SGI-110 (BioDeep_00000645361)
代谢物信息卡片
化学式: C18H24N9O10P (557.1383694)
中文名称: 鸟地西他滨
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(OC1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OC4CC(OC4CO)N5C=NC(=NC5=O)N)O
InChI: InChI=1S/C18H24N9O10P/c19-16-22-6-27(18(31)25-16)12-2-8(9(3-28)35-12)37-38(32,33)34-4-10-7(29)1-11(36-10)26-5-21-13-14(26)23-17(20)24-15(13)30/h5-12,28-29H,1-4H2,(H,32,33)(H2,19,25,31)(H3,20,23,24,30)/t7-,8-,9+,10+,11+,12+/m0/s1
描述信息
C471 - Enzyme Inhibitor > C2083 - DNA Methyltransferase Inhibitor
C274 - Antineoplastic Agent > C132686 - Demethylating Agent
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D10877
- PubChem: 135564655
- DrugBank: DB11918
- ChEMBL: CHEMBL3544916
- CAS: 929901-49-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jonathan Wong, Emily Gruber, Belinda Maher, Mark Waltham, Zahra Sabouri-Thompson, Ian Jong, Quinton Luong, Sidney Levy, Beena Kumar, Daniella Brasacchio, Wendy Jia, Joan So, Hugh Skinner, Alexander Lewis, Simon J Hogg, Stephin Vervoort, Carmen DiCorleto, Micheleine Uhe, Jeanette Gamgee, Stephen Opat, Gareth P Gregory, Galina Polekhina, John Reynolds, Eliza A Hawkes, Gajan Kailainathan, Robin Gasiorowski, Lev M Kats, Jake Shortt. Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma.
Leukemia.
2022 06; 36(6):1654-1665. doi:
10.1038/s41375-022-01571-8. [PMID: 35459873] - Costantine Albany, Zeeshan Fazal, Ratnakar Singh, Emmanuel Bikorimana, Nabil Adra, Nasser H Hanna, Lawrence H Einhorn, Susan M Perkins, George E Sandusky, Brock C Christensen, Harold Keer, Fang Fang, Kenneth P Nephew, Michael J Spinella. A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer.
Cancer medicine.
2021 01; 10(1):156-163. doi:
10.1002/cam4.3583. [PMID: 33135391] - Jeroen Roosendaal, Hilde Rosing, Luc Lucas, Abadi Gebretensae, Alwin D R Huitema, Marloes G van Dongen, Jos H Beijnen, Aram Oganesian. Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer.
Investigational new drugs.
2020 08; 38(4):1085-1095. doi:
10.1007/s10637-019-00854-9. [PMID: 31605293] - Jeroen Roosendaal, Kai Wang, Hilde Rosing, Luc Lucas, Abadi Gebretensae, Aram Oganesian, Jan H M Schellens, Jos H Beijnen, Zhongping John Lin. Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Mar; 1109(?):132-141. doi:
10.1016/j.jchromb.2019.01.011. [PMID: 30754019] - Fang Fang, Joanne Munck, Jessica Tang, Pietro Taverna, Yinu Wang, David F B Miller, Jay Pilrose, Gavin Choy, Mohammad Azab, Katherine S Pawelczak, Pamela VanderVere-Carozza, Michael Wagner, John Lyons, Daniela Matei, John J Turchi, Kenneth P Nephew. The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014 Dec; 20(24):6504-16. doi:
10.1158/1078-0432.ccr-14-1553. [PMID: 25316809] - Carmen S Tellez, Marcie J Grimes, Maria A Picchi, Yushi Liu, Thomas H March, Matthew D Reed, Aram Oganesian, Pietro Taverna, Steven A Belinsky. SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.
International journal of cancer.
2014 Nov; 135(9):2223-31. doi:
10.1002/ijc.28865. [PMID: 24668305]