Sodium phosphonatoformate hexahydrate (BioDeep_00000646655)
代谢物信息卡片
Phosphonoformic acid trisodium salt hexahydrate
化学式: CH12Na3O11P (299.9810332)
中文名称: 六水磷甲酸钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=O)([O-])P(=O)([O-])[O-].O.O.O.O.O.O.[Na+].[Na+].[Na+]
InChI: /p-3
描述信息
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97453 - Non-nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:60269
- KEGGdrug: D02267
- KEGGdrug: D82048
- PubChem: 169569
- ChEMBL: CHEMBL4063154
- MeSH: Foscarnet
- CAS: 34156-56-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yi Zhang, Lei Fang, Yi Zhou, Yongqing Zhang, Bing Liang, Chuanzhu Yan, Ling Li. A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing.
BMC neurology.
2023 May; 23(1):192. doi:
10.1186/s12883-023-03227-1. [PMID: 37194001] - Kei Irie, Nobuhiro Hiramoto, Takayuki Ishikawa, Shoji Fukushima. Use of liquid chromatography-tandem mass spectrometry for foscarnet quantification in human serum and cerebrospinal fluid.
Rapid communications in mass spectrometry : RCM.
2022 Apr; 36(7):e9255. doi:
10.1002/rcm.9255. [PMID: 35001441] - Ryo Inose, Katsuyuki Takahashi, Masaya Takahashi, Takashi Sugimoto, Satoru Nanno, Masayuki Hino, Katsuya Nagayama. Long-term use of foscarnet is associated with an increased incidence of acute kidney injury in hematopoietic stem cell transplant patients: A retrospective observational study.
Transplant infectious disease : an official journal of the Transplantation Society.
2022 Apr; 24(2):e13804. doi:
10.1111/tid.13804. [PMID: 35114030] - Minwen Ding, Qian Zhang, Minmin Zhang, Xinxin Jiang, Mengjing Wang, Li Ni, Wen Gong, Bihong Huang, Jing Chen. Phosphate Overload Stimulates Inflammatory Reaction via PiT-1 and Induces Vascular Calcification in Uremia.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2022 03; 32(2):178-188. doi:
10.1053/j.jrn.2021.03.008. [PMID: 34688540] - Elena Rho, Bettina Näf, Thomas F Müller, Rudolf P Wüthrich, Thomas Schachter, Seraina von Moos. Use of letermovir-valganciclovir combination as a step-down treatment after foscarnet for ganciclovir-resistant CMV infection in kidney transplant recipients.
Clinical transplantation.
2021 11; 35(11):e14401. doi:
10.1111/ctr.14401. [PMID: 34181768] - Paul E Rosenstiel, Glen S Markowitz, Brigani Amante. An Unusual Cause of Kidney Allograft Dysfunction.
Kidney360.
2021 07; 2(7):1207-1208. doi:
10.34067/kid.0001062021. [PMID: 35368358] - Walter Domingo, Isabelle T Nguyen, Joyce J Johnsrud, Janice Wes Brown. Continuous-Infusion Foscarnet Facilitates Administration in Hematopoietic Stem Cell Transplantation Patients.
Transplantation and cellular therapy.
2021 07; 27(7):622.e1-622.e5. doi:
10.1016/j.jtct.2021.03.018. [PMID: 33891883] - Francesco Baldo, Nicolás M Suárez, Andrew J Davison, Davide Zanon, Egidio Barbi, Natalia Maximova. Post-HSCT graft failure due to refractory human cytomegalovirus successfully treated with haploidentical donor-derived immunoglobulins and stem cell graft infusion: A case report.
Antiviral research.
2021 04; 188(?):105024. doi:
10.1016/j.antiviral.2021.105024. [PMID: 33577809] - Jerica Pleško, Damjan Kovač, Zoran Arsov, Jelka Lindič, Andrej Škoberne, Dušan Ferluga, Nika Kojc. Glomerular and tubulointerstitial foscarnet nephropathy of kidney allograft with emphasis on ultrastructural findings: A case report.
Clinical nephrology.
2021 Sup; 96(1):127-132. doi:
10.5414/cnp96s23. [PMID: 34643504] - Gena G Foster, Michael J Grant, Samantha M Thomas, Blake Cameron, Doug Raiff, Kelly Corbet, Gavin Loitsch, Christopher Ferreri, Mitchell Horwitz. Treatment with Foscarnet after Allogeneic Hematopoietic Cell Transplant (Allo-HCT) Is Associated with Long-Term Loss of Renal Function.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2020 09; 26(9):1597-1606. doi:
10.1016/j.bbmt.2020.05.007. [PMID: 32450288] - Y Uwai, R Kondo, T Suzuki, T Kawasaki, T Nabekura. Potent Inhibition of Biphasic Tubular Reabsorption of Lithium by Acetazolamide and Foscarnet in Rats.
Physiological research.
2020 08; 69(4):645-651. doi:
10.33549/physiolres.934285. [PMID: 32584131] - Ryosuke Ota, Atsushi Hirata, Keisuke Noto, Satoshi Yokoyama, Kouichi Hosomi, Mitsutaka Takada, Hiroshi Matsuoka. Relationship between serum calcium and creatinine in hematopoietic stem cell transplantation patients treated with foscarnet
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International journal of clinical pharmacology and therapeutics.
2020 May; 58(5):274-281. doi:
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Transplant infectious disease : an official journal of the Transplantation Society.
2020 Feb; 22(1):e13239. doi:
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Transplant infectious disease : an official journal of the Transplantation Society.
2019 Dec; 21(6):e13168. doi:
10.1111/tid.13168. [PMID: 31498954] - Michael L Spinner, Simon W Lam, Christine E Koval, Vasilios Athans. Recommended foscarnet dose is not associated with improved outcomes in cytomegalovirus salvage therapy.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2019 11; 120(?):12-16. doi:
10.1016/j.jcv.2019.09.001. [PMID: 31514101] - Y Nawashiro, K Shiraki, S Yamamoto, K Takizawa, Y Sasada, M Suehiro, K Miura, M Hattori, T Daikoku, M Hisano. Persistent Primary Cytomegalovirus Infection After Deceased Donor Kidney Transplant: Ganciclovir Susceptibility of Human Cytomegalovirus With UL97 D605E Mutation: A Case Report.
Transplantation proceedings.
2018 Dec; 50(10):3932-3936. doi:
10.1016/j.transproceed.2018.09.010. [PMID: 30577289] - Masao Ogata, Kuniko Takano, Yukiyoshi Moriuchi, Tadakazu Kondo, Toshimitsu Ueki, Nobuaki Nakano, Takehiko Mori, Nobuhiko Uoshima, Koji Nagafuji, Satoshi Yamasaki, Yasuhiko Shibasaki, Rika Sakai, Koji Kato, Ilseung Choi, Yumi Jo, Tetsuya Eto, Shinichi Kako, Kumi Oshima, Takahiro Fukuda. Effects of Prophylactic Foscarnet on Human Herpesvirus-6 Reactivation and Encephalitis in Cord Blood Transplant Recipients: A Prospective Multicenter Trial with an Historical Control Group.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2018 06; 24(6):1264-1273. doi:
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Transplantation proceedings.
2018 Mar; 50(2):575-577. doi:
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International journal of hematology.
2018 Mar; 107(3):363-372. doi:
10.1007/s12185-017-2347-5. [PMID: 29022282] - Yuichi Uwai, Tatsuya Kawasaki, Tomohiro Nabekura. Nonlinear disposition of lithium in rats and saturation of its tubular reabsorption by the sodium-phosphate cotransporter as a cause.
Biopharmaceutics & drug disposition.
2018 Feb; 39(2):83-87. doi:
10.1002/bdd.2116. [PMID: 29214648] - K M Baradhi, R L Aure, J-M El-Amm. High-dose Valganciclovir Treatment for Resistant Cytomegalovirus Colitis due to UL97 and UL54 Mutations.
Transplantation proceedings.
2018 Jan; 50(1):142-144. doi:
10.1016/j.transproceed.2017.11.013. [PMID: 29407298] - Lorraine Py Kwan, Maggie My Mok, Bo Ying Choy, Tak Mao Chan. Acute kidney injury in a renal transplant recipient due to concomitant use of vancomycin and foscarnet.
Nephrology (Carlton, Vic.).
2017 10; 22(10):821-822. doi:
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Transplantation proceedings.
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Ophthalmology.
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The Journal of antimicrobial chemotherapy.
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Nephrology (Carlton, Vic.).
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Journal of medical virology.
2016 Jul; 88(7):1204-10. doi:
10.1002/jmv.24442. [PMID: 26636432] - Isabelle Garrigue, Rémi Moulinas, Patricia Recordon-Pinson, Marie-Laure Delacour, Marie Essig, Hannah Kaminski, Jean-Philippe Rerolle, Pierre Merville, Hervé Fleury, Sophie Alain. Contribution of next generation sequencing to early detection of cytomegalovirus UL97 emerging mutants and viral subpopulations analysis in kidney transplant recipients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2016 07; 80(?):74-81. doi:
10.1016/j.jcv.2016.04.017. [PMID: 27214758] - Yuichi Uwai, Tatsuya Kawasaki, Tomohiro Nabekura. Foscarnet, an inhibitor of the sodium-phosphate cotransporter NaPi-IIa, inhibits phosphorylation of glycogen synthase kinase-3β by lithium in the rat kidney cortex.
Drug metabolism and pharmacokinetics.
2016 Jun; 31(3):256-9. doi:
10.1016/j.dmpk.2016.02.003. [PMID: 27238574] - G W Kang, H L Hong, I H Lee, K S Ahn, J D Kim, D L Choi. Ganciclovir and Foscarnet Therapy of Cytomegalovirus-Associated Meningoencephalitis in a Hemodialysis Patient With Liver Transplantation: Case Report.
Transplantation proceedings.
2016 May; 48(4):1208-11. doi:
10.1016/j.transproceed.2016.01.021. [PMID: 27320588] - Rong Zhou, Xin Kang, Bo Tang, Chandra Mohan, Tianfu Wu, Ai Peng, Jun-Yan Liu. Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics.
Life sciences.
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10.1016/j.lfs.2016.01.003. [PMID: 26773858] - Linto Thomas, Carsten A Wagner, Jürg Biber, Nati Hernando. Adaptation of Opossum Kidney Cells to Luminal Phosphate: Effects of Phosphonoformic Acid and Kinase Inhibitors.
Kidney & blood pressure research.
2016; 41(3):298-310. doi:
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Pediatric transplantation.
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Journal of vascular surgery.
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10.1016/j.jvs.2014.02.040. [PMID: 24797554] - Carole Philipponnet, Pierre-Antoine Michel, Michel Daudon, Isabelle Brocheriou, Jean-Jacques Boffa. Intravascular foscarnet crystal precipitation causing multiorgan failure.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2015 Jan; 65(1):152-5. doi:
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Anales de pediatria (Barcelona, Spain : 2003).
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Antiviral research.
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10.1016/j.antiviral.2014.07.007. [PMID: 25051026] - Yuichi Uwai, Ryosuke Arima, Chihiro Takatsu, Ryo Furuta, Tatsuya Kawasaki, Tomohiro Nabekura. Sodium-phosphate cotransporter mediates reabsorption of lithium in rat kidney.
Pharmacological research.
2014 Sep; 87(?):94-8. doi:
10.1016/j.phrs.2014.06.012. [PMID: 24997387] - Sunwen Chou, Ronald J Ercolani, Malaya K Sahoo, Martina I Lefterova, Lynne M Strasfeld, Benjamin A Pinsky. Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing.
Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4697-702. doi:
10.1128/aac.03214-14. [PMID: 24890586] - Lucio R Minces, M Hong Nguyen, Dimitra Mitsani, Ryan K Shields, Eun J Kwak, Fernanda P Silveira, Rima Abdel-Massih, Joseph M Pilewski, Maria M Crespo, Christian Bermudez, Jay K Bhama, Yoshiya Toyoda, Cornelius J Clancy. Ganciclovir-resistant cytomegalovirus infections among lung transplant recipients are associated with poor outcomes despite treatment with foscarnet-containing regimens.
Antimicrobial agents and chemotherapy.
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The Journal of surgical research.
2013 Sep; 184(1):6-9. doi:
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Antimicrobial agents and chemotherapy.
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Clinical nephrology.
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Transplant infectious disease : an official journal of the Transplantation Society.
2013 Apr; 15(2):E54-7. doi:
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Molecular aspects of medicine.
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Bone marrow transplantation.
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Medycyna wieku rozwojowego.
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Internal medicine (Tokyo, Japan).
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Renal failure.
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Transplantation.
2011 Jul; 92(2):217-23. doi:
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Bone marrow transplantation.
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American journal of nephrology.
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Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
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Przeglad lekarski.
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Ophthalmology.
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American journal of physiology. Cell physiology.
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Bioorganic & medicinal chemistry.
2009 Jan; 17(1):303-10. doi:
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2009 Jan; 81(1):99-105. doi:
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Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
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2008 Dec; 47(12):e93-6. doi:
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Transplant infectious disease : an official journal of the Transplantation Society.
2008 Feb; 10(1):13-8. doi:
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[Rinsho ketsueki] The Japanese journal of clinical hematology.
2008 Jan; 49(1):40-5. doi:
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2007 Nov; 22(11):3334-7. doi:
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Nihon rinsho. Japanese journal of clinical medicine.
2007 Feb; 65 Suppl 2 Pt. 1(?):605-8. doi:
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American journal of physiology. Cell physiology.
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2007 Jan; 51(1):89-94. doi:
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International journal of hematology.
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Toxicology and applied pharmacology.
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Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
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The International journal of artificial organs.
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Transplant infectious disease : an official journal of the Transplantation Society.
2002 Dec; 4(4):189-94. doi:
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Planta medica.
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British journal of haematology.
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Minerva urologica e nefrologica = The Italian journal of urology and nephrology.
2002 Jun; 54(2):93-106. doi:
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African journal of health sciences.
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Transplant infectious disease : an official journal of the Transplantation Society.
2001 Dec; 3(4):195-202. doi:
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