ST 21:2;O5 (BioDeep_00000637540)

 

Secondary id: BioDeep_00000005838, BioDeep_00000005848, BioDeep_00000896077, BioDeep_00000896078, BioDeep_00001869977, BioDeep_00001870464


代谢物信息卡片


3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al

化学式: C21H32O5 (364.2249622)
中文名称: 20-aLpha-二氢可的松
谱图信息: 最多检出来源 Viridiplantae(plant) 0.7%

分子结构信息

SMILES: C1C=C2[C@@](C)([C@@]3([H])[C@@H](O)C[C@@]4(C)[C@@]([H])(CC[C@@]4(C(CO)=O)O)[C@]13[H])CC[C@H](O)C2
InChI: InChI=1S/C21H32O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h12-16,19,22-24H,2-11H2,1H3/t12-,13-,14+,15+,16-,19-,20+,21-/m1/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

24 个代谢物同义名

3alpha,18,21-trihydroxy-5beta-pregnan-11,20-dione; 18-Hydroxy-11-dehydrotetrahydrocorticosterone; 5beta-pregnane-3alpha,18,21-triol-11,20-dione; ST 21:2;O5; 11beta,18,21-trihydroxy-5beta-pregnan-3,20-dione; 5beta-pregnane-11beta,18,21-triol-3,20-dione; 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al; 5beta-pregnane-3alpha,11beta,21-triol-20-one-18-al; Tetrahydroaldosterone; 4-Pregnene-11beta,17alpha,20alpha,21-tetrol-3-one; 20alpha-Dihydrocortisol; 20alpha-Hydroxycortisol; 20-α-DIHYDROCORTISOL; 4-Pregnene-11beta,17alpha,20beta,21-tetrol-3-one; 20beta-Hydroxycortisol; Reichsteins compound E; 20beta-dihydrocortisol; 5beta-pregnane-17alpha,20beta,21-triol-3,11-dione; 5beta-pregnane-17alpha,20alpha,21-triol-3,11-dione; 5beta-pregnane-11beta,17alpha,21-triol-3,20-dione; 5beta-Dihydrocortisol; 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al; 3beta,11beta,17,21-tetrahydroxypregn-5-en-20-one; 11beta,17alpha,21-trihydroxypregnenolone



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Soraya Puglisi, Marta Leporati, Eleonora Amante, Alice Parisi, Anna Rosa Pia, Paola Berchialla, Massimo Terzolo, Marco Vincenti, Giuseppe Reimondo. Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas. Frontiers in endocrinology. 2022; 13(?):833514. doi: 10.3389/fendo.2022.833514. [PMID: 35222288]
  • Jonas Esche, Lijie Shi, Alberto Sánchez-Guijo, Michaela F Hartmann, Stefan A Wudy, Thomas Remer. Higher diet-dependent renal acid load associates with higher glucocorticoid secretion and potentially bioactive free glucocorticoids in healthy children. Kidney international. 2016 08; 90(2):325-333. doi: 10.1016/j.kint.2016.02.033. [PMID: 27165611]
  • Jason M Ridlon, Shigeo Ikegawa, João M P Alves, Biao Zhou, Akiko Kobayashi, Takashi Iida, Kuniko Mitamura, Genzoh Tanabe, Myrna Serrano, Ainee De Guzman, Patsy Cooper, Gregory A Buck, Phillip B Hylemon. Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens. Journal of lipid research. 2013 Sep; 54(9):2437-49. doi: 10.1194/jlr.m038869. [PMID: 23772041]
  • Wassif S Wassif, Declan M McLoughlin, Royce P Vincent, Simon Conroy, Gerald F M Russell, Norman F Taylor. Steroid metabolism and excretion in severe anorexia nervosa: effects of refeeding. The American journal of clinical nutrition. 2011 May; 93(5):911-7. doi: 10.3945/ajcn.111.012666. [PMID: 21367953]
  • Loai A Shakerdi, John M C Connell, Robert Fraser, A Michael Wallace. Analysis of biological samples by gas chromatography-mass spectrometry without a reference standard: measurement of urinary 18-hydroxytetrahydro-11-dehydrocorticosterone excretion rate in human subjects. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Feb; 784(2):367-73. doi: 10.1016/s1570-0232(02)00825-5. [PMID: 12505784]
  • N Picard-Hagen, V Gayrard, V Laroute, C Grandjean, O Andreoletti, J M Elsen, F Schelcher, P L Toutain. Discriminant value of blood and urinary corticoids for the diagnosis of scrapie in live sheep. The Veterinary record. 2002 Jun; 150(22):680-4. doi: 10.1136/vr.150.22.680. [PMID: 12074236]
  • P Heilmann, E Buchheim, J Wacker, R Ziegler. Alteration of the activity of the 11beta-hydroxysteroid dehydrogenase in pregnancy: relevance for the development of pregnancy-induced hypertension?. The Journal of clinical endocrinology and metabolism. 2001 Nov; 86(11):5222-6. doi: 10.1210/jcem.86.11.8049. [PMID: 11701681]
  • M A Popot, E Lacabaratz, P Garcia, V Laroute, Y Bonnaire, P L Toutain, D A Cowan. New approaches to detect cortisol administration in the horse. Equine veterinary journal. 1999 Jul; 31(4):278-84. doi: 10.1111/j.2042-3306.1999.tb03817.x. [PMID: 10454084]
  • F Schelcher, N Picard-Hagen, V Laroute, V Gayrard, M A Popot, O Andreoletti, P L Toutain. Corticoid concentrations are increased in the plasma and urine of ewes with naturally occurring scrapie. Endocrinology. 1999 May; 140(5):2422-5. doi: 10.1210/endo.140.5.6896. [PMID: 10218997]
  • A B Yong, J Montalto, J Pitt, S Oakes, T Preston, C Buchanan. Corticosterone methyl oxidase type II (CMO II) deficiency: biochemical approach to diagnosis. Clinical biochemistry. 1994 Dec; 27(6):491-4. doi: 10.1016/0009-9120(94)00048-z. [PMID: 7697895]
  • M Schöneshöfer, A Kage, B Eisenschmid, P Heilmann, T K Dhar, B Weber. Automated liquid chromatographic determination of the 20-dihydro isomers of cortisol and cortisone in human urine. Journal of chromatography. 1986 Aug; 380(2):267-74. doi: 10.1016/s0378-4347(00)83655-5. [PMID: 3760056]
  • M Schöneshöfer, B Weber, W Oelkers, K Nahoul, F Mantero. Measurement of urinary free 20 alpha-dihydrocortisol in biochemical diagnosis of chronic hypercorticoidism. Clinical chemistry. 1986 May; 32(5):808-10. doi: . [PMID: 3009052]
  • M Schöneshöfer, B Weber, S Nigam. Increased urinary excretion of free 20 alpha- and 20 beta-dihydrocortisol in a hypercortisolemic but hypocortisoluric patient with Cushing's disease. Clinical chemistry. 1983 Feb; 29(2):385-9. doi: . [PMID: 6821952]
  • J D Veldhuis, H E Kulin, T E Wilson, J C Melby. Detection of isolated aldosterone deficiency in the neonate. The Journal of pediatrics. 1983 Jan; 102(1):83-5. doi: 10.1016/s0022-3476(83)80295-9. [PMID: 6848733]
  • S Ulick, W R Eberlein, A R Bliffeld, M D Chu, A M Bongiovanni. Evidence for an aldosterone biosynthetic defect in congenital adrenal hyperplasia. The Journal of clinical endocrinology and metabolism. 1980 Dec; 51(6):1346-53. doi: 10.1210/jcem-51-6-1346. [PMID: 7440699]