Sarpogrelate Hydrochloride (BioDeep_00000645655)
代谢物信息卡片
Sarpogrelate Hydrochloride
化学式: C24H32ClNO6 (465.19180420000004)
中文名称: 盐酸沙格雷酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CC(COC1=CC=CC=C1CCC2=CC(=CC=C2)OC)OC(=O)CCC(=O)O.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
D050299 - Fibrin Modulating Agents
D002317 - Cardiovascular Agents
Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis[1][2][3].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:32122
- KEGGdrug: D01624
- PubChem: 444005
- ChEMBL: CHEMBL541829
- CAS: 135159-51-2
- medchemexpress: HY-10564
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Jing Guan, Xin Tong, Yi Zhang, Fan Xu, Yuxin Zhang, Xiurui Liang, Jiaqi Jin, Hongyan Jing, Liuxian Guo, Xinrui Ni, Jihua Fu. Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules.
Chemico-biological interactions.
2021 Nov; 349(?):109662. doi:
10.1016/j.cbi.2021.109662. [PMID: 34560070] - Mohammed Ahmed Fouad Shalaby, Hekma A Abd El Latif, Mohamed El Yamani, May Ahmed Galal, Sherifa Kamal, Ikhlas Sindi, Raneem Masaood. Therapeutic activity of sarpogrelate and dopamine D2 receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes.
BMC pharmacology & toxicology.
2021 10; 22(1):64. doi:
10.1186/s40360-021-00526-6. [PMID: 34702339] - Seung Ki Kim, Geon Kim, Bo-Hyun Choi, Dayoung Ryu, Sae-Kwang Ku, Mi-Kyoung Kwak. Negative correlation of urinary miR-199a-3p level with ameliorating effects of sarpogrelate and cilostazol in hypertensive diabetic nephropathy.
Biochemical pharmacology.
2021 02; 184(?):114391. doi:
10.1016/j.bcp.2020.114391. [PMID: 33359069] - Jingyi Xu, Zuowei Pei, Meng Yu, Xiang Li, Lu Wang, Yichen Lin, Xinyan Chen, Xiaodan Liu. Combinational Use of Antiplatelet Medication Sarpogrelate with Therapeutic Drug Rosuvastatin in Treating High-Cholesterol Diet-Induced Chronic Kidney Disease in ApoE-Deficient Mice.
BioMed research international.
2020; 2020(?):1809326. doi:
10.1155/2020/1809326. [PMID: 33029491] - You Jeong Ki, Sun A Kwon, Hack Lyoung Kim, Jae Bin Seo, Woo Young Chung. The Prevention of Contrast Induced Nephropathy by Sarpogrelate: a Prospective Randomized Controlled Clinical Trial.
Journal of Korean medical science.
2019 Oct; 34(40):e261. doi:
10.3346/jkms.2019.34.e261. [PMID: 31625293] - Hyunju Yoo, Inwhee Park, Dae Jung Kim, Sukhyang Lee. Effects of sarpogrelate on microvascular complications with type 2 diabetes.
International journal of clinical pharmacy.
2019 Apr; 41(2):563-573. doi:
10.1007/s11096-019-00794-7. [PMID: 30864083] - Wonsuk Choi, Jun Namkung, Inseon Hwang, Hyeongseok Kim, Ajin Lim, Hye Jung Park, Hye Won Lee, Kwang-Hyub Han, Seongyeol Park, Ji-Seon Jeong, Geul Bang, Young Hwan Kim, Vijay K Yadav, Gerard Karsenty, Young Seok Ju, Chan Choi, Jae Myoung Suh, Jun Yong Park, Sangkyu Park, Hail Kim. Serotonin signals through a gut-liver axis to regulate hepatic steatosis.
Nature communications.
2018 11; 9(1):4824. doi:
10.1038/s41467-018-07287-7. [PMID: 30446669] - Annika Gocht, Jörg H W Distler, Bernd Spriewald, Martina Ramsperger-Gleixner, Michael Weyand, Stephan M Ensminger, Christian Heim. Effects of different serotonin receptor subtype antagonists on the development of cardiac allograft vasculopathy in murine aortic allografts.
Transplant immunology.
2018 08; 49(?):43-53. doi:
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Obesity research & clinical practice.
2018 Jan; 12(Suppl 2):16-28. doi:
10.1016/j.orcp.2016.03.015. [PMID: 27133527] - Kyung-Yeon Park, Tae-Hwe Heo. Critical role of TNF inhibition in combination therapy for elderly mice with atherosclerosis.
Cardiovascular therapeutics.
2017 Dec; 35(6):. doi:
10.1111/1755-5922.12280. [PMID: 28643478] - Dong-Hwa Lee, Eun Ju Chun, Jee Hye Hur, Se Hee Min, Jie-Eun Lee, Tae Jung Oh, Kyoung Min Kim, Hak Chul Jang, Seung Jin Han, Doo Kyoung Kang, Hae Jin Kim, Soo Lim. Effect of sarpogrelate, a selective 5-HT2A receptor antagonist, on characteristics of coronary artery disease in patients with type 2 diabetes.
Atherosclerosis.
2017 02; 257(?):47-54. doi:
10.1016/j.atherosclerosis.2016.12.011. [PMID: 28068560] - Eun Soo Lee, Mi Young Lee, Mi-Hye Kwon, Hong Min Kim, Jeong Suk Kang, You Mi Kim, Eun Young Lee, Choon Hee Chung. Sarpogrelate hydrochloride ameliorates diabetic nephropathy associated with inhibition of macrophage activity and inflammatory reaction in db/db mice.
PloS one.
2017; 12(6):e0179221. doi:
10.1371/journal.pone.0179221. [PMID: 28640832] - Hangyeore Lee, Sehyun Chae, Jisook Park, Jingi Bae, Eun-Bi Go, Su-Jin Kim, Hokeun Kim, Daehee Hwang, Sang-Won Lee, Soo-Youn Lee. Comprehensive Proteome Profiling of Platelet Identified a Protein Profile Predictive of Responses to An Antiplatelet Agent Sarpogrelate.
Molecular & cellular proteomics : MCP.
2016 11; 15(11):3461-3472. doi:
10.1074/mcp.m116.059154. [PMID: 27601597] - Kyung-Yeon Park, Euichaul Oh, Mi-Kyoung Kwak, Hyun Sik Jun, Tae-Hwe Heo. Pravastatin and Sarpogrelate Synergistically Ameliorate Atherosclerosis in LDLr-Knockout Mice.
PloS one.
2016; 11(3):e0150791. doi:
10.1371/journal.pone.0150791. [PMID: 26950217] - Jee Sun Min, Doyun Kim, Jung Bae Park, Hyunjin Heo, Soo Hyeon Bae, Jae Hong Seo, Euichaul Oh, Soo Kyung Bae. Application of physiologically based pharmacokinetic modeling in predicting drug-drug interactions for sarpogrelate hydrochloride in humans.
Drug design, development and therapy.
2016; 10(?):2959-2972. doi:
10.2147/dddt.s109141. [PMID: 27695293] - Hiroshi Kataoka, Yuno Ariyama, Michiyo Deushi, Mizuko Osaka, Kosaku Nitta, Masayuki Yoshida. Inhibitory Effect of Serotonin Antagonist on Leukocyte-Endothelial Interactions In Vivo and In Vitro.
PloS one.
2016; 11(1):e0147929. doi:
10.1371/journal.pone.0147929. [PMID: 26824242] - Dong-Hyun Kim, Bo-Hyun Choi, Sae-Kwang Ku, Jeong-Hyeon Park, Euichaul Oh, Mi-Kyoung Kwak. Beneficial Effects of Sarpogrelate and Rosuvastatin in High Fat Diet/Streptozotocin-Induced Nephropathy in Mice.
PloS one.
2016; 11(4):e0153965. doi:
10.1371/journal.pone.0153965. [PMID: 27097221] - Jeong-Soo Yang, Jung-Ryul Kim, EunGi Cho, Wooseong Huh, Jae-Wook Ko, Soo-Youn Lee. A Novel Simultaneous Determination of Sarpogrelate and its Active Metabolite (M-1) in Human Plasma, Using Liquid Chromatography-Tandem Mass Spectrometry: Clinical Application.
Annals of laboratory medicine.
2015 Jul; 35(4):391-8. doi:
10.3343/alm.2015.35.4.391. [PMID: 26131409] - Seung-Ah Lee, Jung-Won Suh, Jin Joo Park, Chang-Hwan Yoon, Young-Suk Cho, Tae-Jin Youn, In-Ho Chae, Hyo-Soo Kim, Sang-Hyun Kim, Dong-Ju Choi. Study design of the influence of SErotonin inhibition on patients with RENAl impairment or diabetes undergoing drug-eluting stent implantation (SERENADE) study: A multicenter, open-label, prospective, randomized study.
Contemporary clinical trials.
2015 Jul; 43(?):20-4. doi:
10.1016/j.cct.2015.04.005. [PMID: 25891091] - Doo-Yeoun Cho, Soo Hyeon Bae, Joeng Kee Lee, Jung Bae Park, Yang-Weon Kim, Sukhyang Lee, Euichaul Oh, Bom-Taeck Kim, Soo Kyung Bae. Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers.
Xenobiotica; the fate of foreign compounds in biological systems.
2015 Mar; 45(3):256-63. doi:
10.3109/00498254.2014.967824. [PMID: 25268386] - Jung Bae Park, Soo Kyung Bae, Soo Hyeon Bae, Euichaul Oh. Simultaneous determination of sarpogrelate and its active metabolite in human plasma by liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of separation science.
2015 Jan; 38(1):42-9. doi:
10.1002/jssc.201400884. [PMID: 25354353] - T-E Kim, J-R Kim, J A Jung, M-J Kim, S-Y Lee, J-W Ko, W-T Jung, Y-W Choi, H J Lee, S-H Kim, W Huh. Pharmacokinetics of a new once-daily controlled-release sarpogrelate hydrochloride compared with immediate-release formulation and the effect of food.
Journal of clinical pharmacy and therapeutics.
2014 Apr; 39(2):192-5. doi:
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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2014 Feb; 18(1):1-8. doi:
10.1111/1744-9987.12051. [PMID: 24499078] - Daiji Nagayama, Masahiro Ohira, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno. Sarpogrelate hydrochloride decreases cardio-ankle vascular index accompanied by increased serum lipoprotein lipase mass in type 2 diabetic patients.
International heart journal.
2014; 55(4):337-41. doi:
10.1536/ihj.13-377. [PMID: 24898600] - Yoshifumi Hamasaki, Kent Doi, Rui Maeda-Mamiya, Emi Ogasawara, Daisuke Katagiri, Tamami Tanaka, Tokunori Yamamoto, Takeshi Sugaya, Masaomi Nangaku, Eisei Noiri. A 5-hydroxytryptamine receptor antagonist, sarpogrelate, reduces renal tubulointerstitial fibrosis by suppressing PAI-1.
American journal of physiology. Renal physiology.
2013 Dec; 305(12):F1796-803. doi:
10.1152/ajprenal.00151.2013. [PMID: 24107419] - In-Hwan Baek, Byung-Yo Lee, Min-Soo Kim, Kwang-Il Kwon. Effect of food intake on the pharmacokinetics of sarpogrelate and its active metabolite following oral administration to beagle dogs.
Xenobiotica; the fate of foreign compounds in biological systems.
2013 Oct; 43(10):895-900. doi:
10.3109/00498254.2013.782078. [PMID: 23536972] - Tae-Eun Kim, Jung-Ryul Kim, Jin Ah Jung, Suk-Ran Kim, Jae Won Lee, Hun Jun, Soo-Youn Lee, Wooseong Huh, Jaewook Ko. Comparison of pharmacokinetics between sarpogrelate hydrochloride immediate-release formulation and controlled-release formulation.
International journal of clinical pharmacology and therapeutics.
2013 Feb; 51(2):114-9. doi:
10.5414/cp201777. [PMID: 23073143] - Sumi Hidaka, Shuzo Kobayashi, Masao Iwagami, Rei Isshiki, Daimu Tsutsumi, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Takayasu Ohtake. Sarpogrelate hydrochloride, a selective 5-HT(2A) receptor antagonist, improves skin perfusion pressure of the lower extremities in hemodialysis patients with peripheral arterial disease.
Renal failure.
2013; 35(1):43-8. doi:
10.3109/0886022x.2012.734758. [PMID: 23110683] - Yan-Jun Xu, Ming Zhang, Lei Ji, Vijayan Elimban, Li Chen, Naranjan S Dhalla. Suppression of high lipid diet induced by atherosclerosis sarpogrelate.
Journal of cellular and molecular medicine.
2012 Oct; 16(10):2394-400. doi:
10.1111/j.1582-4934.2012.01554.x. [PMID: 22348587] - Ichiro Kajiwara, Hirofumi Soejima, Shinzo Miyamoto, Hisao Ogawa. Effects of additional treatment of sarpogrelate to aspirin therapy on platelet aggregation and plasma plasminogen activator inhibitor activity in patients with stable effort angina.
Thrombosis research.
2011 Dec; 128(6):547-51. doi:
10.1016/j.thromres.2011.06.001. [PMID: 21722942] - Ramesh K Goyal, Vijayan Elimban, Yan-Jan Xu, Hideo Kumamoto, Nobuakira Takeda, Naranjan S Dhalla. Mechanism of sarpogrelate action in improving cardiac function in diabetes.
Journal of cardiovascular pharmacology and therapeutics.
2011 Sep; 16(3-4):380-7. doi:
10.1177/1074248410384708. [PMID: 21183729] - Kyungil Park, Woo-Young Chung, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim, Young-Bae Park. The prevention of contrast induced nephropathy by sarpogrelate in patients with chronic kidney disease: a study protocol for a prospective randomized controlled clinical trial.
Trials.
2010 Dec; 11(?):122. doi:
10.1186/1745-6215-11-122. [PMID: 21167080] - Chao Zhang, Lu Wang, Yan Yang, Yantong Sun, Jie Zhang, Guoqing Li, Jingkai Gu. Validated LC-MS/MS method for the determination of sarpogrelate in human plasma: application to a pharmacokinetic and bioequivalence study in Chinese volunteers.
Journal of pharmaceutical and biomedical analysis.
2010 Nov; 53(3):546-51. doi:
10.1016/j.jpba.2010.03.025. [PMID: 20399588] - Ramakrishna Nirogi, Vishwottam Kandikere, Koteshwara Mudigonda, Devender Ajjala, Ramakrishna Suraneni, Parthasarathi Thoddi. Liquid chromatography tandem mass spectrometry method for the quantification of sarpogrelate, a selective 5-HT(₂A) receptor antagonist, in plasma: application to a pre-clinical pharmacokinetic study.
Biomedical chromatography : BMC.
2010 Nov; 24(11):1159-67. doi:
10.1002/bmc.1422. [PMID: 20954206] - Tomoki Nishiyama. Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats.
European journal of pharmacology.
2009 Jul; 614(1-3):122-7. doi:
10.1016/j.ejphar.2009.03.041. [PMID: 19318092] - Shinya Kobayashi, Minoru Satoh, Tamehachi Namikoshi, Yoshisuke Haruna, Sohachi Fujimoto, Sayaka Arakawa, Norio Komai, Naruya Tomita, Tamaki Sasaki, Naoki Kashihara. Blockade of serotonin 2A receptor improves glomerular endothelial function in rats with streptozotocin-induced diabetic nephropathy.
Clinical and experimental nephrology.
2008 Apr; 12(2):119-125. doi:
10.1007/s10157-007-0011-8. [PMID: 18175064] - Susumu Ogawa, Takefumi Mori, Kazuhiro Nako, Tsuneo Ishizuka, Sadayoshi Ito. Reduced albuminuria with sarpogrelate is accompanied by a decrease in monocyte chemoattractant protein-1 levels in type 2 diabetes.
Clinical journal of the American Society of Nephrology : CJASN.
2008 Mar; 3(2):362-8. doi:
10.2215/cjn.03450807. [PMID: 18235151] - Katsunori Nonogaki, Kana Nozue, Yoshitomo Oka. Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice.
Biochemical and biophysical research communications.
2006 Dec; 351(4):1078-82. doi:
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Atherosclerosis.
2006 Jun; 186(2):275-81. doi:
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American journal of hematology.
2006 Feb; 81(2):121-3. doi:
10.1002/ajh.20511. [PMID: 16432874] - Shosaku Nomura, Akira Shouzu, Seitarou Omoto, Mitsushige Nishikawa, Toshiji Iwasaka. 5-HT2A receptor antagonist increases circulating adiponectin in patients with type 2 diabetes.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2005 Sep; 16(6):423-8. doi:
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Expert opinion on investigational drugs.
2004 Jul; 13(7):865-74. doi:
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The Journal of international medical research.
2004 Mar; 32(2):166-9. doi:
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Journal of cardiovascular pharmacology.
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Expert opinion on investigational drugs.
2003 May; 12(5):805-23. doi:
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Experimental eye research.
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Diabetes research and clinical practice.
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European journal of pharmacology.
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Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
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Journal of vascular research.
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The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi.
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The Journal of international medical research.
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The Journal of dermatology.
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European journal of pharmacology.
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Lung.
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Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
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Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
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General pharmacology.
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