ST 27:1;O2;S (BioDeep_00000638263)
代谢物信息卡片
化学式: C27H46O5S (482.3065786)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [C@]12(CC=C3C[C@@H](OS(=O)(O)=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@]([H])([C@@](C)([H])CCCC(O)(C)C)CC[C@@]21[H])[H]
InChI: InChI=1S/C27H46O5S/c1-18(7-6-14-25(2,3)28)22-10-11-23-21-9-8-19-17-20(32-33(29,30)31)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28H,6-7,9-17H2,1-5H3,(H,29,30,31)/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
描述信息
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yaping Wang, William M Pandak, Edward J Lesnefsky, Phillip B Hylemon, Shunlin Ren. 25-Hydroxycholesterol 3-Sulfate Recovers Acetaminophen Induced Acute Liver Injury via Stabilizing Mitochondria in Mouse Models.
Cells.
2021 11; 10(11):. doi:
10.3390/cells10113027. [PMID: 34831255] - Yaping Wang, Weiqi Lin, James E Brown, Lanming Chen, Williams M Pandak, Phillip B Hylemon, Shunlin Ren. 25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes.
Journal of lipid research.
2021; 62(?):100063. doi:
10.1016/j.jlr.2021.100063. [PMID: 33705741] - Yanxia Ning, Jin Kyung Kim, Hae-Ki Min, Shunlin Ren. Cholesterol metabolites alleviate injured liver function and decrease mortality in an LPS-induced mouse model.
Metabolism: clinical and experimental.
2017 06; 71(?):83-93. doi:
10.1016/j.metabol.2016.12.007. [PMID: 28521882] - Shunlin Ren, Yanxia Ning. Sulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation.
American journal of physiology. Endocrinology and metabolism.
2014 Jan; 306(2):E123-30. doi:
10.1152/ajpendo.00552.2013. [PMID: 24302009] - Shunlin Ren, Jin Koung Kim, Genta Kakiyama, Daniel Rodriguez-Agudo, William M Pandak, Hae-Ki Min, Yanxia Ning. Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate.
PloS one.
2014; 9(7):e103621. doi:
10.1371/journal.pone.0103621. [PMID: 25072708] - Leyuan Xu, Jin Koung Kim, Qianming Bai, Xin Zhang, Genta Kakiyama, Hae-Ki Min, Arun J Sanyal, William M Pandak, Shunlin Ren. 5-cholesten-3β,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model.
Molecular pharmacology.
2013 Mar; 83(3):648-58. doi:
10.1124/mol.112.081505. [PMID: 23258548] - Xin Zhang, Qianming Bai, Genta Kakiyama, Leyuan Xu, Jin Kyung Kim, William M Pandak, Shunlin Ren. Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice.
The Journal of steroid biochemistry and molecular biology.
2012 Nov; 132(3-5):262-70. doi:
10.1016/j.jsbmb.2012.06.001. [PMID: 22732306] - Qianming Bai, Xin Zhang, Leyuan Xu, Genta Kakiyama, Douglas Heuman, Arun Sanyal, William M Pandak, Lianhua Yin, Wen Xie, Shunlin Ren. Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease.
Metabolism: clinical and experimental.
2012 Jun; 61(6):836-45. doi:
10.1016/j.metabol.2011.11.014. [PMID: 22225954] - Leyuan Xu, Shanwei Shen, Yongjie Ma, Jin Koung Kim, Daniel Rodriguez-Agudo, Douglas M Heuman, Phillip B Hylemon, William M Pandak, Shunlin Ren. 25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages.
American journal of physiology. Endocrinology and metabolism.
2012 Apr; 302(7):E788-99. doi:
10.1152/ajpendo.00337.2011. [PMID: 22275753] - Qianming Bai, Leyuan Xu, Genta Kakiyama, Melissa Ann Runge-Morris, Phillip B Hylemon, Lianhua Yin, William M Pandak, Shunlin Ren. Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.
Atherosclerosis.
2011 Feb; 214(2):350-6. doi:
10.1016/j.atherosclerosis.2010.11.021. [PMID: 21146170] - Leyuan Xu, Qianming Bai, Daniel Rodriguez-Agudo, Phillip B Hylemon, Douglas M Heuman, William M Pandak, Shunlin Ren. Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate.
Lipids.
2010 Sep; 45(9):821-32. doi:
10.1007/s11745-010-3451-y. [PMID: 20700770] - Yongjie Ma, Leyuan Xu, Daniel Rodriguez-Agudo, Xiaobo Li, Douglas M Heuman, Phillip B Hylemon, William M Pandak, Shunlin Ren. 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.
American journal of physiology. Endocrinology and metabolism.
2008 Dec; 295(6):E1369-79. doi:
10.1152/ajpendo.90555.2008. [PMID: 18854425] - Shunlin Ren, Xiaobo Li, Daniel Rodriguez-Agudo, Gregorio Gil, Phillip Hylemon, William M Pandak. Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes.
Biochemical and biophysical research communications.
2007 Sep; 360(4):802-8. doi:
10.1016/j.bbrc.2007.06.143. [PMID: 17624300]