Kytril (BioDeep_00000645328)
代谢物信息卡片
Granisetron hydrochloride
化学式: C18H25ClN4O (348.171679)
中文名称: 盐酸格拉司琼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist > C94726 - 5-HT3 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:5538
- KEGGdrug: D00677
- PubChem: 6918003
- PubChem: 65264
- ChEMBL: CHEMBL1900758
- ChEMBL: CHEMBL1237080
- MeSH: Granisetron
- CAS: 107007-99-8
- CAS: 1044956-47-9
- medchemexpress: HY-B0071A
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Min Zeng, Junxiang Li, Tingting Zheng, Xi Yan, Feng Yuan, Bingbing Xiang. Electropress Needle Stimulation for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Prospective, Randomized Controlled Trial.
Obesity surgery.
2023 09; 33(9):2831-2840. doi:
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Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses.
2023 Feb; 38(1):39-44. doi:
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Clinical and translational science.
2021 09; 14(5):1906-1916. doi:
10.1111/cts.13045. [PMID: 33982438] - Ashkan Divanbeigi, Mohammad Nasehi, Salar Vaseghi, Sepideh Amiri, Mohammad-Reza Zarrindast. Tropisetron But Not Granisetron Ameliorates Spatial Memory Impairment Induced by Chronic Cerebral Hypoperfusion.
Neurochemical research.
2020 Nov; 45(11):2631-2640. doi:
10.1007/s11064-020-03110-2. [PMID: 32797381] - Mohammad Reza Zirak, Gholamreza Karimi, Reza Rahimian, Amir Hossein Jafarian, A Wallace Hayes, Soghra Mehri. Tropisetron ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats.
European journal of pharmacology.
2020 Sep; 883(?):173310. doi:
10.1016/j.ejphar.2020.173310. [PMID: 32619674] - Qinghua Wu, Kamil Kuca, Eugenie Nepovimova, Wenda Wu. Type A Trichothecene Diacetoxyscirpenol-Induced Emesis Corresponds to Secretion of Peptide YY and Serotonin in Mink.
Toxins.
2020 06; 12(6):. doi:
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The Journal of physiology.
2019 11; 597(21):5247-5264. doi:
10.1113/jp278751. [PMID: 31520534] - Mahmoud A Tantawy, Soheir Alweshahy, Dalia A Elshabasy, Nadia F Youssef. Simultaneous Determination of Co-administrated Deflazacort, Aprepitant and Granisetron in Dosage Forms and Spiked Human Plasma by RP-HPLC/PAD.
Journal of chromatographic science.
2019 Oct; 57(9):790-798. doi:
10.1093/chromsci/bmz062. [PMID: 31504281] - Y Yu, H Fan, Y Cheng, J L Sun. [Effect of intravenous granisetron combined and acupuncture point injection at PC6(Neiguan) with 0.9\% sodium chlorideon postoperative nausea and vomiting after gynecological laparoscopy].
Zhonghua yi xue za zhi.
2019 Sep; 99(33):2606-2610. doi:
10.3760/cma.j.issn.0376-2491.2019.33.010. [PMID: 31510721] - Shenhai Gong, Zhengzheng Yan, Zhanguo Liu, Mengwei Niu, Heng Fang, Na Li, Chenyang Huang, Lei Li, Guiming Chen, Haihua Luo, Xiaojiao Chen, Hongwei Zhou, Jingjuan Hu, Wei Yang, Qiaobing Huang, Bernd Schnabl, Ping Chang, Timothy R Billiar, Yong Jiang, Peng Chen. Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis-Induced Liver Injury by Granisetron Generation in Mice.
Hepatology (Baltimore, Md.).
2019 04; 69(4):1751-1767. doi:
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International journal of clinical pharmacology and therapeutics.
2019 Jan; 57(1):24-31. doi:
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The journal of medical investigation : JMI.
2019; 66(3.4):269-274. doi:
10.2152/jmi.66.269. [PMID: 31656287] - Rehab Abdelmonem, Mohamed El Nabarawi, Alshaimaa Attia. Development of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats.
Drug delivery.
2018 Nov; 25(1):70-77. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):50-58. doi:
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Clinical pharmacokinetics.
2018 06; 57(6):749-768. doi:
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Drug development and industrial pharmacy.
2018 May; 44(5):808-816. doi:
10.1080/03639045.2017.1414230. [PMID: 29216752] - Mihoko Morita, Shinji Kishi, Miyuki Ookura, Yasufumi Matsuda, Katsunori Tai, Takahiro Yamauchi, Takanori Ueda. Efficacy of aprepitant for CHOP chemotherapy-induced nausea, vomiting, and anorexia.
Current problems in cancer.
2017 Nov; 41(6):419-425. doi:
10.1016/j.currproblcancer.2017.09.001. [PMID: 29061362] - Sheila A Doggrell. Granisetron in the treatment of chemotherapy-induced nausea and vomiting (CINV) - is there still a role after comparison with palonosetron?.
Expert opinion on pharmacotherapy.
2017 Jul; 18(10):1019-1026. doi:
10.1080/14656566.2017.1342809. [PMID: 28612633] - Yasmin Moustafa Ahmed, Basim Anwar Shehata Messiha, Ali Ahmed Abo-Saif. Granisetron and carvedilol can protect experimental rats againstadjuvant-induced arthritis.
Immunopharmacology and immunotoxicology.
2017 Apr; 39(2):97-104. doi:
10.1080/08923973.2017.1286502. [PMID: 28211304] - Martha L Bustos, Yang Zhao, Huijun Chen, Steve N Caritis, Raman Venkataramanan. Polymorphisms in CYP1A1 and CYP3A5 Genes Contribute to the Variability in Granisetron Clearance and Exposure in Pregnant Women with Nausea and Vomiting.
Pharmacotherapy.
2016 12; 36(12):1238-1244. doi:
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BMC anesthesiology.
2016 10; 16(1):101. doi:
10.1186/s12871-016-0254-6. [PMID: 27765010] - Steve Caritis, Yang Zhao, Hui-Jun Chen, Raman Venkataramanan. Pharmacodynamics of transdermal granisetron in women with nausea and vomiting of pregnancy.
American journal of obstetrics and gynecology.
2016 07; 215(1):93.e1-4. doi:
10.1016/j.ajog.2016.01.163. [PMID: 26812081] - Qi Shi, Wen Li, Hongjia Li, Qiqi Le, Shanshan Liu, Shaoqi Zong, Leizhen Zheng, Fenggang Hou. Prevention of cisplatin-based chemotherapy-induced delayed nausea and vomiting using triple antiemetic regimens: a mixed treatment comparison.
Oncotarget.
2016 Apr; 7(17):24402-14. doi:
10.18632/oncotarget.8255. [PMID: 27015550] - Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, Virginia Merino, Yogeshvar N Kalia. Controlled transdermal iontophoresis for poly-pharmacotherapy: Simultaneous delivery of granisetron, metoclopramide and dexamethasone sodium phosphate in vitro and in vivo.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Mar; 85(?):31-8. doi:
10.1016/j.ejps.2016.01.027. [PMID: 26826281] - Yang Zhao, Hui-Jun Chen, Steve Caritis, Raman Venkataramanan. Development and validation of a sensitive liquid chromatographic-tandem mass spectrometric method for the simultaneous analysis of granisetron and 7-hydroxy granisetron in human plasma and urine samples: application in a clinical pharmacokinetic study in pregnant subject.
Biomedical chromatography : BMC.
2016 Feb; 30(2):149-54. doi:
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International journal of urology : official journal of the Japanese Urological Association.
2015 Oct; 22(10):911-4. doi:
10.1111/iju.12842. [PMID: 26087891] - Judith A Smith, Justin M Julius, Anjali Gaikwad, Pamela D Berens, Joseph Alcorn, Kenneth J Moise, Jerrie S Refuerzo. Evaluating the potential effect on fetal tissue after exposure to granisetron during pregnancy.
Reproductive toxicology (Elmsford, N.Y.).
2015 Jun; 53(?):92-8. doi:
10.1016/j.reprotox.2015.02.011. [PMID: 25813292] - Howida K Ibrahim, Nevine S Abdel Malak, Sally A Abdel Halim. Formulation of Convenient, Easily Scalable, and Efficient Granisetron HCl Intranasal Droppable Gels.
Molecular pharmaceutics.
2015 Jun; 12(6):2019-25. doi:
10.1021/mp500825n. [PMID: 25936630] - Anita Barzegar-Fallah, Houman Alimoradi, Firouzeh Asadi, Ahmad Reza Dehpour, Mojgan Asgari, Massoumeh Shafiei. Tropisetron ameliorates early diabetic nephropathy in streptozotocin-induced diabetic rats.
Clinical and experimental pharmacology & physiology.
2015 Apr; 42(4):361-8. doi:
10.1111/1440-1681.12373. [PMID: 25676798] - Hironori Nakamura, Haruko Yokoyama, Risa Takayanagi, Koichi Yoshimoto, Akihiro Nakajima, Kiyoshi Okuyama, Osamu Iwase, Yasuhiko Yamada. Theoretical evaluation of antiemetic effects of 5-HT3 receptor antagonists for prevention of vomiting induced by cisplatin.
European journal of drug metabolism and pharmacokinetics.
2015 Mar; 40(1):39-44. doi:
10.1007/s13318-014-0175-z. [PMID: 24470169] - Ying Zhou, Ji Jiang, Pei Hu, Hongyun Wang. A high-performance liquid chromatography-tandem mass spectrometry method coupled with protein precipitation for determination of granisetron in human plasma and its application to a comparative pharmacokinetic study.
Biomedical chromatography : BMC.
2014 Dec; 28(12):1597-600. doi:
10.1002/bmc.3233. [PMID: 24811001] - Justin M Julius, Andrew Tindall, Kenneth J Moise, Jerrie S Refuerzo, Pamela D Berens, Judith A Smith. Evaluation of the maternal-fetal transfer of granisetron in an ex vivo placenta perfusion model.
Reproductive toxicology (Elmsford, N.Y.).
2014 Nov; 49(?):43-7. doi:
10.1016/j.reprotox.2014.06.003. [PMID: 25019977] - Wenda Wu, Melissa A Bates, Steven J Bursian, Brenna Flannery, Hui-Ren Zhou, Jane E Link, Haibin Zhang, James J Pestka. Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin).
Toxicological sciences : an official journal of the Society of Toxicology.
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Colloids and surfaces. B, Biointerfaces.
2013 Jan; 101(?):475-80. doi:
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Biological & pharmaceutical bulletin.
2013; 36(5):780-7. doi:
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Anticancer research.
2012 Sep; 32(9):3939-47. doi:
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The Journal of pharmacology and experimental therapeutics.
2012 May; 341(2):350-9. doi:
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The Journal of pharmacology and experimental therapeutics.
2011 Oct; 339(1):125-31. doi:
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Cancer chemotherapy and pharmacology.
2011 Sep; 68(3):653-9. doi:
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Journal of chromatographic science.
2010 Sep; 48(8):654-62. doi:
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Regulatory peptides.
2010 Apr; 161(1-3):97-105. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2010 Mar; 39(5):387-93. doi:
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Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
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Bioanalysis.
2009 Jun; 1(3):537-48. doi:
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The Lancet. Oncology.
2009 Feb; 10(2):115-24. doi:
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Neuropharmacology.
2009 Jan; 56(1):285-91. doi:
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Cancer chemotherapy and pharmacology.
2008 Dec; 63(1):75-83. doi:
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The oncologist.
2007 Sep; 12(9):1151-5. doi:
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Pain.
2007 Aug; 130(3):235-248. doi:
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Indian journal of dermatology, venereology and leprology.
2007 Jul; 73(4):231-4. doi:
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Archives of pharmacal research.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Journal of pharmaceutical and biomedical analysis.
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Biomedical chromatography : BMC.
2006 Sep; 20(9):888-97. doi:
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Cancer journal (Sudbury, Mass.).
2006 Jan; 12(1):69-72. doi:
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The Journal of biological chemistry.
2005 May; 280(21):20476-82. doi:
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Pain.
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Clinical therapeutics.
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Journal of controlled release : official journal of the Controlled Release Society.
2003 Apr; 89(2):311-20. doi:
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