Oxythiamine (BioDeep_00000645531)
代谢物信息卡片
Oxythiamine
化学式: C12H16N3O2S+ (266.0963176)
中文名称: 盐酸氧乙胺
谱图信息:
最多检出来源 Viridiplantae(plant) 27.18%
分子结构信息
SMILES: CC1=C(SC=[N+]1CC2=CN=C(NC2=O)C)CCO
InChI: InChI=1S/C12H15N3O2S/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17/h5,7,16H,3-4,6H2,1-2H3/p+1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
13 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(3)
- thiamine formation from pyrithiamine and oxythiamine (yeast):
A + H2O + pyrithiamine ⟶ 2-(2-methylpyridin-3-yl)ethanol + 4-amino-2-methyl-5-pyrimidinemethanol + A(H2) - thiamin formation from pyrithiamine and oxythiamine:
5-(2-hydroxyethyl)-4-methylthiazole + ATP ⟶ 4-methyl-5-(2-phosphooxyethyl)thiazole + ADP + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
H2O + oxythiamine ⟶ 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone + H+
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(9)
- thiamine formation from pyrithiamine and oxythiamine (yeast):
H2O + oxythiamine ⟶ 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
H2O + oxythiamine ⟶ 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
H2O + oxythiamine ⟶ 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
5-(2-hydroxyethyl)-4-methylthiazole + ATP ⟶ 4-methyl-5-(2-phosphooxyethyl)thiazole + ADP + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
H2O + oxythiamine ⟶ 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
H2O + oxythiamine ⟶ 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
5-(2-hydroxyethyl)-4-methylthiazole + ATP ⟶ 4-methyl-5-(2-phosphooxyethyl)thiazole + ADP + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
5-(2-hydroxyethyl)-4-methylthiazole + ATP ⟶ 4-methyl-5-(2-phosphooxyethyl)thiazole + ADP + H+ - thiamine formation from pyrithiamine and oxythiamine (yeast):
H2O + oxythiamine ⟶ 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone + H+
COVID-19 Disease Map(0)
PathBank(1)
- Vitamin B1/Thiamine Metabolism:
Adenosine triphosphate + Thiamine ⟶ Adenosine monophosphate + Hydrogen Ion + Thiamine pyrophosphate
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Or Golan, Roger Dyer, Graham Sinclair, Tom Blydt-Hansen. Investigating oxythiamine levels in children undergoing kidney transplantation and the risk of immediate post-operative metabolic and hemodynamic decompensation.
Pediatric nephrology (Berlin, Germany).
2021 04; 36(4):987-993. doi:
10.1007/s00467-020-04797-9. [PMID: 33067673] - Fang Zhang, Jinit Masania, Attia Anwar, Mingzhan Xue, Daniel Zehnder, Hemali Kanji, Naila Rabbani, Paul J Thornalley. The uremic toxin oxythiamine causes functional thiamine deficiency in end-stage renal disease by inhibiting transketolase activity.
Kidney international.
2016 08; 90(2):396-403. doi:
10.1016/j.kint.2016.03.010. [PMID: 27198804] - Hamid Moradi, Hamid M Said. Functional thiamine deficiency in end-stage renal disease: malnutrition despite ample nutrients.
Kidney international.
2016 08; 90(2):252-254. doi:
10.1016/j.kint.2016.04.017. [PMID: 27418090] - H Lu, W X Lan, L Bo, C Niu, J J Zhou, H L Zhu. Metabolic response of LLC xenografted mice to oxythiamine, as measured by [¹H] NMR spectroscopy.
Genetics and molecular research : GMR.
2015 Sep; 14(3):11043-51. doi:
10.4238/2015.september.21.17. [PMID: 26400334] - Aymeric Goyer, Ghulam Hasnain, Océane Frelin, Maria A Ralat, Jesse F Gregory, Andrew D Hanson. A cross-kingdom Nudix enzyme that pre-empts damage in thiamin metabolism.
The Biochemical journal.
2013 Sep; 454(3):533-42. doi:
10.1042/bj20130516. [PMID: 23834287] - Adam Tylicki, Magdalena Siemieniuk, Pawel Dobrzyn, Grazyna Ziolkowska, Magdalena Nowik, Urszula Czyzewska, Aleksandra Pyrkowska. Fatty acid profile and influence of oxythiamine on fatty acid content in Malassezia pachydermatis, Candida albicans and Saccharomyces cerevisiae.
Mycoses.
2012 May; 55(3):e106-13. doi:
10.1111/j.1439-0507.2011.02152.x. [PMID: 22066764] - Chih-Min Yang, Yi-Zih Liu, Jiunn-Wang Liao, Miao-Lin Hu. The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action.
Clinical & experimental metastasis.
2010 May; 27(5):341-9. doi:
10.1007/s10585-010-9331-2. [PMID: 20449639] - Jing Xiao, Wai-Nang Paul Lee, Yingchun Zhao, Rui Cao, Vay Liang W Go, Robert R Recker, Qi Wang, Gary Guishan Xiao. Profiling pancreatic cancer-secreted proteome using 15N amino acids and serum-free media.
Pancreas.
2010 Jan; 39(1):e17-23. doi:
10.1097/mpa.0b013e3181bc44dd. [PMID: 19904223] - Nandita Shangari, Rhea Mehta, Peter J O'brien. Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content.
Chemico-biological interactions.
2007 Jan; 165(2):146-54. doi:
10.1016/j.cbi.2006.11.009. [PMID: 17207784] - Veerle Foulon, Mieke Sniekers, Els Huysmans, Stanny Asselberghs, Vincent Mahieu, Guy P Mannaerts, Paul P Van Veldhoven, Minne Casteels. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids.
The Journal of biological chemistry.
2005 Mar; 280(11):9802-12. doi:
10.1074/jbc.m413362200. [PMID: 15644336] - G Rindi, C Patrini, A Nauti, R Bellazzi, P Magni. Three thiamine analogues differently alter thiamine transport and metabolism in nervous tissue: an in vivo kinetic study using rats.
Metabolic brain disease.
2003 Dec; 18(4):245-63. doi:
10.1023/b:mebr.0000020187.98238.58. [PMID: 15128183] - B Raïs, B Comin, J Puigjaner, J L Brandes, E Creppy, D Saboureau, R Ennamany, W N Lee, L G Boros, M Cascante. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle.
FEBS letters.
1999 Jul; 456(1):113-8. doi:
10.1016/s0014-5793(99)00924-2. [PMID: 10452541] - T N Pyzhik, I G Obrosova. [Effects of nicotinamide and oxythiamine on the lipogenic parameters of the adipose tissue of mice with non-insulin-dependent type of experimental diabetes mellitus and hyperinsulinemia].
Voprosy pitaniia.
1991 Mar; ?(2):49-51. doi:
". [PMID: 1830711] - M Okazaki, H Sakamoto, A Ohtsuki, K Oguchi. Changes in brain lipid composition in thiamine deficient rats.
Japanese journal of pharmacology.
1990 Oct; 54(2):171-8. doi:
10.1254/jjp.54.171. [PMID: 2077183] - L N Dvorianinovich. [Change in nucleic acid synthesis in the spleen of rats with acute deficit of vitamin B1 during immunogenesis].
Voprosy meditsinskoi khimii.
1989 May; 35(3):92-6. doi:
NULL. [PMID: 2475977] - L N Dvorianinovich. [Effect of acute vitamin B1 deficiency caused by oxythiamine on protein biosynthesis in the spleen during immunogenesis].
Voprosy meditsinskoi khimii.
1988 Jul; 34(4):71-4. doi:
NULL. [PMID: 3195135] - I G Obrosova, F S Larin, A S Efimov, N D Tron'ko, V L Tsyruk. [Hypolipidemic effect of the antivitamin B1 oxythiamine in diabetic mice (db/db)].
Voprosy meditsinskoi khimii.
1987 Nov; 33(6):47-51. doi:
NULL. [PMID: 3445544] - Y Ito, Y Niiya, M Otani, S Shima. Effect of thiamine on the excretion of subcutaneously injected lead in rats.
Toxicology letters.
1987 Aug; 37(3):221-8. doi:
10.1016/0378-4274(87)90135-4. [PMID: 3617095] - Z V Gorbach, S S Maglysh, L I Nefedov, Iu M Ostrovskiĭ. [Characteristics of intracellular metabolism of carbohydrates and amino acids in animals with thiamine deficiency].
Biokhimiia (Moscow, Russia).
1987 Jan; 52(1):42-52. doi:
NULL. [PMID: 3814653] - F S Larin, V U Buko, T I Zimatkina, D O Oparin, Iu M Ostrovskiĭ. [Effect of thiochrome capronate on lipid metabolism in rats].
Ukrainskii biokhimicheskii zhurnal (1978).
1986 Sep; 58(5):89-91. doi:
". [PMID: 3775890] - J Greenwood, O E Pratt. Comparison of the effects of some thiamine analogues upon thiamine transport across the blood-brain barrier of the rat.
The Journal of physiology.
1985 Dec; 369(?):79-91. doi:
10.1113/jphysiol.1985.sp015889. [PMID: 4093890] - V U Buko, F S Larin, Iu A Tarasov, V V Vinogradov. [Prostaglandins and 3',5'-AMP in rat tissues following administration of thiamine and its derivatives].
Ukrainskii biokhimicheskii zhurnal (1978).
1983 Jul; 55(4):453-6. doi:
NULL. [PMID: 6578633] - A V Naumov, L I Nefedov, Iu M Ostrovskiĭ. [Some features of [1-14C] leucine exchange in rat liver during acute oxythiamine avitaminosis].
Biokhimiia (Moscow, Russia).
1982 Feb; 47(2):233-9. doi:
NULL. [PMID: 6917766] - R Hobara, M Okazaki, H Yasuhara, K Sakamoto. [Effect of oxythiamine and pyrithiamine on thiamine levels in the blood, liver and urine of rats (author's transl)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1981 Dec; 78(6):529-38. doi:
10.1254/fpj.78.529. [PMID: 7333564] - V U Buko, F S Larin, V S Nikitin, Iu M Ostrovskiĭ. [Importance of insulin- and thiamine-dependent processes in regulating lipid metabolism in the rat liver].
Voprosy meditsinskoi khimii.
1981 Nov; 27(6):795-800. doi:
NULL. [PMID: 7039097] - M G Velichko, V G Petushok, Z V Gorbach, R V Trebukhina, Iu M Ostrovskiĭ. [Lactate level in the tissues of animals with a tumor administered oxythiamine and the properties of lactate dehydrogenase].
Voprosy meditsinskoi khimii.
1981 Sep; 27(5):594-600. doi:
NULL. [PMID: 7314573] - A N Sevost'ianov. [Effect of deficient and excess thiamine on the lipid makeup of the rat liver plasma membranes].
Voprosy meditsinskoi khimii.
1979 Sep; 25(5):520-4. doi:
NULL. [PMID: 494533] - Ostrovskiĭ KuM, A I Voskoboev, B I Gorenshtenĭn, G A Dosta. [Molecular-kinetic parameters of thiamine enzymes and the mechanism of antivitamin action of hydroxythiamine in animal organisms].
Biokhimiia (Moscow, Russia).
1979 Sep; 44(9):1551-7. doi:
NULL. [PMID: 228770] - A D Pletsityĭ. [Change in the activity of specific and nonspecific immunity mechanisms in vitamin B1 deficiency].
Biulleten' eksperimental'noi biologii i meditsiny.
1979 Jul; 88(7):60-2. doi:
NULL. [PMID: 465722] - E Oguchi, M Okazaki, H Yasuhara, K Sakamoto. [Effects of oxythiamine and pyrithiamine on rat liver. --Biochemical and morphological changes in the thiamine deficient rat (author's transl)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1979 May; 75(4):365-81. doi:
10.1254/fpj.75.365. [PMID: 535827] - V U Buko, F S Larin, A K Pavlenia, G A Dosta, Iu M Ostrovskiĭ. [Aspects of the biological activity of thiochrome].
Voprosy pitaniia.
1979 Jan; ?(1):22-6. doi:
". [PMID: 419723] - L I Nefedov, B P Fustochenko, Iu M Ostrovskiĭ. [Free amino acid concentration in the tissues of rats with different forms of thiamine deficiency].
Biokhimiia (Moscow, Russia).
1978 Oct; 43(10):1854-9. doi:
NULL. [PMID: 719055] - R J Oshinsky, Y M Wang, J V Eys. Xylitol infusion and oxalate formation in rabbits.
The Journal of nutrition.
1977 May; 107(5):792-804. doi:
10.1093/jn/107.5.792. [PMID: 870650] - V U Buko, F S Larin, A K Pavlenia. [Influence of oxythiamine on the fatty acid composition of rat liver total lipid fraction and phospholipids].
Voprosy pitaniia.
1977 Jan; ?(1):47-50. doi:
". [PMID: 883216] - P S Pron'ko, E A Gritsenko, Iu M Ostrovskiĭ. [Changes in the activity of alkaline phosphatase and the level of thiamine diphosphatase in simulations of B1 avitaminosis].
Voprosy pitaniia.
1975 May; ?(3):48-54. doi:
NULL. [PMID: 168690] - E SCHWARTZ, R W MANTHEI. ENHANCED METHYLGLYOXAL TOXICITY IN OXYTHIAMINE INDUCED THIAMINE DEFICIENCY IN MICE.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1964 Aug; 116(?):1089-91. doi:
10.3181/00379727-116-29460. [PMID: 14230353]