ST 24:2;O4 (BioDeep_00000638116)

 

Secondary id: BioDeep_00000008769


代谢物信息卡片


4-(3,6-dihydroxy-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid

化学式: C24H38O4 (390.277)
中文名称: 4-(3,6-二羟基-10,13-二甲基-2,3,6,7,8,9,10,11,12,13,14,15,16,17-四氢-1H-环戊基[a]17-菲)戊酸, 5α-胆酸-3-α-醇-6-酮
谱图信息: 最多检出来源 Homo sapiens(otcml) 36.7%

分子结构信息

SMILES: C1[C@]2(C)C3=C[C@@H](O)[C@]4(C)[C@@]([H])([C@]([H])(C)CCC(O)=O)CC[C@@]4([H])[C@]3([H])CC[C@]2([H])C[C@H](O)C1
InChI: InChI=1S/C24H38O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-20,25H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16+,17-,18+,19+,20+,23-,24-/m1/s1

描述信息

A dihydroxy-5beta-cholanic acid that is deoxycholic acid with a double bond at position 6.
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids

同义名列表

57 个代谢物同义名

3alpha,12alpha-Dihydroxy-5beta-chol-6-en-24-oic Acid; 3alpha,12alpha-Dihydroxy-5beta-chol-6-enoate; ST 24:2;O4; 3alpha,7alpha-Dihydroxy-5beta-chol-16-en-24-oic Acid; 3alpha-Hydroxy-7-oxo-5alpha-cholan-24-oic Acid; 3beta,19-Dihydroxychol-5-en-24-oic Acid; 12alpha-Hydroxy-7-oxo-5beta-cholan-24-oic Acid; 7alpha,12alpha-Dihydroxy-5beta-chol-2-en-24-oic Acid; 3alpha-Hydroxy-12-oxo-5alpha-cholan-24-oic Acid; 3alpha,12beta-Dihydroxy-5beta-chol-9(11)-en-24-oic Acid; 3alpha,12alpha-Dihydroxy-5beta-chol-14-en-24-oic Acid; 3alpha,7beta-Dihydroxy-5beta-chol-11-en-24-oic Acid; 3alpha,7alpha-Dihydroxy-5beta-chol-11-en-24-oic Acid; 3alpha,7beta-Dihydroxychol-5-en-24-oic Acid; 3alpha,7alpha-Dihydroxychol-5-en-24-oic Acid; 1alpha-Hydroxy-3-oxo-5beta-cholan-24-oic Acid; (22E)-3alpha,12alpha-Dihydroxy-5beta-chol-22-en-24-oic Acid; (22E)-3alpha,7beta-Dihydroxy-5beta-chol-22-en-24-oic Acid; (22E)-3alpha,7alpha-Dihydroxy-5beta-chol-22-en-24-oic Acid; 7alpha,12alpha-Dihydroxy-5beta-chol-3-en-24-oic Acid; 3alpha,12alpha-Dihydroxy-5beta-chol-9(11)-en-24-oic Acid; 3alpha,12alpha-Dihydroxy-5beta-chol-8-en-24-oic Acid; 3alpha,12alpha-Dihydroxy-5beta-chol-7-en-24-oic Acid; 3alpha,12beta-Dihydroxy-5beta-chol-6-en-24-oic Acid; 3beta,12alpha-Dihydroxychol-5-en-24-oic Acid; 3beta,7beta-Dihydroxychol-5-en-24-oic Acid; 3beta,7alpha-Dihydroxychol-5-en-24-oic Acid; 3beta,7alpha-Dihydroxychol-4-en-24-oic Acid; 4-(3,6-dihydroxy-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid; 3beta,6beta-Dihydroxychol-4-en-24-oic Acid; 12alpha-Hydroxy-7-oxo-5alpha-cholan-24-oic Acid; 12alpha-Hydroxy-3-oxo-5alpha-cholan-24-oic Acid; 12alpha-Hydroxy-3-oxo-5beta-cholan-24-oic Acid; 7beta-Hydroxy-12-oxo-5alpha-cholan-24-oic Acid; 7alpha-Hydroxy-12-oxo-5alpha-cholan-24-oic Acid; 7beta-Hydroxy-12-oxo-5beta-cholan-24-oic Acid; 7alpha-Hydroxy-12-oxo-5beta-cholan-24-oic Acid; 7alpha-Hydroxy-3-oxo-5alpha-cholan-24-oic Acid; 7beta-Hydroxy-3-oxo-5beta-cholan-24-oic Acid; 7alpha-Hydroxy-3-oxo-5beta-cholan-24-oic Acid; 6alpha-Hydroxy-3-oxo-5alpha-cholan-24-oic Acid; 6beta-Hydroxy-3-oxo-5beta-cholan-24-oic Acid; 6alpha-Hydroxy-3-oxo-5beta-cholan-24-oic Acid; 12beta-Hydroxy-3-oxo-5beta-cholan-24-oic Acid; 3beta-Hydroxy-12-oxo-5beta-cholan-24-oic Acid; 3alpha-Hydroxy-12-oxo-5beta-cholan-24-oic Acid; 3beta-Hydroxy-11-oxo-5beta-cholan-24-oic Acid; 3alpha-Hydroxy-11-oxo-5beta-cholan-24-oic Acid; 3beta-Hydroxy-7-oxo-5alpha-cholan-24-oic Acid; 3beta-Hydroxy-7-oxo-5beta-cholan-24-oic Acid; 3alpha-Hydroxy-7-oxo-5beta-cholan-24-oic Acid; 7-oxolithocholic acid; 3beta-Hydroxy-6-oxo-5alpha-cholan-24-oic Acid; Cholan-24-oic acid,3-hydroxy-6-oxo-, (3a,5a)- (9CI); 3alpha-Hydroxy-6-oxo-5alpha-cholan-24-oic Acid; 3beta-Hydroxy-6-oxo-5beta-cholan-24-oic Acid; 3alpha-Hydroxy-6-oxo-5beta-cholan-24-oic Acid



数据库引用编号

170 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • L Riello, L D'Antiga, M Guido, R Alaggio, G Giordano, L Zancan. Titration of bile acid supplements in 3beta-hydroxy-Delta 5-C27-steroid dehydrogenase/isomerase deficiency. Journal of pediatric gastroenterology and nutrition. 2010 Jun; 50(6):655-60. doi: 10.1097/mpg.0b013e3181b97bd2. [PMID: 20400917]
  • Pushpa Subramaniam, Peter T Clayton, Bernard C Portmann, Giorgina Mieli-Vergani, Nedim Hadzić. Variable clinical spectrum of the most common inborn error of bile acid metabolism--3beta-hydroxy-Delta 5-C27-steroid dehydrogenase deficiency. Journal of pediatric gastroenterology and nutrition. 2010 Jan; 50(1):61-6. doi: 10.1097/mpg.0b013e3181b47b34. [PMID: 19915491]
  • Genta Kakiyama, Akina Muto, Miki Shimada, Nariyasu Mano, Junichi Goto, Alan F Hofmann, Takashi Iida. Chemical synthesis of 3beta-sulfooxy-7beta-hydroxy-24-nor-5-cholenoic acid: an internal standard for mass spectrometric analysis of the abnormal delta5-bile acids occurring in Niemann-Pick disease. Steroids. 2009 Sep; 74(9):766-72. doi: 10.1016/j.steroids.2009.04.007. [PMID: 19394355]
  • Genta Kakiyama, Shoujiro Ogawa, Takashi Iida, Yasuo Fujimoto, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara. Nuclear magnetic resonance spectroscopy of 3 beta,7 beta-dihydroxy-5-cholen-24-oic acid multi-conjugates: unusual bile acid metabolites in human urine. Chemistry and physics of lipids. 2006 Apr; 140(1-2):48-54. doi: 10.1016/j.chemphyslip.2006.01.003. [PMID: 16516876]
  • Takashi Iida, Genta Kakiyama, Yohei Hibiya, Shohei Miyata, Takehiko Inoue, Kohsaku Ohno, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara, Alan F Hofmann. Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3beta,7beta-dihydroxy-5-cholen-24-oic acid, and related compounds: unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1. Steroids. 2006 Jan; 71(1):18-29. doi: 10.1016/j.steroids.2005.07.008. [PMID: 16197972]
  • Nariyasu Mano, Yoshiaki Sato, Masanori Nagata, Takaaki Goto, Junichi Goto. Bioconversion of 3beta-hydroxy-5-cholenoic acid into chenodeoxycholic acid by rat brain enzyme systems. Journal of lipid research. 2004 Sep; 45(9):1741-8. doi: 10.1194/jlr.m400157-jlr200. [PMID: 15175361]
  • Y Chen, P Yu, D Lu, D A Tagle, T Cai. A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin. Journal of molecular neuroscience : MN. 2001 Aug; 17(1):59-70. doi: 10.1385/jmn:17:1:59. [PMID: 11665863]
  • E V Udut, V V Zhdanov, L A Gur'yantseva, A M Dygai, V E Gol'dberg, S B Tkachenko. Role of hemopoietic growth factors in regeneration of hemopoiesis during etoposide-induced myelosuppression. Bulletin of experimental biology and medicine. 2001 May; 131(5):432-6. doi: 10.1023/a:1017959528320. [PMID: 11550045]
  • K Nakamura, H Hotta, I Makino. [Clinical significance of 3 beta, 7 beta-dihydroxy-5 beta-cholan-24-oic acid (isoUDCA) in serum during administration of ursodeoxycholic acid]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 1993 Nov; 90(11):2961. doi: NULL. [PMID: 8271473]
  • J Shoda, T Osuga, K Matsuura, R Mahara, M Tohma, N Tanaka, Y Matsuzaki, H Miyazaki. Concurrent occurrence of 3 beta,12 alpha-dihydroxy-5-cholenoic acid associated with 3 beta-hydroxy-5-cholenoic acid and their preferential urinary excretion in liver diseases. Journal of lipid research. 1989 Aug; 30(8):1233-42. doi: 10.1016/s0022-2275(20)38280-8. [PMID: 2769075]
  • NULL. Serum cholesterol and glycosylated hemoglobin. The Journal of family practice. 1989 Jun; 28(6):731-2. doi: NULL. [PMID: 2723601]
  • J Shoda, K Matsuura, R Umahara, T Fujima, H Miyazaki. [Occurrence of urinary 3 beta,7 alpha- and 3 beta,7 beta-dihydroxy-5-cholenoic acids in cholestasis]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 1988 Sep; 85(9):1725. doi: NULL. [PMID: 3246766]
  • M Tohma, H Takeshita, R Mahara, T Kurosawa, I Makino. Determination of 3 beta,12 alpha-dihydroxy-5-cholen-24-oic acid and related bile acids in human serum by gas chromatography-mass spectrometry. Journal of chromatography. 1987 Oct; 421(1):9-19. doi: 10.1016/0378-4347(87)80374-2. [PMID: 3429578]
  • P T Clayton, J V Leonard, A M Lawson, K D Setchell, S Andersson, B Egestad, J Sjövall. Familial giant cell hepatitis associated with synthesis of 3 beta, 7 alpha-dihydroxy-and 3 beta,7 alpha, 12 alpha-trihydroxy-5-cholenoic acids. The Journal of clinical investigation. 1987 Apr; 79(4):1031-8. doi: 10.1172/jci112915. [PMID: 3470305]
  • J Shoda. [Unusual bile acid, 3 beta, 12 alpha-dihydroxy-5-cholenoic acid in hepatobiliary diseases and its significance]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 1987 Mar; 84(3):771. doi: NULL. [PMID: 3599511]
  • B Grego, I R Van Driel, J W Goding, E C Nice, R J Simpson. Use of microbore high-performance liquid chromatography for purifying subnanomole levels of polypeptides for microsequencing. Structural studies on the murine plasma cell antigen PC-1. International journal of peptide and protein research. 1986 Feb; 27(2):201-7. doi: 10.1111/j.1399-3011.1986.tb01811.x. [PMID: 3084398]
  • W M O'Neill, W B Etheridge, H A Bloomer. High-dose corticosteroids: their use in treating idiopathic rapidly progressive glomerulonephritis. Archives of internal medicine. 1979 May; 139(5):514-8. doi: 10.1001/archinte.139.5.514. [PMID: 443944]
  • E C Attwood, D E Probert. An assessment under routine conditions of an immunoelectrophoretic assay for thyroxine-binding globulin. Clinical biochemistry. 1978 Dec; 11(6):226-9. doi: 10.1016/s0009-9120(78)80013-7. [PMID: 104805]
  • G A Lesher, G R Spratto. Brain and plasma concentrations of morphine during the development of physical dependence and tolerance. The Journal of pharmacy and pharmacology. 1976 Nov; 28(11):843-4. doi: 10.1111/j.2042-7158.1976.tb04071.x. [PMID: 11297]
  • M O James, J R Fouts, J R Bend. Hepatic and extrahepatic metabolism, in vitro, of an epoxide (8-(14) C-styrene oxide) in the rabbit. Biochemical pharmacology. 1976 Jan; 25(2):187-93. doi: 10.1016/0006-2952(76)90289-6. [PMID: 4076]
  • V R Zurawski, W J Kohr, J F Foster. Conformational properties of bovine plasma albumin with a cleaved internal peptide bond. Biochemistry. 1975 Dec; 14(26):5579-86. doi: 10.1021/bi00697a007. [PMID: 1086]
  • J Harkness. Why urinalysis?. The Central African journal of medicine. 1975 Aug; 21(8):178-83. doi: NULL. [PMID: 1150]