Phenylephrine hydrochloride (BioDeep_00000646560)
代谢物信息卡片
Phenylephrine hydrochloride
化学式: C9H14ClNO2 (203.0713014)
中文名称: 盐酸去氧肾上腺素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNCC(C1=CC(=CC=C1)O)O.Cl
InChI: 1H/t9-
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
D019141 - Respiratory System Agents > D014663 - Nasal Decongestants
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
D020011 - Protective Agents > D002316 - Cardiotonic Agents
(R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:8094
- KEGGdrug: D00511
- KEGGdrug: D70603
- PubChem: 5284443
- ChEMBL: CHEMBL1200339
- MeSH: Phenylephrine
- CAS: 61-76-7
- CAS: 154-86-9
- medchemexpress: HY-B0471
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kaijing Yang, Xiaoli Shan, Yang Songru, Mengwei Fu, Pei Zhao, Wei Guo, Ming Xu, Huihua Chen, Rong Lu, Chen Zhang. Network pharmacology integrated with experimental validation to elucidate the mechanisms of action of the Guizhi-Gancao Decoction in the treatment of phenylephrine-induced cardiac hypertrophy.
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Scientific reports.
2019 04; 9(1):6696. doi:
10.1038/s41598-019-43193-8. [PMID: 31040342] - Leon J DeLalio, Marie Billaud, Claire A Ruddiman, Scott R Johnstone, Joshua T Butcher, Abigail G Wolpe, Xueyao Jin, T C Stevenson Keller, Alexander S Keller, Thibaud Rivière, Miranda E Good, Angela K Best, Alexander W Lohman, Leigh Anne Swayne, Silvia Penuela, Roger J Thompson, Paul D Lampe, Mark Yeager, Brant E Isakson. Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane.
The Journal of biological chemistry.
2019 04; 294(17):6940-6956. doi:
10.1074/jbc.ra118.006982. [PMID: 30814251] - Hawa Nordin Siti, Yusof Kamisah, Suhaila Mohamed, Kamsiah Jaarin. Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2019 04; 44(4):373-380. doi:
10.1139/apnm-2018-0175. [PMID: 30216735] - Yomna A Salem, Mohammed E A Hammouda, Mohamed A Abu El-Enin, Saadia M El-Ashry. Application of derivative emission fluorescence spectroscopy for determination of ibuprofen and phenylephrine simultaneously in tablets and biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Mar; 210(?):387-397. doi:
10.1016/j.saa.2018.11.054. [PMID: 30503784] - Hong-Mei Li, Kai-Ying Li, Yun Xing, Xiang-Xu Tang, Duo-Meng Yang, Xiao-Meng Dai, Da-Xiang Lu, Hua-Dong Wang. Phenylephrine Attenuated Sepsis-Induced Cardiac Inflammation and Mitochondrial Injury Through an Effect on the PI3K/Akt Signaling Pathway.
Journal of cardiovascular pharmacology.
2019 03; 73(3):186-194. doi:
10.1097/fjc.0000000000000651. [PMID: 30839512] - Chunli Zhu, Siyuan Xu, Xiaopeng Han, Wei Wang, Wei He, Lifang Yin, Lei Yang, Chao Qin. Sustained Release Bilayer Tablet of Ibuprofen and Phenylephrine Hydrochloride: Preparation and Pharmacokinetics in Beagle Dogs.
AAPS PharmSciTech.
2019 Jan; 20(2):86. doi:
10.1208/s12249-018-1271-1. [PMID: 30673916] - Salvatore Smirni, Alison D McNeilly, Michael P MacDonald, Rory J McCrimmon, Faisel Khan. In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress.
Scientific reports.
2019 01; 9(1):186. doi:
10.1038/s41598-018-36970-4. [PMID: 30655574] - Mi Sun Cheong, Deuk Yeong Lee, Kyung Hye Seo, Geun-Hyoung Choi, Yeong Hun Song, Ki Hun Park, Jin-Hyo Kim. Phenylephrine, a small molecule, inhibits pectin methylesterases.
Biochemical and biophysical research communications.
2019 01; 508(1):320-325. doi:
10.1016/j.bbrc.2018.11.117. [PMID: 30502087] - Robert M Rapoport, Amanda J LeBlanc, Jason E Beare, Manoocher Soleimani. Lack of thiazide diuretic inhibition of agonist constriction of mouse mesenteric arterioles ex vivo.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 01; 392(1):117-121. doi:
10.1007/s00210-018-1590-5. [PMID: 30470918] - Maritza Omaña-Molina, Virginia Vanzzini-Zago, Dolores Hernández-Martínez, María Reyes-Batlle, Ismael Castelan-Ramírez, Perla Hernández-Olmos, Lizbeth Salazar-Villatoro, Arturo González-Robles, Elizabeth Ramírez-Flores, Christopher Servín-Flores, Víctor Flores-Alvarado, Marino Alcántara-Castro, Jacob Lorenzo-Morales. Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome.
Experimental parasitology.
2019 Jan; 196(?):22-27. doi:
10.1016/j.exppara.2018.11.005. [PMID: 30472333] - Sumei Cui, Yuqian Cui, Yuan Li, Yongtao Zhang, Hao Wang, Weidong Qin, Xiaomei Chen, Shifang Ding, Dawei Wu, Haipeng Guo. Inhibition of cardiac hypertrophy by aromadendrin through down-regulating NFAT and MAPKs pathways.
Biochemical and biophysical research communications.
2018 12; 506(4):805-811. doi:
10.1016/j.bbrc.2018.10.143. [PMID: 30389139] - Guillaume L Hoareau, Harris Kashtan, Lauren E Walker, Carl Beyer, Andrew Wishy, J Kevin Grayson, James D Ross, Ian J Stewart. A Novel Perfusion System for Damage Control of Hyperkalemia in Swine.
Shock (Augusta, Ga.).
2018 12; 50(6):677-683. doi:
10.1097/shk.0000000000001079. [PMID: 30427323] - Fredi Cifuentes, Javier Palacios, Adrián Paredes, Chukwuemeka R Nwokocha, Cristian Paz. 8-Oxo-9-Dihydromakomakine Isolated from Aristotelia chilensis Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23113050. [PMID: 30469451] - Naoko Matsushita, Nanae Ishida, Miho Ibi, Maki Saito, Atsushi Sanbe, Hisashi Shimojo, Satoshi Suzuki, Hermann Koepsell, Yasuchika Takeishi, Yoshihiro Morino, Eiichi Taira, Yohei Sawa, Masamichi Hirose. Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice.
International heart journal.
2018 Sep; 59(5):1123-1133. doi:
10.1536/ihj.17-565. [PMID: 30101852] - Leon J DeLalio, Alexander S Keller, Jiwang Chen, Andrew K J Boyce, Mykhaylo V Artamonov, Henry R Askew-Page, T C Stevenson Keller, Scott R Johnstone, Rachel B Weaver, Miranda E Good, Sara A Murphy, Angela K Best, Ellen L Mintz, Silvia Penuela, Iain A Greenwood, Roberto F Machado, Avril V Somlyo, Leigh Anne Swayne, Richard D Minshall, Brant E Isakson. Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure.
Arteriosclerosis, thrombosis, and vascular biology.
2018 09; 38(9):2065-2078. doi:
10.1161/atvbaha.118.311290. [PMID: 30026274] - Xiao-Yu Liu, Hai-Han Liao, Hong Feng, Nan Zhang, Jing-Jing Yang, Wen-Jing Li, Si Chen, Wei Deng, Qi-Zhu Tang. Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro.
Journal of pharmacological sciences.
2018 Sep; 138(1):38-45. doi:
10.1016/j.jphs.2018.08.010. [PMID: 30241784] - Sheng-Chang Yang, Ya-Jing Guo, Fu-Yang Yu, Ling-Ling Chen, Wen-Ya Li, En-Sheng Ji. [Bosentan ameliorates hypertension in rats exposed to chronic intermittent hypoxia through inhibiting renal sympathetic nerve activity].
Sheng li xue bao : [Acta physiologica Sinica].
2018 Aug; 70(4):354-360. doi:
NULL. [PMID: 30112560] - Zuheng Liu, Jinghai Hua, Wanqiang Cai, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu. N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes.
Molecular medicine reports.
2018 Aug; 18(2):2142-2152. doi:
10.3892/mmr.2018.9158. [PMID: 29901150] - Hui Gao, Hui Liu, Tiexin Tang, Xiaofei Huang, Dongxiu Wang, Yan Li, Pan Huang, Yingfu Peng. Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway.
Molecular and cellular endocrinology.
2018 07; 470(?):259-268. doi:
10.1016/j.mce.2017.11.007. [PMID: 29138023] - Aline Maria Arlindo de Souza, Crystal A West, Aline Rezende Ribeiro de Abreu, Amrita V Pai, Laura Batista Tavares Mesquita, Hong Ji, Deoclécio Chianca, Rodrigo Cunha Alvim de Menezes, Kathryn Sandberg. Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats.
Scientific reports.
2018 07; 8(1):10327. doi:
10.1038/s41598-018-28593-6. [PMID: 29985423] - Cathy K Gelotte. An open-label, randomized, four-treatment crossover study evaluating the effects of salt form, acetaminophen, and food on the pharmacokinetics of phenylephrine.
Regulatory toxicology and pharmacology : RTP.
2018 Jun; 95(?):333-338. doi:
10.1016/j.yrtph.2018.04.008. [PMID: 29635061] - Rui Tan, Yun Jung Lee, Kyung Woo Cho, Dae Gill Kang, Ho Sub Lee. Beneficial Effect of Berberis amurensis Rupr. on Penile Erection.
Chinese journal of integrative medicine.
2018 Jun; 24(6):448-454. doi:
10.1007/s11655-017-2920-z. [PMID: 29335865] - S-H Ok, I-W Shin, S H Lee, J Park, M S Woo, J-M Hong, J Kim, J-T Sohn. Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model.
Human & experimental toxicology.
2018 Jun; 37(6):636-646. doi:
10.1177/0960327117721963. [PMID: 28741374] - Yasuhiro Takenouchi, Kazuo Ohtake, Koji Nobe, Keizo Kasono. Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice.
Lipids in health and disease.
2018 May; 17(1):118. doi:
10.1186/s12944-018-0770-0. [PMID: 29788974] - Takahisa Suzuki, Atsushi Otsuka, Yoshihiko Ito, Shizuo Yamada, Hideaki Miyake, Seiichiro Ozono. Isosamidin, an extract of Peucedanum japonicum, inhibits phenylephrine-mediated contractions of the human prostate in vitro.
Phytotherapy research : PTR.
2018 May; 32(5):949-952. doi:
10.1002/ptr.6039. [PMID: 29388272] - Xi Han, Yang Liu, Wendy R Kam, David A Sullivan. Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells.
Experimental eye research.
2018 05; 170(?):20-28. doi:
10.1016/j.exer.2018.02.009. [PMID: 29452108] - Jing Yin, Yu-Ming Guo, Ping Chen, He Xiao, Xing-Huan Wang, Michael E DiSanto, Xin-Hua Zhang. Testosterone regulates the expression and functional activity of sphingosine-1-phosphate receptors in the rat corpus cavernosum.
Journal of cellular and molecular medicine.
2018 03; 22(3):1507-1516. doi:
10.1111/jcmm.13416. [PMID: 29266713] - Seema Bansal, Kanwaljit Chopra. Selective ER-α agonist alleviates vascular endothelial dysfunction in ovariectomized type 2 diabetic rats.
Molecular and cellular endocrinology.
2018 01; 460(?):152-161. doi:
10.1016/j.mce.2017.07.017. [PMID: 28736253] - Tsontcho Ianchulev, Robert Weinreb, James C Tsai, Shan Lin, Louis R Pasquale. High-precision piezo-ejection ocular microdosing: Phase II study on local and systemic effects of topical phenylephrine.
Therapeutic delivery.
2018 Jan; 9(1):17-27. doi:
10.4155/tde-2017-0095. [PMID: 29076771] - Chu Shan Tan, Yean Chun Loh, Chiew Hoong Ng, Yung Sing Ch'ng, Mohd Zaini Asmawi, Mariam Ahmad, Mun Fei Yam. Anti-hypertensive and vasodilatory effects of amended Banxia Baizhu Tianma Tang.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):985-994. doi:
10.1016/j.biopha.2017.11.021. [PMID: 29136777] - H Sørensen, J H Thomsen, A S P Meyer, D Terzic, L Hilsted, J Kjærgaard, J P Goetze, T C Barbosa, N H Secher. Phenylephrine increases near-infrared spectroscopy determined muscle oxygenation in men.
Journal of clinical monitoring and computing.
2017 Dec; 31(6):1159-1166. doi:
10.1007/s10877-016-9965-y. [PMID: 27987104] - Danize Aparecida Rizzetti, Ángela Martín, Patricia Corrales, Francisca Fernandez, Maylla Ronacher Simões, Franck Maciel Peçanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers. Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase.
Toxicology letters.
2017 Nov; 281(?):158-174. doi:
10.1016/j.toxlet.2017.10.001. [PMID: 28987480] - K Uerpairojkit, R Anusorntanawat, A Sirisabya, M Chaichalothorn, S Charuluxananan. Neonatal effects after vasopressor during spinal anesthesia for cesarean section: a multicenter, randomized controlled trial.
International journal of obstetric anesthesia.
2017 Nov; 32(?):41-47. doi:
10.1016/j.ijoa.2017.05.009. [PMID: 28689624] - Dante A Suffredini, Yan Li, Wanying Xu, Mahtab Moayeri, Stephen Leppla, Yvonne Fitz, Xizhong Cui, Peter Q Eichacker. Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.
American journal of physiology. Heart and circulatory physiology.
2017 Nov; 313(5):H946-H958. doi:
10.1152/ajpheart.00285.2017. [PMID: 28887331] - Michael R Odom, Elena S Pak, David A Brown, Johanna L Hannan. Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries.
The journal of sexual medicine.
2017 11; 14(11):1285-1296. doi:
10.1016/j.jsxm.2017.09.013. [PMID: 29110801] - Brian J Anderson, Lisa K Christensen, Valerie E Armstead, David P Bilyeu, Kenneth E Johnson, Robert H Friesen. The phenylephrine concentration-response relationship for blood pressure after nasal delivery in children.
Paediatric anaesthesia.
2017 Oct; 27(10):1050-1055. doi:
10.1111/pan.13221. [PMID: 28868789] - Nina Ashraf-Kashani, John Bell. Haemodynamic changes during hyperthermic intra-thoracic chemotherapy for pseudomyxoma peritonei.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.
2017 09; 33(6):675-678. doi:
10.1080/02656736.2017.1300944. [PMID: 28540781] - Marco Henry Santamaria, Federico Aletti, Joyce B Li, Aaron Tan, Monica Chang, Jessica Leon, Geert W Schmid-Schönbein, Erik B Kistler. Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock.
The journal of trauma and acute care surgery.
2017 08; 83(2):263-270. doi:
10.1097/ta.0000000000001513. [PMID: 28422915] - Renata F Medeiros, Thaiane G Gaique, Thais Bento-Bernardes, Raquel Kindlovits, Tamiris M B Gomes, Nadia Alice V Motta, Fernanda Carla Brito, Caroline Fernandes-Santos, Karen J Oliveira, Antonio Claudio L Nóbrega. Arginine and aerobic training prevent endothelial and metabolic alterations in rats at high risk for the development of the metabolic syndrome.
The British journal of nutrition.
2017 Jul; 118(1):1-10. doi:
10.1017/s0007114517001702. [PMID: 28799895] - Jugurtha Aliane, Christian Dualé, Nader Guesmi, Charlotte Baud, Eugenio Rosset, Bruno Pereira, Damien Bouvier, Pierre Schoeffler. Compared effects on cerebral oxygenation of ephedrine vs phenylephrine to treat hypotension during carotid endarterectomy.
Clinical and experimental pharmacology & physiology.
2017 Jul; 44(7):739-748. doi:
10.1111/1440-1681.12759. [PMID: 28378467]