ST 18:4;O2 (BioDeep_00000637481)

   


代谢物信息卡片


estra-1,3,5(10),7-tetraene-3,17alpha-diol

化学式: C18H22O2 (270.1619712)
中文名称: 17α-Dihydro Equilin
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2C3=CC[C@]4(C)C(=O)CC[C@@]4([H])C3=CC=C2C[C@H](O)C1
InChI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16-17,19-20H,2,6-9H2,1H3/t14-,16+,17-,18+/m1/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

3 个代谢物同义名

estra-1,3,5(10),7-tetraene-3,17alpha-diol; ST 18:4;O2; 3beta-hydroxy-estra-5,7,9-trien-17-one



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bhagu R Bhavnani, Mauricio Berco, Julie Binkley. Equine estrogens differentially prevent neuronal cell death induced by glutamate. Journal of the Society for Gynecologic Investigation. 2003 Jul; 10(5):302-8. doi: 10.1016/s1071-5576(03)00087-x. [PMID: 12853093]
  • Bhagu R Bhavnani, Anthony Cecutti, Alan Gerulath. Pharmacokinetics of 17 beta-dihydroequilin sulfate in normal postmenopausal women under steady state conditions. Journal of the Society for Gynecologic Investigation. 2002 Mar; 9(2):102-10. doi: 10.1016/s1071-5576(01)00154-x. [PMID: 12398033]
  • S B Lima, I T Verreschi, L M Ribeiro Neto. Reversed-phase liquid chromatographic method for estrogen determination in equine biological samples. Journal of chromatographic science. 2001 Sep; 39(9):385-7. doi: 10.1093/chromsci/39.9.385. [PMID: 11565948]
  • B R Bhavnani, J A Nisker, J Martin, F Aletebi, L Watson, J K Milne. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. Journal of the Society for Gynecologic Investigation. 2000 May; 7(3):175-83. doi: 10.1016/s1071-5576(00)00049-6. [PMID: 10865186]
  • E Arteaga, P Villaseca. Pharmacokinetic comparison between Conpremin (Premarin) and a generic preparation of conjugated estrogens. Climacteric : the journal of the International Menopause Society. 1998 Dec; 1(4):284-9. doi: 10.3109/13697139809085556. [PMID: 11907935]
  • J G Wilcox, F Z Stanczyk, R S Morris, E Gentzschein, R A Lobo. Biologic effects of 17 alpha-dihydroequilin sulfate. Fertility and sterility. 1996 Nov; 66(5):748-52. doi: 10.1016/s0015-0282(16)58629-4. [PMID: 8893678]
  • S A Washburn, E K Honoré, J M Cline, M Helman, J D Wagner, S J Adelman, T B Clarkson. Effects of 17 alpha-dihydroequilenin sulfate on atherosclerotic male and female rhesus monkeys. American journal of obstetrics and gynecology. 1996 Aug; 175(2):341-9; discussion 349. doi: 10.1016/s0002-9378(96)70144-8. [PMID: 8765251]
  • M Tang, W Abplanalp, S Ayres, M T Subbiah. Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation. Metabolism: clinical and experimental. 1996 Apr; 45(4):411-4. doi: 10.1016/s0026-0495(96)90212-7. [PMID: 8609824]
  • A Chandrasekaran, M Osman, S J Adelman, J Warsheski, J Scatina, S F Sisenwine. Determination of 17 alpha-dihydroequilenin in rat, rabbit and monkey plasma by high-performance liquid chromatography with fluorimetric detection. Journal of chromatography. B, Biomedical applications. 1996 Feb; 676(1):69-75. doi: 10.1016/0378-4347(95)00407-6. [PMID: 8852046]
  • B R Bhavnani, A Cecutti, D Wallace. Metabolism of [3H] 17 beta-dihydroequilin and [3H] 17 beta-dihydroequilin sulfate in normal postmenopausal women. Steroids. 1994 Jun; 59(6):389-94. doi: 10.1016/0039-128x(94)90007-8. [PMID: 7940618]
  • B R Bhavnani, A Cecutti. Pharmacokinetics of 17 beta-dihydroequilin sulfate and 17 beta-dihydroequilin in normal postmenopausal women. The Journal of clinical endocrinology and metabolism. 1994 Jan; 78(1):197-204. doi: 10.1210/jcem.78.1.8288704. [PMID: 8288704]
  • B R Bhavnani, A Cecutti. Metabolic clearance rate of equilin sulfate and its conversion to plasma equilin, conjugated and unconjugated equilenin, 17 beta-dihydroequilin, and 17 beta-dihydroequilenin in normal postmenopausal women and men under steady state conditions. The Journal of clinical endocrinology and metabolism. 1993 Nov; 77(5):1269-74. doi: 10.1210/jcem.77.5.8077320. [PMID: 8077320]
  • S A Washburn, M R Adams, T B Clarkson, S J Adelman. A conjugated equine estrogen with differential effects on uterine weight and plasma cholesterol in the rat. American journal of obstetrics and gynecology. 1993 Aug; 169(2 Pt 1):251-4; discussion 254. doi: 10.1016/0002-9378(93)90072-q. [PMID: 8395768]
  • B R Bhavnani, C A Woolever, D Wallace, C C Pan. Metabolism of [3H]equilin-[35S]sulfate and [3H]equilin sulfate after oral and intravenous administration in normal postmenopausal women and men. The Journal of clinical endocrinology and metabolism. 1989 Apr; 68(4):757-65. doi: 10.1210/jcem-68-4-757. [PMID: 2921309]
  • B R Bhavnani, C A Woolever, H Benoit, T Wong. Pharmacokinetics of equilin and equilin sulfate in normal postmenopausal women and men. The Journal of clinical endocrinology and metabolism. 1983 May; 56(5):1048-56. doi: 10.1210/jcem-56-5-1048. [PMID: 6300173]
  • B R Bhavnani, C A Woolever. In vivo metabolism of [3H]equilin in the pregnant mare. Endocrinology. 1981 Jan; 108(1):232-8. doi: 10.1210/endo-108-1-232. [PMID: 7460819]
  • P N Rao, R H Purdy, P H Moore, J W Goldzieher. Synthesis of new steroid haptens for radioimmunoassay--VI. 3-O-Carboxymethyl ether derivatives of equine estrogens. Highly specific antisera for measurement of equilin and 17 alpha-dihydroequilin in plasma. Journal of steroid biochemistry. 1980 Nov; 13(11):1291-8. doi: 10.1016/0022-4731(80)90089-8. [PMID: 6256584]
  • W L GLEN, R BARBER, H M MCCONKEY, G A GRANT. Isolation of beta-dihydroequilin and alpha-dihydroequilenin from the urine of pregnant mares. Nature. 1956 Apr; 177(4512):753. doi: 10.1038/177753a0. [PMID: 13321954]