Tetrahymanol (BioDeep_00000638776)

Main id: BioDeep_00000006056

 

PANOMIX_OTCML-2023 natural product


Metabolite Card


Tetrahymanol

  Formula: C30H52O (428.4018)
Chinese Names:
  Spectrum Hits: Top Source () %

Molecular Structure

SMILES: CC1(C)CCC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@]21C
InChI: InChI=1S/C30H52O/c1-25(2)15-9-16-27(5)20(25)12-18-29(7)22(27)10-11-23-28(6)17-14-24(31)26(3,4)21(28)13-19-30(23,29)8/h20-24,31H,9-19H2,1-8H3/t20-,21-,22+,23+,24-,27-,28-,29+,30+/m0/s1


Description

Synonyms

2 synonym names

Tetrahymanol; Tetrahymanol



Cross Reference

11 cross reference id

Classification Terms

Related Pathways

Reactome()

BioCyc(1)

PlantCyc()

Biological Process

3 related biological process reactions.

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

34 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

Sub-cellular location Genes
Peripheral membrane protein 1 STOM
Endoplasmic reticulum membrane 5 ACAT1, FADS3, FDFT1, HMGCR, HSP90B1
Nucleus 1 HSP90B1
cytosol 1 HSP90B1
nucleoplasm 1 ATP2B1
Cell membrane 2 ATP2B1, STOM
Lipid-anchor 1 STOM
Cytoplasmic side 1 STOM
Multi-pass membrane protein 6 ACAT1, ATP2B1, FADS3, FDFT1, HMGCR, NPC1
Synapse 1 ATP2B1
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 NPC1
lysosomal membrane 1 NPC1
presynaptic membrane 1 ATP2B1
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 1 NPC1
plasma membrane 3 ATP2B1, NPC1, STOM
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ACAT1, ATP2B1, FADS3, FDFT1, HMGCR, HSP90B1, NPC1, STOM
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ACAT1, ATP2B1, HSP90B1, NPC1, STOM
Lysosome membrane 1 NPC1
endoplasmic reticulum 6 ACAT1, FDFT1, HMGCR, HSP90B1, NPC1, STOM
extracellular space 1 STOM
perinuclear region of cytoplasm 3 HSP90B1, NPC1, STOM
mitochondrion 2 ACAT1, STOM
protein-containing complex 1 HSP90B1
intracellular membrane-bounded organelle 1 ATP2B1
extracellular region 2 HSP90B1, NPC1
mitochondrial matrix 1 ACAT1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
cytoplasmic vesicle 1 STOM
midbody 1 HSP90B1
vesicle 1 STOM
Membrane raft 2 NPC1, STOM
Cytoplasm, cytoskeleton 1 STOM
focal adhesion 1 HSP90B1
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 1 HSP90B1
lateral plasma membrane 1 ATP2B1
Late endosome membrane 1 NPC1
cell projection 1 ATP2B1
cytoskeleton 1 STOM
blood microparticle 1 STOM
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 NPC1
Endomembrane system 1 NPC1
specific granule membrane 1 STOM
tertiary granule membrane 1 STOM
Melanosome 2 HSP90B1, STOM
Presynaptic cell membrane 1 ATP2B1
sperm plasma membrane 1 HSP90B1
Peroxisome membrane 1 HMGCR
endoplasmic reticulum lumen 1 HSP90B1
azurophil granule membrane 1 STOM
immunological synapse 1 ATP2B1
Sarcoplasmic reticulum lumen 1 HSP90B1
endocytic vesicle lumen 1 HSP90B1
endoplasmic reticulum chaperone complex 1 HSP90B1
photoreceptor ribbon synapse 1 ATP2B1


Literature Reference

  • Kiyotaka Takishita, Yoshito Chikaraishi, Goro Tanifuji, Naohiko Ohkouchi, Tetsuo Hashimoto, Katsunori Fujikura, Andrew J Roger. Microbial Eukaryotes that Lack Sterols. The Journal of eukaryotic microbiology. 2017 11; 64(6):897-900. doi: 10.1111/jeu.12426. [PMID: 28509379]
  • Amy B Banta, Jeremy H Wei, Paula V Welander. A distinct pathway for tetrahymanol synthesis in bacteria. Proceedings of the National Academy of Sciences of the United States of America. 2015 Nov; 112(44):13478-83. doi: 10.1073/pnas.1511482112. [PMID: 26483502]
  • Tomoko Toyama, Michiru Tahara, Kisaburo Nagamune, Kenji Arimitsu, Yoshio Hamashima, Nirianne M Q Palacpac, Hiroshi Kawaide, Toshihiro Horii, Kazuyuki Tanabe. Gibberellin biosynthetic inhibitors make human malaria parasite Plasmodium falciparum cells swell and rupture to death. PloS one. 2012; 7(3):e32246. doi: 10.1371/journal.pone.0032246. [PMID: 22412858]
  • Jeferson Gross, Debashish Bhattacharya. Uniting sex and eukaryote origins in an emerging oxygenic world. Biology direct. 2010 Aug; 5(?):53. doi: 10.1186/1745-6150-5-53. [PMID: 20731852]
  • H Kotsifaki, V Kapoulas, G Deliconstantinos. Targeting of liposomes containing methotrexate towards Tetrahymena pyriformis cells. General pharmacology. 1985; 16(6):573-7. doi: 10.1016/0306-3623(85)90145-4. [PMID: 3936748]
  • H Nakayama, M Goto, K Ohki, T Mitsui, Y Nozawa. An X-ray diffraction study on phase transition temperatures of various membranes isolated from Tetrahymena pyriformis cells grown at different temperatures. Biochimica et biophysica acta. 1983 Apr; 730(1):17-24. doi: 10.1016/0005-2736(83)90311-5. [PMID: 6403032]
  • M S SHORB, B E DUNLAP, W O POLLARD. EFFECT OF TRIPARANOL ON SYNTHESIS OF SQUALENE AND TETRAHYMANOL BY TETRAHYMENA PYRIFORMIS. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1965 Apr; 118(?):1140-5. doi: 10.3181/00379727-118-30065. [PMID: 14277681]