Sofosbuvir (BioDeep_00000642623)
代谢物信息卡片
Propan-2-yl 2-[[[5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
化学式: C22H29FN3O9P (529.1625366)
中文名称: 索非布韦, N-[[P(S),2R]-2-脱氧-2-氟-2-甲基-P-苯基-5-尿苷酰基]-D-丙氨酸异丙酯, 索菲布韦杂质27
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
InChI: InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)
描述信息
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AP - Antivirals for treatment of hcv infections
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C25995 - RNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM[1].
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:85083
- KEGGdrug: D10366
- PubChem: 45375808
- PubChem: 91302628
- DrugBank: DB08934
- ChEMBL: CHEMBL1259059
- ChEMBL: CHEMBL3186678
- MeSH: Sofosbuvir
- CAS: 1190307-88-0
- CAS: 1496552-16-9
- CAS: 1496552-28-3
- CAS: 1190308-01-0
- CAS: 1868135-06-1
- medchemexpress: HY-15005
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hala A Hafez, Ali M Atoom, Rana H M Khafaga, Sara A Shaker, Maher A Kamel, Nagwa M Assem, Shimaa A Mahmoud. Direct-Acting Antiviral Drug Modulates the Mitochondrial Biogenesis in Different Tissues of Young Female Rats.
International journal of molecular sciences.
2023 Oct; 24(21):. doi:
10.3390/ijms242115844. [PMID: 37958828] - Hala A Hafez, Shimaa A Mahmoud, Jehad F Alhmoud, Rana H M Khafaga, Maher A Kamel, Sara A Shaker. The Intergeneration Long-Lasting Consequences of Pre-Conceptional Exposure to Sofosbuvir on the Ovarian Tissues of F1 Offspring: Experimental Study on Rats.
International journal of molecular sciences.
2023 Sep; 24(18):. doi:
10.3390/ijms241813675. [PMID: 37761983] - Sadaf Yasmeen, Aslam Khan, Fareeha Anwar, Muhammad Furqan Akhtar, Sidra Yasmeen, Shafeeq Ali Shah. An insight into the hepatoprotective role of Velpatasvir and Sofosbuvir per se and in combination against carbon tetrachloride-induced hepatic fibrosis in rats.
Environmental science and pollution research international.
2023 Aug; ?(?):. doi:
10.1007/s11356-023-29134-z. [PMID: 37556059] - Kyung Min Kwon, Jae-Jun Shim, Gi-Ae Kim, Bo Ok Kim, Helin Han, Hyun Jung Ahn. Comorbidities and the use of comedications among patients with chronic hepatitis C in Korea: A nationwide cross-sectional study.
The Korean journal of internal medicine.
2023 05; 38(3):338-348. doi:
10.3904/kjim.2022.215. [PMID: 37032119] - Walaa S Elseady, Walaa A Keshk, Walaa A Negm, Walaa Elkhalawany, Hend Elhanafy, Marwa A A Ibrahim, Doaa A Radwan. Saffron extract attenuates Sofosbuvir-induced retinal neurodegeneration in albino rat.
Anatomical record (Hoboken, N.J. : 2007).
2023 Feb; 306(2):422-436. doi:
10.1002/ar.24942. [PMID: 35451203] - Jyh-Jou Chen, Yen-Cheng Chiu, Pei-Lun Lee, Hung-Da Tung, Hung-Chih Chiu, Shih-Chieh Chien, Pin-Nan Cheng. Real-world effectiveness and safety of sofosbuvir/velpatasvir and glecaprevir/pibrentasvir for genotype 6 chronic hepatitis C.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2022 Nov; 121(11):2265-2272. doi:
10.1016/j.jfma.2022.04.020. [PMID: 35581112] - Ghulam Rasool Mangrio, Apichit Maneengam, Zunera Khalid, Tassadaq Hussain Jafar, Ghulam Qadir Chanihoon, Rayan Nassani, Ahsanullah Unar. RP-HPLC Method Development, Validation, and Drug Repurposing of Sofosbuvir Pharmaceutical Dosage Form: A Multidimensional Study.
Environmental research.
2022 Sep; 212(Pt C):113282. doi:
10.1016/j.envres.2022.113282. [PMID: 35487258] - Abanoub K Wasef, Sara A Wahdan, Noha M Saeed, Ebtehal El-Demerdash. Effects of aged garlic and ginkgo biloba extracts on the pharmacokinetics of sofosbuvir in rats.
Biopharmaceutics & drug disposition.
2022 Aug; 43(4):152-162. doi:
10.1002/bdd.2326. [PMID: 35975782] - K S Abdelkawy, Fathalla Belal, AbdelazizE Abdelaziz, H A Elmekawy, M Y Abdelgaied, N M El-Khodary. Statins Increase the Bioavailability of Fixed-Dose Combination of Sofosbuvir/Ledipasvir by Inhibition of P-glycoprotein.
Drug research.
2022 Jul; 72(6):319-326. doi:
10.1055/a-1835-1690. [PMID: 35724670] - Ahmad Fariz Malvi Zamzam Zein, Catur Setiya Sulistiyana, Wilson Matthew Raffaello, Arief Wibowo, Raymond Pranata. Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessment.
Postgraduate medical journal.
2022 Jul; 98(1161):509-514. doi:
10.1136/postgradmedj-2021-140287. [PMID: 34103373] - Yi-Kai Wang, Ying-Wen Wang, Chia-Ling Lu, Yi-Hsiang Huang, Ming-Chih Hou, Yuh-Lih Chang, Wei-Ping Lee, Keng-Hsin Lan. Sofosbuvir-based direct-acting antivirals and changes in cholesterol and low density lipoprotein-cholesterol.
Scientific reports.
2022 06; 12(1):9942. doi:
10.1038/s41598-022-13657-5. [PMID: 35705594] - Fredrick Kateera, Fabienne Shumbusho, Linda Manirambona, Jules Kabihizi, Anthere Murangwa, Janvier Serumondo, Jean Damascene Makuza, Sabin Nsanzimana, Claude Mambo Muvunyi, Jean Damascene Kabakambira, Habarurema Sylvain, Gregory Camus, Philip M Grant, Neil Gupta. Safety and efficacy of sofosbuvir-velpatasvir to treat chronic hepatitis C virus infection in treatment-naive patients in Rwanda (SHARED-3): a single-arm trial.
The lancet. Gastroenterology & hepatology.
2022 06; 7(6):533-541. doi:
10.1016/s2468-1253(21)00398-8. [PMID: 35248213] - Sherif Ramzy, Ahmed H Abdelazim. Application of different spectrophotometric methods for quantitative analysis of direct acting antiviral drugs simeprevir and sofosbuvir.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 May; 272(?):121012. doi:
10.1016/j.saa.2022.121012. [PMID: 35158141] - Chung-Feng Huang, Kuo-Chih Tseng, Pin-Nan Cheng, Chao-Hung Hung, Ching-Chu Lo, Cheng-Yuan Peng, Ming-Jong Bair, Ming-Lun Yeh, Chien-Hung Chen, Pei-Lun Lee, Chun-Yen Lin, Hsing-Tao Kuo, Chun-Ting Chen, Chi-Chieh Yang, Jee-Fu Huang, Chi-Ming Tai, Jui-Ting Hu, Chih-Lang Lin, Wei-Wen Su, Wei-Lun Tsai, Yi-Hsiang Huang, Chien-Yu Cheng, Chih-Lin Lin, Chia-Chi Wang, Sheng-Shun Yang, Lein-Ray Mo, Guei-Ying Chen, Chun-Chao Chang, Szu-Jen Wang, Chia-Sheng Huang, Tsai-Yuan Hsieh, Chih-Wen Lin, Tzong-Hsi Lee, Lee-Won Chong, Chien-Wei Huang, Shiuh-Nan Chang, Ming-Chang Tsai, Shih-Jer Hsu, Jia-Horng Kao, Chun-Jen Liu, Chen-Hua Liu, Han-Chieh Lin, Mei-Hsuan Lee, Pei-Chien Tsai, Chia-Yen Dai, Wan-Long Chuang, Chi-Yi Chen, Ming-Lung Yu. Impact of Sofosbuvir-Based Direct-Acting Antivirals on Renal Function in Chronic Hepatitis C Patients With Impaired Renal Function: A Large Cohort Study From the Nationwide HCV Registry Program (TACR).
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2022 05; 20(5):1151-1162.e6. doi:
10.1016/j.cgh.2021.07.037. [PMID: 34333150] - Mark Sulkowski, Laura E Telep, Massimo Colombo, Francois Durand, K Rajender Reddy, Eric Lawitz, Marc Bourlière, Nelson Cheinquer, Stacey Scherbakovsky, Liyun Ni, Lindsey Force, Heribert Ramroth, Anuj Gaggar, Anand P Chokkalingam, Meghan E Sise. Sofosbuvir and risk of estimated glomerular filtration rate decline or end-stage renal disease in patients with renal impairment.
Alimentary pharmacology & therapeutics.
2022 05; 55(9):1169-1178. doi:
10.1111/apt.16830. [PMID: 35235245] - Vincenzo Messina, Riccardo Nevola, Antonio Izzi, Pellegrino De Lucia Sposito, Aldo Marrone, Roberto Rega, Raffaele Fusco, Paolina Lumino, Luca Rinaldi, Pasqualina Gaglione, Filomena Simeone, Ferdinando Carlo Sasso, Paolo Maggi, Luigi Elio Adinolfi. Efficacy and safety of the sofosbuvir/velpatasvir combination for the treatment of patients with early mild to moderate COVID-19.
Scientific reports.
2022 04; 12(1):5771. doi:
10.1038/s41598-022-09741-5. [PMID: 35388092] - Chia Siang Kow, Amaan Javed, Dinesh Ramachandram, Syed Shahzad Hasan. Clinical outcomes of sofosbuvir-based antivirals in patients with COVID-19: a systematic review and meta-analysis of randomized trials.
Expert review of anti-infective therapy.
2022 Apr; 20(4):567-575. doi:
10.1080/14787210.2022.2000861. [PMID: 34719324] - Hsin-Yun Sun, Chien-Yu Cheng, Chi-Ying Lin, Chia-Jui Yang, Nan-Yao Lee, Bo-Huang Liou, Hung-Jen Tang, Yuang-Meng Liu, Chun-Yuan Lee, Tun-Chieh Chen, Yi-Chia Huang, Yuan-Ti Lee, Ming-Jui Tsai, Po-Liang Lu, Hung-Chin Tsai, Ning-Chi Wang, Tung-Che Hung, Shu-Hsing Cheng, Chien-Ching Hung. Real-world effectiveness of direct-acting antivirals in people living with human immunodeficiency virus and hepatitis C virus genotype 6 infections.
World journal of gastroenterology.
2022 Mar; 28(11):1172-1183. doi:
10.3748/wjg.v28.i11.1172. [PMID: 35431505] - Kathleen M Ward, Oluwaseun Falade-Nwulia, Juhi Moon, Catherine G Sutcliffe, Sherilyn Brinkley, Taryn Haselhuhn, Stephanie Katz, Kayla Herne, Lilian Arteaga, Shruti H Mehta, Carl Latkin, Robert K Brooner, Mark S Sulkowski. Nonadherence to Ledipasvir/Sofosbuvir Did Not Predict Sustained Virologic Response in a Randomized Controlled Trial of Human Immunodeficiency Virus/Hepatitis C Virus Coinfected Persons Who Use Drugs.
The Journal of infectious diseases.
2022 03; 225(5):903-911. doi:
10.1093/infdis/jiab477. [PMID: 34543417] - Chi-Kuei Hsu, Ching-Yi Chen, Wang-Chun Chen, Chih-Cheng Lai, Shun-Hsing Hung, Wei-Ting Lin. Effect of sofosbuvir-based treatment on clinical outcomes of patients with COVID-19: a systematic review and meta-analysis of randomised controlled trials.
International journal of antimicrobial agents.
2022 Mar; 59(3):106545. doi:
10.1016/j.ijantimicag.2022.106545. [PMID: 35134505] - Mohamed Abdel-Salam Elgohary, Eman Medhat Hasan, Amany Ahmad Ibrahim, Mohamed Farouk Ahmed Abdelsalam, Raafat Zaher Abdel-Rahman, Ashraf Ibrahim Zaki, Mohamed Bakr Elaatar, Mohamed Thabet Elnagar, Mohamed Emam Emam, Mahmoud Moustafa Hamada, Taimour Mohamed Abdel-Hamid, Ahmad Samir Abdel-Hafez, Mohamed Gomaa Seadawy, Ahmad Rashad Fatoh, Mohamed Ali Elsaied, Marwa Abdel-Rahman Sakr, Ahmed Omar Elkady, Mohamed Muawad Shehata, Osama Mohamed Nawar, Mohamed Abu-Elnaga Selem, Mohamed Saeed Abd-Aal, Hany Hafez Lotfy, Tarek Refaat Elnagdy, Sherine Helmy, Magdy Amin Mubark. Efficacy of Sofosbuvir plus Ledipasvir in Egyptian patients with COVID-19 compared to standard treatment: a randomized controlled trial.
Journal of medicine and life.
2022 Mar; 15(3):350-358. doi:
10.25122/jml-2021-0175. [PMID: 35449996] - Hussein A AbdEl-Maksoud, Mohamed G Elharrif, Omnia Abd El-Hamid, Saad M Alsaab, Eman M El-Sorady. Monitoring of iron, lipid and liver profiles in Egyptian hepatitis C virus patients on sofosbuvir therapy.
Journal of infection and public health.
2022 Mar; 15(3):277-281. doi:
10.1016/j.jiph.2022.01.008. [PMID: 35077948] - Sara Mobarak, Mehdi Salasi, Ahmad Hormati, Javad Khodadadi, Masood Ziaee, Farshid Abedi, Azadeh Ebrahimzadeh, Zohreh Azarkar, Fariborz Mansour-Ghanaei, Farahnaz Joukar, Sara Yeganeh, Tofigh Yaghubi Kalurazi, Mohammadreza Naghipour, Zeinab Mehrabi, Amir Reza Bahadori, Shoeleh Yaghoubi, Rohollah Moslemi, Hamideh Abbaspour Kasgari, Hafez Fakheri, Minoo Moghimi, Amir Mohammad Shabani, Zahra Nekoukar, Farhang Babamahmoodi, Ali Reza Davoudi Badabi, Lotfollah Davoodi, Mehdi Hassaniazad, Elham Barahimi, Abdolali Tousi, Anahita Sadeghi, Hadiseh Hosamirudsari, Ali Ali Asgari, Mohammad Abdollahi, Amir Anushiravani, Minoosh Shabani, Shervin Shokouhi, Nasim Khajavirad, Mohammadreza Salehi, Seyed Ali Dehghan Manshadi, Hashem Mousavi, Farnaz Zolfaghari, Elmira Azimi, Aida Zeinali, Elham Akbarpour, Dorsa Merat, Gholamali Eslami, Sajedeh Mousaviasl, Sara Sayar, Esmat Radmanesh, Mona Ebrahimzadeh, Zahra Arizavi, Saeed Jelvay, Shokrollah Salmanzadeh, Hani Esmaeilian, Morteza Mobarak, Jalal Karimi, Zahra Poormontaseri, Nasrollah Hasooni Bahrini, Atefeh Bonyadi, Fatemeh Dehghani, Hadi Mirzaei, Masoome Noori Jangi, Hossein Pourmasoomi, Lili Rezaie Keikhaie, Mahdi Afshari, Alireza Nateghi Baygi, Helia Nateghi Baygi, Jacob Levi, Kaitlyn McCann, Hannah Wentzel, Bryony Simmons, Andrew Hill, Shahin Merat. Evaluation of the effect of sofosbuvir and daclatasvir in hospitalized COVID-19 patients: a randomized double-blind clinical trial (DISCOVER).
The Journal of antimicrobial chemotherapy.
2022 02; 77(3):758-766. doi:
10.1093/jac/dkab433. [PMID: 34849957] - Hanan I El-Shorbagy, Fathalla Belal. Innovative derivative/zero ratio spectrophotometric method for simultaneous determination of sofosbuvir and ledipasvir: Application to average content and uniformity of dosage units.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Feb; 267(Pt 2):120623. doi:
10.1016/j.saa.2021.120623. [PMID: 34810100] - Cheng-Kun Wu, Li-Wei Chen, Te-Sheng Chang, Shui-Yi Tung, Chun-Yen Lin, Chao-Hung Hung, Sheng-Nan Lu, Chih-Lang Lin, Chien-Hung Chen, Chao-Wei Hsu, Tsung-Hui Hu, I-Shyan Sheen. The Novel Finding of Dynamic Change in eGFR Up to One Year after End of Treatment in HCV-Infected Patients Receiving Sofosbuvir and Velpatasvir.
Viruses.
2022 02; 14(2):. doi:
10.3390/v14020362. [PMID: 35215955] - Mahmoud El-Bendary, Sherief Abd-Elsalam, Tamer Elbaz, Wafaa El-Akel, Ahmed Cordie, Tamer Elhadidy, Hatem Elalfy, Khaled Farid, Mohamed Elegezy, Adel El-Badrawy, Mustafa Neamatallah, Mohamed Abd Elghafar, Marwa Salama, Mohamed AbdAllah, Mahmoud Essam, Mostafa El-Shazly, Gamal Esmat. Efficacy of combined Sofosbuvir and Daclatasvir in the treatment of COVID-19 patients with pneumonia: a multicenter Egyptian study.
Expert review of anti-infective therapy.
2022 02; 20(2):291-295. doi:
10.1080/14787210.2021.1950532. [PMID: 34225541] - Abdo A Elfiky, Eman B Azzam, Medhat W Shafaa. The anti-HCV, Sofosbuvir, versus the anti-EBOV Remdesivir against SARS-CoV-2 RNA dependent RNA polymerase in silico.
Molecular diversity.
2022 Feb; 26(1):171-181. doi:
10.1007/s11030-020-10178-z. [PMID: 33389441] - Chen-Hua Liu, Chi-Yi Chen, Wei-Wen Su, Kuo-Chih Tseng, Ching-Chu Lo, Chun-Jen Liu, Jyh-Jou Chen, Cheng-Yuan Peng, Yu-Lueng Shih, Sheng-Shun Yang, Chia-Sheng Huang, Ke-Jhang Huang, Chi-Yang Chang, Ming-Chang Tsai, Wei-Yu Kao, Yo-Jen Fang, Po-Yueh Chen, Pei-Yuan Su, Chih-Wei Tseng, Jow-Jyh Huang, Pei-Lun Lee, Hsueh-Chou Lai, Tsai-Yuan Hsieh, Chung-Hsin Chang, Yi-Jie Huang, Fu-Jen Lee, Chun-Chao Chang, Jia-Horng Kao. Sofosbuvir/velpatasvir with or without low-dose ribavirin for patients with chronic hepatitis C virus infection and severe renal impairment.
Gut.
2022 01; 71(1):176-184. doi:
10.1136/gutjnl-2020-323569. [PMID: 33408122] - Israel Silva Maia, Aline Marcadenti, Fernando Godinho Zampieri, Lucas Petri Damiani, Renato Hideo Nakagawa Santos, Karina Leal Negrelli, Samara Pinheiro do Carmo Gomes, Jaqueline Oliveira Gomes, Mariana Barbosa Dos Santos Carollo, Tamiris Abait Miranda, Eliana Santucci, Nanci Valeis, Ligia Nasi Laranjeira, Glauco Adrieno Westphal, Jacques Gabriel Alvares Horta, Uri Adrian Prync Flato, Camilo Fernandes, Waldemar Carlos Barros, Renata S Bolan, Otávio Celso Eluf Gebara, Meton Soares de Alencar Filho, Victor Augusto Hamamoto, Mauro Esteves Hernandes, Nicole Alberti Golin, Ronald Torres de Olinda, Flávia Ribeiro Machado, Régis Goulart Rosa, Viviane Cordeiro Veiga, Luciano César Pontes de Azevedo, Alvaro Avezum, Renato Delascio Lopes, Tiago Moreno L Souza, Otávio Berwanger, Alexandre Biasi Cavalcanti. Antivirals for adult patients hospitalized with SARS-CoV-2 infection: A randomized, Phase II/III, multicenter, placebo-controlled, adaptive study, with multiple arms and stages. COALITION COVID-19 BRAZIL IX - REVOLUTIOn: protocol and statistical analysis plan.
Revista Brasileira de terapia intensiva.
2022 Jan; 34(1):44-55. doi:
10.5935/0103-507x.20220002-pt. [PMID: 35766657] - Muhammed Abdel-Hamied Abdel-Tawab, Muhammad G Abd El-Moghny, Rasha Mohamed El Nashar. Recent advances in the chromatographic determination of the most commonly used anti-hepatitis C drug sofosbuvir and its co-administered drugs in human plasma.
Biomedical chromatography : BMC.
2022 Jan; 36(1):e5238. doi:
10.1002/bmc.5238. [PMID: 34469609] - Jinyu Liu, Min Guo, Lei Ke, Ruxu You. Cost-Effectiveness of Elbasvir/Grazoprevir for the Treatment of Chronic Hepatitis C: A Systematic Review.
Frontiers in public health.
2022; 10(?):836986. doi:
10.3389/fpubh.2022.836986. [PMID: 35646774] - Arka De, Akash Roy, Nipun Verma, Saurabh Mishra, Madhumita Premkumar, Sunil Taneja, Virendra Singh, Ajay Duseja. Sofosbuvir plus velpatasvir combination for the treatment of chronic hepatitis C in patients with end stage renal disease on renal replacement therapy: A systematic review and meta-analysis.
Nephrology (Carlton, Vic.).
2022 Jan; 27(1):82-89. doi:
10.1111/nep.13968. [PMID: 34453374] - Ilaria Mastrorosa, Massimo Tempestilli, Stefania Notari, Patrizia Lorenzini, Gabriele Fabbri, Elisabetta Grilli, Rita Bellagamba, Alessandra Vergori, Stefania Cicalini, Adriana Ammassari, Chiara Agrati, Andrea Antinori. Association of Sofosbuvir and Daclatasvir Plasma Trough Concentrations with Patient-, Treatment-, and Disease-Related Factors Among HIV/HCV-Coinfected Persons.
European journal of drug metabolism and pharmacokinetics.
2022 Jan; 47(1):135-142. doi:
10.1007/s13318-021-00725-w. [PMID: 34623616] - Mahmoud Abdo, Ahmed Rabiee, Zeinab Abdellatif, Shereen Abdel Alem, Ahmed Moustafa. Impact of sustained virological response on metabolic disorders in diabetic chronic hepatitis C virus patients after treatment with generic sofosbuvir and daclatasvir.
European journal of gastroenterology & hepatology.
2021 12; 33(12):1588-1594. doi:
10.1097/meg.0000000000001903. [PMID: 32804853] - Sherif Abbass, Ehab Kamal, Mohsen Salama, Tary Salman, Alyaa Sabry, Wael Abdel-Razek, Sherine Helmy, Ahmed Abdelgwad, Neamt Sakr, Mohamed Elgazzar, Mohamed Einar, Mahmoud Farouk, Mounir Saif, Ismail Shehab, Eman El-Hosieny, Mai Mansour, Doaa Mahdi, El-Sayed Tharwa, Mostafa Salah, Ola Elrouby, Imam Waked. Efficacy and safety of sofosbuvir plus daclatasvir or ravidasvir in patients with COVID-19: A randomized controlled trial.
Journal of medical virology.
2021 12; 93(12):6750-6759. doi:
10.1002/jmv.27264. [PMID: 34379337] - Q Xu, W Zhang, Y X Ma, C N He, L T Zhang, Yilihamu Abulitifu, Y Li, N Wang, H L Wang, Y Y Zhao, X Gao, P G Gao, X Y Su, S Li, Y Y Liu, F Guo, Z Q Chen, H L Liu, X Q Gao, J J Fu, G Y Yu, X Z Wang, J P Wang, Y P Zhang, F P Ji. [Twelve-week of sofosbuvir/velpatasvir therapeutic regimen for chronic hepatitis C patients in northwest region of China: a real-world multicenter clinical study].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2021 Nov; 29(11):1046-1052. doi:
10.3760/cma.j.cn501113-20201010-00548. [PMID: 34933421] - Toshifumi Tada, Masayuki Kurosaki, Shinichiro Nakamura, Chitomi Hasebe, Yuji Kojima, Koichiro Furuta, Haruhiko Kobashi, Hiroyuki Kimura, Chikara Ogawa, Hitoshi Yagisawa, Yasushi Uchida, Kouji Joko, Takehiro Akahane, Hirotaka Arai, Hiroyuki Marusawa, Ryoichi Narita, Yasushi Ide, Takashi Sato, Atsunori Kusakabe, Keiji Tsuji, Nami Mori, Masahiko Kondo, Akeri Mitsuda, Namiki Izumi. Real-world clinical outcomes of sofosbuvir and velpatasvir treatment in HCV genotype 1- and 2-infected patients with decompensated cirrhosis: A nationwide multicenter study by the Japanese Red Cross Liver Study Group.
Journal of medical virology.
2021 11; 93(11):6247-6256. doi:
10.1002/jmv.27157. [PMID: 34170517] - Fabrizio Fabrizi, Cristina Alonso, Ana Palazzo, Margarita Anders, Maria Virginia Reggiardo, Hugo Cheinquer, Maria Grazia Videla Zuain, Sebastian Figueroa, Manuel Mendizabal, Marcelo Silva, Ezequiel Ridruejo. 'Real-life' experience with direct-acting antiviral agents for HCV after kidney transplant.
Annals of hepatology.
2021 Nov; 25(?):100337. doi:
10.1016/j.aohep.2021.100337. [PMID: 33684523] - Gaurav Gupta, Idris Yakubu, Yiran Zhang, Pamela Kimball, Le Kang, Kimberly Mitchell, Stephen Ijioma, Norman Carroll, Julie Patterson, Meagan Shinbashi, Dhiren Kumar, Irfan Moinuddin, Layla Kamal, Anne King, Chandra Bhati, Marlon Levy, Adrian Cotterell, Aamir Khan, Amit Sharma, Richard Sterling. Outcomes of short-duration antiviral prophylaxis for hepatitis C positive donor kidney transplants.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2021 11; 21(11):3734-3742. doi:
10.1111/ajt.16747. [PMID: 34212479] - Sonia Younas, Hamid Mukhtar, Umar Farooq Gohar, Abdullah Alsrhani, Badr Alzahrani, Kashaf Junaid, Muhammad Usman Qamar, Hasan Ejaz. Diagnostic approach to elucidate the efficacy and side effects of direct-acting antivirals in HCV infected patients.
Journal of infection in developing countries.
2021 10; 15(10):1489-1496. doi:
10.3855/jidc.12912. [PMID: 34780372] - Chih-Cheng Lai, Chien-Ming Chao, Po-Ren Hsueh. Clinical efficacy of antiviral agents against coronavirus disease 2019: A systematic review of randomized controlled trials.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2021 Oct; 54(5):767-775. doi:
10.1016/j.jmii.2021.05.011. [PMID: 34253490] - Chen-Hua Liu, Chi-Yi Chen, Wei-Wen Su, Chun-Jen Liu, Ching-Chu Lo, Ke-Jhang Huang, Jyh-Jou Chen, Kuo-Chih Tseng, Chi-Yang Chang, Cheng-Yuan Peng, Yu-Lueng Shih, Chia-Sheng Huang, Wei-Yu Kao, Sheng-Shun Yang, Ming-Chang Tsai, Jo-Hsuan Wu, Po-Yueh Chen, Pei-Yuan Su, Jow-Jyh Hwang, Yu-Jen Fang, Pei-Lun Lee, Chi-Wei Tseng, Fu-Jen Lee, Hsueh-Chou Lai, Tsai-Yuan Hsieh, Chun-Chao Chang, Chung-Hsin Chang, Yi-Jie Huang, Jia-Horng Kao. Sofosbuvir/velpatasvir plus ribavirin for Child-Pugh B and Child-Pugh C hepatitis C virus-related cirrhosis.
Clinical and molecular hepatology.
2021 10; 27(4):575-588. doi:
10.3350/cmh.2021.0155. [PMID: 34255961] - Chung-Feng Huang, Yu-Ju Wei, Yu-Tse Wu, Yi-Wen Chiu, Ming-Lung Yu. Real-world experience of serial serum levels of GS-331007 in chronic hepatitis C hemodialysis patients during and after sofosbuvir/velpatasvir therapy.
Journal of hepatology.
2021 10; 75(4):1006-1007. doi:
10.1016/j.jhep.2021.05.016. [PMID: 34051333] - Yun-Sook Lim, Lap P Nguyen, Gun-Hee Lee, Sung-Geun Lee, Kwang-Soo Lyoo, Bumseok Kim, Soon B Hwang. Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation.
Molecules and cells.
2021 Sep; 44(9):688-695. doi:
10.14348/molcells.2021.0076. [PMID: 34518443] - Amit Goel, Dharmendra S Bhadauria, Anupma Kaul, Abhai Verma, Prachi Tiwari, Sumit Rungta, Praveer Rai, Amit Gupta, Rakesh Aggarwal. Acute hepatitis C treatment in advanced renal failure using 8 weeks of pan-genotypic daclatasvir and reduced-dose sofosbuvir.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 09; 36(10):1867-1871. doi:
10.1093/ndt/gfaa187. [PMID: 33097949] - Ying-Wen Wang, Wei-Ping Lee, Yi-Hsiang Huang, Ming-Chih Hou, Keng-Hsin Lan. Effect of sofosbuvir-based DAAs on changes in lower-density lipoprotein in HCV patients: a systematic review and meta-analysis.
BMC infectious diseases.
2021 Sep; 21(1):984. doi:
10.1186/s12879-021-06657-9. [PMID: 34548026] - Abolghasem Jouyban, Mir Ali Farajzadeh, Fariba Khodadadeian, Maryam Khoubnasabjafari, Mohammad Reza Afshar Mogaddam. Development of a deep eutectic solvent-based ultrasound-assisted homogenous liquid-liquid microextraction method for simultaneous extraction of daclatasvir and sofosbuvir from urine samples.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 204(?):114254. doi:
10.1016/j.jpba.2021.114254. [PMID: 34256327] - Ruoyang Chen, Dawei Li, Ming Zhang, Xiaodong Yuan. Sofosbuvir/Velpatasvir Prophylaxis for 12 Weeks in Hepatitis C Virus (HCV)-Negative Recipients Receiving Kidney Transplantation from HCV-Positive Donors.
Annals of transplantation.
2021 Sep; 26(?):e933313. doi:
10.12659/aot.933313. [PMID: 34489392] - H A Elmekawy, F Belal, A E Abdelaziz, K S Abdelkawy, A A Ali, F Elbarbry. Pharmacokinetic interaction between atorvastatin and fixed-dose combination of sofosbuvir/ledipasvir in healthy male Egyptian volunteers.
European journal of clinical pharmacology.
2021 Sep; 77(9):1369-1379. doi:
10.1007/s00228-021-03130-z. [PMID: 33791829] - Fei Kong, Xiaoyu Wen, Xiaofeng Wen, Xiaozhong Wang, Guicheng Wu, Shide Lin, Li Wang, Huichun Xing, Xuebing Yan, Sujun Zheng, Qin Ning, Zheng Wang, Liaoyun Zhang, Jianmei Lin, Zhaowei Tong, Chengyu Huang, Minghua Su, Lixin Tong, Jidong Jia, Yongning Xin, Qingjing Zhu, Jing Wang, Li Chen, Xiaowen Li, Xuegang Wu, Duan Niu, Quan Liu, Wei Wei, Yuexin Zhang, Guangming Li, Junqi Niu. Seraprevir and sofosbuvir for treatment of chronic hepatitis C virus infection: A single-arm, open-label, phase 3 trial.
Journal of gastroenterology and hepatology.
2021 Sep; 36(9):2375-2382. doi:
10.1111/jgh.15412. [PMID: 33491236] - Wan-Long Chuang, Tsung-Hui Hu, Peter Buggisch, Christophe Moreno, Wei-Wen Su, Luigi Biancone, Marianne Camargo, Robert Hyland, Sophia Lu, Brian J Kirby, Hadas Dvory-Sobol, Anu Osinusi, Anuj Gaggar, Cheng-Yuan Peng, Chen-Hua Liu, Meghan E Sise, Alessandra Mangia. Ledipasvir/Sofosbuvir for 8, 12, or 24 Weeks in Hepatitis C Patients Undergoing Dialysis for End-Stage Renal Disease.
The American journal of gastroenterology.
2021 09; 116(9):1924-1928. doi:
10.14309/ajg.0000000000001281. [PMID: 34465694] - Babak Sayad, Reza Khodarahmi, Farid Najafi, Ronak Miladi, Zeinab Mohseni Afshar, Feizollah Mansouri, Zohreh Rahimi, Maria Shirvani, Mehdi Salimi, Siavash Vaziri, Alireza Janbakhsh, Fatemeh Khosravi Shadmani, Arezoo Bozorgomid, Mohammad Hossein Zamanian, Mandana Afsharian. Efficacy and safety of sofosbuvir/velpatasvir versus the standard of care in adults hospitalized with COVID-19: a single-centre, randomized controlled trial.
The Journal of antimicrobial chemotherapy.
2021 07; 76(8):2158-2167. doi:
10.1093/jac/dkab152. [PMID: 34037760] - Nazim Hussain, Nimrah Farooq, Muhammad Maqsood, Muhammad Shahid Riaz Rajoka, Muhammad Bilal. Expression profiling of miRNA-196a biomarker in naïve hepatitis C virus-infected and Sofosbuvir plus Daclatasvir-treated patients.
Archives of microbiology.
2021 Jul; 203(5):2365-2371. doi:
10.1007/s00203-021-02233-6. [PMID: 33660021] - Amany F Mohamed, Amany M Abo-Ouf, Mona A A Arafa. Histological and biochemical studies on effect of Sofosbuvir (Sovaldi) on adult male albino rat kidney.
Ultrastructural pathology.
2021 Jul; 45(4-5):286-296. doi:
10.1080/01913123.2021.1966148. [PMID: 34392788] - Carolina Q Sacramento, Natalia Fintelman-Rodrigues, Jairo R Temerozo, Aline de Paula Dias Da Silva, Suelen da Silva Gomes Dias, Carine Dos Santos da Silva, André C Ferreira, Mayara Mattos, Camila R R Pão, Caroline S de Freitas, Vinicius Cardoso Soares, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes, Frederico Silva Castelo Branco, Mônica Macedo Bastos, Núbia Boechat, Felipe B Saraiva, Marcelo Alves Ferreira, Steffen Jockusch, Xuanting Wang, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw Patel, Aitor Garzia, Thomas Tuschl, James J Russo, Rajith K R Rajoli, Carolina S G Pedrosa, Gabriela Vitória, Letícia R Q Souza, Livia Goto-Silva, Marilia Zaluar Guimarães, Stevens K Rehen, Andrew Owen, Fernando A Bozza, Dumith Chequer Bou-Habib, Jingyue Ju, Patrícia T Bozza, Thiago Moreno L Souza. In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19.
The Journal of antimicrobial chemotherapy.
2021 06; 76(7):1874-1885. doi:
10.1093/jac/dkab072. [PMID: 33880524] - Chen-Hua Liu, Hsin-Yun Sun, Szu-Min Hsieh, Wen-Chun Liu, Wang-Hui Sheng, Chun-Jen Liu, Tung-Hung Su, Tai-Chung Tseng, Pei-Jer Chen, Chien-Ching Hung, Jia-Horng Kao. Evolution of estimated glomerular filtration rate in human immunodeficiency virus and hepatitis C virus-coinfected patients receiving sofosbuvir-based direct-acting antivirals and antiretroviral therapy.
Journal of viral hepatitis.
2021 06; 28(6):887-896. doi:
10.1111/jvh.13502. [PMID: 33759290] - Joel V Chua, Afua Ntem-Mensah, Ameer Abutaleb, Jennifer Husson, Lydiah Mutumbi, Ka Wing Lam, Alip Ghosh, Sara Romani, Bhawna Poonia, Sam Lee, M Luz Pascual, Lyn R Frumkin, Shyamsundaran Kottilil. Short-duration treatment with the novel non-nucleoside inhibitor CDI-31244 plus sofosbuvir/velpatasvir for chronic hepatitis C: An open-label study.
Journal of medical virology.
2021 06; 93(6):3752-3760. doi:
10.1002/jmv.26652. [PMID: 33150966] - Norah A Terrault, James Burton, Mark Ghobrial, Elizabeth Verna, Johanna Bayer, Christina Klein, David Victor, Sumit Mohan, James Trotter, Jennifer Dodge, Claus U Niemann, Raymond A Rubin. Prospective Multicenter Study of Early Antiviral Therapy in Liver and Kidney Transplant Recipients of HCV-Viremic Donors.
Hepatology (Baltimore, Md.).
2021 06; 73(6):2110-2123. doi:
10.1002/hep.31551. [PMID: 32926749] - Bassam Shaaban Mohammed, Sayed M Derayea, Amal E Hamad. Feasible TLC-Spectro-Densitometry Technique for Simultaneous Determination of Two Hepatitis C Antiviral Drugs, Sofosbuvir and Simeprevir: Application to Combined Pharmaceutical Dosage Forms and Human Plasma.
Journal of chromatographic science.
2021 May; 59(6):576-583. doi:
10.1093/chromsci/bmab034. [PMID: 33822903] - Kiarash Keyvan, Mahmoud Reza Sohrabi, Fereshteh Motiee. Improved spectral resolution for the rapid simultaneous spectrophotometric determination of sofosbuvir and daclatasvir as anti hepatitis C virus drugs in pharmaceutical formulation and biological fluid using continuous wavelet and derivative transform.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Apr; 251(?):119429. doi:
10.1016/j.saa.2021.119429. [PMID: 33477087] - Virginia Solitano, Alessio Aghemo. Sofosbuvir in HCV patients with chronic kidney disease: No time for caution.
Liver international : official journal of the International Association for the Study of the Liver.
2021 04; 41(4):646-648. doi:
10.1111/liv.14845. [PMID: 33730762] - Marwa A A Ibrahim, Heba E M Sharaf Eldin, Noha R M Elswaidy. Role of aqueous extract of saffron in ameliorating effect of sofosbuvir on the cerebellar cortex in rat.
Anatomical record (Hoboken, N.J. : 2007).
2021 04; 304(4):714-724. doi:
10.1002/ar.24501. [PMID: 32721089] - Huan-Tee Chan, Chien-Ming Chao, Chih-Cheng Lai. Sofosbuvir/daclatasvir in the treatment of COVID-19 infection: A meta-analysis.
The Journal of infection.
2021 04; 82(4):e34-e35. doi:
10.1016/j.jinf.2020.12.021. [PMID: 33373651] - Mohamed Darwish Ahmed Abd Alla, Reham M Dawood, Hassan Abd El-Hafeth Rashed, Galal Farrag, Islam Abdelmawla Emran Ammar, Mohamed Mahmoud Abdel-Halim Mahmoud, Ghada M Salum, Ahmed Mohamed Abdulhamid Altanbouly, Mai A El Meguid, Mostafa K El Awady. Treatment of hepatitis C virus infection with direct-acting antivirals plus ribavirin eliminates viral RNA from peripheral blood mononuclear cells and reduces virologic relapse in diverse hepatic parenchymal changes.
Archives of virology.
2021 Apr; 166(4):1071-1081. doi:
10.1007/s00705-021-04969-4. [PMID: 33533976] - Sunil Taneja, Ajay Duseja, Manu Mehta, Arka De, Nipun Verma, Madhumita Premkumar, Radha K Dhiman, Virendra Singh, Mini P Singh, Radha K Ratho, Raja Ramachandran, Vivek Kumar, Harbir S Kohli. Sofosbuvir and Velpatasvir combination is safe and effective in treating chronic hepatitis C in end-stage renal disease on maintenance haemodialysis.
Liver international : official journal of the International Association for the Study of the Liver.
2021 04; 41(4):705-709. doi:
10.1111/liv.14685. [PMID: 33025685] - Tzu-Sheng Cheng, Po-Cheng Liang, Chung-Feng Huang, Ming-Lun Yeh, Ching-I Huang, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Chia-Yen Dai, Ping-Hsin Hsieh, Wan-Long Chuang, Ming-Lung Yu. Real-world effectiveness of direct-acting antiviral agents for chronic hepatitis C patients with genotype-2 infection after completed treatment.
The Kaohsiung journal of medical sciences.
2021 Apr; 37(4):334-345. doi:
10.1002/kjm2.12315. [PMID: 33151016] - Hung-Chih Chiu, Yen-Cheng Chiu, Er-Hsiang Yang, Ting-Tsung Chang, Shih-Chieh Chien, I-Chin Wu, Chun-Hsien Wu, Pin-Nan Cheng. Effectiveness and safety of ledipasvir/sofosbuvir for genotype 2 chronic hepatitis C infection: Real-world experience from Taiwan.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2021 Mar; 120(3):983-990. doi:
10.1016/j.jfma.2020.08.033. [PMID: 32891488] - Mohammad Bagher Majnooni, Seid-Shahram Miraghaee, Samira Keshavarzi, Bahareh Mohammadi, Soraya Sajadimajd, Razieh Hatami, Gholamreza Bahrami. Rapid and sensitive UHPLC-DAD method for simultaneous determination of sofosbuvir and ledipasvir in human serum.
Journal of pharmaceutical and biomedical analysis.
2021 Feb; 195(?):113860. doi:
10.1016/j.jpba.2020.113860. [PMID: 33387837] - Fatemeh Roozbeh, Majid Saeedi, Reza Alizadeh-Navaei, Akbar Hedayatizadeh-Omran, Shahin Merat, Hannah Wentzel, Jacob Levi, Andrew Hill, Amir Shamshirian. Sofosbuvir and daclatasvir for the treatment of COVID-19 outpatients: a double-blind, randomized controlled trial.
The Journal of antimicrobial chemotherapy.
2021 02; 76(3):753-757. doi:
10.1093/jac/dkaa501. [PMID: 33338232] - Melissa Laub, Matt Harris, Scott Sanoff, Carl Berg, Jennifer Byrns. Effects of Sofosbuvir-Based Hepatitis C Treatment Regimens on Calcineurin Inhibitor Dosing in Liver and Kidney Transplant Recipients.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2021 02; 19(2):142-148. doi:
10.6002/ect.2019.0289. [PMID: 31875466] - Bryony Simmons, Hannah Wentzel, Sara Mobarak, Gholamali Eslami, Anahita Sadeghi, Ali Ali Asgari, Hamideh Abbaspour Kasgari, Hafez Tirgar Fakheri, Shahin Merat, Andrew Hill. Sofosbuvir/daclatasvir regimens for the treatment of COVID-19: an individual patient data meta-analysis.
The Journal of antimicrobial chemotherapy.
2021 01; 76(2):286-291. doi:
10.1093/jac/dkaa418. [PMID: 33063117] - Ahmed M Mostafa, Hesham A Saafan, Ahmed S Al-Tawashi, Muhannad H Kasem, Ahmed M Alaa, Mahmoud M Eltobgy, Ahmed S Moubarak, Manar M Gharib, Mohamed A Awwad, Hazem M Omar, Marwa O El-Derany. Interleukin-17 haplotyping predicts hepatocellular carcinoma in sofosbuvir, pegylated interferon-alpha-2a & ribavirin treated chronic hepatitis C patients.
Virus research.
2021 01; 292(?):198226. doi:
10.1016/j.virusres.2020.198226. [PMID: 33171166] - Po-Yao Hsu, Yu-Ju Wei, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ming-Lun Yeh, Ching-I Huang, Po-Cheng Liang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Shang-Jyh Hwang, Wan-Long Chuang, Chung-Feng Huang, Yi-Wen Chiu, Ming-Lung Yu. Comedications and potential drug-drug interactions with direct-acting antivirals in hepatitis C patients on hemodialysis.
Clinical and molecular hepatology.
2021 01; 27(1):186-196. doi:
10.3350/cmh.2020.0180. [PMID: 33317251] - Yang Zhang, Wuhui Song, Shuiye Chen, Zhenghong Yuan, Zhigang Yi. A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2.
Antiviral research.
2021 01; 185(?):104974. doi:
10.1016/j.antiviral.2020.104974. [PMID: 33217430] - Rasha Eletreby, Mahmoud Anees, Mariam Naguib, Abdelrahman Kobtan, Amal Helmy, Nahla Khalaf, Shimaa Mansour, Mohamed Hassany, Wafaa El Akel, Ahmed Hashem, Wahid Doss, Gamal Esmat. The interrelation between lipid profile in chronic HCV patients and their response to antiviral agents.
Expert review of gastroenterology & hepatology.
2021 Jan; 15(1):103-110. doi:
10.1080/17474124.2020.1823831. [PMID: 32933323] - Paul Carrier, Marilyne Debette-Gratien, Malika Bettayeb, Marie Essig, Véronique Loustaud-Ratti. Sofosbuvir and the risk of kidney dysfunction.
Journal of hepatology.
2021 01; 74(1):256-257. doi:
10.1016/j.jhep.2020.08.019. [PMID: 33071010] - Chen-Hua Liu, Jia-Horng Kao. Reply to: 'Sofosbuvir and the risk of kidney dysfunction'.
Journal of hepatology.
2021 01; 74(1):257-258. doi:
10.1016/j.jhep.2020.09.028. [PMID: 33071008] - Sara Majd Jabbari, Khadije Maajani, Shahin Merat, Hossein Poustchi, Sadaf G Sepanlou. An updated systematic review and meta-analysis on efficacy of Sofosbuvir in treating hepatitis C-infected patients with advanced chronic kidney disease.
PloS one.
2021; 16(2):e0246594. doi:
10.1371/journal.pone.0246594. [PMID: 33566846] - Joy Y Feng, Adrian S Ray. HCV RdRp, sofosbuvir and beyond.
The Enzymes.
2021; 49(?):63-82. doi:
10.1016/bs.enz.2021.06.003. [PMID: 34696839] - Marius Djoumbissie Tchoupe, Hanen Chaker, Mona Boudabbous, Salma Toumi, François Pegdebamba Kissou, Saba Gargouri, Khawla Kammoun, Faiçal Jarraya, Nabil Tahri, Soumaya Yaich, Mohamed Ben Hmida. Treatment of chronic hepatitis C with sofosbuvir in a hemodialysis patient: a case report.
The Pan African medical journal.
2021; 38(?):137. doi:
10.11604/pamj.2021.38.137.20560. [PMID: 33912307] - Juan C Duque, Adriana Dejman, Vasuki Venkat, Maria Hernandez, David Roth, Marco A Ladino. Acute interstitial nephritis following treatment with direct-acting antiviral agents in hepatitis C virus-infected patients: A case series.
Clinical nephrology.
2021 Jan; 95(1):22-27. doi:
10.5414/cn110276. [PMID: 32909545] - Young Joo Han, Keum Hwa Lee, Sojung Yoon, Seoung Wan Nam, Seohyun Ryu, Dawon Seong, Jae Seok Kim, Jun Young Lee, Jae Won Yang, Jinhee Lee, Ai Koyanagi, Sung Hwi Hong, Elena Dragioti, Joaquim Radua, Lee Smith, Hans Oh, Ramy Abou Ghayda, Andreas Kronbichler, Maria Effenberger, Daniela Kresse, Sara Denicolò, Woosun Kang, Louis Jacob, Hanwul Shin, Jae Il Shin. Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials.
Theranostics.
2021; 11(3):1207-1231. doi:
10.7150/thno.48342. [PMID: 33391531] - Yuki Tahata, Hayato Hikita, Satoshi Mochida, Norifumi Kawada, Nobuyuki Enomoto, Akio Ido, Hitoshi Yoshiji, Daiki Miki, Yoichi Hiasa, Yasuhiro Takikawa, Ryotaro Sakamori, Masayuki Kurosaki, Hiroshi Yatsuhashi, Ryosuke Tateishi, Yoshiyuki Ueno, Yoshito Itoh, Taro Yamashita, Tatsuya Kanto, Goki Suda, Yasunari Nakamoto, Naoya Kato, Yasuhiro Asahina, Kentaro Matsuura, Shuji Terai, Kazuhiko Nakao, Masahito Shimizu, Taro Takami, Norio Akuta, Ryoko Yamada, Takahiro Kodama, Tomohide Tatsumi, Tomomi Yamada, Tetsuo Takehara. Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study.
Journal of gastroenterology.
2021 Jan; 56(1):67-77. doi:
10.1007/s00535-020-01733-4. [PMID: 33001338] - Yen-Chun Chen, Chen-Hao Li, Ping-Hung Ko, Chi-Che Lee, Ru-Jiang Syu, Chih-Wei Tseng, Kuo-Chih Tseng. Neutrophil gelatinase-associated lipocalin partly reflects the dynamic changes of renal function among chronic hepatitis C patients receiving direct-acting antivirals.
PloS one.
2021; 16(8):e0256505. doi:
10.1371/journal.pone.0256505. [PMID: 34437608] - Keivan Zandi, Franck Amblard, Katie Musall, Jessica Downs-Bowen, Ruby Kleinbard, Adrian Oo, Dongdong Cao, Bo Liang, Olivia O Russell, Tamara McBrayer, Leda Bassit, Baek Kim, Raymond F Schinazi. Repurposing Nucleoside Analogs for Human Coronaviruses.
Antimicrobial agents and chemotherapy.
2020 12; 65(1):. doi:
10.1128/aac.01652-20. [PMID: 33122172] - Jingyue Ju, Xiaoxu Li, Shiv Kumar, Steffen Jockusch, Minchen Chien, Chuanjuan Tao, Irina Morozova, Sergey Kalachikov, Robert N Kirchdoerfer, James J Russo. Nucleotide analogues as inhibitors of SARS-CoV Polymerase.
Pharmacology research & perspectives.
2020 12; 8(6):e00674. doi:
10.1002/prp2.674. [PMID: 33124786] - Marianne Joseph Naguib, Amira Moustafa Kamel, Ahmed Thabet Negmeldin, Ahmed Hassen Elshafeey, Ibrahim Elsayed. Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency.
Drug delivery.
2020 Dec; 27(1):996-1009. doi:
10.1080/10717544.2020.1787557. [PMID: 32611266] - Satoshi Takakusagi, Megumi Shimizu, Yozo Yokoyama, Kazuko Kizawa, Kyoko Marubashi, Takashi Kosone, Ken Sato, Satoru Kakizaki, Hitoshi Takagi, Toshio Uraoka. Hepatitis C virus-associated decompensated liver cirrhosis with refractory hepatic encephalopathy successfully treated by balloon-occluded retrograde transvenous obliteration after sofosbuvir/velpatasvir.
Clinical journal of gastroenterology.
2020 Dec; 13(6):1303-1309. doi:
10.1007/s12328-020-01229-x. [PMID: 32914297] - Eloi Chevallier, Matthias Büchler, Sophie Caillard, Nicolas Bouvier, Charlotte Colosio, Joseph Rivalan, Johnny Sayegh, Dominique Bertrand, Yannick Le Meur, Antoine Thierry, Cyril Garrouste, Jean-Philippe Rerolle, Lionel Rostaing, Philippe Gatault. Chronic Hepatitis C Virus Infection After Kidney Transplantation With or Without Direct-Acting Antivirals in a Real-Life Setting: A French Multicenter Experience.
Transplantation proceedings.
2020 Dec; 52(10):3179-3185. doi:
10.1016/j.transproceed.2020.06.005. [PMID: 32636068] - Mohammad El-Sayed, Zeinab Abdellatif, Aisha Elsharkawy, Mohamed El Kassas, Reham Abd Elmoniem, Amaal Marzouk, Rabab Fouad, Gamal Esmat, Shereen Abdel Alem. Renal profile of chronic hepatitis C patients with sofosbuvir-based therapy.
Infection.
2020 Dec; 48(6):913-922. doi:
10.1007/s15010-020-01505-5. [PMID: 32816249] - Bülent Değertekin, Mehmet Demir, Ulus S Akarca, Haluk Tarık Kani, Enver Üçbilek, Emre Yıldırım, Fatih Güzelbulut, Ayhan Balkan, Sezgin Vatansever, Nilay Danış, Melek Demircan, Aliye Soylu, Serkan Yaras, Aysun Kartal, Ayşe Kefeli, Feyza Gündüz, Kendal Yalçın, Elife Erarslan, Murat Aladağ, Murat Harputluoğlu, Ayşegül Özakyol, Tuncer Temel, Mesut Akarsu, Hale Sümer, Mete Akın, Bülent Albayrak, İlker Sen, Hüseyin Alkım, Ahmet Uyanıkoğlu, Kader Irak, Sinem Öztaşkın, Çağrı Burak Uğurlu, Şevkican Güneş, Selim Gürel, Kenan Nuriyev, İsmail İnci, Sabite Kaçar, Dinç Dinçer, Levent Doğanay, Hüseyin Savaş Göktürk, Ali Mert, Arif Mansur Coşar, Hakan Dursun, Roni Atalay, Sabiye Akbulut, Yasemin Balkan, Hayrettin Koklu, Halis Şimşek, Osman Özdoğan, Mehmet Çoban. Real-world efficacy and safety of Ledipasvir + Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir ± Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2020 12; 31(12):883-893. doi:
10.5152/tjg.2020.20696. [PMID: 33626001] - Hossein Khalili, Anahid Nourian, Zahra Ahmadinejad, Hamid Emadi Kouchak, Sirous Jafari, Sayed Ali Dehghan Manshadi, Mehrnaz Rasolinejad, Abbas Kebriaeezadeh. Efficacy and safety of sofosbuvir/ ledipasvir in treatment of patients with COVID-19; A randomized clinical trial.
Acta bio-medica : Atenei Parmensis.
2020 11; 91(4):e2020102. doi:
10.23750/abm.v91i4.10877. [PMID: 33525212] - Minchen Chien, Thomas K Anderson, Steffen Jockusch, Chuanjuan Tao, Xiaoxu Li, Shiv Kumar, James J Russo, Robert N Kirchdoerfer, Jingyue Ju. Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19.
Journal of proteome research.
2020 11; 19(11):4690-4697. doi:
10.1021/acs.jproteome.0c00392. [PMID: 32692185] - Gholamali Eslami, Sajedeh Mousaviasl, Esmat Radmanesh, Saeed Jelvay, Saeid Bitaraf, Bryony Simmons, Hannah Wentzel, Andrew Hill, Anahita Sadeghi, James Freeman, Shokrollah Salmanzadeh, Hani Esmaeilian, Morteza Mobarak, Ramin Tabibi, Amir Hosein Jafari Kashi, Zahra Lotfi, Seyed Mehdi Talebzadeh, Aseni Wickramatillake, Mahboobeh Momtazan, Majid Hajizadeh Farsani, Sedigheh Marjani, Sara Mobarak. The impact of sofosbuvir/daclatasvir or ribavirin in patients with severe COVID-19.
The Journal of antimicrobial chemotherapy.
2020 11; 75(11):3366-3372. doi:
10.1093/jac/dkaa331. [PMID: 32812051] - Rita Calça, Cristina Jorge, Luís Lebre, Eunice Cacheira, Sara Querido, Célia Nascimento, Teresa Adragão, Margarida Bruges, André Weigert, Domingos Machado. Hepatocellular carcinoma after direct-acting antiviral therapy in kidney transplant recipients infected with hepatitis C virus.
Nefrologia.
2020 Nov; 40(6):675-676. doi:
10.1016/j.nefro.2019.11.005. [PMID: 31937466] - Hamideh Abbaspour Kasgari, Siavash Moradi, Amir Mohammad Shabani, Farhang Babamahmoodi, Ali Reza Davoudi Badabi, Lotfollah Davoudi, Ahmad Alikhani, Akbar Hedayatizadeh Omran, Majid Saeedi, Shahin Merat, Hannah Wentzel, Anna Garratt, Jacob Levi, Bryony Simmons, Andrew Hill, Hafez Tirgar Fakheri. Evaluation of the efficacy of sofosbuvir plus daclatasvir in combination with ribavirin for hospitalized COVID-19 patients with moderate disease compared with standard care: a single-centre, randomized controlled trial.
The Journal of antimicrobial chemotherapy.
2020 11; 75(11):3373-3378. doi:
10.1093/jac/dkaa332. [PMID: 32812025] - Kristina M Brooks, Jose R Castillo-Mancilla, Mary Morrow, Samantha MaWhinney, Joshua Blum, David L Wyles, Sarah E Rowan, Mustafa E Ibrahim, Jia-Hua Zheng, Bethany Johnson, Joe Gomez, Ye Ji Choi, Francesca Cendali, Hannah Haas, Laura Roon, Lane R Bushman, Peter L Anderson, Jennifer J Kiser. Pharmacokinetics and renal safety of tenofovir alafenamide with boosted protease inhibitors and ledipasvir/sofosbuvir.
The Journal of antimicrobial chemotherapy.
2020 11; 75(11):3303-3310. doi:
10.1093/jac/dkaa299. [PMID: 32766700] - Chung-Feng Huang, Chia-Yen Dai, Ming-Lun Yeh, Ching-I Huang, Hsiang-Chun Lee, Wen-Ter Lai, Po-Cheng Liang, Yi-Hung Lin, Ming-Yen Hsieh, Nai-Jen Hou, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu. Cure or curd: Modification of lipid profiles and cardio-cerebrovascular events after hepatitis C virus eradication.
The Kaohsiung journal of medical sciences.
2020 Nov; 36(11):920-928. doi:
10.1002/kjm2.12275. [PMID: 32643842] - Yanhang Gao, Fei Kong, Guangming Li, Cheng Li, Sujun Zheng, Jianmei Lin, Xiaofeng Wen, Jinghua Hu, Xiaozhong Wang, Xiaofeng Wu, Huichun Xing, Jidong Jia, Zhansheng Jia, Yujuan Guan, Chenghao Li, Guicheng Wu, Zhiliang Gao, Zhuangbo Mou, Qin Ning, Qing Mao, Yongfeng Yang, Jing Ning, Li Li, Hai Pan, Desheng Zhou, Yanhua Ding, Hong Qin, Junqi Niu. Coblopasvir and sofosbuvir for treatment of chronic hepatitis C virus infection in China: A single-arm, open-label, phase 3 trial.
Liver international : official journal of the International Association for the Study of the Liver.
2020 11; 40(11):2685-2693. doi:
10.1111/liv.14633. [PMID: 33047868]