propoxyphene hydrochloride (BioDeep_00000643456)

   


代谢物信息卡片


propoxyphene hydrochloride

化学式: C22H30ClNO2 (375.196495)
中文名称: 盐酸右丙氧芬
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=O)OC(CC1=CC=CC=C1)(C2=CC=CC=C2)C(C)CN(C)C.Cl
InChI: /m1./s1

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics

同义名列表

1 个代谢物同义名

propoxyphene hydrochloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Guillermo Alberto Keller, Cecilia Villa Etchegoyen, Nicolás Fernandez, Nancy Mónica Olivera, Patricia Noemí Quiroga, Roberto Alejandro Diez, Guillermo Di Girolamo. Dextrophropoxyphene effects on QTc-interval prolongation: Frequency and characteristics in relation to plasma levels. Journal of opioid management. 2018 Sep; 14(5):335-344. doi: 10.5055/jom.2018.0466. [PMID: 30387857]
  • Nicolás Fernández, Nancy Mónica Olivera, Guillermo Alberto Keller, Roberto Alberto Diez, Guillermo Di Girolamo, Patricia Noemí Quiroga. Simultaneous quantitation of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma using solid-phase extraction and gas chromatography/mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses. Rapid communications in mass spectrometry : RCM. 2017 Sep; 31(18):1519-1533. doi: 10.1002/rcm.7933. [PMID: 28686794]
  • James Price. A trend analysis of laboratory positive propoxyphene workplace urine drug screens before and after the product recall. Journal of addiction medicine. 2015 Mar; 9(2):136-8. doi: 10.1097/adm.0000000000000108. [PMID: 25622125]
  • Brandi Puet, Anne DePriest, Julie Knight, Rebecca Heltsley, David L Black, Yale H Caplan, Edward J Cone. Urine drug testing of chronic pain patients. V. Prevalence of propoxyphene following its withdrawal from the United States market. Journal of analytical toxicology. 2013 Jan; 37(1):1-4. doi: 10.1093/jat/bks083. [PMID: 23129731]
  • Yatan Pal Singh Balhara, Raka Jain. Urinalysis-based comparative evaluation of pattern of use of dextropropoxyphene and buprenorphine among opioid-dependent subjects. Journal of opioid management. 2012 Jan; 8(1):45-9. doi: . [PMID: 22479884]
  • Lysander Hin Chau, Dominic Chi Kin Tai, Berry Tat Chow Fung, James Cheuk Man Li, Chi Wai Fan, Michael Ka Wah Li. Medical expulsive therapy using alfuzosin for patient presenting with ureteral stone less than 10mm: a prospective randomized controlled trial. International journal of urology : official journal of the Japanese Urological Association. 2011 Jul; 18(7):510-4. doi: 10.1111/j.1442-2042.2011.02780.x. [PMID: 21592234]
  • Ophelia Q P Yin, Brian Tomlinson, Moses S S Chow. CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition. Journal of clinical pharmacology. 2010 Oct; 50(10):1136-41. doi: 10.1177/0091270009359006. [PMID: 20133509]
  • Pritsana Raungrut, Verawan Uchaipichat, David J Elliot, Benjamas Janchawee, Andrew A Somogyi, John O Miners. In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans. The Journal of pharmacology and experimental therapeutics. 2010 Aug; 334(2):609-18. doi: 10.1124/jpet.110.167916. [PMID: 20484152]
  • Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Amadeo Pesce. Unstable propoxyphene metabolite excreted in human urine is detected by liquid chromatography-tandem mass spectrometry. Journal of analytical toxicology. 2009 Sep; 33(7):379-83. doi: 10.1093/jat/33.7.379. [PMID: 19796508]
  • Gabriella Iohom, Hamza Abdalla, James O'Brien, Szilvia Szarvas, Vivienne Larney, Elisabeth Buckley, Mark Butler, George Declan Shorten. The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery. Anesthesia and analgesia. 2006 Oct; 103(4):995-1000. doi: 10.1213/01.ane.0000240415.49180.4a. [PMID: 17000819]
  • Pankaj Shah, Jarek Aniszweski, F John Service. Propoxyphene-induced hypoglycemia in renal failure. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2006 Mar; 12(2):170-3. doi: 10.4158/ep.12.2.170. [PMID: 16690465]
  • P J Hutchinson, A Gimson, P G Al-Rawi, M T O'Connell, M Czosnyka, D K Menon. Microdialysis in the management of hepatic encephalopathy. Neurocritical care. 2006; 5(3):202-5. doi: 10.1385/ncc:5:3:202. [PMID: 17290089]
  • R Afshari, S Maxwell, A Dawson, D N Bateman. ECG abnormalities in co-proxamol (paracetamol/dextropropoxyphene) poisoning. Clinical toxicology (Philadelphia, Pa.). 2005; 43(4):255-9. doi: . [PMID: 16035201]
  • Ophelia Q P Yin, Sherry S L Lam, Moses S S Chow. Simultaneous determination of paracetamol and dextropropoxyphene in human plasma by liquid chromatography/tandem mass spectrometry: application to clinical bioequivalence studies. Rapid communications in mass spectrometry : RCM. 2005; 19(6):767-74. doi: 10.1002/rcm.1850. [PMID: 15714600]
  • A A Somogyi, A Menelaou, S V Fullston. CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement. Xenobiotica; the fate of foreign compounds in biological systems. 2004 Oct; 34(10):875-87. doi: 10.1080/00498250400008371. [PMID: 15764408]
  • Alphonse Poklis, Justin L Poklis, Lisa D Tarnai, Ronald C Backer. Evaluation of the Triage PPY on-site testing device for the detection of dextropropoxyphene in urine. Journal of analytical toxicology. 2004 Sep; 28(6):485-8. doi: 10.1093/jat/28.6.485. [PMID: 15516300]
  • Raka Jain. Self-reported drug use and urinalysis results. Indian journal of physiology and pharmacology. 2004 Jan; 48(1):101-5. doi: NULL. [PMID: 15270376]
  • Hans-Ake Lakso, Ake Norström. Determination of dextropropoxyphene and nordextropropoxyphene in urine by liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Aug; 794(1):57-65. doi: 10.1016/s1570-0232(03)00397-0. [PMID: 12888198]
  • George R Bailie, Curtis A Johnson. Safety of propoxyphene in dialysis patients. Seminars in dialysis. 2002 Sep; 15(5):375. doi: 10.1046/j.1525-139x.2002.t01-1-00911.x. [PMID: 12358644]
  • K Fu, R J Konrad, R W Hardy, R M Brissie, C A Robinson. An unusual multiple drug intoxication case involving citalopram. Journal of analytical toxicology. 2000 Oct; 24(7):648-50. doi: 10.1093/jat/24.7.648. [PMID: 11043674]
  • S Schneider, R Wennig. Interference of diphenhydramine with the EMIT II immunoassay for propoxyphene. Journal of analytical toxicology. 1999 Nov; 23(7):637-8. doi: 10.1093/jat/23.7.637. [PMID: 10595854]
  • M A ElSohly, S J Salamone. Prevalence of drugs used in cases of alleged sexual assault. Journal of analytical toxicology. 1999 May; 23(3):141-6. doi: 10.1093/jat/23.3.141. [PMID: 10369321]
  • D Simpson, R A Braithwaite, D R Jarvie, M J Stewart, S Walker, I W Watson, B Widdop. Screening for drugs of abuse (II): Cannabinoids, lysergic acid diethylamide, buprenorphine, methadone, barbiturates, benzodiazepines and other drugs. Annals of clinical biochemistry. 1997 Sep; 34 ( Pt 5)(?):460-510. doi: 10.1177/000456329703400502. [PMID: 9293303]
  • J Pérez de los Cobos, J Trujols, E Ribalta, M Casas. Cocaine use immediately prior to entry in an inpatient heroin detoxification unit as a predictor of discharges against medical advice. The American journal of drug and alcohol abuse. 1997 May; 23(2):267-79. doi: 10.3109/00952999709040946. [PMID: 9143638]
  • F Mersch, M Yegles, R Wennig. Quantification of dextropropoxyphene and its metabolite by HPLC in hair of overdose cases. Forensic science international. 1997 Jan; 84(1-3):237-42. doi: 10.1016/s0379-0738(96)02067-1. [PMID: 9042729]
  • L Bergendal, A Friberg, A M Schaffrath, M Holmdahl, S Landahl. The clinical relevance of the interaction between carbamazepine and dextropropoxyphene in elderly patients in Gothenburg, Sweden. European journal of clinical pharmacology. 1997; 53(3-4):203-6. doi: 10.1007/s002280050363. [PMID: 9476032]
  • A J McNally, I Pilcher, R Wu, S J Salamone, S Brewington, J W King, J Irving. Evaluation of the online immunoassay for propoxyphene: comparison to EMIT II and GC-MS. Journal of analytical toxicology. 1996 Nov; 20(7):537-40. doi: 10.1093/jat/20.7.537. [PMID: 8934302]
  • G Amalfitano, J Bessard, F Vincent, H Eysseric, G Bessard. Gas chromatographic quantitation of dextropropoxyphene and norpropoxyphene in urine after solid-phase extraction. Journal of analytical toxicology. 1996 Nov; 20(7):547-54. doi: 10.1093/jat/20.7.547. [PMID: 8934304]
  • D J Pounder, E Adams, C Fuke, A M Langford. Site to site variability of postmortem drug concentrations in liver and lung. Journal of forensic sciences. 1996 Nov; 41(6):927-32. doi: NULL. [PMID: 8914282]
  • M Franke, C L Winek, H M Kingston. Extraction of selected drugs from serum using microwave irradiation. Forensic science international. 1996 Jul; 81(1):51-9. doi: 10.1016/0379-0738(96)01943-3. [PMID: 8784994]
  • A H Sarris, A Younes, P McLaughlin, D Moore, F Hagemeister, F Swan, M A Rodriguez, J Romaguera, L North, P Mansfield, D Callendar, O Mesina, F Cabanillas. Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin's lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1996 Jan; 14(1):233-9. doi: 10.1200/jco.1996.14.1.233. [PMID: 8558203]
  • G Sloop, M Hall, G T Simmons, C A Robinson. False-positive postmortem EMIT drugs-of-abuse assay due to lactate dehydrogenase and lactate in urine. Journal of analytical toxicology. 1995 Nov; 19(7):554-6. doi: 10.1093/jat/19.7.554. [PMID: 8577177]
  • N L Kerry, A A Somogyi, F Bochner, G Mikus. The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes. British journal of clinical pharmacology. 1994 Sep; 38(3):243-8. doi: 10.1111/j.1365-2125.1994.tb04348.x. [PMID: 7826826]
  • Y Horsmans, J P Desager, C Daenens, C Harvengt, A P Geubel. D-propoxyphene and norpropoxyphene kinetics after the oral administration of D-propoxyphene: a new approach to liver function?. Journal of hepatology. 1994 Sep; 21(3):283-91. doi: 10.1016/s0168-8278(05)80303-4. [PMID: 7836695]
  • J W King, L J King. Propoxyphene and norpropoxyphene quantitation in the same solid-phase extraction using Toxi-Lab Spec VC MP3 system. Journal of analytical toxicology. 1994 Jul; 18(4):217-9. doi: 10.1093/jat/18.4.217. [PMID: 7967543]
  • P Kintz, P Mangin. Abbott propoxyphene assay: evaluation and comparison of TDx FPIA and GC/MS methods. Journal of analytical toxicology. 1993 Jul; 17(4):222-4. doi: 10.1093/jat/17.4.222. [PMID: 8371551]
  • J Segura, J A Pascual, R Ventura, J I Ustaran, A Cuevas, R Gonzalez. International cooperation in analytical chemistry: experience of antidoping control at the XI Pan American Games. Clinical chemistry. 1993 May; 39(5):836-45. doi: NULL. [PMID: 8485874]
  • A Elman, B Debaene, C Magny-Metrot, G Murciano. Interpleural analgesia with bupivacaine following thoracotomy: ineffective results of a controlled study and pharmacokinetics. Journal of clinical anesthesia. 1993 Mar; 5(2):118-21. doi: 10.1016/0952-8180(93)90138-5. [PMID: 8476617]
  • K Sivaloganathan, P A Johnson, G P Bray, R Williams. Pericoronitis and accidental paracetamol overdose: a cautionary tale. British dental journal. 1993 Jan; 174(2):69-71. doi: 10.1038/sj.bdj.4808080. [PMID: 8422319]
  • D E Cox, D J Pounder. Evaluating suspected co-proxamol overdose. Forensic science international. 1992 Dec; 57(2):147-56. doi: 10.1016/0379-0738(92)90007-j. [PMID: 1473806]
  • K J Pettersson, L B Nilsson. Determination of dextropropoxyphene and norpropoxyphene in plasma by high-performance liquid chromatography. Journal of chromatography. 1992 Oct; 581(1):161-4. doi: 10.1016/0378-4347(92)80462-y. [PMID: 1430002]
  • A Sunshine, N Z Olson, I Zighelboim, A DeCastro, F L Minn. Analgesic oral efficacy of tramadol hydrochloride in postoperative pain. Clinical pharmacology and therapeutics. 1992 Jun; 51(6):740-6. doi: 10.1038/clpt.1992.86. [PMID: 1351804]
  • S Mützell. Computed tomography of the brain, hepatotoxic drugs and high alcohol consumption in male alcoholic patients and a random sample from the general male population. Upsala journal of medical sciences. 1992; 97(2):183-94. doi: 10.3109/03009739209179295. [PMID: 1361697]
  • P H Mogensen, L Jórgensen, J Boas, M Dam, A Vesterager, G Flesch, P K Jensen. Effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites. Acta neurologica Scandinavica. 1992 Jan; 85(1):14-7. doi: 10.1111/j.1600-0404.1992.tb03989.x. [PMID: 1546529]
  • D J Pounder, K Yonemitsu. Postmortem absorption of drugs and ethanol from aspirated vomitus--an experimental model. Forensic science international. 1991 Oct; 51(2):189-95. doi: 10.1016/0379-0738(91)90185-l. [PMID: 1765335]
  • C Girre, M Hirschhorn, L Bertaux, S Palombo, F Dellatolas, R Ngo, M Moreno, P E Fournier. Enhancement of propoxyphene bioavailability by ethanol. Relation to psychomotor and cognitive function in healthy volunteers. European journal of clinical pharmacology. 1991; 41(2):147-52. doi: 10.1007/bf00265908. [PMID: 1743247]
  • R A Klinger, L M Blum, F Rieders. Direct automated EMIT d.a.u. analysis of N,N-dimethylformamide-modified serum, plasma, and postmortem blood for amphetamines, barbiturates, methadone, methaqualone, phencyclidine, and propoxyphene. Journal of analytical toxicology. 1990 Sep; 14(5):288-91. doi: 10.1093/jat/14.5.288. [PMID: 2263063]
  • P Kintz, A Tracqui, P Mangin, A A Lugnier, A A Chaumont. Simultaneous determination of dextropropoxyphene, norpropoxyphene and methaqualone in plasma by gas chromatography with selective nitrogen detection. Journal de toxicologie clinique et experimentale. 1990 Mar; 10(2):89-94. doi: . [PMID: 2388178]
  • P Brodin, L A Skoglund. Dose-response inhibition of rat compound nerve action potential by dextropropoxyphene and codeine compared to morphine and cocaine in vitro. General pharmacology. 1990; 21(4):551-3. doi: 10.1016/0306-3623(90)90713-v. [PMID: 2379806]
  • R J Flanagan, A Johnston, A S White, P Crome. Pharmacokinetics of dextropropoxyphene and nordextropropoxyphene in young and elderly volunteers after single and multiple dextropropoxyphene dosage. British journal of clinical pharmacology. 1989 Oct; 28(4):463-9. doi: 10.1111/j.1365-2125.1989.tb03527.x. [PMID: 2590604]
  • K S Oles, W Mirza, J K Penry. Catastrophic neurologic signs due to drug interaction: Tegretol and Darvon. Surgical neurology. 1989 Aug; 32(2):144-51. doi: 10.1016/0090-3019(89)90203-6. [PMID: 2749458]
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  • T Lang-Jensen, B Thisted, T Krantz, M B Sørensen, E Jacobsen, H R Angelo. Cardiovascular function measured by ultrasound Doppler in healthy young men after ingestion of dextropropoxyphene napsylat. Pharmacology & toxicology. 1989 Feb; 64(2):228-32. doi: 10.1111/j.1600-0773.1989.tb00635.x. [PMID: 2569194]
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