Glucuronosylestradiol (BioDeep_00000638292)

   

Volatile Flavor Compounds


代谢物信息卡片


3-hydroxyestra-1,3,5(10)-trien-17beta-yl beta-D-glucopyranosiduronic acid

化学式: C24H32O8 (448.20970719999997)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC3C(C1CCC2OC4C(C(C(C(O4)C(=O)O)O)O)O)CCC5=C3C=CC(=C5)O
InChI: InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

8 个代谢物同义名

3-hydroxyestra-1,3,5(10)-trien-17beta-yl beta-D-glucopyranosiduronic acid; 17beta-Estradiol 17-(beta-D-glucuronide); 7beta-estradiol 17-glucosiduronic acid; 17-beta-estradiol glucuronide; Estradiol-17beta-glucuronide; Glucuronosylestradiol; ST 18:3;O2;GlcA; 17beta-Estradiol 17-(beta-D-glucuronide)



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai, Hong-Guang Xie. Multidrug Resistance-Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood. Drug metabolism and disposition: the biological fate of chemicals. 2020 10; 48(10):966-971. doi: 10.1124/dmd.119.089193. [PMID: 31900255]
  • Im-Sook Song, Hyeon-Uk Jeong, Min-Koo Choi, Mihwa Kwon, Yongho Shin, Jeong Han Kim, Hye-Suk Lee. Interactions between cyazofamid and human drug transporters. Journal of biochemical and molecular toxicology. 2020 Apr; 34(4):e22459. doi: 10.1002/jbt.22459. [PMID: 32003934]
  • Gwenaëlle Conseil, May Arama-Chayoth, Yossi Tsfadia, Susan P C Cole. Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 10; 33(10):10692-10704. doi: 10.1096/fj.201900140r. [PMID: 31268744]
  • Mingxiang Liao, Qing Zhu, Andy Zhu, Christopher Gemski, Bingli Ma, Emily Guan, Albert P Li, Guangqing Xiao, Cindy Q Xia. Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Jul; 49(7):852-862. doi: 10.1080/00498254.2018.1512017. [PMID: 30132394]
  • Alexandra Crowe, Wei Zheng, Jonathan Miller, Sonia Pahwa, Khondoker Alam, Kar-Ming Fung, Erin Rubin, Feng Yin, Kai Ding, Wei Yue. Characterization of Plasma Membrane Localization and Phosphorylation Status of Organic Anion Transporting Polypeptide (OATP) 1B1 c.521 T>C Nonsynonymous Single-Nucleotide Polymorphism. Pharmaceutical research. 2019 May; 36(7):101. doi: 10.1007/s11095-019-2634-3. [PMID: 31093828]
  • Guillermo Nicolás Tocchetti, Agostina Arias, Maite Rocío Arana, Juan Pablo Rigalli, Camila Juliana Domínguez, Felipe Zecchinati, María Laura Ruiz, Silvina Stella Maris Villanueva, Aldo Domingo Mottino. Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-D-glucuronide in rat intestine and Caco-2 cells. Archives of toxicology. 2018 Feb; 92(2):777-788. doi: 10.1007/s00204-017-2092-9. [PMID: 29052767]
  • Mayukh Banerjee, Vanessa Marensi, Gwenaëlle Conseil, X Chris Le, Susan P C Cole, Elaine M Leslie. Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions. Biochemical pharmacology. 2016 Nov; 120(?):72-82. doi: 10.1016/j.bcp.2016.09.016. [PMID: 27659809]
  • Moritz Gruetz, Heinrich Sticht, Hartmut Glaeser, Martin F Fromm, Jörg König. Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1). Biochimica et biophysica acta. 2016 Nov; 1858(11):2894-2902. doi: 10.1016/j.bbamem.2016.08.018. [PMID: 27594653]
  • Nisreen Hoosain, Brendon Pearce, Clifford Jacobs, Mongi Benjeddou. Mapping SLCO1B1 Genetic Variation for Global Precision Medicine in Understudied Regions in Africa: A Focus on Zulu and Cape Admixed Populations. Omics : a journal of integrative biology. 2016 09; 20(9):546-54. doi: 10.1089/omi.2016.0115. [PMID: 27631194]
  • Caley B Shukalek, Diane P Swanlund, Rodney K Rousseau, Kevin E Weigl, Vanessa Marensi, Susan P C Cole, Elaine M Leslie. Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23. Molecular pharmacology. 2016 08; 90(2):127-39. doi: 10.1124/mol.116.103648. [PMID: 27297967]
  • Khondoker Alam, Sonia Pahwa, Xueying Wang, Pengyue Zhang, Kai Ding, Alaa H Abuznait, Lang Li, Wei Yue. Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions. Molecular pharmaceutics. 2016 Mar; 13(3):839-51. doi: 10.1021/acs.molpharmaceut.5b00763. [PMID: 26750564]
  • Feng Deng, Noora Sjöstedt, Heidi Kidron. The Effect of Albumin on MRP2 and BCRP in the Vesicular Transport Assay. PloS one. 2016; 11(10):e0163886. doi: 10.1371/journal.pone.0163886. [PMID: 27706255]
  • Gloria Wissel, Pavel Kudryavtsev, Leo Ghemtio, Päivi Tammela, Peter Wipf, Marjo Yliperttula, Moshe Finel, Arto Urtti, Heidi Kidron, Henri Xhaard. Exploring the structure-activity relationships of ABCC2 modulators using a screening approach. Bioorganic & medicinal chemistry. 2015 Jul; 23(13):3513-25. doi: 10.1016/j.bmc.2015.04.029. [PMID: 25935289]
  • Saki Izumi, Yoshitane Nozaki, Kazuya Maeda, Takafumi Komori, Osamu Takenaka, Hiroyuki Kusuhara, Yuichi Sugiyama. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug metabolism and disposition: the biological fate of chemicals. 2015 Feb; 43(2):235-47. doi: 10.1124/dmd.114.059105. [PMID: 25414411]
  • E van de Steeg, R Greupink, M Schreurs, I H G Nooijen, K C M Verhoeckx, R Hanemaaijer, D Ripken, M Monshouwer, M L H Vlaming, J DeGroot, M Verwei, F G M Russel, M T Huisman, H M Wortelboer. Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1. Drug metabolism and disposition: the biological fate of chemicals. 2013 Mar; 41(3):592-601. doi: 10.1124/dmd.112.049023. [PMID: 23248200]
  • Anett Engel, Stefan Oswald, Werner Siegmund, Markus Keiser. Pharmaceutical excipients influence the function of human uptake transporting proteins. Molecular pharmaceutics. 2012 Sep; 9(9):2577-81. doi: 10.1021/mp3001815. [PMID: 22808947]
  • Lei Qin, Shui-Pang Tam, Roger G Deeley. Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jul; 40(7):1403-13. doi: 10.1124/dmd.112.044867. [PMID: 22511347]
  • Heidi Kidron, Gloria Wissel, Nenad Manevski, Marika Häkli, Raimo A Ketola, Moshe Finel, Marjo Yliperttula, Henri Xhaard, Arto Urtti. Impact of probe compound in MRP2 vesicular transport assays. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2012 May; 46(1-2):100-5. doi: 10.1016/j.ejps.2012.02.016. [PMID: 22406294]
  • Surtaj H Iram, Susan P C Cole. Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). The Journal of biological chemistry. 2012 Mar; 287(10):7543-55. doi: 10.1074/jbc.m111.310409. [PMID: 22232552]
  • Dirk R de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C Paulusma, Ronald P J Oude Elferink. Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):515-21. doi: 10.1124/dmd.111.041731. [PMID: 22166395]
  • Rick Greupink, Lieve Dillen, Mario Monshouwer, Maarten T Huisman, Frans G M Russel. Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP). European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2011 Nov; 44(4):487-96. doi: 10.1016/j.ejps.2011.09.009. [PMID: 21945488]
  • Megan Roth, Juan J Araya, Barbara N Timmermann, Bruno Hagenbuch. Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). The Journal of pharmacology and experimental therapeutics. 2011 Nov; 339(2):624-32. doi: 10.1124/jpet.111.184564. [PMID: 21846839]
  • Maria Ulvestad, Petter Björquist, Espen Molden, Anders Asberg, Tommy B Andersson. OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture. Biochemical pharmacology. 2011 Nov; 82(9):1219-26. doi: 10.1016/j.bcp.2011.07.076. [PMID: 21787759]
  • Maciej J Zamek-Gliszczynski, Jeffrey S Day, Kathleen M Hillgren, Diane L Phillips. Efflux transport is an important determinant of ethinylestradiol glucuronide and ethinylestradiol sulfate pharmacokinetics. Drug metabolism and disposition: the biological fate of chemicals. 2011 Oct; 39(10):1794-800. doi: 10.1124/dmd.111.040162. [PMID: 21708882]
  • Lei Gong, Nelly Aranibar, Yong-Hae Han, Youcai Zhang, Lloyd Lecureux, Vasanthi Bhaskaran, Purnima Khandelwal, Curtis D Klaassen, Lois D Lehman-McKeeman. Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Aug; 122(2):587-97. doi: 10.1093/toxsci/kfr114. [PMID: 21561886]
  • Vandana Megaraj, Tianyong Zhao, Christian M Paumi, Phillip M Gerk, Richard B Kim, Mary Vore. Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). Pharmacogenetics and genomics. 2011 Aug; 21(8):506-15. doi: 10.1097/fpc.0b013e328348c786. [PMID: 21691255]
  • Valentina L Kouznetsova, Igor F Tsigelny, Megha A Nagle, Sanjay K Nigam. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorganic & medicinal chemistry. 2011 Jun; 19(11):3320-40. doi: 10.1016/j.bmc.2011.04.045. [PMID: 21571536]
  • Pablo Martinez-Becerra, Oscar Briz, Marta R Romero, Rocio I R Macias, Maria J Perez, Carlos Sancho-Mateo, Maria P Lostao, Jose M Fernandez-Abalos, Jose J G Marin. Further characterization of the electrogenicity and pH sensitivity of the human organic anion-transporting polypeptides OATP1B1 and OATP1B3. Molecular pharmacology. 2011 Mar; 79(3):596-607. doi: 10.1124/mol.110.069971. [PMID: 21173039]
  • Emi Kimoto, Jonathan Chupka, Yongling Xiao, Yi-An Bi, David B Duignan. Characterization of digoxin uptake in sandwich-cultured human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 2011 Jan; 39(1):47-53. doi: 10.1124/dmd.110.034298. [PMID: 20926619]
  • Asier Vallejo, Aresatz Usobiaga, Maren Ortiz-Zarragoitia, Miren P Cajaraville, Luis A Fernández, Olatz Zuloaga. Focused ultrasound-assisted acceleration of enzymatic hydrolysis of alkylphenols and 17β-oestradiol glucuronide in fish bile. Analytical and bioanalytical chemistry. 2010 Nov; 398(5):2307-14. doi: 10.1007/s00216-010-4156-z. [PMID: 20835815]
  • Chunshan Gui, Bruno Hagenbuch. Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2010 Apr; 151(3):393-9. doi: 10.1016/j.cbpc.2010.01.005. [PMID: 20079461]
  • Yi M Weaver, David J Ehresman, John L Butenhoff, Bruno Hagenbuch. Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths. Toxicological sciences : an official journal of the Society of Toxicology. 2010 Feb; 113(2):305-14. doi: 10.1093/toxsci/kfp275. [PMID: 19915082]
  • P Sharma, V E Holmes, R Elsby, C Lambert, D Surry. Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica; the fate of foreign compounds in biological systems. 2010 Jan; 40(1):24-37. doi: 10.3109/00498250903351013. [PMID: 19919292]
  • Masakazu Hirouchi, Hiroyuki Kusuhara, Reiko Onuki, Brian W Ogilvie, Andrew Parkinson, Yuichi Sugiyama. Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4. Drug metabolism and disposition: the biological fate of chemicals. 2009 Oct; 37(10):2103-11. doi: 10.1124/dmd.109.027193. [PMID: 19628752]
  • Dirk R de Waart, Maria L H Vlaming, Cindy Kunne, Alfred H Schinkel, Ronald P J Oude Elferink. Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug metabolism and disposition: the biological fate of chemicals. 2009 Aug; 37(8):1698-702. doi: 10.1124/dmd.108.026146. [PMID: 19443695]
  • Tomomi Furihata, Naoki Satoh, Tomoharu Ohishi, Miyuki Ugajin, Yoshio Kameyama, Kaori Morimoto, Sayaka Matsumoto, Keiko Yamashita, Kaoru Kobayashi, Kan Chiba. Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy. The pharmacogenomics journal. 2009 Jun; 9(3):185-93. doi: 10.1038/tpj.2009.3. [PMID: 19238167]
  • Koen van de Wetering, Alexander Burkon, Wouter Feddema, Alice Bot, Hugo de Jonge, Veronika Somoza, Piet Borst. Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol. Molecular pharmacology. 2009 Apr; 75(4):876-85. doi: 10.1124/mol.108.052019. [PMID: 19114588]
  • M-K Choi, H Kim, Y-H Han, I-S Song, C-K Shim. Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. Xenobiotica; the fate of foreign compounds in biological systems. 2009 Feb; 39(2):171-81. doi: 10.1080/00498250802642256. [PMID: 19255943]
  • Fernando A Crocenzi, Enrique J Sánchez Pozzi, María Laura Ruiz, Andrés E Zucchetti, Marcelo G Roma, Aldo D Mottino, Mary Vore. Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat. Hepatology (Baltimore, Md.). 2008 Dec; 48(6):1885-95. doi: 10.1002/hep.22532. [PMID: 18972403]
  • Giulia Ghibellini, Elaine M Leslie, Gary M Pollack, Kim L R Brouwer. Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. Pharmaceutical research. 2008 Aug; 25(8):1851-60. doi: 10.1007/s11095-008-9597-0. [PMID: 18509604]
  • Naoko Yoshida, Tappei Takada, Yoshikazu Yamamura, Isao Adachi, Hiroshi Suzuki, Junichi Kawakami. Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1206-11. doi: 10.1124/dmd.107.019513. [PMID: 18436619]
  • Chunshan Gui, Yi Miao, Lucas Thompson, Bret Wahlgren, Melissa Mock, Bruno Stieger, Bruno Hagenbuch. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. European journal of pharmacology. 2008 Apr; 584(1):57-65. doi: 10.1016/j.ejphar.2008.01.042. [PMID: 18321482]
  • Soichiro Matsushima, Kazuya Maeda, Naoki Ishiguro, Takashi Igarashi, Yuichi Sugiyama. Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans. Drug metabolism and disposition: the biological fate of chemicals. 2008 Apr; 36(4):663-9. doi: 10.1124/dmd.107.017814. [PMID: 18180276]
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  • Alexander Treiber, Ralph Schneiter, Stephanie Häusler, Bruno Stieger. Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug metabolism and disposition: the biological fate of chemicals. 2007 Aug; 35(8):1400-7. doi: 10.1124/dmd.106.013615. [PMID: 17496208]
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  • Markus Grube, Sebastian Reuther, Henriette Meyer Zu Schwabedissen, Kathleen Köck, Katrin Draber, Christoph A Ritter, Christoph Fusch, Gabriele Jedlitschky, Heyo K Kroemer. Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. Drug metabolism and disposition: the biological fate of chemicals. 2007 Jan; 35(1):30-5. doi: 10.1124/dmd.106.011411. [PMID: 17020956]
  • Naoki Ishiguro, Kazuya Maeda, Wataru Kishimoto, Asami Saito, Akiko Harada, Thomas Ebner, Willy Roth, Takashi Igarashi, Yuichi Sugiyama. Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug metabolism and disposition: the biological fate of chemicals. 2006 Jul; 34(7):1109-15. doi: 10.1124/dmd.105.009175. [PMID: 16611857]
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  • Cuiping Chen, Rouchelle J Mireles, Scott D Campbell, Jian Lin, Jessica B Mills, Jinghai J Xu, Teresa A Smolarek. Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug metabolism and disposition: the biological fate of chemicals. 2005 Apr; 33(4):537-46. doi: 10.1124/dmd.104.002477. [PMID: 15616150]
  • Kevin J Spears, Jillian Ross, Alasdair Stenhouse, Clive J Ward, Lay-Beng Goh, C Roland Wolf, Paul Morgan, Andy Ayrton, Thomas H Friedberg. Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2. Biochemical pharmacology. 2005 Feb; 69(3):415-23. doi: 10.1016/j.bcp.2004.09.026. [PMID: 15652233]
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  • Tappei Takada, H Markus Weiss, Olivier Kretz, Gerhard Gross, Yuichi Sugiyama. Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154. Drug metabolism and disposition: the biological fate of chemicals. 2004 Nov; 32(11):1272-8. doi: 10.1124/dmd.104.000497. [PMID: 15280219]
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  • Sumio Ohtsuki, Tazuru Kikkawa, Shinobu Mori, Satoko Hori, Hitomi Takanaga, Masaki Otagiri, Tetsuya Terasaki. Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. The Journal of pharmacology and experimental therapeutics. 2004 Jun; 309(3):1273-81. doi: 10.1124/jpet.103.063370. [PMID: 14762099]
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