Ferric ammonium citrate (BioDeep_00000641250)
PANOMIX_OTCML-2023
代谢物信息卡片
Iron(III) ammonium citrate
化学式: C6H8FeNO7 (261.96501479999995)
中文名称: 柠檬酸铁铵
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 4.35%
分子结构信息
SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.N.[Fe+3]
InChI: +3
描述信息
V - Various > V08 - Contrast media > V08C - Magnetic resonance imaging contrast media > V08CA - Paramagnetic contrast media
D006401 - Hematologic Agents > D006397 - Hematinics > D005290 - Ferric Compounds
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ye Yuan, Chunyu Tian, Qi Wang, Xinyu Qiu, Yufang Wang, Hulin Jiang, Jifu Hao, Yujing He. Synergistic Amplification of Ferroptosis with Liposomal Oxidation Catalyst and Gpx4 Inhibitor for Enhanced Cancer Therapy.
Advanced healthcare materials.
2023 11; 12(28):e2301292. doi:
10.1002/adhm.202301292. [PMID: 37458333] - Wei Cheng, Yue Zhou, Hange Chen, Qian Wu, Yan Li, Hui Wang, Yan Feng, Yan Wang. The iron matters: Aged microplastics disrupted the iron homeostasis in the liver organoids.
The Science of the total environment.
2023 Oct; ?(?):167529. doi:
10.1016/j.scitotenv.2023.167529. [PMID: 37788777] - Mikaela L Wagers, Ashley Starks, Maya O Abul-Khoudoud, Sufia M Ahmed, Abraham W Alhamdani, Clair Ashley, Patrick C Bidros, Constance O Bledsoe, Kayli E Bolton, Jerone G Capili, Jamie N Henning, Bethany J Ison, Madison Moon, Panhavuth Phe, Samuel B Stonecipher, Isabelle N Taylor, Logan T Turner, Aaron K West, Robin L Cooper. An invertebrate model in examining the effect of acute ferric iron exposure on proprioceptive neurons.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2023 Apr; 266(?):109558. doi:
10.1016/j.cbpc.2023.109558. [PMID: 36717044] - Qi He, Junzheng Yang, Zhaofeng Pan, Gangyu Zhang, Baihao Chen, Shaocong Li, Jiacong Xiao, Fengjin Tan, Zihao Wang, Peng Chen, Haibin Wang. Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jan; 157(?):113915. doi:
10.1016/j.biopha.2022.113915. [PMID: 36379122] - Zhuan Feng, Yifei Qin, Fei Huo, Zhe Jian, Xiaomin Li, Jiejie Geng, Yong Li, Jiao Wu. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Biochimica et biophysica acta. Molecular basis of disease.
2022 01; 1868(1):166287. doi:
10.1016/j.bbadis.2021.166287. [PMID: 34626772] - Dingxi Li, Mengli Zhang, Hongtu Chao. Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells-'utilization' of ferroptosis mechanism.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2021 Dec; 70(10-12):1177-1189. doi:
10.1007/s00011-021-01495-6. [PMID: 34537856] - Yingrui Liu, Brent A Bell, Ying Song, Hye J Kim, Jacob K Sterling, Benjamin J Kim, Maura Poli, Michelle Guo, Kevin Zhang, Aditya Rao, Janet R Sparrow, Guanfang Su, Joshua L Dunaief. Intraocular iron injection induces oxidative stress followed by elements of geographic atrophy and sympathetic ophthalmia.
Aging cell.
2021 11; 20(11):e13490. doi:
10.1111/acel.13490. [PMID: 34626070] - Allison L Fisher, Daniel N Srole, Nicolaos J Palaskas, David Meriwether, Srinivasa T Reddy, Tomas Ganz, Elizabeta Nemeth. Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis.
The Journal of biological chemistry.
2021 10; 297(4):101156. doi:
10.1016/j.jbc.2021.101156. [PMID: 34480898] - Fang Wang, Zebin Weng, Haizhao Song, Yifang Bao, Huilin Sui, Yong Fang, Xiaozhi Tang, Xinchun Shen. Ferric ammonium citrate (FAC)-induced inhibition of osteoblast proliferation/differentiation and its reversal by soybean-derived peptides (SDP).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Oct; 156(?):112527. doi:
10.1016/j.fct.2021.112527. [PMID: 34464636] - Haikang Zhao, Xiaoqiang Li, Lei Yang, Liang Zhang, Xiaobing Jiang, Wenwen Gao, Peng Chen, Yingying Cheng, Fenglu Wang, Jianrong Liu. Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway.
Neurochemical research.
2021 Aug; 46(8):1981-1994. doi:
10.1007/s11064-021-03320-2. [PMID: 33942214] - Wei Wu, Zixiang Geng, Haoran Bai, Te Liu, Bimeng Zhang. Ammonium Ferric Citrate induced Ferroptosis in Non-Small-Cell Lung Carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.
International journal of medical sciences.
2021; 18(8):1899-1909. doi:
10.7150/ijms.54860. [PMID: 33746607] - Linfeng Sun, Xiaoding Lin, Sakorn Pornprasert, Xiaomei Lü, Bing Ran, Yan Lin. L-type calcium channel blockers decrease the iron overload-mediated oxidative stress in renal epithelial cells by reducing iron accumulation.
European journal of pharmacology.
2020 Nov; 886(?):173513. doi:
10.1016/j.ejphar.2020.173513. [PMID: 32898550] - Jian Zhang, Penghai Qiao, Gang Yao, Hai Zhao, Yanjun Wu, Shuguang Wu. Ionizing Radiation Exacerbates the Bone Loss Induced by Iron Overload in Mice.
Biological trace element research.
2020 Aug; 196(2):502-511. doi:
10.1007/s12011-019-01929-7. [PMID: 31691189] - Berta Capella Roca, Nga T Lao, Martin Clynes, Padraig Doolan. Investigation and circumvention of transfection inhibition by ferric ammonium citrate in serum-free media for Chinese hamster ovary cells.
Biotechnology progress.
2020 05; 36(3):e2954. doi:
10.1002/btpr.2954. [PMID: 31850663] - Dongyu Xie, Haina Xie, Lin Liu, Guangwei Feng, Wenjing Jiang, Wei Huang, Donghao Xie. Qizhufang (ZSF) Ameliorates Hepatic Iron Overload via Signal Transducer and Activator of Transcription 3 (STAT3) Pathway.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Oct; 25(?):7836-7844. doi:
10.12659/msm.916595. [PMID: 31628297] - Giuseppina Camiolo, Daniele Tibullo, Cesarina Giallongo, Alessandra Romano, Nunziatina L Parrinello, Giuseppe Musumeci, Michelino Di Rosa, Nunzio Vicario, Maria V Brundo, Francesco Amenta, Margherita Ferrante, Chiara Copat, Roberto Avola, Giovanni Li Volti, Antonio Salvaggio, Francesco Di Raimondo, Giuseppe A Palumbo. α-Lipoic Acid Reduces Iron-induced Toxicity and Oxidative Stress in a Model of Iron Overload.
International journal of molecular sciences.
2019 Jan; 20(3):. doi:
10.3390/ijms20030609. [PMID: 30708965] - Oreoluwa Adedoyin, Ravindra Boddu, Amie Traylor, Jeremie M Lever, Subhashini Bolisetty, James F George, Anupam Agarwal. Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells.
American journal of physiology. Renal physiology.
2018 05; 314(5):F702-F714. doi:
10.1152/ajprenal.00044.2017. [PMID: 28515173] - Chiara Macchi, Liliana Steffani, Roberto Oleari, Antonella Lettieri, Luca Valenti, Paola Dongiovanni, Antonio Romero-Ruiz, Manuel Tena-Sempere, Anna Cariboni, Paolo Magni, Massimiliano Ruscica. Iron overload induces hypogonadism in male mice via extrahypothalamic mechanisms.
Molecular and cellular endocrinology.
2017 10; 454(?):135-145. doi:
10.1016/j.mce.2017.06.019. [PMID: 28648620] - Lei Shi, Fumiya Ito, Yue Wang, Yasumasa Okazaki, Hiromasa Tanaka, Masaaki Mizuno, Masaru Hori, Tasuku Hirayama, Hideko Nagasawa, Des R Richardson, Shinya Toyokuni. Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.
Free radical biology & medicine.
2017 07; 108(?):904-917. doi:
10.1016/j.freeradbiomed.2017.04.368. [PMID: 28465262] - Donald J Messner, Todd Robinson, Kris V Kowdley. Curcumin and Turmeric Modulate the Tumor-Promoting Effects of Iron In Vitro.
Nutrition and cancer.
2017 Apr; 69(3):481-489. doi:
10.1080/01635581.2017.1274407. [PMID: 28129008] - Fan Yang, Gege Yan, Yuan Li, Zhenbo Han, Lai Zhang, Simon Chen, Chao Feng, Qi Huang, Fengzhi Ding, Ying Yu, Chongwei Bi, Benzhi Cai, Lei Yang. Astragalus Polysaccharide Attenuated Iron Overload-Induced Dysfunction of Mesenchymal Stem Cells via Suppressing Mitochondrial ROS.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 39(4):1369-79. doi:
10.1159/000447841. [PMID: 27607448] - Qi Wang, Jiajie Ji, Tong Qiao. [Testing the influence of lipid laden and iron-overloading on ceruloplasmin expression in RAW 264.7 cells].
Zhonghua yi xue za zhi.
2015 Aug; 95(32):2639-43. doi:
". [PMID: 26711617] - Xiao Wang, Lulin Liu, Chao Gao, Guoyang Zhao, Guangsi Shen, Wen Zhang, Zhanli Xie, Youjia Xu. [Antagonistic effects of estrogen on iron-induced bone resorption and its mechanism].
Zhonghua yi xue za zhi.
2014 Sep; 94(33):2613-7. doi:
NULL. [PMID: 25511496] - D J Pogge, M E Drewnoski, S L Hansen. Feeding ferric ammonium citrate to decrease the risk of sulfur toxicity: effects on trace mineral absorption and status of beef steers.
Journal of animal science.
2014 Sep; 92(9):4005-13. doi:
10.2527/jas.2014-7799. [PMID: 25006066] - Andrew J Ghio, Joleen M Soukup, Lisa A Dailey, Judy H Richards, Kelly E Duncan, James Lehmann. Iron decreases biological effects of ozone exposure.
Inhalation toxicology.
2014 Jun; 26(7):391-9. doi:
10.3109/08958378.2014.908330. [PMID: 24862973] - Remil Linggatong Galay, Rika Umemiya-Shirafuji, Eugene T Bacolod, Hiroki Maeda, Kodai Kusakisako, Jiro Koyama, Naotoshi Tsuji, Masami Mochizuki, Kozo Fujisaki, Tetsuya Tanaka. Two kinds of ferritin protect ixodid ticks from iron overload and consequent oxidative stress.
PloS one.
2014; 9(3):e90661. doi:
10.1371/journal.pone.0090661. [PMID: 24594832] - Donald J Messner, Byung Han Rhieu, Kris V Kowdley. Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytes.
Digestive diseases and sciences.
2013 Jul; 58(7):1899-908. doi:
10.1007/s10620-013-2648-3. [PMID: 23558563] - C Salis, C Davio, V Usach, N Urtasun, B Goitia, R Martinez-Vivot, J M Pasquini, C P Setton-Avruj. Iron and holotransferrin induce cAMP-dependent differentiation of Schwann cells.
Neurochemistry international.
2012 Oct; 61(5):798-806. doi:
10.1016/j.neuint.2012.06.023. [PMID: 22776360] - Fabia Febbraro, Marcello Giorgi, Sara Caldarola, Fabrizio Loreni, Marina Romero-Ramos. α-Synuclein expression is modulated at the translational level by iron.
Neuroreport.
2012 Jun; 23(9):576-80. doi:
10.1097/wnr.0b013e328354a1f0. [PMID: 22581044] - Nootchanat Mairuae, James R Connor, Poonlarp Cheepsunthorn. Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia.
Neuroscience letters.
2011 Aug; 500(1):36-40. doi:
10.1016/j.neulet.2011.06.001. [PMID: 21683124] - Ryan M Mitchell, Sang Y Lee, Zachary Simmons, James R Connor. HFE polymorphisms affect cellular glutamate regulation.
Neurobiology of aging.
2011 Jun; 32(6):1114-23. doi:
10.1016/j.neurobiolaging.2009.05.016. [PMID: 19560233] - Luca Valenti, Paola Dongiovanni, Benedetta Maria Motta, Dorine W Swinkels, Paola Bonara, Raffaela Rametta, Larry Burdick, Cecelia Frugoni, Anna Ludovica Fracanzani, Silvia Fargion. Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations.
Arteriosclerosis, thrombosis, and vascular biology.
2011 Mar; 31(3):683-90. doi:
10.1161/atvbaha.110.214858. [PMID: 21183736] - Samuele Marro, Deborah Chiabrando, Erika Messana, Jens Stolte, Emilia Turco, Emanuela Tolosano, Martina U Muckenthaler. Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.
Haematologica.
2010 Aug; 95(8):1261-8. doi:
10.3324/haematol.2009.020123. [PMID: 20179090] - Joseph M Leimberg, Eugenia Prus, Gabriela Link, Eitan Fibach, Abraham M Konijn. Iron-chelator complexes as iron sources for early developing human erythroid precursors.
Translational research : the journal of laboratory and clinical medicine.
2008 Feb; 151(2):88-96. doi:
10.1016/j.trsl.2007.12.002. [PMID: 18201676] - Ryan W Bogard, James D Oliver. Role of iron in human serum resistance of the clinical and environmental Vibrio vulnificus genotypes.
Applied and environmental microbiology.
2007 Dec; 73(23):7501-5. doi:
10.1128/aem.01551-07. [PMID: 17933938] - H González, C Mendoza, F E Viteri. Absorption of unlabeled reduced iron of small particle size from a commercial source. A method to predict absorption of unlabeled iron compounds in humans.
Archivos latinoamericanos de nutricion.
2001 Sep; 51(3):217-24. doi:
NULL. [PMID: 11791474] - R Mattera, G P Stone, N Bahhur, Y A Kuryshev. Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes.
Circulation.
2001 May; 103(19):2395-401. doi:
10.1161/01.cir.103.19.2395. [PMID: 11352890] - M J Raley, D J Loegering. Role of an oxidative stress in the macrophage dysfunction caused by erythrophagocytosis.
Free radical biology & medicine.
1999 Dec; 27(11-12):1455-64. doi:
10.1016/s0891-5849(99)00193-8. [PMID: 10641741] - D R Richardson, A C Chua, E Baker. Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes: implications for the pathogenesis of iron-overload disease.
The Journal of laboratory and clinical medicine.
1999 Feb; 133(2):144-51. doi:
10.1016/s0022-2143(99)90007-0. [PMID: 9989766] - J Keenan, M Clynes. Replacement of transferrin by simple iron compounds for MDCK cells grown and subcultured in serum-free medium.
In vitro cellular & developmental biology. Animal.
1996 Sep; 32(8):451-3. doi:
10.1007/bf02723044. [PMID: 8889596] - B Magariños, J L Romalde, M L Lemos, J L Barja, A E Toranzo. Iron uptake by Pasteurella piscicida and its role in pathogenicity for fish.
Applied and environmental microbiology.
1994 Aug; 60(8):2990-8. doi:
10.1128/aem.60.8.2990-2998.1994. [PMID: 8085835] - L L Gershbein, V K Rezai, E Amir-Mokri, K C Rao. Adenocarcinoma production in rats administered 1,2-dimethylhydrazine and fed iron salt and guar gum diets.
Anticancer research.
1993 Nov; 13(6A):2027-30. doi:
". [PMID: 8297110] - A Berczi, W P Faulk. Iron-reducing activity of plasma membranes.
Biochemistry international.
1992 Dec; 28(4):577-84. doi:
NULL. [PMID: 1482396] - F Hashimoto, Y Fujii, M Toba, H Okamatsu, H Kohri. Determination of absorption and endogenous excretion of iron in man by monitoring fecal excretion of a stable iron isotope (58Fe).
Journal of nutritional science and vitaminology.
1992 Oct; 38(5):435-49. doi:
10.3177/jnsv.38.435. [PMID: 1294703] - D L Rubin, H H Muller, S W Young. Formulation of radiographically detectable gastrointestinal contrast agents for magnetic resonance imaging: effects of a barium sulfate additive on MR contrast agent effectiveness.
Magnetic resonance in medicine.
1992 Jan; 23(1):154-65. doi:
10.1002/mrm.1910230116. [PMID: 1734177] - M Taniguchi, H Imamura, T Shirota, H Okamatsu, Y Fujii, M Toba, F Hashimoto. Improvement in iron deficiency anemia through therapy with ferric ammonium citrate and vitamin C and the effects of aerobic exercise.
Journal of nutritional science and vitaminology.
1991 Apr; 37(2):161-71. doi:
10.3177/jnsv.37.161. [PMID: 1919803] - J J Bullen, C G Ward, H J Rogers. Iron, infection, and the role of bicarbonate.
FEMS microbiology letters.
1990 Sep; 59(1-2):27-9. doi:
10.1016/0378-1097(90)90027-n. [PMID: 2276612] - L Schiaffonati, E Rappocciolo, L Tacchini, L Bardella, P Arosio, A Cozzi, G B Cantu, G Cairo. Mechanisms of regulation of ferritin synthesis in rat liver during experimental inflammation.
Experimental and molecular pathology.
1988 Apr; 48(2):174-81. doi:
10.1016/0014-4800(88)90054-8. [PMID: 2450778] - C A Bolin. Effects of exogenous iron on Escherichia coli septicemia of turkeys.
American journal of veterinary research.
1986 Aug; 47(8):1813-6. doi:
NULL. [PMID: 3530066] - R C Lindenschmidt, L E Sendelbach, H P Witschi, D J Price, J Fleming, J G Joshi. Ferritin and in vivo beryllium toxicity.
Toxicology and applied pharmacology.
1986 Feb; 82(2):344-50. doi:
10.1016/0041-008x(86)90211-5. [PMID: 3945960] - R R Reddel, D W Hedley, R L Sutherland. Cell cycle effects of iron depletion on T-47D human breast cancer cells.
Experimental cell research.
1985 Dec; 161(2):277-84. doi:
10.1016/0014-4827(85)90085-0. [PMID: 2998833] - A A Miles, J P Maskell. The antagonism of tetracycline and ferric iron in vivo.
Journal of medical microbiology.
1985 Aug; 20(1):17-26. doi:
10.1099/00222615-20-1-17. [PMID: 4020849] - G E Wesbey, R C Brasch, H I Goldberg, B L Engelstad, A A Moss. Dilute oral iron solutions as gastrointestinal contrast agents for magnetic resonance imaging; initial clinical experience.
Magnetic resonance imaging.
1985; 3(1):57-64. doi:
10.1016/0730-725x(85)90009-8. [PMID: 3923293] - M Titeux, U Testa, F Louache, P Thomopoulos, H Rochant, J Breton-Gorius. The role of iron in the growth of human leukemic cell lines.
Journal of cellular physiology.
1984 Oct; 121(1):251-6. doi:
10.1002/jcp.1041210131. [PMID: 6592167] - W M Artis, T R Wade, H E Jones. Restoration of Trichophyton mentagrophytes growth in medium depleted of metals by chelation: importance of iron.
Sabouraudia.
1983 Mar; 21(1):41-8. doi:
NULL. [PMID: 6845111] - R L Duncan, W M Artis. Fungistatic capacity of sera from guinea pigs injected with various iron solutions: differences between Trichophyton mentagrophytes and Rhizopus oryzae.
Infection and immunity.
1982 Jan; 35(1):368-70. doi:
10.1128/iai.35.1.368-370.1982. [PMID: 7054128] - A C Wright, L M Simpson, J D Oliver. Role of iron in the pathogenesis of Vibrio vulnificus infections.
Infection and immunity.
1981 Nov; 34(2):503-7. doi:
10.1128/iai.34.2.503-507.1981. [PMID: 7309236] - C J Czuprynski, E Balish. Killing of Listeria monocytogens by conventional and germfree rat sera.
Infection and immunity.
1981 Aug; 33(2):348-54. doi:
10.1128/iai.33.2.348-354.1981. [PMID: 6792076]