N,N-Bis(2-chloroethyl)aniline (BioDeep_00000643159)
代谢物信息卡片
化学式: C10H13Cl2N (217.0424998)
中文名称: N,N-双(2-氯乙基)苯胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)N(CCCl)CCCl
InChI: InChI=1S/C10H13Cl2N/c11-6-8-13(9-7-12)10-4-2-1-3-5-10/h1-5H,6-9H2
描述信息
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chien-Han Chen, Tsung-Hao Hu, Tzu-Chiao Huang, Ying-Lan Chen, Yet-Ran Chen, Chien-Chung Cheng, Chao-Tsen Chen. Delineation of G-Quadruplex Alkylation Sites Mediated by 3,6-Bis(1-methyl-4-vinylpyridinium iodide)carbazole-Aniline Mustard Conjugates.
Chemistry (Weinheim an der Bergstrasse, Germany).
2015 Nov; 21(48):17379-90. doi:
10.1002/chem.201502595. [PMID: 26769627] - Naval Kapuriya, Kalpana Kapuriya, Xiuguo Zhang, Ting-Chao Chou, Rajesh Kakadiya, Yu-Tse Wu, Tung-Hu Tsai, Yu-Ting Chen, Te-Chang Lee, Anamik Shah, Yogesh Naliapara, Tsann-Long Su. Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.
Bioorganic & medicinal chemistry.
2008 May; 16(10):5413-23. doi:
10.1016/j.bmc.2008.04.024. [PMID: 18450456] - Tian-Lu Cheng, Kuang-Wen Liao, Shey-Cherng Tzou, Chiu-Min Cheng, Bing-Mae Chen, Steve R Roffler. Hapten-directed targeting to single-chain antibody receptors.
Cancer gene therapy.
2004 May; 11(5):380-8. doi:
10.1038/sj.cgt.7700712. [PMID: 15044963] - T L Cheng, B M Chen, J W Chern, M F Wu, S R Roffler. Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy.
Bioconjugate chemistry.
2000 Mar; 11(2):258-66. doi:
10.1021/bc990147j. [PMID: 10725103] - P Kestell, F B Pruijn, B G Siim, B D Palmer, W R Wilson. Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5.
Cancer chemotherapy and pharmacology.
2000; 46(5):365-74. doi:
10.1007/s002800000165. [PMID: 11127940] - T L Cheng, W C Chou, B M Chen, J W Chern, S R Roffler. Characterization of an antineoplastic glucuronide prodrug.
Biochemical pharmacology.
1999 Jul; 58(2):325-8. doi:
10.1016/s0006-2952(99)00072-6. [PMID: 10423174] - T L Cheng, P Y Wu, M F Wu, J W Chern, S R Roffler. Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgM.
Bioconjugate chemistry.
1999 May; 10(3):520-8. doi:
10.1021/bc980143z. [PMID: 10346886] - S Manfredini, D Simoni, R Ferroni, R Bazzanini, S Vertuani, S Hatse, J Balzarini, E De Clercq. Retinoic acid conjugates as potential antitumor agents: synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties.
Journal of medicinal chemistry.
1997 Nov; 40(23):3851-7. doi:
10.1021/jm9602322. [PMID: 9371251] - B M Chen, L Y Chan, S M Wang, M F Wu, J W Chern, S R Roffler. Cure of malignant ascites and generation of protective immunity by monoclonal antibody-targeted activation of a glucuronide prodrug in rats.
International journal of cancer.
1997 Nov; 73(3):392-402. doi:
10.1002/(sici)1097-0215(19971104)73:3<392::aid-ijc14>3.0.co;2-f. [PMID: 9359487] - T L Cheng, B M Chen, L Y Chan, P Y Wu, J W Chern, S R Roffler. Poly(ethylene glycol) modification of beta-glucuronidase-antibody conjugates for solid-tumor therapy by targeted activation of glucuronide prodrugs.
Cancer immunology, immunotherapy : CII.
1997 Aug; 44(6):305-15. doi:
10.1007/s002620050387. [PMID: 9298932] - C Benckhuysen, H G Ter Hart, P J Van Dijk. Enhanced cytostatic effectiveness of aniline mustard against 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors during regression in response to ovariectomy.
Cancer treatment reports.
1981 Jul; 65(7-8):567-74. doi:
. [PMID: 6788369] - L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate.
The Journal of urology.
1979 May; 121(5):630-4. doi:
10.1016/s0022-5347(17)56913-x. [PMID: 439260] - C W Young, A Yagoda, E S Bittar, S W Smith, H Grabstald, W Whitmore. Therapeutic trial of aniline mustard in patients with advanced cancer. Comparison of therapeutic response with cytochemical assessment of tumor cell beta-glucuronidase activity.
Cancer.
1976 Nov; 38(5):1887-95. doi:
10.1002/1097-0142(197611)38:5<1887::aid-cncr2820380504>3.0.co;2-#. [PMID: 991104] - G Baumann, A Chrambach. Quantitative removal of carrier ampholytes from protein fractions derived from isoelectric focusing.
Analytical biochemistry.
1975 Dec; 69(2):649-51. doi:
10.1016/0003-2697(75)90173-6. [PMID: 3125]