Brodimoprim (BioDeep_00000645948)

   


代谢物信息卡片


Brodimoprim

化学式: C13H15BrN4O2 (338.037831)
中文名称: 布罗地莫素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=CC(=C1Br)OC)CC2=CN=C(N=C2N)N
InChI: InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18)

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EA - Trimethoprim and derivatives
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
D000890 - Anti-Infective Agents

同义名列表

1 个代谢物同义名

Brodimoprim



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Naining Song, Shaoyu Zhang, Quansheng Li, Changxiao Liu. Liquid chromatographic/mass spectrometry assay of bromotetrandrine in rat plasma and its application to pharmacokinetic study. Biomedical chromatography : BMC. 2009 Jun; 23(6):623-9. doi: 10.1002/bmc.1163. [PMID: 19277964]
  • Naining Song, Shaoyu Zhang, Quansheng Li, Changxiao Liu. Establishment of a liquid chromatographic/mass spectrometry method for quantification of tetrandrine in rat plasma and its application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2008 Nov; 48(3):974-9. doi: 10.1016/j.jpba.2008.06.002. [PMID: 18650047]
  • Shaoyu Zhang, Naining Song, Quansheng Li, Huirong Fan, Changxiao Liu. Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Aug; 871(1):78-89. doi: 10.1016/j.jchromb.2008.06.034. [PMID: 18614408]
  • Y Si, R Xu, M Kong, W He, S Zhang. [Solid-phase extraction coupled with high-field proton nuclear magnetic resonance spectroscopy: application to the analysis of brodimoprim metabolites in rat urine]. Yao xue xue bao = Acta pharmaceutica Sinica. 1998 Sep; 33(9):697-701. doi: NULL. [PMID: 12016875]
  • M Fresta, P M Furneri, E Mezzasalma, V M Nicolosi, G Puglisi. Correlation of trimethoprim and brodimoprim physicochemical and lipid membrane interaction properties with their accumulation in human neutrophils. Antimicrobial agents and chemotherapy. 1996 Dec; 40(12):2865-73. doi: 10.1128/aac.40.12.2865. [PMID: 9124856]
  • P C Braga, M Dal Sasso, S Maci, G Bondiolotti, E Fonti, S Reggio. Penetration of brodimoprim into human neutrophils and intracellular activity. Antimicrobial agents and chemotherapy. 1996 Oct; 40(10):2392-8. doi: 10.1128/aac.40.10.2392. [PMID: 8891150]
  • R M Richards, J Z Xing. Brodimoprim synergy against Enterococcus faecalis evaluated in vitro. The Journal of antimicrobial chemotherapy. 1996 Jul; 38(1):27-37. doi: 10.1093/jac/38.1.27. [PMID: 8858454]
  • E V Cosmi, L Cantini, P A Monici Preti, G C Di Renzo, F Abate, G Balsotti, G Carlomagno, E Cirese, R Indraccolo, G B La Sala, L Mearini, M Minozzi, F Scarpello. Efficacy and tolerability of brodimoprim at two different dosage schedules in the treatment of acute uncomplicated bacterial cystitis: comparative study vs. pefloxacin. European journal of obstetrics, gynecology, and reproductive biology. 1996 Feb; 64(2):207-11. doi: 10.1016/0301-2115(95)02292-9. [PMID: 8820004]
  • E Weidekamm. Pharmacokinetics of brodimoprim. Journal of chemotherapy (Florence, Italy). 1993 Dec; 5(6):475-9. doi: 10.1080/1120009x.1993.11741099. [PMID: 8195840]
  • A Stockis, F Borzio, X Deroubaix, F Gaspari, B Jeanbaptiste, E Lebacq, R Lins, D Pavesio, G C Pelozi, D Rosillon. Pharmacokinetics of brodimoprim in special populations. Journal of chemotherapy (Florence, Italy). 1993 Dec; 5(6):480-7. doi: 10.1080/1120009x.1993.11741100. [PMID: 8195841]
  • F Scaglione, R Cogo, J P Pintucci, G Demartini, S Dugnani, G Maccarinelli, F Fraschini. Brodimoprim concentrations in bronchial mucosa, bronchial secretions and middle ear effusions. Journal of chemotherapy (Florence, Italy). 1993 Dec; 5(6):490-3. doi: 10.1080/1120009x.1993.11741102. [PMID: 8195843]
  • A Novelli, T Mazzei, E Meli, M I Cassetta, S Fallani, P Periti. Pharmacokinetics and blister fluid penetration of brodimoprim in adults. Journal of chemotherapy (Florence, Italy). 1993 Dec; 5(6):494-8. doi: 10.1080/1120009x.1993.11741103. [PMID: 8195844]
  • S G Amyes. Comparative antibacterial spectrum of trimethoprim and brodimoprim. Journal of chemotherapy (Florence, Italy). 1993 Dec; 5(6):417-21. doi: 10.1080/1120009x.1993.11741089. [PMID: 8195832]
  • T Bergan. Pharmacokinetic profile of brodimoprim: oral bioavailability and penetration into interstitial fluid. Journal of chemotherapy (Florence, Italy). 1993 Dec; 5(6):488-9. doi: 10.1080/1120009x.1993.11741101. [PMID: 8195842]
  • M Stephan-Güldner. Preclinical toxicology and safety pharmacology of brodimoprim in comparison to trimethoprim and analogs. Journal of chemotherapy (Florence, Italy). 1993 Dec; 5(6):400-10. doi: 10.1080/1120009x.1993.11741087. [PMID: 8195831]
  • F Gaspari, L Taiocchi, M G Pochobradsky. Determination of brodimoprim and its hydroxy metabolite in human plasma, blood and urine by high-performance liquid chromatography. Journal of chromatography. 1992 May; 577(1):123-8. doi: 10.1016/0378-4347(92)80606-q. [PMID: 1400731]
  • T Kalager, A Digranes, A Salveson, T Bergan. Pharmacokinetics of brodimoprim in serum and skin blister fluid. Chemotherapy. 1985; 31(6):405-9. doi: 10.1159/000238367. [PMID: 4075857]
  • P Iversen, P O Madsen. Trimethoprim, metioprim, tetroxoprim, and RO 10-5970 in canine bone. Acta pharmacologica et toxicologica. 1982 Nov; 51(5):446-9. doi: 10.1111/j.1600-0773.1982.tb01051.x. [PMID: 7164825]