - María Eugenia Letelier, Miguel López-Valladares, Liliana Peredo-Silva, Daniel Rojas-Sepúlveda, Paula Aracena. Microsomal oxidative damage promoted by acetaminophen metabolism.
Toxicology in vitro : an international journal published in association with BIBRA.
2011 Oct; 25(7):1310-3. doi:
10.1016/j.tiv.2011.04.022. [PMID: 21569833] - Hang Ruan, Zhen Zhang, Xin-fang Liang, Yan Fu, Mei-qin Su, Qi-lin Liu, Xiu-min Wang, Xuan Zhu. Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry.
Archives of pharmacal research.
2011 Aug; 34(8):1311-21. doi:
10.1007/s12272-011-0811-y. [PMID: 21910053] - Yasuhiro Ishihara, Satomi Ishii, Yufu Sakai, Nobue Yamamura, Yukiko Onishi, Norio Shimamoto. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats.
Journal of applied toxicology : JAT.
2011 Mar; 31(2):173-8. doi:
10.1002/jat.1578. [PMID: 20803752] - Saloua Benmansour, Thierry Deltheil, Jonathan Piotrowski, Lorelei Nicolas, Christelle Reperant, Alain M Gardier, Alan Frazer, Denis J David. Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents.
European journal of pharmacology.
2008 Jun; 587(1-3):90-8. doi:
10.1016/j.ejphar.2008.03.048. [PMID: 18474368] - Young H Choi, Soo K Bae, Jung M Oh, Sun-Ok Kim, Myung G Lee. Pharmacokinetics of intravenous methotrexate in mutant Nagase analbuminemic rats.
Biopharmaceutics & drug disposition.
2007 Oct; 28(7):385-92. doi:
10.1002/bdd.565. [PMID: 17657787] - Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara, Masao Hattori. In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Oct; 35(10):1832-9. doi:
10.1124/dmd.107.016311. [PMID: 17639025] - Lawrence H Lash, David A Putt, Paul Huang, Sarah E Hueni, Jean C Parker. Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.
Toxicology.
2007 Jun; 235(1-2):11-26. doi:
10.1016/j.tox.2007.03.001. [PMID: 17433522] - Young H Choi, Soo K Bae, Sun O Kim, Myung G Lee. Pharmacokinetics of 5-fluorouracil in mutant Nagase analbuminemic rats: faster metabolism of 5-fluorouracil via CYP1A.
Biopharmaceutics & drug disposition.
2007 Mar; 28(2):87-95. doi:
10.1002/bdd.534. [PMID: 17230597] - Mayumi Ishizuka, Fumie Okajima, Tsutomu Tanikawa, Heewon Min, Kazuyuki D Tanaka, Kentaro Q Sakamoto, Shoichi Fujita. Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Jan; 35(1):62-6. doi:
10.1124/dmd.106.011775. [PMID: 17012541] - Diana Nieves, Juan José Moreno. Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth.
Journal of lipid research.
2006 Dec; 47(12):2681-9. doi:
10.1194/jlr.m600212-jlr200. [PMID: 16980726] - Katsuo Kamata, Masao Hosokawa, Takayuki Matsumoto, Tsuneo Kobayashi. Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2006 Oct; 42(5):171-87. doi:
10.1540/jsmr.42.171. [PMID: 17159333] - Yasuhiro Ishihara, Dai Shiba, Norio Shimamoto. Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition.
Toxicology and applied pharmacology.
2006 Jul; 214(2):109-17. doi:
10.1016/j.taap.2005.12.003. [PMID: 16430935] - Wei Zhou, Tong Lu, Arthur A Spector, Hon-Chi Lee. Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells.
Prostaglandins & other lipid mediators.
2006 Jul; 80(1-2):28-34. doi:
10.1016/j.prostaglandins.2006.03.005. [PMID: 16846784] - N Somchit, C W Wong, A Zuraini, A Ahmad Bustamam, A H Hasiah, H M Khairi, M R Sulaiman, D A Israf. Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats.
Drug and chemical toxicology.
2006; 29(3):237-53. doi:
10.1080/01480540600651535. [PMID: 16777703] - Chikakazu Iwata, Noriko Akimoto, Takashi Sato, Yuki Morokuma, Akira Ito. Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production.
The Journal of investigative dermatology.
2005 Nov; 125(5):865-72. doi:
10.1111/j.0022-202x.2005.23866.x. [PMID: 16297182] - Hui-Di Jiang, Jun Cai, Juan-Hua Xu, Xin-Mei Zhou, Qiang Xia. Endothelium-dependent and direct relaxation induced by ethyl acetate extract from Flos Chrysanthemi in rat thoracic aorta.
Journal of ethnopharmacology.
2005 Oct; 101(1-3):221-6. doi:
10.1016/j.jep.2005.04.018. [PMID: 15950416] - Soo K Bae, Eun J Kim, Jong W Kwon, Won B Kim, Inchul Lee, Myung G Lee. Excretion and metabolism of DA-7867, a new oxazolidinone, in rats.
Biopharmaceutics & drug disposition.
2005 Mar; 26(2):67-75. doi:
10.1002/bdd.434. [PMID: 15617136] - Pi-Lo Tsai, Tung-Hu Tsai. Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study.
Planta medica.
2004 Nov; 70(11):1069-74. doi:
10.1055/s-2004-832649. [PMID: 15549664] - Alan H Tseng, Joseph W Harding, Rebecca M Craft. Pharmacokinetic factors in sex differences in Delta 9-tetrahydrocannabinol-induced behavioral effects in rats.
Behavioural brain research.
2004 Sep; 154(1):77-83. doi:
10.1016/j.bbr.2004.01.029. [PMID: 15302113] - Hiroko Moroe, Hiroyuki Fujii, Hideo Honda, Katsunori Arai, Masao Kanazawa, Yoko Notoya, Hiroshi Kogo. Characterization of endothelium-dependent relaxation and modulation by treatment with pioglitazone in the hypercholesterolemic rabbit renal artery.
European journal of pharmacology.
2004 Aug; 497(3):317-25. doi:
10.1016/j.ejphar.2004.06.062. [PMID: 15336950] - M Sanchez-Gonzalez, J P N Rosazza. Microbial transformations of chalcones: hydroxylation, O-demethylation, and cyclization to flavanones.
Journal of natural products.
2004 Apr; 67(4):553-8. doi:
10.1021/np030448o. [PMID: 15104483] - H Z Rofael, R M Turkall, M S Abdel-Rahman. Effect of ketamine on cocaine-induced immunotoxicity in rats.
International journal of toxicology.
2003 Sep; 22(5):343-58. doi:
10.1177/109158180302200503. [PMID: 14555406] - Vincent Tong, Thomas K H Chang, Jie Chen, Frank S Abbott. The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Free radical biology & medicine.
2003 Jun; 34(11):1435-46. doi:
10.1016/s0891-5849(03)00151-5. [PMID: 12757854] - Marina Sergeeva, Mikhail Strokin, Hong Wang, Joachim J Ubl, Georg Reiser. Arachidonic acid in astrocytes blocks Ca(2+) oscillations by inhibiting store-operated Ca(2+) entry, and causes delayed Ca(2+) influx.
Cell calcium.
2003 Apr; 33(4):283-92. doi:
10.1016/s0143-4160(03)00011-3. [PMID: 12618149] - R A Towner, R P Mason, L A Reinke. In vivo detection of aflatoxin-induced lipid free radicals in rat bile.
Biochimica et biophysica acta.
2002 Oct; 1573(1):55-62. doi:
10.1016/s0304-4165(02)00326-4. [PMID: 12383942] - Ramez Labib, Rita Turkall, Mohamed S Abdel-Rahman. Inhibition of cocaine oxidative metabolism attenuates endotoxin potentiation of cocaine mediated hepatotoxicity.
Toxicology.
2002 Sep; 179(1-2):9-19. doi:
10.1016/s0300-483x(02)00247-0. [PMID: 12204538] - Yukari Totsuka, Hiroyuki Kataoka, Takeji Takamura-Enya, Takashi Sugimura, Keiji Wakabayashi. In vitro and in vivo formation of aminophenylnorharman from norharman and aniline.
Mutation research.
2002 Sep; 506-507(?):49-54. doi:
10.1016/s0027-5107(02)00151-3. [PMID: 12351144] - Hirokazu Doi, Hiromi Iwasaki, Yasuhiro Masubuchi, Ryuichiro Nishigaki, Toshiharu Horie. Chemiluminescence associated with the oxidative metabolism of salicylic acid in rat liver microsomes.
Chemico-biological interactions.
2002 May; 140(2):109-19. doi:
10.1016/s0009-2797(02)00004-2. [PMID: 12076519] - Jianxin Sun, XinXin Sui, J Alyce Bradbury, Darryl C Zeldin, Michael S Conte, James K Liao. Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.
Circulation research.
2002 May; 90(9):1020-7. doi:
10.1161/01.res.0000017727.35930.33. [PMID: 12016269] - K Yamamoto, Y Masubuchi, S Narimatsu, S Kobayashi, T Horie. Toxicity of ethacrynic acid in isolated rat hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA.
2002 Apr; 16(2):151-8. doi:
10.1016/s0887-2333(01)00107-2. [PMID: 11869877] - A I Archakov, I I Karuzina, N A Petushkova, A V Lisitsa, V G Zgoda. Production of carbon monoxide by cytochrome P450 during iron-dependent lipid peroxidation.
Toxicology in vitro : an international journal published in association with BIBRA.
2002 Feb; 16(1):1-10. doi:
10.1016/s0887-2333(01)00094-7. [PMID: 11812634] - B S Cummings, J C Parker, L H Lash. Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney.
Toxicological sciences : an official journal of the Society of Toxicology.
2001 Mar; 60(1):11-9. doi:
10.1093/toxsci/60.1.11. [PMID: 11222868] - B Szende, G Bökönyi, J Bocsi, G Kéri, F Timár, K Magyar. Anti-apoptotic and apoptotic action of (-)-deprenyl and its metabolites.
Journal of neural transmission (Vienna, Austria : 1996).
2001; 108(1):25-33. doi:
10.1007/s007020170094. [PMID: 11261744] - M C Martínez, J M Freyssinet. Deciphering the plasma membrane hallmarks of apoptotic cells: phosphatidylserine transverse redistribution and calcium entry.
BMC cell biology.
2001; 2(?):20. doi:
10.1186/1471-2121-2-20. [PMID: 11701087] - Z I Krutetskaia, O E Lebedev, N I Krutetskaia, L S Kurilova. [Effect of arachidonic and other fatty acids on the intracellular calcium concentration and calcium signaling in peritoneal macrophages].
Tsitologiia.
2001; 43(11):1051-60. doi:
NULL. [PMID: 11840781] - S Ohhira, H Matsui, K Watanabe. Effects of pretreatment with SKF-525A on triphenyltin metabolism and toxicity in mice.
Toxicology letters.
2000 Nov; 117(3):145-50. doi:
10.1016/s0378-4274(00)00255-1. [PMID: 11087980] - W G Chung, C S Park, H K Roh, W K Lee, Y N Cha. Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450.
Japanese journal of pharmacology.
2000 Oct; 84(2):213-20. doi:
10.1254/jjp.84.213. [PMID: 11128045] - M A Tirmenstein, F A Nicholls-Grzemski, J G Zhang, M W Fariss. Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions.
Chemico-biological interactions.
2000 Jul; 127(3):201-17. doi:
10.1016/s0009-2797(00)00180-0. [PMID: 10967318] - E Hurh, E Lee, A Lee, Y Kim, S Kim, S Kim, M Lee. Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats.
Biopharmaceutics & drug disposition.
2000 Jul; 21(5):193-204. doi:
10.1002/1099-081x(200007)21:5<193::aid-bdd229>3.0.co;2-6. [PMID: 11180198] - S Bu, Y Kim, S Kim, M Lee. Effects of enzyme inducers and inhibitor on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats.
Biopharmaceutics & drug disposition.
2000 May; 21(4):157-64. doi:
10.1002/1099-081x(200005)21:4<157::aid-bdd226>3.0.co;2-c. [PMID: 11180194] - A M Bermejo, R Seara, A C dos Santos Lucas, M J Tabernero, P Fernández, R Marsili. Use of solid-phase microextraction (SPME) for the determination of methadone and its main metabolite, EDDP, in plasma by gas chromatography-mass spectrometry.
Journal of analytical toxicology.
2000 Jan; 24(1):66-9. doi:
10.1093/jat/24.1.66. [PMID: 10654572] - J Iley, E Mendes, R Moreira, S Souza. Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
1999 Dec; 9(2):201-5. doi:
10.1016/s0928-0987(99)00057-3. [PMID: 10620732] - M Strolin-Benedetti, G Brogin, M Bani, F Oesch, J G Hengstler. Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate.
Xenobiotica; the fate of foreign compounds in biological systems.
1999 Nov; 29(11):1171-80. doi:
10.1080/004982599238038. [PMID: 10598750] - A M Mostafa, A B Abdel-Naim, O Abo-Salem, A H Abdel-Aziz, F M Hamada. Renal metabolism of acrylonitrile to cyanide: in vitro studies.
Pharmacological research.
1999 Aug; 40(2):195-200. doi:
10.1006/phrs.1999.0502. [PMID: 10433881] - R J Prince, S M Sine. Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models.
The Journal of biological chemistry.
1999 Jul; 274(28):19623-9. doi:
10.1074/jbc.274.28.19623. [PMID: 10391899] - H J Lee, M G Lee. Effects of dexamethasone on the pharmacokinetics of adriamycin after intravenous administration to rats.
Research communications in molecular pathology and pharmacology.
1999; 105(1-2):87-96. doi:
. [PMID: 10850372] - K Furuno, T Suetsugu, K Shimomichi, Y Tsuruta, N Sugihara. Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes.
Pharmacology & toxicology.
1998 Oct; 83(4):176-82. doi:
10.1111/j.1600-0773.1998.tb01465.x. [PMID: 9820879] - B Can-Eke, M O Puskullu, E Buyukbingol, M Iscan. A study on the antioxidant capacities of some benzimidazoles in rat tissues.
Chemico-biological interactions.
1998 May; 113(1):65-77. doi:
10.1016/s0009-2797(98)00020-9. [PMID: 9630848] - Y J Choi, H J Lee, J W Kwon, W B Kim, J Yang, M G Lee. Pharmacokinetic changes of M1, M2, M3 and M4 after intravenous administration of a new anthracycline, DA-125, to rats pretreated with phenobarbital, 3-methylcholanthrene, chloramphenicol, or SKF-525A.
Biopharmaceutics & drug disposition.
1998 Mar; 19(2):79-89. doi:
10.1002/(sici)1099-081x(199803)19:2<79::aid-bdd79>3.0.co;2-o. [PMID: 9533107] - M N Graber, A Alfonso, D L Gill. Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid.
The Journal of biological chemistry.
1997 Nov; 272(47):29546-53. doi:
10.1074/jbc.272.47.29546. [PMID: 9368016] - R A Kramp, N Caron, J Genard, C Lejeune, E Gulbis, A Herman. Differential effects of sulindac on renal hemodynamics and function in the rat.
European journal of pharmacology.
1997 Jul; 330(2-3):165-76. doi:
10.1016/s0014-2999(97)00178-7. [PMID: 9253950] - S Pennanen, A Kojo, M Pasanen, J Liesivuori, R O Juvonen, H Komulainen. CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver.
Human & experimental toxicology.
1996 May; 15(5):435-42. doi:
10.1177/096032719601500512. [PMID: 8735469] - B I Ghanayem, L T Burka. Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Apr; 24(4):390-4. doi:
NULL. [PMID: 8801052] - L H Lash, J J Tokarz. Oxidative stress and cytotoxicity of 4-(2-thienyl)butyric acid in isolated rat renal proximal tubular and distal tubular cells.
Toxicology.
1995 Dec; 103(3):167-75. doi:
10.1016/s0300-483x(95)03137-5. [PMID: 8553360] - M I Colado, J L Williams, A R Green. The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
British journal of pharmacology.
1995 Aug; 115(7):1281-9. doi:
10.1111/j.1476-5381.1995.tb15037.x. [PMID: 7582557] - S Ueno, N Susa, Y Furukawa, M Sugiyama. Role of cytochrome P450 in hepatotoxicity induced by di- and tributyltin compounds in mice.
Archives of toxicology.
1995; 69(9):655-8. doi:
10.1007/s002040050228. [PMID: 8660145] - M Martínez, M Mourelle, P Muriel. Protective effect of colchicine on acute liver damage induced by CCl4. Role of cytochrome P-450.
Journal of applied toxicology : JAT.
1995 Jan; 15(1):49-52. doi:
10.1002/jat.2550150111. [PMID: 7745225] - H Yokoyama, T Horie, S Awazu. Lipid peroxidation and chemiluminescence during naproxen metabolism in rat liver microsomes.
Human & experimental toxicology.
1994 Dec; 13(12):831-8. doi:
10.1177/096032719401301203. [PMID: 7718302] - F Serino, J Grevel, K L Napoli, B D Kahan, H W Strobel. Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
Transplantation proceedings.
1994 Oct; 26(5):2916-7. doi:
". [PMID: 7940922] - A R Goeptar, E J Groot, H Scheerens, J N Commandeur, N P Vermeulen. Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450.
Cancer research.
1994 May; 54(9):2411-8. doi:
". [PMID: 8162589] - L T Burka, I M Sanchez, A E Ahmed, B I Ghanayem. Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats.
Archives of toxicology.
1994; 68(10):611-8. doi:
10.1007/bf03208340. [PMID: 7857200] - G Fantuzzi, L Cantoni, M Sironi, P Ghezzi. Inhibitors of cytochrome P450 suppress tumor necrosis factor production.
Cellular immunology.
1993 Sep; 150(2):417-24. doi:
10.1006/cimm.1993.1209. [PMID: 8370080] - F Serino, J Grevel, K L Napoli, B D Kahan, H W Strobel. Generation of oxygen free radicals during the metabolism of cyclosporine A: a cause-effect relationship with metabolism inhibition.
Molecular and cellular biochemistry.
1993 May; 122(2):101-12. doi:
10.1007/bf01076094. [PMID: 8232241] - S M Bagnasco, M H Montrose, J S Handler. Role of calcium in organic osmolyte efflux when MDCK cells are shifted from hypertonic to isotonic medium.
The American journal of physiology.
1993 May; 264(5 Pt 1):C1165-70. doi:
10.1152/ajpcell.1993.264.5.c1165. [PMID: 8498477] - E D Hall, P K Andrus, J S Althaus, P F VonVoigtlander. Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain.
Journal of neuroscience research.
1993 Jan; 34(1):107-12. doi:
10.1002/jnr.490340111. [PMID: 8380874] - H Yamada, H Kaneko, K Takeuchi, K Oguri, H Yoshimura. Tissue-specific expression, induction, and inhibition through metabolic intermediate-complex formation of guinea pig cytochrome P450 belonging to the CYP2B subfamily.
Archives of biochemistry and biophysics.
1992 Dec; 299(2):248-54. doi:
10.1016/0003-9861(92)90271-w. [PMID: 1444463] - E E Muirhead, D H Streeten, B Brooks, E T Schroeder, L W Byers. Persistent hypotension associated with hypermedullipinemia: a new syndrome.
Blood pressure.
1992 Oct; 1(3):138-48. doi:
10.3109/08037059209077509. [PMID: 1345046] - L L Wu, M S Liu. Altered ryanodine receptor of canine cardiac sarcoplasmic reticulum and its underlying mechanism in endotoxin shock.
The Journal of surgical research.
1992 Jul; 53(1):82-90. doi:
10.1016/0022-4804(92)90017-t. [PMID: 1383610] - C U Lambe, A Resetar, T Spector, G W Koszalka, D J Nelson. Metabolism and pharmacokinetics of the anti-varicella-zoster virus agent 6-dimethylaminopurine arabinoside.
Antimicrobial agents and chemotherapy.
1992 Feb; 36(2):353-60. doi:
10.1128/aac.36.2.353. [PMID: 1318679] - J M Vaugeois, J J Bonnet, J Costentin. In vivo labelling of the neuronal dopamine uptake complex in the mouse striatum by [3H]GBR 12783.
European journal of pharmacology.
1992 Jan; 210(1):77-84. doi:
10.1016/0014-2999(92)90654-m. [PMID: 1350989] - M Toraason, M J Breitenstein, H E Wey. Reversible inhibition of intercellular communication among cardiac myocytes by halogenated hydrocarbons.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1992 Jan; 18(1):59-65. doi:
10.1016/0272-0590(92)90195-n. [PMID: 1601210] - K A Bachmann, M S Madhira, G O Rankin. The effects of cobalt chloride, SKF-525A, and N-(3,5-dichlorophenyl)succinimide on in vivo hepatic mixed function oxidase activity as determined by single-sample plasma clearances.
Xenobiotica; the fate of foreign compounds in biological systems.
1992 Jan; 22(1):27-31. doi:
10.3109/00498259209053099. [PMID: 1615705] - J R Zhang, A Sevanian. Effect of vitamin E on arachidonic acid peroxidation and its binding to Chinese hamster V79 cell DNA.
Biochimica et biophysica acta.
1991 Sep; 1085(2):159-66. doi:
10.1016/0005-2760(91)90090-5. [PMID: 1892884] - M M Mumtaz, M Y Farooqui, B I Ghanayem, A E Ahmed. The urotoxic effects of N,N'-dimethylaminopropionitrile. 2. In vivo and in vitro metabolism.
Toxicology and applied pharmacology.
1991 Aug; 110(1):61-9. doi:
10.1016/0041-008x(91)90289-q. [PMID: 1871772] - E E Muirhead, B Brooks, L W Byers, P Brown, J A Pitcock. Secretion of medullipin I by isolated kidneys perfused under elevated pressure.
Clinical and experimental pharmacology & physiology.
1991 Jun; 18(6):409-17. doi:
10.1111/j.1440-1681.1991.tb01472.x. [PMID: 1914243] - S N Giri, D M Siegel. Characterization of covalent binding of [14C]-2-chloro-4-acetotoluidide to microsomes of starling liver and kidney.
Journal of biochemical toxicology.
1991; 6(2):137-45. doi:
10.1002/jbt.2570060208. [PMID: 1941900] - L Dahlström-King, J Couture, C Lamoureux, T Vaillancourt, G L Plaa. Dose-dependent cytotoxicity of chlorinated hydrocarbons in isolated rat hepatocytes.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1990 May; 14(4):833-41. doi:
. [PMID: 2361581] - J E Smolen, R R Sandborg. Ca2(+)-induced secretion by electropermeabilized human neutrophils. The roles of Ca2+, nucleotides and protein kinase C.
Biochimica et biophysica acta.
1990 Apr; 1052(1):133-42. doi:
10.1016/0167-4889(90)90068-o. [PMID: 2322590] - S B Ross. Further studies on the high-affinity binding of 3H-alaproclate to membranes from rat liver and some other tissues.
Pharmacology & toxicology.
1990 Mar; 66(3):170-5. doi:
10.1111/j.1600-0773.1990.tb00727.x. [PMID: 2333272] - W R Christenson, M E Davis, W O Berndt. Effect in the rat of the interaction of dichloromaleic acid and carbon tetrachloride on renal and hepatic function.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1989 Oct; 13(3):493-9. doi:
10.1016/0272-0590(89)90285-6. [PMID: 2612781] - W J Adams, J J Kocsis, R Snyder. Acute toxicity and urinary excretion of diphenyldiselenide.
Toxicology letters.
1989 Sep; 48(3):301-10. doi:
10.1016/0378-4274(89)90057-x. [PMID: 2781599] - C F Nhachi, O Chikuni. A comparative study of the hepatotoxicity of 1-fluoropentane and 1-fluorohexane.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1988 Aug; 26(8):705-13. doi:
10.1016/0278-6915(88)90070-1. [PMID: 3198037] - J J Freeman, E P Hayes. Microsomal metabolism of acetonitrile to cyanide. Effects of acetone and other compounds.
Biochemical pharmacology.
1988 Mar; 37(6):1153-9. doi:
10.1016/0006-2952(88)90524-2. [PMID: 3355589] - B Chindavijak, F M Belpaire, M G Bogaert. Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes.
Pharmacology.
1988; 36(4):279-82. doi:
10.1159/000138395. [PMID: 3380881] - J F Nagelkerke, R B Tijdens, E P Schwarz, M F Winters, L C Paul, G J Mulder. The covalent binding of cyclosporin A to rat liver macromolecules in vivo and in vitro: the role of cytochrome P-450.
Toxicology.
1987 Dec; 47(3):277-84. doi:
10.1016/0300-483x(87)90057-6. [PMID: 3424383] - M J Moor, M H Bickel. Tissue distribution of phenoxybenzamine in the rat. Lack of adipose tissue storage.
Life sciences.
1987 Oct; 41(17):2041-6. doi:
10.1016/0024-3205(87)90478-4. [PMID: 3669910] - S K Duddy, M T Hsia. Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1987 Aug; 9(2):304-13. doi:
10.1016/0272-0590(87)90053-4. [PMID: 3653573] - T Yoshida, T Oguro, Y Kuroiwa. Hepatic and extrahepatic metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor, of amphetamines in rats: sex and strain differences.
Xenobiotica; the fate of foreign compounds in biological systems.
1987 Aug; 17(8):957-63. doi:
10.3109/00498258709044194. [PMID: 3118583] - P Fromowicz, M T Brondeau, P Bonnet, J De Ceaurriz. Effect of SKF525-A on the glutathione-conjugating enzyme system and on liver toxicity.
Toxicology letters.
1987 May; 36(3):275-80. doi:
10.1016/0378-4274(87)90196-2. [PMID: 3590222] - S P Adams, A C Notides. Reduction of irreversible binding of diethylstilbestrol in hamster renal cortex by inhibitors of cytochrome P-450.
Toxicology and applied pharmacology.
1987 Mar; 88(1):113-22. doi:
10.1016/0041-008x(87)90275-4. [PMID: 2436352] - F M Belpaire, B Chindavijak, M G Bogaert. SKF 525A displaces drugs from serum alpha 1-acid glycoprotein binding sites.
The Journal of pharmacology and experimental therapeutics.
1987 Feb; 240(2):628-30. doi:
. [PMID: 3806415] - E Muirhead, L W Byers, J Capdevila, B Brooks, J A Pitcock, P Brown, R Dowell. Effect of cytochrome P-450 induction and inhibition on the antihypertensive function of the kidney.
Transactions of the Association of American Physicians.
1987; 100(?):196-203. doi:
NULL. [PMID: 3455065] - S Borrello, T Galeotti, G Palombini, G Minotti. Restoration of hydroperoxide-dependent lipid peroxidation by 3-methylcholanthrene induction of cytochrome P-448 in hepatoma microsomes.
FEBS letters.
1986 Dec; 209(2):305-10. doi:
10.1016/0014-5793(86)81132-2. [PMID: 3792550] - R J Gerson, A Serroni, D Gilfor, J M Ellen, J L Farber. Killing of cultured hepatocytes by the mixed-function oxidation of ethoxycoumarin.
Biochemical pharmacology.
1986 Dec; 35(23):4311-9. doi:
10.1016/0006-2952(86)90711-2. [PMID: 3790155] - M E Kyle, J J Kocsis. Metabolism of salicylate by isolated kidney and liver mitochondria.
Chemico-biological interactions.
1986 Oct; 59(3):325-35. doi:
10.1016/s0009-2797(86)80077-1. [PMID: 3094966] - M M Gad-El Karim, V M Sadagopa Ramanujam, M S Legator. Correlation between the induction of micronuclei in bone marrow by benzene exposure and the excretion of metabolites in urine of CD-1 mice.
Toxicology and applied pharmacology.
1986 Sep; 85(3):464-77. doi:
10.1016/0041-008x(86)90354-6. [PMID: 3764927] - L H Bruner, L J Carpenter, P Hamlow, R A Roth. Effect of a mixed function oxidase inducer and inhibitor on monocrotaline pyrrole pneumotoxicity.
Toxicology and applied pharmacology.
1986 Sep; 85(3):416-27. doi:
10.1016/0041-008x(86)90349-2. [PMID: 3094196]
