Met Kinase Inhibitor (BioDeep_00000644971)
代谢物信息卡片
化学式: C28H30ClN5O4S (567.170693)
中文名称: SU11274
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
InChI: InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Shouzhen Chen, Yong Wang, Lipeng Chen, Yangyang Xia, Jianfeng Cui, Wenfu Wang, Xuewen Jiang, Jian Wang, Yaofeng Zhu, Shuna Sun, Yongxin Zou, Yaoqin Gong, Benkang Shi. CUL4B promotes aggressive phenotypes of renal cell carcinoma via upregulating c-Met expression.
The international journal of biochemistry & cell biology.
2021 01; 130(?):105887. doi:
10.1016/j.biocel.2020.105887
. [PMID: 33227394] - Oxana V Serova, Alexander N Orsa, Natalia A Chachina, Alexander G Petrenko, Igor E Deyev. с-Met receptor can be activated by extracellular alkaline medium.
Journal of receptor and signal transduction research.
2019 Feb; 39(1):67-72. doi:
10.1080/10799893.2019.1620775
. [PMID: 31215287] - Zhihui Lu, Nana Song, Bo Shen, XiaLian Xu, Yi Fang, Yiqin Shi, Yichun Ning, Jiachang Hu, Yan Dai, Xiaoqiang Ding, Jianzhou Zou, Jie Teng. Syndecan-1 Shedding Inhibition to Protect Against Ischemic Acute Kidney Injury Through HGF Target Signaling Pathway.
Transplantation.
2018 07; 102(7):e331-e344. doi:
10.1097/tp.0000000000002170
. [PMID: 29557914] - Ze-Ping Hu, Xiao-Ling Fang, Hai-Yan Qian, Nan Fang, Bang-Ning Wang, Yuan Wang. Telmisartan prevents angiotensin II-induced endothelial dysfunction in rabbit aorta via activating HGF/Met system and PPARγ pathway.
Fundamental & clinical pharmacology.
2014 Oct; 28(5):501-11. doi:
10.1111/fcp.12057
. [PMID: 24188213] - Michele Moschetta, Antonio Basile, Arianna Ferrucci, Maria Antonia Frassanito, Luigia Rao, Roberto Ria, Antonio Giovanni Solimando, Nicola Giuliani, Angelina Boccarelli, Fabio Fumarola, Mauro Coluccia, Bernardo Rossini, Simona Ruggieri, Beatrice Nico, Eugenio Maiorano, Domenico Ribatti, Aldo M Roccaro, Angelo Vacca. Novel targeting of phospho-cMET overcomes drug resistance and induces antitumor activity in multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2013 Aug; 19(16):4371-82. doi:
10.1158/1078-0432.ccr-13-0039
. [PMID: 23804425] - G T Gibney, S A Aziz, R L Camp, P Conrad, B E Schwartz, C R Chen, W K Kelly, H M Kluger. c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology.
2013 Feb; 24(2):343-349. doi:
10.1093/annonc/mds463
. [PMID: 23022995] - Hong Im Kim, Huang Huang, Satish Cheepala, Shile Huang, Jun Chung. Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion.
Cancer prevention research (Philadelphia, Pa.).
2008 Oct; 1(5):385-91. doi:
10.1158/1940-6207.capr-08-0087
. [PMID: 19138983] - Steven F Bellon, Paula Kaplan-Lefko, Yajing Yang, Yihong Zhang, Jodi Moriguchi, Karen Rex, Carol W Johnson, Paul E Rose, Alexander M Long, Anne B O'Connor, Yan Gu, Angela Coxon, Tae-Seong Kim, Andrew Tasker, Teresa L Burgess, Isabelle Dussault. c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations.
The Journal of biological chemistry.
2008 Feb; 283(5):2675-83. doi:
10.1074/jbc.m705774200
. [PMID: 18055465] - Ramasamy Jagadeeswaran, Patrick C Ma, Tanguy Y Seiwert, Sujatha Jagadeeswaran, Osvaldo Zumba, Vidya Nallasura, Salman Ahmed, Rosangela Filiberti, Michela Paganuzzi, Riccardo Puntoni, Robert A Kratzke, Gavin J Gordon, David J Sugarbaker, Raphael Bueno, Varalakshmi Janamanchi, Vytas P Bindokas, Hedy L Kindler, Ravi Salgia. Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma.
Cancer research.
2006 Jan; 66(1):352-61. doi:
10.1158/0008-5472.can-04-4567
. [PMID: 16397249] - P Longati, P M Comoglio, A Bardelli. Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene.
Current drug targets.
2001 Mar; 2(1):41-55. doi:
10.2174/1389450013348920
. [PMID: 11465538]